TCR Signaling (Qiagen)

Pathway network for the TCR Signaling (Qiagen) SuperPath

Sources:

QIAGEN

Pathways in the TCR Signaling (Qiagen) SuperPath

#	Name	Source	Genes
1	TCR Signaling	QIAGEN	AKT1 AKT2 AKT3 ATF2 BCL10 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 CARD11 CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CD8A CDC42 CHUK CSK CTLA4 DUSP3 ELK1 FYB1 FYN GNAL GRAP2 GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HRAS IKBKB IKBKE IKBKG ITK ITPR1 ITPR2 ITPR3 JUN KRAS LAT LCK LCP2 MALT1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NRAS PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCQ PTPRC RAC1 RAC2 RAC3 RAF1 RRAS RRAS2 SOS1 SOS2 SRF TRAT1 VAV1 VAV2 VAV3 ZAP70 (see all 144) (see less)
2	ITK and TCR Signaling	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ACTR2 ACTR3 ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF7 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CD247 CD3D CD3E CD3G CD4 CDC42 FOS FOSB FOSL1 FOSL2 FYB1 FYN GNAL GRAP2 GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ITK ITPR1 ITPR2 ITPR3 JUN JUNB JUND LAT LCK LCP2 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NCK1 NCK2 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAC1 RAC2 RAC3 RASGRP1 RASGRP2 RASGRP3 SOS1 SOS2 VAV1 VAV2 VAV3 WAS ZAP70 (see all 129) (see less)
3	PKC-Theta Pathway	QIAGEN	BCL10 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CAMK2A CAMK2B CAMK2D CAMK2G CARD10 CARD11 CARD14 CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CD8A CHUK FOS FYN GNAL GRAP2 GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HRAS IKBKB IKBKE IKBKG JUN KRAS LAT LCK LCP2 MALT1 MAP2K4 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAPK10 MAPK8 MAPK9 MRAS NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 POU2F1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCQ RAC1 RAC2 RAC3 RRAS RRAS2 SOS1 SOS2 VAV1 VAV2 VAV3 ZAP70 (see all 117) (see less)
4	PDGF Pathway	QIAGEN	ARFIP2 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CDC42 CHUK ELK1 FOS GRB2 HRAS IKBKB IKBKE IKBKG JAK1 JAK2 JAK3 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MRAS NFKB1 NFKBIA NFKBIB NFKBIE NRAS PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLA2G1B PLA2G2A PLCG1 PLCG2 PTGS2 RAC1 RAF1 RASA1 RHOA RRAS RRAS2 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A6 SOS1 SOS2 SRC SRF STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TIAM1 VAV1 VAV2 WASL (see all 106) (see less)
5	Fc-EpsilonRI Pathway	QIAGEN	ATF2 BTK CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 ELK1 FCER1A FCER1G FOS GRB2 HRAS ITPR1 ITPR2 ITPR3 JUN KRAS LAT LCP2 LYN MAP2K1 MAP2K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NRAS PAK2 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G5 PLA2G6 PLA2G7 PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 RAC1 RAC2 RAC3 RAF1 RRAS RRAS2 SOS1 SOS2 SYK VAV1 VAV2 VAV3 (see all 102) (see less)

