Telomere C-strand (Lagging Strand) Synthesis

Pathway network for the Telomere C-strand (Lagging Strand) Synthesis SuperPath

Sources:

Reactome

Pathways in the Telomere C-strand (Lagging Strand) Synthesis SuperPath

#	Name	Source	Genes
1	Telomere C-strand (Lagging Strand) Synthesis	Reactome	ACD BLM CHTF18 CHTF8 CTC1 DNA2 DSCC1 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POT1 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 STN1 TEN1 TERF1 TERF2 TERF2IP TINF2 WRN (see all 34) (see less)
2	Extension of Telomeres	Reactome	ACD ANKRD28 BLM CCNA1 CCNA2 CDK2 CHTF18 CHTF8 CTC1 DKC1 DNA2 DSCC1 FEN1 GAR1 LIG1 NHP2 NOP10 PCNA PIF1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POT1 PPP6C PPP6R3 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RTEL1 RUVBL1 RUVBL2 SHQ1 STN1 TEN1 TERF1 TERF2 TERF2IP TERT TINF2 WRAP53 WRN (see all 51) (see less)
3	Polymerase switching on the C-strand of the telomere	Reactome	ACD CHTF18 CHTF8 CTC1 DSCC1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POT1 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 STN1 TEN1 TERF1 TERF2 TERF2IP TINF2 (see all 26) (see less)
4	Telomere Extension By Telomerase	Reactome	ACD ANKRD28 CCNA1 CCNA2 CDK2 DKC1 GAR1 NHP2 NOP10 PIF1 POT1 PPP6C PPP6R3 RTEL1 RUVBL1 RUVBL2 SHQ1 TERF1 TERF2 TERF2IP TERT TINF2 WRAP53 (see all 23) (see less)
5	Processive synthesis on the C-strand of the telomere	Reactome	ACD BLM DNA2 FEN1 LIG1 PCNA POLD1 POLD2 POLD3 POLD4 POT1 RPA1 RPA2 RPA3 TERF1 TERF2 TERF2IP TINF2 WRN (see all 19) (see less)
6	Removal of the Flap Intermediate from the C-strand	Reactome	ACD DNA2 FEN1 PCNA POLD1 POLD2 POLD3 POLD4 POT1 RPA1 RPA2 RPA3 TERF1 TERF2 TERF2IP TINF2 WRN (see all 17) (see less)
7	Leading Strand Synthesis	Reactome	PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 (see all 14) (see less)
8	Polymerase switching	Reactome	PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 (see all 14) (see less)
9	Telomere C-strand synthesis initiation	Reactome	ACD CTC1 POLA1 POLA2 POT1 PRIM1 PRIM2 STN1 TEN1 TERF1 TERF2 TERF2IP TINF2 (see all 13) (see less)

Gene overlap in member pathways for Telomere C-strand (Lagging Strand) Synthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	7
2	POT1	Protection Of Telomeres 1	Protein Coding	7
3	TINF2	TERF1 Interacting Nuclear Factor 2	Protein Coding	7
4	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	7
5	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	7
6	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	7
7	TERF2IP	TERF2 Interacting Protein	Protein Coding	7
8	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	7
9	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	7
10	TERF1	Telomeric Repeat Binding Factor 1	Protein Coding	7
11	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	7
12	POLA2	DNA Polymerase Alpha 2, Accessory Subunit	Protein Coding	6
13	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	6
14	PRIM1	DNA Primase Subunit 1	Protein Coding	6
15	PRIM2	DNA Primase Subunit 2	Protein Coding	6
16	RFC1	Replication Factor C Subunit 1	Protein Coding	5
17	RFC2	Replication Factor C Subunit 2	Protein Coding	5
18	RFC3	Replication Factor C Subunit 3	Protein Coding	5
19	RFC4	Replication Factor C Subunit 4	Protein Coding	5
20	RFC5	Replication Factor C Subunit 5	Protein Coding	5
21	TEN1	TEN1 Subunit Of CST Complex	Protein Coding	4
22	DNA2	DNA Replication Helicase/Nuclease 2	Protein Coding	4
23	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	4
24	RPA1	Replication Protein A1	Protein Coding	4
25	RPA2	Replication Protein A2	Protein Coding	4
26	RPA3	Replication Protein A3	Protein Coding	4
27	WRN	WRN RecQ Like Helicase	Protein Coding	4
28	STN1	STN1 Subunit Of CST Complex	Protein Coding	4
29	CTC1	CST Telomere Replication Complex Component 1	Protein Coding	4
30	LIG1	DNA Ligase 1	Protein Coding	3
31	CHTF8	Chromosome Transmission Fidelity Factor 8	Protein Coding	3
32	CHTF18	Chromosome Transmission Fidelity Factor 18	Protein Coding	3
33	BLM	BLM RecQ Like Helicase	Protein Coding	3
34	DSCC1	DNA Replication And Sister Chromatid Cohesion 1	Protein Coding	3
35	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
36	RUVBL2	RuvB Like AAA ATPase 2	Protein Coding	2
37	DKC1	Dyskerin Pseudouridine Synthase 1	Protein Coding	2
38	ANKRD28	Ankyrin Repeat Domain 28	Protein Coding	2
39	RTEL1	Regulator Of Telomere Elongation Helicase 1	Protein Coding	2
40	GAR1	GAR1 Ribonucleoprotein	Protein Coding	2
41	WRAP53	WD Repeat Containing Antisense To TP53	Protein Coding	2
42	SHQ1	SHQ1, H/ACA Ribonucleoprotein Assembly Factor	Protein Coding	2
43	PPP6R3	Protein Phosphatase 6 Regulatory Subunit 3	Protein Coding	2
44	PPP6C	Protein Phosphatase 6 Catalytic Subunit	Protein Coding	2
45	NOP10	NOP10 Ribonucleoprotein	Protein Coding	2
46	NHP2	NHP2 Ribonucleoprotein	Protein Coding	2
47	TERT	Telomerase Reverse Transcriptase	Protein Coding	2
48	PIF1	PIF1 5''-To-3'' DNA Helicase	Protein Coding	2
49	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	2
50	CCNA2	Cyclin A2	Protein Coding	2
51	CCNA1	Cyclin A1	Protein Coding	2

