TCR signaling in naïve CD4+ T cells

No Pathway Network information available for TCR signaling in naïve CD4+ T cells

Pathways in the TCR signaling in naïve CD4+ T cells SuperPath

#	Name	Source	Genes
1	TCR signaling in naïve CD4+ T cells	PubChem	AKT1 BCL10 CARD11 CBL CD247 CD28 CD3D CD3E CD3G CD4 CDC42 CHUK CSK DBNL FLNA FYB1 FYN GAB2 GRAP2 GRB2 HLA-DRA IKBKB IKBKG ITK LAT LCK LCP2 MALT1 MAP3K14 MAP3K8 MAP4K1 NCK1 ORAI1 PAG1 PDPK1 PIK3CA PLCG1 PRKCA PRKCB PRKCE PRKCQ PTEN PTPN11 PTPN6 PTPRC RAP1A RASGRP1 RASGRP2 RASSF5 SH3BP2 SHC1 SLA2 SOS1 STIM1 STK39 TRAF6 TRPV6 VAV1 WAS ZAP70 (see all 60) (see less)
2	TCR signaling in naïve CD8+ T cells	PubChem	AKT1 B2M BCL10 CARD11 CBL CD247 CD28 CD3D CD3E CD3G CD8A CD8B CHUK CSK FYN GRAP2 GRB2 HLA-A IKBKB IKBKG LAT LCK LCP2 MALT1 MAP3K14 MAP3K8 ORAI1 PAG1 PDPK1 PIK3CA PLCG1 PRF1 PRKCA PRKCB PRKCE PRKCQ PTPN6 PTPRC RAP1A RASGRP1 RASGRP2 RASSF5 SHC1 SOS1 STIM1 TRAF6 TRPV6 VAV1 ZAP70 (see all 49) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RASSF5	Ras Association Domain Family Member 5	Protein Coding	2
2	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	2
3	TRPV6	Transient Receptor Potential Cation Channel Subfamily V Member 6	Protein Coding	2
4	CD247	CD247 Molecule	Protein Coding	2
5	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	2
6	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
7	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
8	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
9	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	2
10	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	2
11	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	2
12	MALT1	MALT1 Paracaspase	Protein Coding	2
13	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	2
14	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	2
15	CD28	CD28 Molecule	Protein Coding	2
16	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
17	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	2
18	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
19	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
20	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
21	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
22	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
23	PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Protein Coding	2
24	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
25	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
26	CSK	C-Terminal Src Kinase	Protein Coding	2
27	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
28	LAT	Linker For Activation Of T Cells	Protein Coding	2
29	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	2
30	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
31	STIM1	Stromal Interaction Molecule 1	Protein Coding	2
32	ORAI1	ORAI Calcium Release-Activated Calcium Modulator 1	Protein Coding	2
33	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	2
34	PRKCA	Protein Kinase C Alpha	Protein Coding	2
35	PRKCQ	Protein Kinase C Theta	Protein Coding	2
36	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
37	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	2
38	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
39	CBL	Cbl Proto-Oncogene	Protein Coding	2
40	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
41	PRKCB	Protein Kinase C Beta	Protein Coding	2
42	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
43	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
44	SHC1	SHC Adaptor Protein 1	Protein Coding	2
45	SH3BP2	SH3 Domain Binding Protein 2	Protein Coding	1
46	STK39	Serine/Threonine Kinase 39	Protein Coding	1
47	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1
48	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
49	SLA2	Src Like Adaptor 2	Protein Coding	1
50	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
51	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
52	CD4	CD4 Molecule	Protein Coding	1
53	DBNL	Drebrin Like	Protein Coding	1
54	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
55	FLNA	Filamin A	Protein Coding	1
56	FYB1	FYN Binding Protein 1	Protein Coding	1
57	NCK1	NCK Adaptor Protein 1	Protein Coding	1
58	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
59	CDC42	Cell Division Cycle 42	Protein Coding	1
60	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
61	PRF1	Perforin 1	Protein Coding	1
62	CD8A	CD8 Subunit Alpha	Protein Coding	1
63	CD8B	CD8 Subunit Beta	Protein Coding	1
64	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
65	B2M	Beta-2-Microglobulin	Protein Coding	1

