TAR syndrome

No Pathway Network information available for TAR syndrome

Pathways in the TAR syndrome SuperPath

#	Name	Source	Genes
1	TAR syndrome	WikiPathways	AKAP10 ANKRD35 BCL2L13 BRF1 CCAR2 CD160 CD247 CD3D CFTR CLCN3 CXCR4 DDIT4 DNM1 EGFR EIF4A3 FARP2 FLT3 FURIN GNRHR2 GPR89A HAMP HDAC2 HJV HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G IFNG ITGA10 ITGB1 LCK MAGOH MET MITD1 MTA1 NFKB1 NHERF1 NUDT17 PDZK1 PDZK1IP1 PEX11B PEX19 PIAS3 POLR3C POLR3F POLR3G POLR3GL PYM1 RBCK1 SIRT1 SLC22A12 SLC22A4 SLC34A3 SLK STAT3 SUMO2 TNFRSF14 TXN UBE2I ZFHX3 (see all 62) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FARP2	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2	Protein Coding	1
2	EIF4A3	Eukaryotic Translation Initiation Factor 4A3	Protein Coding	1
3	SLK	STE20 Like Kinase	Protein Coding	1
4	NHERF1	NHERF Family PDZ Scaffold Protein 1	Protein Coding	1
5	CD247	CD247 Molecule	Protein Coding	1
6	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
7	MTA1	Metastasis Associated 1	Protein Coding	1
8	PEX11B	Peroxisomal Biogenesis Factor 11 Beta	Protein Coding	1
9	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	1
10	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
11	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
12	TXN	Thioredoxin	Protein Coding	1
13	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
14	SLC22A4	Solute Carrier Family 22 Member 4	Protein Coding	1
15	PEX19	Peroxisomal Biogenesis Factor 19	Protein Coding	1
16	HAMP	Hepcidin Antimicrobial Peptide	Protein Coding	1
17	CCAR2	Cell Cycle And Apoptosis Regulator 2	Protein Coding	1
18	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
19	PDZK1	PDZ Domain Containing 1	Protein Coding	1
20	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
21	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
22	ZFHX3	Zinc Finger Homeobox 3	Protein Coding	1
23	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
24	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
25	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
26	IFNG	Interferon Gamma	Protein Coding	1
27	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	1
28	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	1
29	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	1
30	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
31	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
32	HDAC2	Histone Deacetylase 2	Protein Coding	1
33	BRF1	BRF1 General Transcription Factor IIIB Subunit	Protein Coding	1
34	SIRT1	Sirtuin 1	Protein Coding	1
35	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
36	NUDT17	Nudix Hydrolase 17	Protein Coding	1
37	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
38	DNM1	Dynamin 1	Protein Coding	1
39	HJV	Hemojuvelin BMP Co-Receptor	Protein Coding	1
40	SLC34A3	Solute Carrier Family 34 Member 3	Protein Coding	1
41	CLCN3	Chloride Voltage-Gated Channel 3	Protein Coding	1
42	SLC22A12	Solute Carrier Family 22 Member 12	Protein Coding	1
43	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
44	RBCK1	RANBP2-Type And C3HC4-Type Zinc Finger Containing 1	Protein Coding	1
45	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
46	PDZK1IP1	PDZK1 Interacting Protein 1	Protein Coding	1
47	ANKRD35	Ankyrin Repeat Domain 35	Protein Coding	1
48	ITGA10	Integrin Subunit Alpha 10	Protein Coding	1
49	PYM1	PYM1 Exon Junction Complex Associated Factor	Protein Coding	1
50	POLR3GL	RNA Polymerase III Subunit GL	Protein Coding	1
51	MITD1	Microtubule Interacting And Trafficking Domain Containing 1	Protein Coding	1
52	GNRHR2	Gonadotropin Releasing Hormone Receptor 2 (Pseudogene)	Pseudogene	1
53	AKAP10	A-Kinase Anchoring Protein 10	Protein Coding	1
54	CD160	CD160 Molecule	Protein Coding	1
55	POLR3C	RNA Polymerase III Subunit C	Protein Coding	1
56	POLR3G	RNA Polymerase III Subunit G	Protein Coding	1
57	POLR3F	RNA Polymerase III Subunit F	Protein Coding	1
58	SUMO2	Small Ubiquitin Like Modifier 2	Protein Coding	1
59	GPR89A	G Protein-Coupled Receptor 89A	Protein Coding	1
60	MAGOH	Mago Homolog, Exon Junction Complex Subunit	Protein Coding	1
61	HLA-F	Major Histocompatibility Complex, Class I, F	Protein Coding	1
62	BCL2L13	BCL2 Like 13	Protein Coding	1

