TCR signaling (REACTOME)

Pathway network for the TCR signaling (REACTOME) SuperPath

Sources:

Reactome

Pathways in the TCR signaling (REACTOME) SuperPath

#	Name	Source	Genes
1	TCR signaling	Reactome	ADRM1 BTRC CD101 CD247 CD3D CD3E CD3G CD4 CDC34 CHUK CSK CUL1 ENAH EVL FBXW11 FYB1 GRAP2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IKBKB IKBKG INPP5D ITK LAT LCK LCP2 MAP3K7 NCK1 NFKB1 NFKBIA PAG1 PAK1 PAK2 PAK3 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLCG2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTEN PTPN22 PTPRC PTPRJ RELA RIPK2 RPS27A SEM1 SKP1 TAB2 TRAF6 TRAT1 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2N UBE2V1 VASP WAS ZAP70 (see all 102) (see less)
2	Downstream TCR signaling	Reactome	ADRM1 BTRC CD247 CD3D CD3E CD3G CD4 CDC34 CHUK CUL1 FBXW11 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IKBKB IKBKG INPP5D LCK MAP3K7 NFKB1 NFKBIA PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTEN RELA RIPK2 RPS27A SEM1 SKP1 TAB2 TRAF6 TRAT1 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2N UBE2V1 (see all 80) (see less)
3	Translocation of ZAP-70 to Immunological synapse	Reactome	CD247 CD3D CD3E CD3G CD4 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LCK PTPN22 ZAP70 (see all 19) (see less)

Gene overlap in member pathways for TCR signaling (REACTOME) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	3
2	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	3
3	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	3
4	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	3
5	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	3
6	HLA-DQB2	Major Histocompatibility Complex, Class II, DQ Beta 2	Protein Coding	3
7	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	3
8	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	3
9	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	3
10	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	3
11	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	3
12	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
13	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	3
14	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	3
15	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	3
16	CD247	CD247 Molecule	Protein Coding	3
17	CD4	CD4 Molecule	Protein Coding	3
18	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
19	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
20	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
21	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
22	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	2
23	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	2
24	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
25	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	2
26	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
27	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
28	TRAT1	T Cell Receptor Associated Transmembrane Adaptor 1	Protein Coding	2
29	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
30	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
31	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
32	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
33	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
34	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
35	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
36	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
37	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
38	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
39	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
40	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
41	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
42	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
43	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
44	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
45	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
46	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
47	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
48	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
49	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
50	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
51	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
52	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
53	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
54	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
55	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
56	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
57	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
58	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
59	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
60	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
61	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
62	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
63	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
64	RPS27A	Ribosomal Protein S27a	Protein Coding	2
65	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	2
66	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
67	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
68	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
69	UBB	Ubiquitin B	Protein Coding	2
70	UBC	Ubiquitin C	Protein Coding	2
71	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
72	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
73	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
74	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	2
75	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	2
76	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
77	CUL1	Cullin 1	Protein Coding	2
78	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
79	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
80	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	2
81	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
82	CDC34	Cell Division Cycle 34, Ubiquitin Conjugating Enzyme	Protein Coding	2
83	CSK	C-Terminal Src Kinase	Protein Coding	1
84	FYB1	FYN Binding Protein 1	Protein Coding	1
85	LAT	Linker For Activation Of T Cells	Protein Coding	1
86	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
87	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
88	NCK1	NCK Adaptor Protein 1	Protein Coding	1
89	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
90	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
91	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
92	EVL	Enah/Vasp-Like	Protein Coding	1
93	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
94	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
95	ENAH	ENAH Actin Regulator	Protein Coding	1
96	PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Protein Coding	1
97	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
98	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	1
99	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
100	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
101	CD101	CD101 Molecule	Protein Coding	1
102	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	1

