TGF-beta receptor signaling

No Pathway Network information available for TGF-beta receptor signaling

Pathways in the TGF-beta receptor signaling SuperPath

#	Name	Source	Genes
1	TGF-beta receptor signaling	PubChem	ARRB2 AXIN1 BAMBI CAMK2A CAV1 CCN2 CTNNB1 DAB2 DACT2 DAXX DYNLRB1 EIF2A FKBP1A GRB2 ITCH MAP3K7 NEDD4L OCLN PARD6A PDPK1 PML PPP1CA PPP1R15A PPP2CA PPP2CB PPP2R2A RNF111 RPS6KB1 SHC1 SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SOS1 SPTBN1 STRAP TFAP2B TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 WWP1 XIAP YAP1 YWHAE ZFYVE16 ZFYVE9 (see all 50) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	1
2	DYNLRB1	Dynein Light Chain Roadblock-Type 1	Protein Coding	1
3	DACT2	Dishevelled Binding Antagonist Of Beta Catenin 2	Protein Coding	1
4	EIF2A	Eukaryotic Translation Initiation Factor 2A	Protein Coding	1
5	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
6	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	1
7	WWP1	WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
8	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
9	DAXX	Death Domain Associated Protein	Protein Coding	1
10	TFAP2B	Transcription Factor AP-2 Beta	Protein Coding	1
11	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
12	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
13	PML	PML Nuclear Body Scaffold	Protein Coding	1
14	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
15	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
16	AXIN1	Axin 1	Protein Coding	1
17	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1
18	ZFYVE16	Zinc Finger FYVE-Type Containing 16	Protein Coding	1
19	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
20	NEDD4L	NEDD4 Like E3 Ubiquitin Protein Ligase	Protein Coding	1
21	SMAD7	SMAD Family Member 7	Protein Coding	1
22	BAMBI	BMP And Activin Membrane Bound Inhibitor	Protein Coding	1
23	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
24	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
25	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
26	PPP1R15A	Protein Phosphatase 1 Regulatory Subunit 15A	Protein Coding	1
27	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
28	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	1
29	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
30	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
31	RNF111	Ring Finger Protein 111	Protein Coding	1
32	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
33	OCLN	Occludin	Protein Coding	1
34	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
35	CAV1	Caveolin 1	Protein Coding	1
36	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
37	ARRB2	Arrestin Beta 2	Protein Coding	1
38	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
39	STRAP	Serine/Threonine Kinase Receptor Associated Protein	Protein Coding	1
40	CTNNB1	Catenin Beta 1	Protein Coding	1
41	SMAD4	SMAD Family Member 4	Protein Coding	1
42	SMAD2	SMAD Family Member 2	Protein Coding	1
43	SMAD3	SMAD Family Member 3	Protein Coding	1
44	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
45	DAB2	DAB Adaptor Protein 2	Protein Coding	1
46	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
47	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
48	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
49	SHC1	SHC Adaptor Protein 1	Protein Coding	1
50	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1

