tetrahydrobiopterin de novo biosynthesis

Sources:

#	Name	Source	Genes
1	tetrahydrobiopterin de novo biosynthesis	PubChem	GCH1 PTS SPR
2	erythro-tetrahydrobiopterin biosynthesis II	PubChem	GCH1 PTS SPR
3	erythro-tetrahydrobiopterin biosynthesis I	PubChem	GCH1 PTS SPR

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GCH1	GTP Cyclohydrolase 1	Protein Coding	3
2	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	3
3	SPR	Sepiapterin Reductase	Protein Coding	3

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperphenylalaninemia, bh4-deficient, b	Enrichment	GCH1, PTS	7.01
2	Hyperphenylalaninemia, bh4-deficient, a	Enrichment	GCH1, PTS	6.31
3	Dystonia	Enrichment	GCH1, SPR	4.71
4	Dystonia, dopa-responsive, due to sepiapterin reductase deficiency	Enrichment	SPR	3.35
5	Dystonia, dopa-responsive	Enrichment	GCH1	3.18
6	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	GCH1	3.18
7	Hyperphenylalaninemia due to tetrahydrobiopterin deficiency	Enrichment	PTS	3.18
8	Sleep disorder	Enrichment	GCH1	2.96

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for tetrahydrobiopterin de novo biosynthesis