Disorders associated with TCR signaling in naïve CD4+ T cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB, LCK, MALT1, PTPRC, ZAP70	16.00
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.35
3	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42, PTPN11	6.48
4	Lymphoma, non-hodgkin, familial	Enrichment	B2M, BCL10, PRF1	5.61
5	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	5.17
6	Stormorken syndrome	Enrichment	ORAI1, STIM1	4.89
7	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	4.75
8	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, PTPN11, SOS1	4.44
9	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	3.90
10	Noonan syndrome 1	Enrichment	CBL, PTPN11, SOS1	3.86
11	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.72
12	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	3.72
13	Rasopathy	Enrichment	CBL, PTPN11, SOS1	3.70
14	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.54
15	Patent ductus arteriosus	Enrichment	FLNA, PTPN11	3.54
16	Breast cancer	Enrichment	AKT1, PIK3CA, PTEN, SHC1	3.48
17	Myopathy, tubular aggregate, 1	Enrichment	ORAI1, STIM1	3.45
18	Noonan syndrome 3	Enrichment	PTPN11, SOS1	3.40
19	Combined immunodeficiency	Enrichment	MALT1, ZAP70	3.16
20	Combined t cell and b cell immunodeficiency	Enrichment	MALT1, ZAP70	3.16
21	Combined t and b cell immunodeficiency	Enrichment	MALT1, ZAP70	3.16
22	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN	3.02
23	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	2.91
24	Rhabdomyosarcoma	Enrichment	CBL, PTEN	2.65
25	Patent foramen ovale	Enrichment	FLNA, PTPN11	2.55
26	Macrodactyly	Enrichment	PIK3CA	2.44
27	Proteus syndrome	Enrichment	AKT1	2.44
28	Incontinentia pigmenti	Enrichment	IKBKG	2.44
29	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.44
30	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.44
31	Noonan syndrome 4	Enrichment	SOS1	2.44
32	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.44
33	Cowden syndrome 5	Enrichment	PIK3CA	2.44
34	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.44
35	Fetal encasement syndrome	Enrichment	CHUK	2.44
36	Immunodeficiency 116	Enrichment	CD8A	2.44
37	Immunodeficiency 43	Enrichment	B2M	2.44
38	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.44
39	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.44
40	Immunodeficiency 15b	Enrichment	IKBKB	2.44
41	Immunodeficiency 81	Enrichment	LCP2	2.44
42	Immunodeficiency 15a	Enrichment	IKBKB	2.44
43	Immunodeficiency 48	Enrichment	ZAP70	2.44
44	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.44
45	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.44
46	Immunodeficiency 18	Enrichment	CD3E	2.44
47	Dialysis-related amyloidosis	Enrichment	B2M	2.44
48	Persistent polyclonal b-cell lymphocytosis	Enrichment	CARD11	2.44
49	Immunodeficiency 10	Enrichment	STIM1	2.44
50	Immunodeficiency 25	Enrichment	CD247	2.44
51	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.44
52	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.44
53	Birdshot chorioretinopathy	Enrichment	HLA-A	2.44
54	Cowden syndrome 6	Enrichment	AKT1	2.44
55	Hyperparathyroidism	Enrichment	TRPV6	2.44
56	Immunodeficiency 12	Enrichment	MALT1	2.44
57	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.44
58	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.44
59	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.44
60	Immunodeficiency 22	Enrichment	LCK	2.44
61	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.44
62	Cd45 deficiency	Enrichment	PTPRC	2.44
63	Hyperparathyroidism, transient neonatal	Enrichment	TRPV6	2.44
64	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.44
65	Sezary's disease	Enrichment	BCL10	2.44
66	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.44
67	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.44
68	Hypospadias	Enrichment	PIK3CA	2.44
69	Immunodeficiency 112	Enrichment	MAP3K14	2.44
70	Rare venous malformation	Enrichment	PIK3CA	2.44
71	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.44
72	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.44
73	Immunodeficiency 64	Enrichment	RASGRP1	2.44
74	Diaphragmatic eventration	Enrichment	PIK3CA	2.44
75	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.44
76	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.44
77	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.44
78	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.44
79	Immunodeficiency 19	Enrichment	CD3D	2.44
80	Rare combined vascular malformation	Enrichment	PIK3CA	2.44
81	Cavernous lymphangioma	Enrichment	PIK3CA	2.44
82	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.44
83	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.44
84	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.44
85	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.44