Gene overlap in member pathways for TCR Signaling (Qiagen) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	5
2	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	5
3	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	5
4	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	5
5	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	5
6	CACNA1F	Calcium Voltage-Gated Channel Subunit Alpha1 F	Protein Coding	5
7	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	5
8	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	5
9	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	5
10	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	5
11	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	5
12	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	5
13	CACNA2D3	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3	Protein Coding	5
14	CACNA2D4	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4	Protein Coding	5
15	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	5
16	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	5
17	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	5
18	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	5
19	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	5
20	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	5
21	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	5
22	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	5
23	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	5
24	CACNG6	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 6	Protein Coding	5
25	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	5
26	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	5
27	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	5
28	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
29	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	5
30	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	5
31	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	5
32	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	5
33	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5
34	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	5
35	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	5
36	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	5
37	PLCG1	Phospholipase C Gamma 1	Protein Coding	5
38	RAC1	Rac Family Small GTPase 1	Protein Coding	5
39	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	5
40	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	5
41	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	5
42	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	5
43	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
44	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4
45	LAT	Linker For Activation Of T Cells	Protein Coding	4
46	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	4
47	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	4
48	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
49	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	4
50	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	4
51	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	4
52	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	4
53	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	4
54	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	4
55	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	4
56	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	4
57	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	4
58	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	4
59	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	4
60	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	4
61	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	4
62	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	4
63	RAC2	Rac Family Small GTPase 2	Protein Coding	4
64	RAC3	Rac Family Small GTPase 3	Protein Coding	4
65	RRAS	RAS Related	Protein Coding	4
66	RRAS2	RAS Related 2	Protein Coding	4
67	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	4
68	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
69	ATF2	Activating Transcription Factor 2	Protein Coding	3
70	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	3
71	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	3
72	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	3
73	CD247	CD247 Molecule	Protein Coding	3
74	CD4	CD4 Molecule	Protein Coding	3
75	CDC42	Cell Division Cycle 42	Protein Coding	3
76	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
77	ELK1	ETS Transcription Factor ELK1	Protein Coding	3
78	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
79	GNAL	G Protein Subunit Alpha L	Protein Coding	3
80	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	3
81	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	3
82	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	3
83	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	3
84	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	3
85	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	3
86	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	3
87	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	3
88	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	3
89	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	3
90	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	3
91	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	3
92	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	3
93	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	3
94	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
95	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
96	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
97	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
98	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
99	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
100	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
101	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
102	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	3
103	PRKCQ	Protein Kinase C Theta	Protein Coding	3
104	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
105	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	3
106	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
107	NFKBIB	NFKB Inhibitor Beta	Protein Coding	3
108	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	3
109	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	2
110	CALM1	Calmodulin 1	Protein Coding	2
111	CALM2	Calmodulin 2	Protein Coding	2
112	CALM3	Calmodulin 3	Protein Coding	2
113	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	2
114	CD28	CD28 Molecule	Protein Coding	2
115	CD80	CD80 Molecule	Protein Coding	2
116	CD86	CD86 Molecule	Protein Coding	2
117	CD8A	CD8 Subunit Alpha	Protein Coding	2
118	FYB1	FYN Binding Protein 1	Protein Coding	2
119	ITK	IL2 Inducible T Cell Kinase	Protein Coding	2
120	MALT1	MALT1 Paracaspase	Protein Coding	2
121	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
122	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
123	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
124	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
125	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	2
126	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	2
127	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
128	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
129	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	2
130	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
131	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
132	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
133	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
134	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
135	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
136	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
137	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	2
138	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	2
139	SRF	Serum Response Factor	Protein Coding	2
140	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	2
141	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	2
142	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
143	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
144	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
145	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
146	CSK	C-Terminal Src Kinase	Protein Coding	1
147	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
148	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	1
149	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
150	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
151	TRAT1	T Cell Receptor Associated Transmembrane Adaptor 1	Protein Coding	1
152	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
153	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
154	ACTB	Actin Beta	Protein Coding	1
155	ACTG1	Actin Gamma 1	Protein Coding	1
156	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
157	ACTR2	Actin Related Protein 2	Protein Coding	1
158	ACTR3	Actin Related Protein 3	Protein Coding	1
159	ATF1	Activating Transcription Factor 1	Protein Coding	1
160	ATF3	Activating Transcription Factor 3	Protein Coding	1
161	ATF4	Activating Transcription Factor 4	Protein Coding	1
162	ATF5	Activating Transcription Factor 5	Protein Coding	1
163	ATF6	Activating Transcription Factor 6	Protein Coding	1
164	ATF7	Activating Transcription Factor 7	Protein Coding	1
165	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
166	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
167	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
168	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
169	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
170	NCK1	NCK Adaptor Protein 1	Protein Coding	1
171	NCK2	NCK Adaptor Protein 2	Protein Coding	1
172	PRKCA	Protein Kinase C Alpha	Protein Coding	1
173	PRKCB	Protein Kinase C Beta	Protein Coding	1
174	PRKCD	Protein Kinase C Delta	Protein Coding	1
175	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
176	PRKCG	Protein Kinase C Gamma	Protein Coding	1
177	PRKCH	Protein Kinase C Eta	Protein Coding	1
178	PRKCI	Protein Kinase C Iota	Protein Coding	1
179	PRKD1	Protein Kinase D1	Protein Coding	1
180	PRKD3	Protein Kinase D3	Protein Coding	1
181	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
182	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
183	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
184	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
185	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
186	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
187	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
188	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
189	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
190	CARD10	Caspase Recruitment Domain Family Member 10	Protein Coding	1
191	CARD14	Caspase Recruitment Domain Family Member 14	Protein Coding	1
192	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
193	ARFIP2	ARF Interacting Protein 2	Protein Coding	1
194	RHOA	Ras Homolog Family Member A	Protein Coding	1
195	JAK1	Janus Kinase 1	Protein Coding	1
196	JAK2	Janus Kinase 2	Protein Coding	1
197	JAK3	Janus Kinase 3	Protein Coding	1
198	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
199	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
200	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
201	PDGFC	Platelet Derived Growth Factor C	Protein Coding	1
202	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
203	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
204	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
205	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
206	PDGFD	Platelet Derived Growth Factor D	Protein Coding	1
207	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
208	SLC9A2	Solute Carrier Family 9 Member A2	Protein Coding	1
209	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	1
210	SLC9A4	Solute Carrier Family 9 Member A4	Protein Coding	1
211	SLC9A6	Solute Carrier Family 9 Member A6	Protein Coding	1
212	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
213	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
214	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
215	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
216	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
217	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
218	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
219	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
220	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
221	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
222	BTK	Bruton Tyrosine Kinase	Protein Coding	1
223	FCER1A	Fc Epsilon Receptor Ia	Protein Coding	1
224	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	1
225	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
226	PLA2G10	Phospholipase A2 Group X	Protein Coding	1
227	PLA2G12A	Phospholipase A2 Group XIIA	Protein Coding	1
228	PLA2G12B	Phospholipase A2 Group XIIB	Protein Coding	1
229	PLA2G2D	Phospholipase A2 Group IID	Protein Coding	1
230	PLA2G2E	Phospholipase A2 Group IIE	Protein Coding	1
231	PLA2G2F	Phospholipase A2 Group IIF	Protein Coding	1
232	PLA2G3	Phospholipase A2 Group III	Protein Coding	1
233	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
234	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
235	PLA2G5	Phospholipase A2 Group V	Protein Coding	1
236	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
237	PLA2G7	Phospholipase A2 Group VII	Protein Coding	1
238	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1

