Telomere Extension by Telomerase

No Pathway Network information available for Telomere Extension by Telomerase

Pathways in the Telomere Extension by Telomerase SuperPath

#	Name	Source	Genes
1	Telomere Extension by Telomerase	QIAGEN	HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPF MRE11 NBN POT1 RAD50 TERF1 TERF2 TERF2IP TERT TINF2 TNKS TNKS2 XRCC5 XRCC6 (see all 19) (see less)
2	XAV939 stabilizes AXIN	Reactome	TNKS TNKS2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNKS	Tankyrase	Protein Coding	2
2	TNKS2	Tankyrase 2	Protein Coding	2
3	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
4	HNRNPA1	Heterogeneous Nuclear Ribonucleoprotein A1	Protein Coding	1
5	HNRNPA2B1	Heterogeneous Nuclear Ribonucleoprotein A2/B1	Protein Coding	1
6	HNRNPAB	Heterogeneous Nuclear Ribonucleoprotein A/B	Protein Coding	1
7	HNRNPC	Heterogeneous Nuclear Ribonucleoprotein C	Protein Coding	1
8	HNRNPD	Heterogeneous Nuclear Ribonucleoprotein D	Protein Coding	1
9	HNRNPF	Heterogeneous Nuclear Ribonucleoprotein F	Protein Coding	1
10	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
11	NBN	Nibrin	Protein Coding	1
12	POT1	Protection Of Telomeres 1	Protein Coding	1
13	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
14	TERF1	Telomeric Repeat Binding Factor 1	Protein Coding	1
15	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	1
16	TERF2IP	TERF2 Interacting Protein	Protein Coding	1
17	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
18	TINF2	TERF1 Interacting Nuclear Factor 2	Protein Coding	1
19	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1

Disorders associated with Telomere Extension by Telomerase SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma, cutaneous malignant 1	Enrichment	POT1, TERF2IP, TERT	5.81
2	Dyskeratosis congenita	Enrichment	POT1, TERT, TINF2	5.65
3	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TERT	5.45
4	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	HNRNPA1, HNRNPA2B1	5.25
5	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.95
6	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT, TINF2	4.56
7	Hoyeraal-hreidarsson syndrome	Enrichment	TERT, TINF2	4.56
8	Inherited cancer-predisposing syndrome	Enrichment	MRE11, NBN, POT1, RAD50	4.53
9	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT, TINF2	4.41
10	Hereditary breast ovarian cancer syndrome	Enrichment	MRE11, NBN, RAD50	4.23
11	Aplastic anemia	Enrichment	NBN, TERT	4.08
12	Breast cancer	Enrichment	MRE11, NBN, RAD50	3.83
13	Ovarian cancer	Enrichment	MRE11, NBN, RAD50	3.45
14	Tumor predisposition syndrome 3	Enrichment	POT1	2.85
15	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 3	Enrichment	HNRNPA1	2.85
16	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8	Enrichment	POT1	2.85
17	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.85
18	Myopathy, distal, 3	Enrichment	HNRNPA1	2.85
19	High-grade astrocytoma with piloid features	Enrichment	POT1	2.85
20	Cerebroretinal microangiopathy with calcifications and cysts 3	Enrichment	POT1	2.85
21	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Enrichment	HNRNPA2B1	2.85
22	Amyotrophic lateral sclerosis 20	Enrichment	HNRNPA1	2.85
23	Finnish upper limb-onset distal myopathy	Enrichment	HNRNPA1	2.85
24	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.85
25	Intellectual developmental disorder, autosomal dominant 74	Enrichment	HNRNPC	2.85
26	Oculopharyngeal muscular dystrophy 2	Enrichment	HNRNPA2B1	2.85
27	Relapsing-remitting multiple sclerosis	Enrichment	HNRNPA1	2.85
28	Hereditary breast carcinoma	Enrichment	NBN, RAD50	2.77
29	Revesz syndrome	Enrichment	TINF2	2.55
30	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.55
31	Dyskeratosis congenita, autosomal dominant 3	Enrichment	TINF2	2.55
32	Oligodendroglioma	Enrichment	POT1	2.55
33	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.55
34	Idiopathic interstitial pneumonia	Enrichment	TERT	2.55
35	Anaplastic oligodendroglioma	Enrichment	POT1	2.55
36	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	HNRNPA1, HNRNPA2B1	2.53
37	Nijmegen breakage syndrome	Enrichment	NBN	2.38
38	Distal myopathy	Enrichment	HNRNPA1	2.38
39	Interstitial lung disease	Enrichment	TERT	2.38
40	Macrocytic anemia	Enrichment	TERT	2.38
41	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.25
42	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	HNRNPA2B1	2.25
43	Lung sarcomatoid carcinoma	Enrichment	TERT	2.25
44	Idiopathic aplastic anemia	Enrichment	TERT	2.16
45	Pulmonary fibrosis	Enrichment	TERT	2.08
46	Adrenocortical carcinoma	Enrichment	TERT	2.08
47	Kidney clear cell sarcoma	Enrichment	TERT	2.08
48	Colonic benign neoplasm	Enrichment	MRE11	1.90
49	Leukemia, chronic lymphocytic	Enrichment	POT1	1.86
50	Leukemia, acute lymphoblastic	Enrichment	NBN	1.82
51	Meningioma	Enrichment	TERT	1.78
52	Breast-ovarian cancer, familial 1	Enrichment	NBN	1.74
53	Premature menopause	Enrichment	NBN	1.74
54	Interstitial lung disease 2	Enrichment	TERT	1.63
55	Diffuse large b-cell lymphoma	Enrichment	NBN	1.58
56	Lissencephaly	Enrichment	NBN	1.54
57	Hepatoblastoma	Enrichment	TERT	1.54
58	Pancreatic cancer	Enrichment	NBN	1.46
59	Bladder cancer	Enrichment	TERT	1.40
60	Prostate cancer	Enrichment	NBN	1.40
61	Differentiated thyroid carcinoma	Enrichment	TERT	1.40
62	Leukemia, acute myeloid	Enrichment	TERT	1.26
63	Gastric cancer	Enrichment	NBN	1.23
64	Primary ovarian insufficiency	Enrichment	NBN	1.10
65	Microcephaly	Enrichment	NBN	0.80
66	Complex neurodevelopmental disorder	Enrichment	HNRNPC	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Telomere Extension by Telomerase

Pathway Network for Telomere Extension by Telomerase

Member Pathways for Telomere Extension by Telomerase

Pathways in the Telomere Extension by Telomerase SuperPath

Associated Genes for Telomere Extension by Telomerase

Associated Disorders for Telomere Extension by Telomerase

Disorders associated with Telomere Extension by Telomerase SuperPath

STRING Interaction Network for Telomere Extension by Telomerase

Sources for Telomere Extension by Telomerase