Disorders associated with Telomere C-strand (Lagging Strand) Synthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hoyeraal-hreidarsson syndrome	Enrichment	ACD, DKC1, RTEL1, TERT, TINF2	11.20
2	Dyskeratosis congenita	Enrichment	CTC1, DKC1, NHP2, NOP10, POT1, RTEL1, TERT, TINF2, WRAP53	11.00
3	Melanoma, cutaneous malignant 1	Enrichment	ACD, POT1, TERF2IP, TERT	7.83
4	Cerebroretinal microangiopathy with calcifications and cysts 1	Enrichment	CTC1, STN1	5.59
5	Dyskeratosis congenita, x-linked	Enrichment	DKC1, RTEL1	5.08
6	Interstitial lung disease 2	Enrichment	RTEL1, STN1, TERT	4.48
7	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT, TINF2	4.39
8	Pulmonary fibrosis	Enrichment	RTEL1, TERT	4.39
9	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT, TINF2	4.24
10	Seckel syndrome	Enrichment	DNA2, PRIM1	3.26
11	Inherited cancer-predisposing syndrome	Enrichment	BLM, POLD1, POT1	3.11
12	Van esch-o'driscoll syndrome	Enrichment	POLA1	3.02
13	Tumor predisposition syndrome 3	Enrichment	POT1	3.02
14	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	3.02
15	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8	Enrichment	POT1	3.02
16	High-grade astrocytoma with piloid features	Enrichment	POT1	3.02
17	Cerebroretinal microangiopathy with calcifications and cysts 3	Enrichment	POT1	3.02
18	Cerebroretinal microangiopathy with calcifications and cysts 2	Enrichment	STN1	3.02
19	Colorectal cancer 10	Enrichment	POLD1	2.99
20	Immunodeficiency 120	Enrichment	POLD1	2.99
21	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.99
22	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.99
23	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.99
24	Immunodeficiency 122	Enrichment	POLD3	2.99
25	Seckel syndrome 8	Enrichment	DNA2	2.90
26	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.90
27	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6	Enrichment	DNA2	2.90
28	Rothmund-thomson syndrome, type 4	Enrichment	DNA2	2.90
29	Bloom syndrome	Enrichment	BLM	2.85
30	Immunodeficiency 96	Enrichment	LIG1	2.85
31	Dyskeratosis congenita, autosomal recessive 1	Enrichment	NOP10	2.77
32	Dyskeratosis congenita, autosomal recessive 3	Enrichment	WRAP53	2.77
33	Neurodevelopmental disorder with dystonia and seizures	Enrichment	SHQ1	2.77
34	Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 2	Enrichment	NOP10	2.77
35	Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1	Enrichment	DKC1	2.77
36	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9	Enrichment	NOP10	2.77
37	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.77
38	Dystonia 35, childhood-onset	Enrichment	SHQ1	2.77
39	Revesz syndrome	Enrichment	TINF2	2.72
40	Dyskeratosis congenita, autosomal dominant 3	Enrichment	TINF2	2.72
41	Oligodendroglioma	Enrichment	POT1	2.72
42	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	2.72
43	Anaplastic oligodendroglioma	Enrichment	POT1	2.72
44	Leukemia, acute myeloid	Enrichment	RTEL1, TERT	2.69
45	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	2.69
46	Rothmund-thomson syndrome, type 2	Enrichment	DNA2	2.60
47	Werner syndrome	Enrichment	WRN	2.60
48	Partington syndrome	Enrichment	POLA1	2.54
49	Dyskeratosis congenita, autosomal dominant 6	Enrichment	ACD	2.54
50	Childhood apraxia of speech	Enrichment	RFC3	2.51
51	Polymerase proofreading-related polyposis	Enrichment	POLD1	2.51