Disorders associated with TCR signaling (REACTOME) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, LCK, ZAP70	10.98
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	8.63
3	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1, HLA-DPB1, PTPN22	7.33
4	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	5.73
5	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	5.73
6	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	5.73
7	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1, PTPN22	5.25
8	Temporal arteritis	Enrichment	HLA-DRB1, PTPN22	4.95
9	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	4.95
10	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	4.73
11	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.46
12	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, PTPN22	4.41
13	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, PTPN22	4.41
14	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	4.29
15	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.99
16	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	3.78
17	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.69
18	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	3.47
19	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.29
20	Isolated split hand-split foot malformation	Enrichment	BTRC, SEM1	3.03
21	Cowden syndrome	Enrichment	PIK3CA, PTEN	2.92
22	Systemic lupus erythematosus	Enrichment	HLA-DRB1, PTPN22	2.87
23	Immunodeficiency 48	Enrichment	ZAP70	2.85
24	Okt4 epitope deficiency	Enrichment	CD4	2.85
25	Immunodeficiency 18	Enrichment	CD3E	2.85
26	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.85
27	Immunodeficiency 25	Enrichment	CD247	2.85
28	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.85
29	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.85
30	Immunodeficiency 22	Enrichment	LCK	2.85
31	Berylliosis	Enrichment	HLA-DPB1	2.85
32	Immunodeficiency 79	Enrichment	CD4	2.85
33	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.85
34	Immunodeficiency 19	Enrichment	CD3D	2.85
35	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.85
36	Meningioma	Enrichment	PIK3CA, PTEN	2.66
37	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	2.55
38	Sarcoidosis 1	Enrichment	HLA-DRB1	2.55
39	Immunodeficiency 17	Enrichment	CD3G	2.55
40	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	2.38
41	Patent foramen ovale	Enrichment	PSMC3, TAB2	2.31
42	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	2.25
43	Macrodactyly	Enrichment	PIK3CA	2.23
44	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.23
45	Vacterl association with hydrocephalus	Enrichment	PTEN	2.23
46	Incontinentia pigmenti	Enrichment	IKBKG	2.23
47	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.23
48	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.23
49	Cowden syndrome 5	Enrichment	PIK3CA	2.23
50	Fetal encasement syndrome	Enrichment	CHUK	2.23
51	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.23
52	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.23
53	Immunodeficiency 15b	Enrichment	IKBKB	2.23
54	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.23
55	Immunodeficiency 15a	Enrichment	IKBKB	2.23
56	Short syndrome	Enrichment	PIK3R1	2.23
57	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.23
58	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.23
59	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.23
60	Papillary tumor of the pineal region	Enrichment	PTEN	2.23
61	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.23
62	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.23
63	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.23
64	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.23
65	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.23
66	Glioma susceptibility 2	Enrichment	PTEN	2.23
67	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.23
68	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.23
69	Hypospadias	Enrichment	PIK3CA	2.23
70	Rare venous malformation	Enrichment	PIK3CA	2.23
71	Diaphragmatic eventration	Enrichment	PIK3CA	2.23
72	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.23
73	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.23
74	Rare combined vascular malformation	Enrichment	PIK3CA	2.23
75	Cavernous lymphangioma	Enrichment	PIK3CA	2.23
76	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.23
77	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.23
78	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.23
79	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.23
80	Macrodactyly of toe	Enrichment	PIK3CA	2.23
81	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.23
82	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.17
83	Follicular lymphoma	Enrichment	HLA-DRB1	2.16
84	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	2.16
85	Thrombocytopenia 1	Enrichment	WAS	2.12
86	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.12
87	Immunodeficiency 81	Enrichment	LCP2	2.12
88	Knobloch syndrome 2	Enrichment	PAK2	2.12
89	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.12
90	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.12
91	Thrombocytopenia 3	Enrichment	FYB1	2.12
92	Lymphoproliferative syndrome 1	Enrichment	ITK	2.12
93	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.12
94	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.12
95	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.12
96	Was-related disorders	Enrichment	WAS	2.12
97	Congenital autosomal recessive small-platelet thrombocytopenia	Enrichment	FYB1	2.12
98	Cd45 deficiency	Enrichment	PTPRC	2.12
99	Thrombocytopenia 10	Enrichment	PTPRJ	2.12
100	Limited scleroderma	Enrichment	HLA-DRB1	2.08
101	Immunodeficiency 33	Enrichment	IKBKG	1.93
102	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.93
103	Keratosis, seborrheic	Enrichment	PIK3CA	1.93
104	Noonan syndrome 8	Enrichment	PIK3CA	1.93
105	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.93
106	Birk-aharoni syndrome	Enrichment	PSMC1	1.93