Disorders associated with TCR Signaling (Qiagen) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.66
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.52
4	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB, LCK, MALT1, PTPRC, ZAP70	10.26
5	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	6.98
6	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.33
7	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.20
8	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS	6.02
9	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.78
10	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.73
11	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.73
12	Long qt syndrome 1	Enrichment	CACNA1C, CALM1, CALM2, CALM3, ITPR3	5.57
13	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.85
14	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, RASA1	4.80
15	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.65
16	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.65
17	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, RASA1	4.42
18	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, RASA1	4.27
19	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.25
20	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.22
21	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNA1I, CACNG2, CAMK2A, CAMK2B, PPP3CA	4.17
22	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	4.13
23	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	4.13
24	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	4.13
25	Long qt syndrome	Enrichment	CACNA1C, CACNA1S, CALM1, CALM2	4.09
26	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.06
27	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.05
28	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.78
29	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	3.78
30	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.78
31	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1, ITPR1	3.55
32	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.48
33	Mycosis fungoides	Enrichment	CD28, CTLA4	3.48
34	Adult-onset myasthenia gravis	Enrichment	CTLA4, HLA-DQA1	3.48
35	Saczary syndrome	Enrichment	CD28, CTLA4	3.48
36	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS, MAP3K6	3.36
37	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	3.36
38	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB, FOSB	3.27
39	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	3.22
40	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.18
41	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.18
42	Spastic ataxia	Enrichment	CACNA1G, CACNB4, ITPR1, PLA2G6	3.18
43	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	3.14
44	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	3.14
45	Follicular lymphoma	Enrichment	BCL10, HLA-DRB1	3.14
46	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B, CACNA2D1, PPP3CA	3.09
47	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.06
48	Brugada syndrome	Enrichment	CACNA1C, CACNA2D1, CACNB2	3.02
49	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.94
50	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.94
51	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.94
52	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.94
53	Myelofibrosis	Enrichment	JAK2, SRC	2.91
54	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.88
55	Lennox-gastaut syndrome	Enrichment	CACNA1A, MAPK10	2.82
56	Granulomatosis with polyangiitis	Enrichment	CTLA4, HLA-DPA1	2.79
57	Breast adenocarcinoma	Enrichment	AKT1, KRAS	2.79
58	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	2.78
59	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C, RAC1	2.71
60	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	2.70
61	Cerebral palsy	Enrichment	CACNA1A, CACNA1C, PDGFRB	2.46
62	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	2.43
63	Combined immunodeficiency	Enrichment	MALT1, ZAP70	2.41
64	Combined t cell and b cell immunodeficiency	Enrichment	MALT1, ZAP70	2.41
65	Combined t and b cell immunodeficiency	Enrichment	MALT1, ZAP70	2.41
66	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	2.35
67	Colorectal cancer	Enrichment	NRAS, PIK3R1, PLA2G2A, SRC	2.32
68	Cone-rod dystrophy 6	Enrichment	CACNA1F, CACNA2D4	2.32
69	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.20
70	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.12
71	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	2.12
72	Oculoectodermal syndrome	Enrichment	KRAS	2.12
73	Noonan syndrome 5	Enrichment	RAF1	2.12
74	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	2.12
75	Noonan syndrome 4	Enrichment	SOS1	2.12
76	Epilepsy, idiopathic generalized 9	Enrichment	CACNB4	2.12
77	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.12
78	Brugada syndrome 4	Enrichment	CACNB2	2.12
79	Melorheostosis, isolated	Enrichment	MAP2K1	2.12
80	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.12
81	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.12
82	Melanosis, neurocutaneous	Enrichment	NRAS	2.12
83	Fleck retina, familial benign	Enrichment	PLA2G5	2.12
84	Noonan syndrome 9	Enrichment	SOS2	2.12
85	Noonan syndrome 6	Enrichment	NRAS	2.12
86	Episodic ataxia, type 5	Enrichment	CACNB4	2.12
87	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.12
88	Noonan syndrome 11	Enrichment	MRAS	2.12
89	Noonan syndrome 13	Enrichment	MAPK1	2.12
