TCA cycle in senescence

No Pathway Network information available for TCA cycle in senescence

Pathways in the TCA cycle in senescence SuperPath

#	Name	Source	Genes
1	TCA cycle in senescence	WikiPathways	BRAF FH GOT1 MDH1 ME1 ME2 PDHA1 PDK1 PDP2 TP53 (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ME2	Malic Enzyme 2	Protein Coding	1
2	TP53	Tumor Protein P53	Protein Coding	1
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
4	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
5	ME1	Malic Enzyme 1	Protein Coding	1
6	MDH1	Malate Dehydrogenase 1	Protein Coding	1
7	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	1
8	FH	Fumarate Hydratase	Protein Coding	1
9	PDP2	Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2	Protein Coding	1
10	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1

Disorders associated with TCA cycle in senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	5.53
2	Gallbladder cancer	Enrichment	BRAF, TP53	4.99
3	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	4.86
4	Primary hyperaldosteronism	Enrichment	BRAF, TP53	4.76
5	Lip and oral cavity carcinoma	Enrichment	BRAF, TP53	4.49
6	Lung cancer susceptibility 3	Enrichment	BRAF, TP53	4.35
7	Diffuse large b-cell lymphoma	Enrichment	BRAF, TP53	4.08
8	Hepatocellular carcinoma	Enrichment	FH, TP53	3.95
9	Hereditary leiomyomatosis and renal cell cancer	Enrichment	FH	3.13
10	Fumarase deficiency	Enrichment	FH	3.13
11	Noonan syndrome 7	Enrichment	BRAF	3.13
12	Leopard syndrome 3	Enrichment	BRAF	3.13
13	Bone marrow failure syndrome 5	Enrichment	TP53	3.13
14	Papilloma of choroid plexus	Enrichment	TP53	3.13
15	Basal cell carcinoma 7	Enrichment	TP53	3.13
16	Anaplastic thyroid carcinoma	Enrichment	TP53	3.13
17	Lymphangioma	Enrichment	BRAF	3.13
18	Leiomyoma cutis	Enrichment	FH	3.13
19	Phace association	Enrichment	BRAF	3.13
20	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	3.13
21	Ductal carcinoma in situ	Enrichment	TP53	3.13
22	Fumarate hydratase deficiency	Enrichment	FH	3.13
23	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.13
24	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.13
25	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.13
26	Choroid plexus cancer	Enrichment	TP53	3.13
27	Syringocystadenoma papilliferum	Enrichment	BRAF	3.13
28	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.13
29	Ganglioglioma	Enrichment	BRAF	3.13
30	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.13
31	Phace syndrome	Enrichment	BRAF	3.13
32	Classic hairy cell leukemia	Enrichment	BRAF	3.13
33	Myeloma, multiple	Enrichment	BRAF, TP53	3.13
34	Leiomyoma, uterine	Enrichment	FH	2.83
35	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.83
36	Cervical cancer	Enrichment	TP53	2.83
37	Pulmonic stenosis	Enrichment	BRAF	2.83
38	Lymphoma, hodgkin, classic	Enrichment	TP53	2.83
39	Developmental and epileptic encephalopathy 88	Enrichment	MDH1	2.83
40	Congenital fibrosarcoma	Enrichment	TP53	2.83
41	Li-fraumeni syndrome 1	Enrichment	TP53	2.83
42	Sarcoma	Enrichment	TP53	2.83
43	Cervix carcinoma	Enrichment	TP53	2.83
44	Hodgkin's lymphoma	Enrichment	TP53	2.83
45	Spinocerebellar ataxia 45	Enrichment	FH	2.83
46	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.83
47	Colorectal cancer	Enrichment	BRAF, TP53	2.75
48	Ataxia-telangiectasia	Enrichment	BRAF	2.66
49	Langerhans cell histiocytosis	Enrichment	BRAF	2.66
50	Osteogenic sarcoma	Enrichment	TP53	2.66
51	Nasopharyngeal carcinoma	Enrichment	TP53	2.66
52	Tethered spinal cord syndrome	Enrichment	BRAF	2.66
53	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.66
54	Anaplastic astrocytoma	Enrichment	TP53	2.66
55	Squamous cell carcinoma	Enrichment	TP53	2.66