Disorders associated with TAR syndrome SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe cutaneous adverse reaction	Enrichment	HLA-A, HLA-B	4.69
2	Hjv or hamp-related hemochromatosis	Enrichment	HAMP, HJV	4.69
3	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D	4.21
4	Digenic hemochromatosis	Enrichment	HAMP, HJV	3.91
5	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3, HLA-C	3.37
6	Severe combined immunodeficiency	Enrichment	CD247, CD3D, LCK	3.35
7	Hemochromatosis, type 1	Enrichment	HAMP, HJV	3.25
8	Neonatal adrenoleukodystrophy	Enrichment	PEX11B, PEX19	2.81
9	Peroxisome biogenesis disorder 1b	Enrichment	PEX11B, PEX19	2.68
10	Zellweger syndrome	Enrichment	PEX11B, PEX19	2.68
11	Human immunodeficiency virus type 1	Enrichment	HLA-C, IFNG	2.52
12	Spondyloarthropathy 1	Enrichment	HLA-B	2.34
13	Hypouricemia, renal, 1	Enrichment	SLC22A12	2.34
14	Robin sequence with cleft mandible and limb anomalies	Enrichment	EIF4A3	2.34
15	Nephrolithiasis/osteoporosis, hypophosphatemic, 2	Enrichment	NHERF1	2.34
16	Psoriasis 1	Enrichment	HLA-C	2.34
17	Polyglucosan body myopathy 1 with or without immunodeficiency	Enrichment	RBCK1	2.34
18	Peroxisome biogenesis disorder 12a	Enrichment	PEX19	2.34
19	Peroxisome biogenesis disorder 14b	Enrichment	PEX11B	2.34
20	Whim syndrome 1	Enrichment	CXCR4	2.34
21	Cerebellofaciodental syndrome	Enrichment	BRF1	2.34
22	Neurodevelopmental disorder with seizures and brain abnormalities	Enrichment	CLCN3	2.34
23	Immunodeficiency 69	Enrichment	IFNG	2.34
24	Hemochromatosis, type 2a	Enrichment	HJV	2.34
25	Osteofibrous dysplasia	Enrichment	MET	2.34
26	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.34
27	Immunodeficiency 101	Enrichment	POLR3F	2.34
28	Ankylosing spondylitis 1	Enrichment	HLA-B	2.34
29	Deafness, autosomal recessive 97	Enrichment	MET	2.34
30	Immunodeficiency 25	Enrichment	CD247	2.34
31	Atrial fibrillation, familial, 8	Enrichment	ZFHX3	2.34
32	Birdshot chorioretinopathy	Enrichment	HLA-A	2.34
33	Autism 9	Enrichment	MET	2.34
34	Hemochromatosis, type 2b	Enrichment	HAMP	2.34
35	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.34
36	Reactive arthritis	Enrichment	HLA-B	2.34
37	Immunodeficiency 22	Enrichment	LCK	2.34
38	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.34
39	Neurodevelopmental disorder with hypotonia and brain abnormalities	Enrichment	CLCN3	2.34
40	Autosomal recessive hypophosphatemic bone disease	Enrichment	SLC34A3	2.34
41	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.34
42	Arthrogryposis, distal, type 11	Enrichment	MET	2.34
43	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.34
44	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.34
45	Inner ear disease	Enrichment	BRF1	2.34
46	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.34
47	Immunodeficiency 19	Enrichment	CD3D	2.34
48	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.34
49	Severe covid-19	Enrichment	HLA-A, RBCK1	2.11
50	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.04
51	Lipoyltransferase 1 deficiency	Enrichment	MITD1	2.04
52	Hypophosphatemic rickets with hypercalciuria, hereditary	Enrichment	SLC34A3	2.04
53	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.04
54	Short stature, oligodontia, dysmorphic facies, and motor delay	Enrichment	POLR3GL	2.04
55	Hypophosphatemia	Enrichment	NHERF1	2.04
56	Childhood hepatocellular carcinoma	Enrichment	MET	2.04
57	Stevens-johnson syndrome	Enrichment	HLA-B	2.04
58	Nephrolithiasis/osteoporosis, hypophosphatemic, 1	Enrichment	SLC34A3	2.04
59	Papillary renal cell carcinoma	Enrichment	MET	2.04
60	Familial renal hypouricemia	Enrichment	SLC22A12	2.04
61	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.04
62	Hyperostosis	Enrichment	POLR3GL	2.04
63	Hemochromatosis type 2	Enrichment	HJV	2.04
64	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.04
65	Dominant hypophosphatemia with nephrolithiasis or osteoporosis	Enrichment	NHERF1	2.04
66	Common variable immunodeficiency 12	Enrichment	NFKB1	2.04
67	Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Enrichment	RBCK1	2.04
68	Lung cancer	Enrichment	EGFR, MET	2.03
69	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.86
70	Glycogen storage disease iv	Enrichment	RBCK1	1.86
71	Takayasu arteritis	Enrichment	HLA-B	1.86
72	Tuberous sclerosis 1	Enrichment	IFNG	1.86
73	Spinocerebellar ataxia 4	Enrichment	ZFHX3	1.86