107	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.93
108	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.93
109	Rela fusion-positive ependymoma	Enrichment	RELA	1.93
110	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.93
111	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.93
112	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.93
113	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.93
114	Vacterl with hydrocephalus	Enrichment	PTEN	1.93
115	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.93
116	Common variable immunodeficiency 12	Enrichment	NFKB1	1.93
117	Juvenile polyposis of infancy	Enrichment	PTEN	1.93
118	Submucosal cleft palate	Enrichment	UBB	1.93
119	Cleft hard palate	Enrichment	UBB	1.93
120	Bladder cancer	Enrichment	PIK3CA, PTEN	1.90
121	Prostate cancer	Enrichment	PIK3CA, PTEN	1.90
122	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.82
123	Wiskott-aldrich syndrome	Enrichment	WAS	1.82
124	Lymphoproliferative syndrome	Enrichment	ITK	1.82
125	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.82
126	Immunodeficiency 52	Enrichment	LAT	1.82
127	Combined immunodeficiency	Enrichment	ZAP70	1.82
128	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.82
129	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.82
130	Pelvic organ prolapse	Enrichment	TAB2	1.75
131	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.75
132	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.75
133	Uvula, bifid	Enrichment	UBB	1.75
134	Cleft soft palate	Enrichment	UBB	1.75
135	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.75
136	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.75
137	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.75
138	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.75
139	Immunodeficiency 14	Enrichment	PIK3R1	1.75
140	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.75
141	Thyroid hemiagenesis	Enrichment	PSMD3	1.75
142	Keratoacanthoma	Enrichment	PIK3CA	1.75
143	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.63
144	Cerebrovascular disease	Enrichment	PIK3CA	1.63
145	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.63
146	Glioma	Enrichment	PTEN	1.63
147	Gastric cancer	Enrichment	PIK3CA, PTEN	1.58
148	Hereditary breast carcinoma	Enrichment	PIK3CA, PTEN	1.56
149	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, PTPRJ	1.56
150	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.54
151	Capillary malformations, congenital	Enrichment	PIK3CA	1.54
152	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.54
153	Macrocephaly/autism syndrome	Enrichment	PTEN	1.54
154	Hemangioma	Enrichment	PTEN	1.54
155	Acute megakaryocytic leukemia	Enrichment	PTEN	1.54
156	Knobloch syndrome	Enrichment	PAK2	1.53
157	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.46
158	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.46
159	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.46
160	Patent ductus arteriosus	Enrichment	PSMC3	1.46
161	Breast adenocarcinoma	Enrichment	PIK3CA	1.46
162	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.46
163	Knobloch syndrome 1	Enrichment	PAK2	1.43
164	Severe covid-19	Enrichment	HLA-DQB1	1.40
165	Nevus, epidermal	Enrichment	PIK3CA	1.39
166	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.39
167	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.39
168	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.39
169	Gallbladder cancer	Enrichment	PIK3CA	1.39
170	Common variable immunodeficiency	Enrichment	NFKB1	1.39
171	Follicular thyroid carcinoma	Enrichment	PTEN	1.39
172	Overgrowth syndrome	Enrichment	PIK3R1	1.39
173	Coronary heart disease 5	Enrichment	IKBKG	1.29
174	Arteriovenous malformation	Enrichment	PIK3CA	1.29
175	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.29
176	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.24
177	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.24
178	Polymicrogyria	Enrichment	PSMC3	1.24
179	Melanoma	Enrichment	PTEN	1.24
180	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.24
181	Migraine with or without aura 1	Enrichment	TAB2	1.20
182	Meningioma, familial	Enrichment	PTEN	1.20
183	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.20
184	Uterine corpus cancer	Enrichment	PTEN	1.20
185	Complex neurodevelopmental disorder	Enrichment	FBXW11, PAK3, PSMD12	1.18
186	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.16
187	Breast cancer	Enrichment	PIK3CA, PTEN	1.14
188	Aortic valve disease 1	Enrichment	TAB2	1.13
189	Nk-cell enteropathy	Enrichment	PIK3CB	1.13
190	Lynch syndrome	Enrichment	PIK3CA	1.07
191	Rhabdomyosarcoma	Enrichment	PTEN	1.04
192	Gliosarcoma	Enrichment	NFKBIA	1.04
193	Giant cell glioblastoma	Enrichment	NFKBIA	1.02
194	Diffuse large b-cell lymphoma	Enrichment	PTEN	0.97
195	Ovarian cancer	Enrichment	PIK3CA, PTEN	0.92
196	Hepatocellular carcinoma	Enrichment	PIK3CA	0.91
197	Myocardial infarction	Enrichment	PSMA6	0.91
198	Malaria	Enrichment	IKBKG	0.90
199	Lung cancer	Enrichment	PIK3CA	0.76
200	Microcephaly	Enrichment	PAK3, PSMC3	0.63
201	Hypertelorism	Enrichment	PIK3CA	0.58
202	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.56
203	Myeloma, multiple	Enrichment	PIK3R2	0.55
204	Thrombocytopenia	Enrichment	WAS	0.52
205	Dilated cardiomyopathy	Enrichment	TAB2	0.42
206	Congenital nervous system abnormality	Enrichment	PTEN	0.33
207	Nervous system disease	Enrichment	PTEN	0.33
208	Autism spectrum disorder	Enrichment	PTEN	0.32
209	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TCR signaling (REACTOME)

Pathway Network for TCR signaling (REACTOME)

Pathway network for the TCR signaling (REACTOME) SuperPath

Member Pathways for TCR signaling (REACTOME)

Pathways in the TCR signaling (REACTOME) SuperPath

Gene overlap in member pathways for TCR signaling (REACTOME) SuperPath

Associated Genes for TCR signaling (REACTOME)

Associated Disorders for TCR signaling (REACTOME)

Disorders associated with TCR signaling (REACTOME) SuperPath

STRING Interaction Network for TCR signaling (REACTOME)

Sources for TCR signaling (REACTOME)