56	Adenocarcinoma	Enrichment	TP53	2.66
57	Bone osteosarcoma	Enrichment	TP53	2.66
58	Ovarian cancer	Enrichment	FH, TP53	2.62
59	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	2.53
60	Small cell cancer of the lung	Enrichment	TP53	2.53
61	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1	2.53
62	Cardiofaciocutaneous syndrome	Enrichment	BRAF	2.53
63	Lung sarcomatoid carcinoma	Enrichment	TP53	2.53
64	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.53
65	Craniopharyngioma	Enrichment	BRAF	2.53
66	Noonan syndrome with multiple lentigines	Enrichment	BRAF	2.53
67	Newborn respiratory distress syndrome	Enrichment	BRAF	2.53
68	Rhabdomyosarcoma 2	Enrichment	TP53	2.43
69	Lymphoma	Enrichment	TP53	2.43
70	Acute megakaryocytic leukemia	Enrichment	TP53	2.43
71	Inherited cancer-predisposing syndrome	Enrichment	FH, TP53	2.40
72	Li-fraumeni syndrome	Enrichment	TP53	2.35
73	Wilms tumor 5	Enrichment	BRAF	2.35
74	Adrenocortical carcinoma	Enrichment	TP53	2.35
75	Breast adenocarcinoma	Enrichment	TP53	2.35
76	Esophageal cancer	Enrichment	TP53	2.29
77	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	2.29
78	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.29
79	Essential thrombocythemia	Enrichment	TP53	2.29
80	Pilomyxoid astrocytoma	Enrichment	BRAF	2.29
81	Follicular thyroid carcinoma	Enrichment	BRAF	2.29
82	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.29
83	Melanocytic nevus syndrome, congenital	Enrichment	BRAF	2.23
84	Glioma susceptibility 1	Enrichment	TP53	2.23
85	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.18
86	Adult hepatocellular carcinoma	Enrichment	TP53	2.18
87	Ventricular septal defect	Enrichment	BRAF	2.18
88	Leukemia, chronic lymphocytic	Enrichment	TP53	2.13
89	Melanoma	Enrichment	BRAF	2.13
90	Familial colorectal cancer	Enrichment	TP53	2.13
91	Myelodysplastic syndrome	Enrichment	TP53	2.09
92	Lung non-small cell carcinoma	Enrichment	BRAF	2.09
93	Wilms tumor 1	Enrichment	BRAF	1.96
94	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF	1.96
95	Rhabdomyosarcoma	Enrichment	TP53	1.93
96	Gliosarcoma	Enrichment	TP53	1.93
97	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.90
98	Dandy-walker syndrome	Enrichment	BRAF	1.90
99	Sudden infant death syndrome	Enrichment	PDHA1	1.90
100	Giant cell glioblastoma	Enrichment	TP53	1.90
101	Arteriovenous malformations of the brain	Enrichment	BRAF	1.86
102	Hepatoblastoma	Enrichment	TP53	1.81
103	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	FH	1.81
104	Diamond-blackfan anemia 1	Enrichment	TP53	1.77
105	Noonan syndrome 1	Enrichment	BRAF	1.77
106	Pancreatic cancer	Enrichment	TP53	1.74
107	Rasopathy	Enrichment	BRAF	1.72
108	Bladder cancer	Enrichment	TP53	1.67
109	Prostate cancer	Enrichment	TP53	1.67
110	Differentiated thyroid carcinoma	Enrichment	BRAF	1.67
111	Lung cancer	Enrichment	BRAF	1.63
112	Diamond-blackfan anemia	Enrichment	TP53	1.58
113	Leukemia, acute myeloid	Enrichment	TP53	1.54
114	Gastric cancer	Enrichment	TP53	1.50
115	Hereditary breast carcinoma	Enrichment	TP53	1.50
116	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.40
117	Breast cancer	Enrichment	TP53	1.27
118	Dilated cardiomyopathy	Enrichment	BRAF	1.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TCA cycle in senescence

Pathway Network for TCA cycle in senescence

Member Pathways for TCA cycle in senescence

Pathways in the TCA cycle in senescence SuperPath

Associated Genes for TCA cycle in senescence

Associated Disorders for TCA cycle in senescence

Disorders associated with TCA cycle in senescence SuperPath

STRING Interaction Network for TCA cycle in senescence

Sources for TCA cycle in senescence