74	Nuchal bleb, familial	Enrichment	CFTR	1.86
75	Hepatitis c virus	Enrichment	IFNG	1.86
76	Tuberous sclerosis 2	Enrichment	IFNG	1.86
77	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.86
78	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.86
79	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.86
80	Hyper ige syndrome	Enrichment	STAT3	1.86
81	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.86
82	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.86
83	Renal cell carcinoma	Enrichment	MET	1.86
84	Temporal arteritis	Enrichment	HLA-B	1.74
85	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.74
86	Idiopathic bronchiectasis	Enrichment	CFTR	1.74
87	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3	1.74
88	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.64
89	Acute myeloid leukemia with maturation	Enrichment	FLT3	1.64
90	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3	1.64
91	Idiopathic aplastic anemia	Enrichment	IFNG	1.64
92	Cowden syndrome 1	Enrichment	EGFR	1.57
93	Lung squamous cell carcinoma	Enrichment	EGFR	1.57
94	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.50
95	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.50
96	Common variable immunodeficiency	Enrichment	NFKB1	1.50
97	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.50
98	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.50
99	Arthrogryposis, distal, type 1a	Enrichment	MET	1.44
100	Lennox-gastaut syndrome	Enrichment	DNM1	1.44
101	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.44
102	Zellweger spectrum disorder	Enrichment	PEX19	1.44
103	Rheumatoid arthritis	Enrichment	SLC22A4	1.39
104	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.39
105	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.39
106	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.39
107	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.35
108	Aplastic anemia	Enrichment	IFNG	1.35
109	Optic nerve disease	Enrichment	MITD1	1.35
110	Nephrolithiasis	Enrichment	NHERF1	1.35
111	Asthma	Enrichment	HLA-G	1.31
112	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.31
113	Lung non-small cell carcinoma	Enrichment	EGFR	1.31
114	Lip and oral cavity carcinoma	Enrichment	EGFR	1.27
115	Neural tube defects	Enrichment	ITGB1	1.24
116	Acute promyelocytic leukemia	Enrichment	STAT3	1.24
117	Stereotypic movement disorder	Enrichment	DNM1	1.24
118	Colorectal cancer	Enrichment	BRF1, MET	1.22
119	Lung cancer susceptibility 3	Enrichment	EGFR	1.21
120	Hereditary chronic pancreatitis	Enrichment	CFTR	1.21
121	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.18
122	Lynch syndrome	Enrichment	CFTR	1.18
123	Gliosarcoma	Enrichment	EGFR	1.15
124	Isolated congenital microcephaly	Enrichment	BRF1	1.15
125	Pancreatitis, hereditary	Enrichment	CFTR	1.13
126	Giant cell glioblastoma	Enrichment	EGFR	1.13
127	Ovarian cancer	Enrichment	EGFR, MET	1.11
128	Heart, malformation of	Enrichment	BRF1	1.10
129	Arteriovenous malformations of the brain	Enrichment	EGFR	1.08
130	Behcet syndrome	Enrichment	HLA-B	1.08
131	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.08
132	Hepatocellular carcinoma	Enrichment	MET	1.02
133	Tooth agenesis	Enrichment	POLR3GL	1.02
134	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.00
135	Inherited cancer-predisposing syndrome	Enrichment	EGFR, MET	0.91
136	Bladder cancer	Enrichment	EGFR	0.90
137	Prostate cancer	Enrichment	ZFHX3	0.90
138	Cystic fibrosis	Enrichment	CFTR	0.86
139	Male infertility	Enrichment	CFTR	0.84
140	Leukemia, acute myeloid	Enrichment	FLT3	0.78
141	West syndrome	Enrichment	DNM1	0.74
142	Sensorineural hearing loss	Enrichment	BRF1	0.70
143	Myeloma, multiple	Enrichment	FLT3	0.64
144	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.64
145	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.64
146	Leigh disease	Enrichment	MITD1	0.53
147	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.47
148	Complex neurodevelopmental disorder	Enrichment	CLCN3	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TAR syndrome

Pathway Network for TAR syndrome

Member Pathways for TAR syndrome

Pathways in the TAR syndrome SuperPath

Associated Genes for TAR syndrome

Associated Disorders for TAR syndrome

Disorders associated with TAR syndrome SuperPath

STRING Interaction Network for TAR syndrome

Sources for TAR syndrome