90	Immunodeficiency 81	Enrichment	LCP2	2.12
91	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.12
92	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	2.12
93	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.12
94	Neurodevelopmental disorder with speech impairment and with or without seizures	Enrichment	CACNA1I	2.12
95	Knobloch syndrome 2	Enrichment	PAK2	2.12
96	Congenital myopathy 18	Enrichment	CACNA1S	2.12
97	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.12
98	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.12
99	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.12
100	Short syndrome	Enrichment	PIK3R1	2.12
101	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.12
102	Cone-rod dystrophy, x-linked, 3	Enrichment	CACNA1F	2.12
103	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.12
104	Retinal cone dystrophy 4	Enrichment	CACNA2D4	2.12
105	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.12
106	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.12
107	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.12
108	Brugada syndrome 3	Enrichment	CACNA1C	2.12
109	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.12
110	Malignant hyperthermia 5	Enrichment	CACNA1S	2.12
111	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	2.12
112	Melorheostosis	Enrichment	MAP2K1	2.12
113	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	2.12
114	Leopard syndrome 2	Enrichment	RAF1	2.12
115	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	2.12
116	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.12
117	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.12
118	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.12
119	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.12
120	Long qt syndrome 16	Enrichment	CALM3	2.12
121	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.12
122	Spinocerebellar ataxia 42	Enrichment	CACNA1G	2.12
123	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	2.12
124	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.12
125	Platelet-activating factor acetylhydrolase deficiency	Enrichment	PLA2G7	2.12
126	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	2.12
127	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	2.12
128	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.12
129	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.12
130	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.12
131	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.12
132	Trigonitis	Enrichment	RAF1	2.12
133	Long qt syndrome 15	Enrichment	CALM2	2.12
134	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.12
135	Colitis	Enrichment	SYK	2.12
136	Conn's syndrome	Enrichment	CACNA1H	2.12
137	Congenital pulmonary airway malformation	Enrichment	KRAS	2.12
138	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.12
139	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.12
140	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.12
141	Atypical timothy syndrome	Enrichment	CACNA1C	2.12
142	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.12
143	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.12
144	Timothy syndrome type 2	Enrichment	CACNA1C	2.12
145	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.12
146	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	2.12
147	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.12
148	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.12
149	Timothy syndrome type 1	Enrichment	CACNA1C	2.12
150	Familial benign flecked retina	Enrichment	PLA2G5	2.12
151	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.12
152	Neurocutaneous melanocytosis	Enrichment	NRAS	2.12
153	Cacna1c-related disorders	Enrichment	CACNA1C	2.12
154	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.12
155	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.11
156	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.11
157	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.11
158	Incontinentia pigmenti	Enrichment	IKBKG	2.11
159	Intellectual developmental disorder, x-linked, syndromic, christianson type	Enrichment	SLC9A6	2.11
160	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.11
161	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.11
162	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.11
163	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.11
164	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.11
165	Fetal encasement syndrome	Enrichment	CHUK	2.11
166	Gist-plus syndrome	Enrichment	PDGFRA	2.11
167	Immunodeficiency 15b	Enrichment	IKBKB	2.11
168	Pseudo-torch syndrome 3	Enrichment	STAT2	2.11
169	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.11
170	Immunodeficiency 15a	Enrichment	IKBKB	2.11
171	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.11
172	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.11
173	Neurodegenerative disorder, x-linked, female-restricted, with parkinsonism and cognitive impairment	Enrichment	SLC9A6	2.11
174	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.11
175	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.11
176	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.11
177	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.11
178	Systemic lupus erythematosus 11	Enrichment	STAT4	2.11
179	Immunodeficiency 31a	Enrichment	STAT1	2.11
180	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.11
