Tezacaftor Pathway, Pharmacokinetics

Pathway network for the Tezacaftor Pathway, Pharmacokinetics SuperPath

Sources:

PharmGKB
WikiPathways
Reactome

Pathways in the Tezacaftor Pathway, Pharmacokinetics SuperPath

#	Name	Source	Genes
1	Tezacaftor Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP3A4 CYP3A5 SLCO1B1
2	Irinotecan Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC1 ABCC2 ABCC5 ABCG1 ABCG2 BCHE CES1 CES2 CYP3A4 CYP3A5 SLCO1B1 UGT1A1 UGT1A10 UGT1A6 UGT1A7 UGT1A9 (see all 17) (see less)
3	Irinotecan pathway	WikiPathways	ABCC1 ABCC2 ABCG2 BCHE CES1 CES2 CYP3A4 CYP3A5 SLCO1B1 UGT1A1 UGT1A10 UGT1A9 (see all 12) (see less)
4	Simvastatin Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC2 CES1 CYP2C8 CYP3A4 CYP3A5 HMGCR PON1 SLCO1B1 UGT1A1 UGT1A3 (see all 11) (see less)
5	Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCC2 CYP3A4 ORM1 SLCO1B1 SLCO1B3 (see all 6) (see less)
6	Ticagrelor Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP3A4 CYP3A5 SLCO1B1 UGT1A9
7	Ivacaftor and Lumacaftor Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 CFTR CYP3A4 CYP3A5
8	Edoxaban Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CES1 CYP3A4 F10 SLCO1B1
9	Lovastatin Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP3A4 CYP3A5 SLCO1B1
10	Tacrolimus/Cyclosporine Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP3A4 CYP3A5
11	Amlodipine Pathway, Pharmacokinetics	PharmGKB	CYP3A4 CYP3A5
12	Defective ABCC2 causes DJS	Reactome	ABCC2

Gene overlap in member pathways for Tezacaftor Pathway, Pharmacokinetics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	11
2	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	9
3	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	8
4	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	8
5	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	5
6	CES1	Carboxylesterase 1	Protein Coding	4
7	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	3
8	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	3
9	BCHE	Butyrylcholinesterase	Protein Coding	2
10	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	2
11	CES2	Carboxylesterase 2	Protein Coding	2
12	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	2
13	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2
14	ABCG1	ATP Binding Cassette Subfamily G Member 1	Protein Coding	1
15	UGT1A7	UDP Glucuronosyltransferase Family 1 Member A7	Protein Coding	1
16	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	1
17	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	1
18	PON1	Paraoxonase 1	Protein Coding	1
19	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	1
20	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
21	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
22	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	1
23	ORM1	Orosomucoid 1	Protein Coding	1
24	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
25	F10	Coagulation Factor X	Protein Coding	1

Disorders associated with Tezacaftor Pathway, Pharmacokinetics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dubin-johnson syndrome	Direct
2	Gilbert syndrome	Enrichment	SLCO1B1, UGT1A1, UGT1A10, UGT1A6, UGT1A7, UGT1A9	16.00
3	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A7, UGT1A9	16.00
4	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A7, UGT1A9	16.00
5	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A7, UGT1A9	16.00
6	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A7, UGT1A9	16.00
7	Bilirubin metabolic disorder	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A7, UGT1A9	16.00
8	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1, SLCO1B3	6.31
9	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.83
10	Colchicine resistance	Enrichment	ABCB1	3.66
11	Encephalopathy, acute transient	Enrichment	ABCB1	3.66
12	Inflammatory bowel disease 13	Enrichment	ABCB1	3.66
13	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	3.53
14	Drug metabolism, altered, ces1-related	Enrichment	CES1	3.53
15	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	3.23
16	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.09
17	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	3.09
18	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	3.09
19	Nuchal bleb, familial	Enrichment	CFTR	3.05
20	Factor x deficiency	Enrichment	F10	3.05
21	Congenital factor x deficiency	Enrichment	F10	3.05
22	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.05
23	Deafness, autosomal dominant 77	Enrichment	ABCC1	3.05
24	Blood group, junior system	Enrichment	ABCG2	3.05
25	Butyrylcholinesterase deficiency	Enrichment	BCHE	3.05
26	Idiopathic bronchiectasis	Enrichment	CFTR	2.93
27	Microvascular complications of diabetes 5	Enrichment	PON1	2.79
28	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.61
29	Hypertension, essential	Enrichment	CYP3A5	2.60
30	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.58
31	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	2.58
32	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	2.58
33	Hereditary chronic pancreatitis	Enrichment	CFTR	2.38
34	Lynch syndrome	Enrichment	CFTR	2.35
35	Pancreatitis, hereditary	Enrichment	CFTR	2.30
36	Limb-girdle muscular dystrophy	Enrichment	HMGCR	2.14
37	Cystic fibrosis	Enrichment	CFTR	2.03
38	Male infertility	Enrichment	CFTR	2.00
39	Thrombocytopenia	Enrichment	F10	1.85
40	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	1.78
41	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.35
42	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PON1	1.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Tezacaftor Pathway, Pharmacokinetics

Pathway Network for Tezacaftor Pathway, Pharmacokinetics

Pathway network for the Tezacaftor Pathway, Pharmacokinetics SuperPath

Member Pathways for Tezacaftor Pathway, Pharmacokinetics

Pathways in the Tezacaftor Pathway, Pharmacokinetics SuperPath

Gene overlap in member pathways for Tezacaftor Pathway, Pharmacokinetics SuperPath

Associated Genes for Tezacaftor Pathway, Pharmacokinetics

Associated Disorders for Tezacaftor Pathway, Pharmacokinetics

Disorders associated with Tezacaftor Pathway, Pharmacokinetics SuperPath

STRING Interaction Network for Tezacaftor Pathway, Pharmacokinetics

Sources for Tezacaftor Pathway, Pharmacokinetics