86	Mucosa-associated lymphoma	Enrichment	BCL10	2.44
87	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.44
88	Macrodactyly of toe	Enrichment	PIK3CA	2.44
89	Nik deficiency	Enrichment	MAP3K14	2.44
90	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.44
91	Colorectal cancer	Enrichment	AKT1, BCL10, PIK3CA	2.42
92	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.42
93	Metachondromatosis	Enrichment	PTPN11	2.35
94	Vacterl association with hydrocephalus	Enrichment	PTEN	2.35
95	Thrombocytopenia 1	Enrichment	WAS	2.35
96	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.35
97	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.35
98	Cherubism	Enrichment	SH3BP2	2.35
99	Leopard syndrome 1	Enrichment	PTPN11	2.35
100	Terminal osseous dysplasia	Enrichment	FLNA	2.35
101	Okt4 epitope deficiency	Enrichment	CD4	2.35
102	Fg syndrome 2	Enrichment	FLNA	2.35
103	Thrombocytopenia 3	Enrichment	FYB1	2.35
104	Papillary tumor of the pineal region	Enrichment	PTEN	2.35
105	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.35
106	Lymphoproliferative syndrome 1	Enrichment	ITK	2.35
107	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.35
108	Glioma susceptibility 2	Enrichment	PTEN	2.35
109	Was-related disorders	Enrichment	WAS	2.35
110	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.35
111	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.35
112	Congenital autosomal recessive small-platelet thrombocytopenia	Enrichment	FYB1	2.35
113	Immunodeficiency 79	Enrichment	CD4	2.35
114	Fibrous dysplasia of jaw	Enrichment	SH3BP2	2.35
115	Nocarh syndrome	Enrichment	CDC42	2.35
116	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.35
117	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.35
118	Malignant astrocytoma	Enrichment	PTPN11	2.35
119	Lung cancer	Enrichment	MAP3K8, PIK3CA	2.23
120	Fibromatosis, gingival, 1	Enrichment	SOS1	2.14
121	Hyperparathyroidism, neonatal severe	Enrichment	TRPV6	2.14
122	Ovarian germ cell cancer	Enrichment	CBL	2.14
123	Immunodeficiency 33	Enrichment	IKBKG	2.14
124	Severe cutaneous adverse reaction	Enrichment	HLA-A	2.14
125	Pulmonic stenosis	Enrichment	SOS1	2.14
126	Keratosis, seborrheic	Enrichment	PIK3CA	2.14
127	Immunodeficiency 9	Enrichment	ORAI1	2.14
128	Immunodeficiency 11a	Enrichment	CARD11	2.14
129	Immunodeficiency 37	Enrichment	BCL10	2.14
130	Noonan syndrome 8	Enrichment	PIK3CA	2.14
131	Immunodeficiency 11b with atopic dermatitis	Enrichment	CARD11	2.14
132	Myopathy, tubular aggregate, 2	Enrichment	ORAI1	2.14
133	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.14
134	B-cell expansion with nfkb and t-cell anergy	Enrichment	CARD11	2.14
135	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.14
136	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.14
137	Immunodeficiency 17	Enrichment	CD3G	2.14
138	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.14
139	Immunodeficiency 52	Enrichment	LAT	2.14
140	Malignant germ cell tumor of ovary	Enrichment	CBL	2.14
141	Bladder cancer	Enrichment	PIK3CA, PTEN	2.14
142	Prostate cancer	Enrichment	PIK3CA, PTEN	2.14
143	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.05
144	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.05
145	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.05
146	Melnick-needles syndrome	Enrichment	FLNA	2.05
147	Wiskott-aldrich syndrome	Enrichment	WAS	2.05
148	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.05
149	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.05
150	Werner syndrome	Enrichment	PTPN11	2.05
151	Lymphoproliferative syndrome	Enrichment	ITK	2.05
152	Immune system disease	Enrichment	CDC42	2.05
153	Vacterl with hydrocephalus	Enrichment	PTEN	2.05
154	Juvenile polyposis of infancy	Enrichment	PTEN	2.05
155	Ovarian cancer	Enrichment	AKT1, PIK3CA, PTEN	2.00
156	Mesothelioma, malignant	Enrichment	BCL10	1.97
157	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.97
158	Mycosis fungoides	Enrichment	CD28	1.97
159	Nuchal bleb, familial	Enrichment	SOS1	1.97
160	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.97
161	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.97
162	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	1.97
163	Testicular cancer	Enrichment	BCL10	1.97
164	Keratoacanthoma	Enrichment	PIK3CA	1.97
165	Saczary syndrome	Enrichment	CD28	1.97
166	Prune belly syndrome	Enrichment	FLNA	1.88
167	Arterial tortuosity syndrome	Enrichment	FLNA	1.88
168	Periventricular nodular heterotopia 1	Enrichment	FLNA	1.88
169	Congenital short bowel syndrome	Enrichment	FLNA	1.88
170	Frontometaphyseal dysplasia	Enrichment	FLNA	1.88
171	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.88
172	Tricuspid valve insufficiency	Enrichment	PTPN11	1.88
173	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.84