181	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.11
182	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.11
183	Immunodeficiency 31b	Enrichment	STAT1	2.11
184	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.11
185	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.11
186	Thrombocytopenia 6	Enrichment	SRC	2.11
187	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.11
188	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.11
189	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.11
190	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.11
191	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.11
192	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.11
193	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.11
194	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.11
195	Gorham's disease	Enrichment	RASA1	2.11
196	Nocarh syndrome	Enrichment	CDC42	2.11
197	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.11
198	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.11
199	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.11
200	Breast cancer	Enrichment	AKT1, CACNA2D1, JUN, KRAS	2.08
201	Pityriasis rubra pilaris	Enrichment	CARD14	2.06
202	Psoriasis 2	Enrichment	CARD14	2.06
203	Immunodeficiency 116	Enrichment	CD8A	2.06
204	46,xy sex reversal 6	Enrichment	MAP3K1	2.06
205	Immunodeficiency 89 and autoimmunity	Enrichment	CARD10	2.06
206	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.06
207	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.06
208	Immunodeficiency 48	Enrichment	ZAP70	2.06
209	Okt4 epitope deficiency	Enrichment	CD4	2.06
210	Immunodeficiency 18	Enrichment	CD3E	2.06
211	Persistent polyclonal b-cell lymphocytosis	Enrichment	CARD11	2.06
212	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.06
213	Immunodeficiency 25	Enrichment	CD247	2.06
214	Dystonia 25	Enrichment	GNAL	2.06
215	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.06
216	Immunodeficiency 12	Enrichment	MALT1	2.06
217	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.06
218	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.06
219	Immunodeficiency 22	Enrichment	LCK	2.06
220	Immunodeficiency 79	Enrichment	CD4	2.06
221	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.06
222	Sezary's disease	Enrichment	BCL10	2.06
223	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.06
224	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.06
225	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.06
226	Immunodeficiency 19	Enrichment	CD3D	2.06
227	Verrucous hemangioma	Enrichment	MAP3K3	2.06
228	Mucosa-associated lymphoma	Enrichment	BCL10	2.06
229	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.06
230	Baraitser-winter syndrome 1	Enrichment	ACTB	2.02
231	Thrombocytopenia 1	Enrichment	WAS	2.02
232	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.02
233	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.02
234	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.02
235	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.02
236	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.02
237	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.02
238	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.02
239	Thrombocytopenia 3	Enrichment	FYB1	2.02
240	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.02
241	Lymphoproliferative syndrome 1	Enrichment	ITK	2.02
242	Becker nevus syndrome	Enrichment	ACTB	2.02
243	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.02
244	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.02
245	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.02
246	Achromatopsia 7	Enrichment	ATF6	2.02
247	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.02
248	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.02
249	Was-related disorders	Enrichment	WAS	2.02
250	Congenital autosomal recessive small-platelet thrombocytopenia	Enrichment	FYB1	2.02
251	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.02
252	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.02
253	Baraitser-winter syndrome	Enrichment	ACTB	2.02
254	Immunodeficiency 64	Enrichment	RASGRP1	2.02
255	Zebra body myopathy	Enrichment	ACTA1	2.02
256	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.02
257	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.02
258	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.02
259	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.02
260	Actin-accumulation myopathy	Enrichment	ACTA1	2.02
261	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.02
262	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.02
263	Actg2 visceral myopathy	Enrichment	ACTG2	2.02
264	Proteus syndrome	Enrichment	AKT1	1.97
265	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.97
266	Celiac disease 3	Enrichment	CTLA4	1.97
267	Type 1 diabetes mellitus 12	Enrichment	CTLA4	1.97
268	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.97
269	Cowden syndrome 6	Enrichment	AKT1	1.97
270	Immunodeficiency 105, severe combined	Enrichment	PTPRC	1.97
271	Cd45 deficiency	Enrichment	PTPRC	1.97
272	Capillary hemangioma	Enrichment	AKT3	1.97
273	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.97
274	Congenital stationary night blindness	Enrichment	CACNA1F, CACNA2D4	1.89
275	Congenital myopathy	Enrichment	ACTA1, CACNA1S	1.86
276	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C, RAF1	1.86