52	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.47
53	Dyskeratosis congenita, autosomal recessive 5	Enrichment	RTEL1	2.47
54	Dyskeratosis congenita, autosomal recessive 2	Enrichment	NHP2	2.47
55	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	2.47
56	Autosomal dominant dyskeratosis congenita 4	Enrichment	RTEL1	2.47
57	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.47
58	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 3	Enrichment	RTEL1	2.47
59	Idiopathic interstitial pneumonia	Enrichment	TERT	2.47
60	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	2.29
61	Torsion dystonia 1	Enrichment	SHQ1	2.29
62	Interstitial lung disease	Enrichment	TERT	2.29
63	Macrocytic anemia	Enrichment	TERT	2.29
64	Colorectal cancer	Enrichment	BLM, POLD1	2.19
65	Epilepsy, progressive myoclonic, 4, with or without renal failure	Enrichment	RTEL1	2.17
66	Lung sarcomatoid carcinoma	Enrichment	TERT	2.17
67	Combined oxidative phosphorylation deficiency 24	Enrichment	RTEL1	2.17
68	Idiopathic aplastic anemia	Enrichment	TERT	2.07
69	Ovarian cancer	Enrichment	BLM, WRN	2.06
70	Leukemia, chronic lymphocytic	Enrichment	POT1	2.02
71	Isolated growth hormone deficiency, type ia	Enrichment	DNA2	2.00
72	Li-fraumeni syndrome	Enrichment	WRAP53	1.99
73	Adrenocortical carcinoma	Enrichment	TERT	1.99
74	Kidney clear cell sarcoma	Enrichment	TERT	1.99
75	Combined immunodeficiency	Enrichment	POLD1	1.95
76	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.95
77	Familial colorectal cancer type x	Enrichment	POLD1	1.95
78	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.95
79	Aplastic anemia	Enrichment	TERT	1.77
80	Medulloblastoma	Enrichment	WRN	1.76
81	Cataract	Enrichment	WRN	1.76
82	Parkinson's disease	Enrichment	RFC1	1.71
83	Meningioma	Enrichment	TERT	1.70
84	Williams-beuren syndrome	Enrichment	RFC2	1.69
85	Parkinson disease, late-onset	Enrichment	RFC1	1.61
86	Pancreatic cancer	Enrichment	POLD1	1.59
87	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DKC1	1.57
88	Polycystic liver disease	Enrichment	RUVBL1	1.55
89	Autosomal dominant polycystic liver disease	Enrichment	RUVBL1	1.55
90	Endometrial cancer	Enrichment	BLM	1.54
91	Hepatoblastoma	Enrichment	TERT	1.46
92	Hepatocellular carcinoma	Enrichment	TERT	1.44
93	Bladder cancer	Enrichment	TERT	1.32
94	Differentiated thyroid carcinoma	Enrichment	TERT	1.32
95	Type 2 diabetes mellitus	Enrichment	WRN	1.29
96	Hereditary breast carcinoma	Enrichment	BLM	1.22
97	Hereditary breast ovarian cancer syndrome	Enrichment	BLM	1.13
98	Breast cancer	Enrichment	BLM	1.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Telomere C-strand (Lagging Strand) Synthesis

Pathway Network for Telomere C-strand (Lagging Strand) Synthesis

Pathway network for the Telomere C-strand (Lagging Strand) Synthesis SuperPath

Member Pathways for Telomere C-strand (Lagging Strand) Synthesis

Pathways in the Telomere C-strand (Lagging Strand) Synthesis SuperPath

Gene overlap in member pathways for Telomere C-strand (Lagging Strand) Synthesis SuperPath

Associated Genes for Telomere C-strand (Lagging Strand) Synthesis

Associated Disorders for Telomere C-strand (Lagging Strand) Synthesis

Disorders associated with Telomere C-strand (Lagging Strand) Synthesis SuperPath

STRING Interaction Network for Telomere C-strand (Lagging Strand) Synthesis

Sources for Telomere C-strand (Lagging Strand) Synthesis