174	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	STIM1	1.84
175	Bone mineral density quantitative trait locus 15	Enrichment	TRPV6	1.84
176	Cerebrovascular disease	Enrichment	PIK3CA	1.84
177	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.84
178	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M	1.84
179	Gingival fibromatosis	Enrichment	SOS1	1.84
180	Gastric cancer	Enrichment	PIK3CA, PTEN	1.81
181	Glycogen storage disease x	Enrichment	DBNL	1.76
182	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.76
183	Glioma	Enrichment	PTEN	1.76
184	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.75
185	Capillary malformations, congenital	Enrichment	PIK3CA	1.75
186	Amyloidosis, hereditary systemic 2	Enrichment	B2M	1.75
187	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.75
188	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.75
189	Follicular lymphoma	Enrichment	BCL10	1.75
190	Myeloproliferative neoplasm	Enrichment	CBL	1.75
191	Aggressive systemic mastocytosis	Enrichment	CBL	1.75
192	Idiopathic aplastic anemia	Enrichment	PRF1	1.75
193	Thrombocytopenia	Enrichment	PTPN11, WAS	1.72
194	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.67
195	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.67
196	Testicular germ cell tumor	Enrichment	BCL10	1.67
197	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.67
198	Macrocephaly/autism syndrome	Enrichment	PTEN	1.66
199	Lymphoma	Enrichment	PTPN11	1.66
200	Hemangioma	Enrichment	PTEN	1.66
201	Acute megakaryocytic leukemia	Enrichment	PTEN	1.66
202	Nevus, epidermal	Enrichment	PIK3CA	1.60
203	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.60
204	Gallbladder cancer	Enrichment	PIK3CA	1.60
205	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.60
206	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.60
207	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.51
208	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.51
209	Follicular thyroid carcinoma	Enrichment	PTEN	1.51
210	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.49
211	Coronary heart disease 5	Enrichment	IKBKG	1.49
212	Arteriovenous malformation	Enrichment	PIK3CA	1.49
213	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.49
214	Fanconi anemia, complementation group c	Enrichment	FLNA	1.46
215	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.45
216	Aplastic anemia	Enrichment	PRF1	1.45
217	Asthma	Enrichment	CARD11	1.41
218	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.41
219	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.37
220	Melanoma	Enrichment	PTEN	1.36
221	Aortic valve disease 1	Enrichment	SOS1	1.34
222	Pectus excavatum	Enrichment	PTPN11	1.32
223	Meningioma, familial	Enrichment	PTEN	1.32
224	Uterine corpus cancer	Enrichment	PTEN	1.32
225	Specific learning disability	Enrichment	PTPN11	1.32
226	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.31
227	Epicanthus	Enrichment	PTPN11	1.29
228	Congenital long qt syndrome	Enrichment	PTPN11	1.29
229	Lynch syndrome	Enrichment	PIK3CA	1.28
230	Pancreatitis, hereditary	Enrichment	TRPV6	1.22
231	Periventricular nodular heterotopia	Enrichment	FLNA	1.22
232	Cleft palate, isolated	Enrichment	FLNA	1.14
233	Hepatocellular carcinoma	Enrichment	PIK3CA	1.12
234	Malaria	Enrichment	IKBKG	1.10
235	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.09
236	Autoinflammatory disease	Enrichment	PRF1	1.08
237	Autism spectrum disorder	Enrichment	PTEN, PTPN11	1.08
238	Severe covid-19	Enrichment	HLA-A	1.00
239	Scoliosis	Enrichment	PTPN11	1.00
240	Hydrops fetalis, nonimmune	Enrichment	PTPN11	0.96
241	Strabismus	Enrichment	PTPN11	0.95
242	Inherited cancer-predisposing syndrome	Enrichment	PTEN, PTPN11	0.94
243	Long qt syndrome 1	Enrichment	PTPN11	0.90
244	Non-immune hydrops fetalis	Enrichment	PTPN11	0.89
245	Hypertelorism	Enrichment	PIK3CA	0.76
246	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.76
247	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA	0.75
248	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.66
249	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.66
250	Congenital nervous system abnormality	Enrichment	PTEN	0.42
251	Nervous system disease	Enrichment	PTEN	0.42
252	Microcephaly	Enrichment	PTPN11	0.37

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TCR signaling in naïve CD4+ T cells

Pathway Network for TCR signaling in naïve CD4+ T cells

Member Pathways for TCR signaling in naïve CD4+ T cells

Pathways in the TCR signaling in naïve CD4+ T cells SuperPath

Associated Genes for TCR signaling in naïve CD4+ T cells

Associated Disorders for TCR signaling in naïve CD4+ T cells

Disorders associated with TCR signaling in naïve CD4+ T cells SuperPath

STRING Interaction Network for TCR signaling in naïve CD4+ T cells

Sources for TCR signaling in naïve CD4+ T cells