277	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.82
278	Fibromatosis, gingival, 1	Enrichment	SOS1	1.82
279	Costello syndrome	Enrichment	HRAS	1.82
280	Timothy syndrome	Enrichment	CACNA1C	1.82
281	Night blindness, congenital stationary, type 2a	Enrichment	CACNA1F	1.82
282	Pulmonic stenosis	Enrichment	SOS1	1.82
283	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.82
284	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.82
285	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	1.82
286	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.82
287	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.82
288	Long qt syndrome 14	Enrichment	CALM1	1.82
289	Long qt syndrome 8	Enrichment	CACNA1C	1.82
290	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.82
291	Agammaglobulinemia, x-linked	Enrichment	BTK	1.82
292	Noonan syndrome 12	Enrichment	RRAS2	1.82
293	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	1.82
294	Immunodeficiency 52	Enrichment	LAT	1.82
295	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	1.82
296	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.82
297	Arthritis	Enrichment	SYK	1.82
298	Progressive bulbar palsy	Enrichment	CACNA1A	1.82
299	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	1.82
300	Wooly hair nevus	Enrichment	HRAS	1.82
301	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.81
302	Hemangiopericytoma, malignant	Enrichment	STAT6	1.81
303	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	1.81
304	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.81
305	Immunodeficiency 33	Enrichment	IKBKG	1.81
306	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.81
307	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.81
308	Thrombocythemia 3	Enrichment	JAK2	1.81
309	Immunodeficiency 31c	Enrichment	STAT1	1.81
310	Diarrhea 8, secretory sodium, congenital	Enrichment	SLC9A3	1.81
311	Infantile myofibromatosis	Enrichment	PDGFRB	1.81
312	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.81
313	Immune system disease	Enrichment	CDC42	1.81
314	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.81
315	Polycythemia	Enrichment	JAK2	1.81
316	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.81
317	Hypereosinophilic syndrome	Enrichment	JAK2	1.81
318	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.81
319	Common variable immunodeficiency 12	Enrichment	NFKB1	1.81
320	Tafro syndrome	Enrichment	MAP2K2	1.81
321	Laron syndrome with immunodeficiency	Enrichment	STAT5B	1.81
322	Centronuclear myopathy	Enrichment	ACTA1, CACNA1S	1.78
323	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	1.77
324	Immunodeficiency 11a	Enrichment	CARD11	1.77
325	Sarcoidosis 1	Enrichment	HLA-DRB1	1.77
326	Immunodeficiency 37	Enrichment	BCL10	1.77
327	Immunodeficiency 11b with atopic dermatitis	Enrichment	CARD11	1.77
328	B-cell expansion with nfkb and t-cell anergy	Enrichment	CARD11	1.77
329	Immunodeficiency 17	Enrichment	CD3G	1.77
330	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.72
331	Wiskott-aldrich syndrome	Enrichment	WAS	1.72
332	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.72
333	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.72
334	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.72
335	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.72
336	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.72
337	Moyamoya disease 5	Enrichment	ACTA2	1.72
338	Lymphoproliferative syndrome	Enrichment	ITK	1.72
339	Intestinal obstruction	Enrichment	ACTG2	1.72
340	Bladder cancer	Enrichment	HRAS, KRAS	1.70
341	Hashimoto thyroiditis	Enrichment	CTLA4	1.68
342	Senior-loken syndrome 7	Enrichment	AKT3	1.68
343	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.68
344	Bardet-biedl syndrome 16	Enrichment	AKT3	1.68
345	Van der woude syndrome 1	Enrichment	CACNA1E	1.65
346	Gillespie syndrome	Enrichment	ITPR1	1.65
347	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.65
348	Nuchal bleb, familial	Enrichment	SOS1	1.65
349	Late-onset retinal degeneration	Enrichment	PLA2G5	1.65
350	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.65
351	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.65
352	Agammaglobulinemia 1	Enrichment	BTK	1.65
353	Immunodeficiency 14	Enrichment	PIK3R1	1.65
354	Spermatocytoma	Enrichment	HRAS	1.65
355	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.65
356	Hereditary episodic ataxia	Enrichment	CACNA1A	1.65
357	Ovarian cancer	Enrichment	AKT1, KRAS, MAP3K1, RRAS2	1.65
358	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.65
359	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.63
360	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.63
361	Polycythemia vera	Enrichment	JAK2	1.63
362	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SLC9A3	1.63
363	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.63
364	Hyper ige syndrome	Enrichment	STAT3	1.63
365	Wieacker-wolff syndrome	Enrichment	RASA1	1.63
366	Immunodeficiency 44	Enrichment	STAT2	1.63
367	Mesothelioma, malignant	Enrichment	BCL10	1.59
368	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	1.59
369	Testicular cancer	Enrichment	BCL10	1.59
370	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	1.59
371	Cone-rod dystrophy 2	Enrichment	ATF6, CACNA1F, CACNA2D4	1.57
372	Melanoma of soft tissue	Enrichment	ATF1	1.55
373	Eye disease	Enrichment	CACNA1F, CACNA2D4	1.55
