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Telomere C-strand (Lagging Strand) Synthesis
SuperPath
Pathway network
for
Telomere C-strand (Lagging Strand) Synthesis
SuperPath
30
Pathways
in the
Telomere C-strand (Lagging Strand) Synthesis
SuperPath
Telomere C-strand (Lagging Strand) Synthesis
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Cell cycle Transition and termination of DNA replication
Displacement of DNA glycosylase by APEX1
Base Excision Repair
Base-Excision Repair, AP Site Formation
Gap-filling DNA repair synthesis and ligation in GG-NER
Processive synthesis on the C-strand of the telomere
Base excision repair
Extension of Telomeres
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching
Removal of the Flap Intermediate from the C-strand
POLB-Dependent Long Patch Base Excision Repair
Resolution of Abasic Sites (AP sites)
Leading Strand Synthesis
Processive synthesis on the lagging strand
DNA strand elongation
DNA replication initiation
PCNA-Dependent Long Patch Base Excision Repair
Lagging Strand Synthesis
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Resolution of AP sites via the single-nucleotide replacement pathway
DNA replication
Unwinding of DNA
Removal of the Flap Intermediate
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
100
Genes
in the
Telomere C-strand (Lagging Strand) Synthesis
SuperPath
PCNA
POLD1
POLD2
POLD3
POLD4
FEN1
LIG1
RFC1
RFC2
RFC3
RFC4
RFC5
RPA1
RPA2
RPA3
POLA1
POLE
POLE2
PRIM1
PRIM2
POLA2
POLE3
POLE4
DNA2
APEX1
POLB
OGG1
LIG3
XRCC1
PARP1
PARP2
MPG
MUTYH
NTHL1
TDG
UNG
MBD4
SMUG1
NEIL1
NEIL2
PARG
MCM2
UBA52
UBB
UBC
PNKP
MCM3
MCM4
MCM5
MCM6
MCM7
RNASEH1
RPS27A
DKC1
TERT
RUVBL1
RUVBL2
WRAP53
NHP2
MIR664B
CDC45
GINS1
GINS2
GINS3
GINS4
MCM8
BARD1
BRCA1
CCNA2
CDK1
CDK2
E2F1
E2F4
TFDP1
TOP1
TOP2A
TOP2B
WRN
CCNA1
POLK
PARP3
PARP4
APEX2
POLL
HMGB1
NEIL3
DDB1
UBE2B
USP1
CUL4B
CUL4A
RBX1
ZBTB32
DTL
RAD18
RNASEH2A
RPA4
SSBP1
RNASEH2B
RNASEH2C
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Telomere C-strand (Lagging Strand) Synthesis
SuperPath