374	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.53
375	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.53
376	Aland island eye disease	Enrichment	CACNA1F	1.53
377	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	1.53
378	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	1.53
379	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.53
380	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.53
381	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.53
382	Congenital generalized lipodystrophy	Enrichment	FOS	1.53
383	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	1.53
384	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	1.53
385	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.53
386	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.53
387	Pilocytic astrocytoma	Enrichment	KRAS	1.53
388	Epidermolytic nevus	Enrichment	HRAS	1.53
389	Malignant hyperthermia	Enrichment	CACNA1S	1.53
390	Episodic ataxia	Enrichment	CACNA1A	1.53
391	Knobloch syndrome	Enrichment	PAK2	1.53
392	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	1.53
393	Gingival fibromatosis	Enrichment	SOS1	1.53
394	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.53
395	Developmental and epileptic encephalopathy	Enrichment	CACNA1E, CACNA2D2	1.52
396	Erythrocytosis, familial, 1	Enrichment	JAK2	1.51
397	Budd-chiari syndrome	Enrichment	JAK2	1.51
398	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.51
399	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.51
400	Adenosine deaminase deficiency	Enrichment	JAK3	1.51
401	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.51
402	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	1.50
403	Asparagine synthetase deficiency	Enrichment	CTLA4	1.50
404	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	1.50
405	Temporal arteritis	Enrichment	HLA-DRB1	1.47
406	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.47
407	Dystonia	Enrichment	CAMK2B, GNAL	1.44
408	Episodic ataxia, type 2	Enrichment	CACNA1A	1.43
409	Knobloch syndrome 1	Enrichment	PAK2	1.43
410	Heart conduction disease	Enrichment	CACNA1C	1.43
411	Amblyopia	Enrichment	CACNA1F	1.43
412	Cardiac arrest	Enrichment	CACNA2D1	1.43
413	Congenital short qt syndrome	Enrichment	CACNA2D1	1.43
414	Nemaline myopathy 2	Enrichment	ACTA1	1.43
415	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.43
416	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.43
417	Aminoacylase 1 deficiency	Enrichment	ACTB	1.43
418	Hereditary ataxia	Enrichment	PRKCG	1.43
419	Intermediate nemaline myopathy	Enrichment	ACTA1	1.43
420	Capillary malformations, congenital	Enrichment	RASA1	1.41
421	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.41
422	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.41
423	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.41
424	Myeloproliferative neoplasm	Enrichment	JAK2	1.41
425	Sleep disorder	Enrichment	SLC9A6	1.41
426	Immunodeficiency, common variable, 1	Enrichment	CTLA4	1.38
427	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.37
428	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	1.35
429	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.35
430	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.35
431	Lung squamous cell carcinoma	Enrichment	KRAS	1.35
432	Childhood absence epilepsy	Enrichment	CACNA1H	1.35
433	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.34
434	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.34
435	Hemihyperplasia, isolated	Enrichment	RHOA	1.34
436	Hemangioma, capillary infantile	Enrichment	RASA1	1.34
437	Basal cell carcinoma 1	Enrichment	RASA1	1.34
438	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.34
439	Visceral myopathy 1	Enrichment	ACTG2	1.33
440	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.33
441	Coloboma of choroid and retina	Enrichment	ACTG1	1.33
442	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.33
443	Glaucoma, primary open angle	Enrichment	CARD10	1.30
444	Mucopolysaccharidosis, type iiia	Enrichment	CARD14	1.30
445	Testicular germ cell tumor	Enrichment	BCL10	1.30
446	Mucopolysaccharidosis iii	Enrichment	CARD14	1.30
447	Limited scleroderma	Enrichment	HLA-DRB1	1.30
448	Brugada syndrome 1	Enrichment	CACNA2D1	1.29
449	Gallbladder cancer	Enrichment	KRAS	1.29
450	Overgrowth syndrome	Enrichment	PIK3R1	1.29
451	Hemimegalencephaly	Enrichment	AKT3	1.28
452	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.27
453	Essential thrombocythemia	Enrichment	JAK2	1.27
454	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.27
455	Common variable immunodeficiency	Enrichment	NFKB1	1.27
456	Oligoarticular juvenile idiopathic arthritis	Enrichment	STAT4	1.27
457	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	STAT4	1.27
458	Moyamoya disease 1	Enrichment	ACTA2	1.25
459	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.25
460	Typical nemaline myopathy	Enrichment	ACTA1	1.25
461	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.23
462	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.23
463	Difference of sex development	Enrichment	CACNA1A	1.23
464	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.22
465	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.22
466	Systemic lupus erythematosus	Enrichment	CTLA4, HLA-DRB1	1.19
467	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.19
468	Primary hyperaldosteronism	Enrichment	CACNA1H	1.18
469	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.18
470	Lymphoma, non-hodgkin, familial	Enrichment	BCL10	1.17
471	Coronary heart disease 5	Enrichment	IKBKG	1.17
472	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.17
473	Megacolon	Enrichment	AKT3	1.14
474	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	1.14
475	Familial colorectal cancer	Enrichment	PLA2G2A	1.14
476	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.14
477	Complex neurodevelopmental disorder	Enrichment	CACNA1C, PAK3, TIAM1	1.14
478	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.12
479	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.12
480	Hereditary breast carcinoma	Enrichment	AKT1, KRAS	1.10
481	Migraine with or without aura 1	Enrichment	CACNA1A	1.10
482	Epilepsy, myoclonic juvenile	Enrichment	CACNB4	1.10
483	Immune deficiency disease	Enrichment	SYK	1.10
484	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.10
485	Specific learning disability	Enrichment	MAPK1	1.10
486	Meningioma, familial	Enrichment	PDGFB	1.08
487	Cardiac conduction defect	Enrichment	CACNA1C	1.06
488	Lip and oral cavity carcinoma	Enrichment	HRAS	1.06
489	Congenital long qt syndrome	Enrichment	ITPR3	1.06
490	Meningioma	Enrichment	PDGFB	1.05
491	Asthma	Enrichment	CARD11	1.04
492	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.04
493	Cat eye syndrome	Enrichment	ACTG1	1.04
494	Stroke, ischemic	Enrichment	PRKCH	1.04
495	Nemaline myopathy	Enrichment	ACTA1	1.04
496	Achromatopsia	Enrichment	ATF6	1.04
497	Cowden syndrome	Enrichment	AKT1	1.04
498	Aortic valve disease 1	Enrichment	SOS1	1.03
499	Protein-deficiency anemia	Enrichment	NRAS	1.03
500	Nk-cell enteropathy	Enrichment	JAK3	1.01
501	Lung cancer susceptibility 3	Enrichment	KRAS	1.00
502	Polymicrogyria	Enrichment	AKT3	0.99
503	Osteoporosis	Enrichment	SRC	0.98
504	Cleft lip/palate	Enrichment	PDGFRA	0.98
505	Myopia	Enrichment	CACNA1F	0.97
506	Anterior segment dysgenesis	Enrichment	ITPR1	0.97
507	Lynch syndrome	Enrichment	KRAS	0.97
508	Hydrocephalus	Enrichment	PDGFRB	0.95
509	Microcephaly	Enrichment	ACTB, ACTG1, MAPK1	0.95
510	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	0.94
511	Rhabdomyosarcoma	Enrichment	HRAS	0.94
512	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.93
513	Gliosarcoma	Enrichment	NFKBIA	0.93
514	Sudden infant death syndrome	Enrichment	CALM2	0.92
515	Dandy-walker syndrome	Enrichment	PDGFRB	0.90
516	Giant cell glioblastoma	Enrichment	NFKBIA	0.90
517	Heart, malformation of	Enrichment	MAPK1	0.90
518	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	0.87
519	Arteriovenous malformations of the brain	Enrichment	KRAS	0.87
520	Diffuse large b-cell lymphoma	Enrichment	BTK	0.87
521	Behcet syndrome	Enrichment	STAT4	0.86
522	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.83
523	Neuromuscular disease	Enrichment	ACTA1	0.80
524	Malaria	Enrichment	IKBKG	0.78
525	Cone dystrophy	Enrichment	CACNA2D4	0.78
526	Scoliosis	Enrichment	SLC9A6	0.77
527	Pancreatic cancer	Enrichment	KRAS	0.76
528	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.75
529	Auditory neuropathy	Enrichment	CACNA1A	0.75
530	Lissencephaly	Enrichment	ACTG1	0.74
531	Strabismus	Enrichment	CACNA1A	0.73
532	Congenital nervous system abnormality	Enrichment	CACNA1A, PLA2G6	0.72
533	Nervous system disease	Enrichment	CACNA1A, PLA2G6	0.72
534	Severe covid-19	Enrichment	JAK3	0.69
535	Lung cancer	Enrichment	KRAS	0.67
536	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.66
537	Cystic fibrosis	Enrichment	SLC9A3	0.65
538	Left ventricular noncompaction	Enrichment	RAF1	0.63
539	Connective tissue disease	Enrichment	ACTA2	0.58
540	Gastric cancer	Enrichment	KRAS	0.56
541	Cakut	Enrichment	ACTG1	0.56
542	Optic atrophy plus syndrome	Enrichment	CACNA1F	0.55
543	Non-syndromic genetic deafness	Enrichment	ACTG1	0.54
544	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.53
545	Thrombocytopenia	Enrichment	SRC	0.50
546	Myopathy	Enrichment	ACTA1	0.50
547	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.48
548	Distal arthrogryposis	Enrichment	ACTA1	0.48
549	Nonsyndromic hearing loss	Enrichment	ACTG1	0.48
550	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.47
551	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.46
552	Type 2 diabetes mellitus	Enrichment	AKT2	0.44
553	Primary ovarian insufficiency	Enrichment	JAK2	0.43
554	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.41
555	Dilated cardiomyopathy	Enrichment	RAF1	0.34
556	Autism	Enrichment	CAMK2G	0.33
557	Retinitis pigmentosa	Enrichment	CACNA1F, CACNA2D4	0.32
558	Hereditary retinal dystrophy	Enrichment	ATF6, CACNA1F, CACNA2D4	0.28
559	Fundus dystrophy	Enrichment	ATF6, CACNA1F, CACNA2D4	0.28
560	Rare genetic deafness	Enrichment	ACTG1	0.27
561	Autism spectrum disorder	Enrichment	MAP2K1	0.25
562	Inherited cancer-predisposing syndrome	Enrichment	PDGFRA	0.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TCR Signaling (Qiagen)

Pathway Network for TCR Signaling (Qiagen)

Pathway network for the TCR Signaling (Qiagen) SuperPath

Member Pathways for TCR Signaling (Qiagen)

Pathways in the TCR Signaling (Qiagen) SuperPath

Gene overlap in member pathways for TCR Signaling (Qiagen) SuperPath

Associated Genes for TCR Signaling (Qiagen)

Associated Disorders for TCR Signaling (Qiagen)

Disorders associated with TCR Signaling (Qiagen) SuperPath

STRING Interaction Network for TCR Signaling (Qiagen)

Sources for TCR Signaling (Qiagen)