Disorders associated with TGF-beta receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB3, TGFBR1, TGFBR2	10.08
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB3, TGFBR1, TGFBR2	7.93
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	7.33
4	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.88
5	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.10
6	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1, CCN2	3.88
7	Limited scleroderma	Enrichment	CAV1, CCN2	3.70
8	Gallbladder cancer	Enrichment	CTNNB1, SMAD4	3.56
9	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	3.33
10	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.23
11	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	2.66
12	Hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	2.53
13	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.43
14	Pseudo-torch syndrome 1	Enrichment	OCLN	2.43
15	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.43
16	Noonan syndrome 4	Enrichment	SOS1	2.43
17	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.43
18	Char syndrome	Enrichment	TFAP2B	2.43
19	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.43
20	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.43
21	Caudal duplication anomaly	Enrichment	AXIN1	2.43
22	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.43
23	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.43
24	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.43
25	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.43
26	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.43
27	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.43
28	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.43
29	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.43
30	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.43
31	Colorectal cancer 3	Enrichment	SMAD7	2.43
32	Patent ductus arteriosus 2	Enrichment	TFAP2B	2.43
33	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.43
34	Periventricular nodular heterotopia 7	Enrichment	NEDD4L	2.43
35	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.43
36	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.43
37	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.43
38	Adenoid ameloblastoma	Enrichment	CTNNB1	2.43
39	Heritable thoracic aortic disease	Enrichment	SMAD4	2.43
40	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.43
41	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.43
42	Microcystic stromal tumor	Enrichment	CTNNB1	2.43
43	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.21
44	Fibromatosis, gingival, 1	Enrichment	SOS1	2.13
45	Myhre syndrome	Enrichment	SMAD4	2.13
46	Camurati-engelmann disease 1	Enrichment	TGFB1	2.13
47	Kyphomelic dysplasia	Enrichment	CCN2	2.13
48	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.13
49	Pulmonic stenosis	Enrichment	SOS1	2.13
50	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.13
51	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.13
52	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.13
53	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.13
54	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.13
55	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.13
56	Camurati-engelmann disease	Enrichment	TGFB1	2.13
57	Loeys-dietz syndrome 4	Enrichment	TGFB3	2.13
58	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.13
59	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.13
60	Teratoma	Enrichment	CTNNB1	2.13
61	Familial patent arterial duct	Enrichment	TFAP2B	2.13
62	Desmoid disease, hereditary	Enrichment	CTNNB1	1.96
63	Juvenile polyposis syndrome	Enrichment	SMAD4	1.96
64	Nuchal bleb, familial	Enrichment	SOS1	1.96
65	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	NEDD4L	1.96
66	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.96
67	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.96
68	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	1.96
69	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.96
70	Anus, imperforate	Enrichment	CTNNB1	1.96
71	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.96
72	Desmoid tumor	Enrichment	CTNNB1	1.96
73	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.96
74	Pilomatrixoma	Enrichment	CTNNB1	1.83
75	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.83
76	Alazami syndrome	Enrichment	CTNNB1	1.83
77	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	1.83
78	Craniopharyngioma	Enrichment	CTNNB1	1.83
79	Gingival fibromatosis	Enrichment	SOS1	1.83
80	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.74
81	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.74
82	Pervasive developmental disorder	Enrichment	SPTBN1	1.74
83	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.74
84	Endometrial stromal sarcoma	Enrichment	YWHAE	1.74
85	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.74
86	Rare pervasive developmental disorder	Enrichment	SPTBN1	1.74
87	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.74
88	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.66
89	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.66
90	Intestinal pseudo-obstruction	Enrichment	TFAP2B	1.66
91	Adrenocortical carcinoma	Enrichment	CTNNB1	1.66
92	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.66
93	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.66
94	Kidney clear cell sarcoma	Enrichment	YWHAE	1.66
95	Esophageal cancer	Enrichment	TGFBR2	1.59
96	Noonan syndrome 3	Enrichment	SOS1	1.59
97	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.59
98	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.54
99	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.49
100	Pectus excavatum	Enrichment	TGFBR1	1.40
101	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.40
102	Colorectal cancer	Enrichment	CTNNB1, SMAD4	1.39
103	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.36
104	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.36
105	Aortic valve disease 1	Enrichment	SOS1	1.33
106	Microphthalmia/coloboma 12	Enrichment	YAP1	1.33
107	Acute promyelocytic leukemia	Enrichment	PML	1.33
108	Medulloblastoma	Enrichment	CTNNB1	1.30
109	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.30
110	Periventricular nodular heterotopia	Enrichment	NEDD4L	1.30
111	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.30
112	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.30
113	Coloboma of macula	Enrichment	YAP1	1.27
114	Lynch syndrome	Enrichment	TGFBR2	1.27
115	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.27
116	Isolated congenital microcephaly	Enrichment	OCLN	1.24
117	Polycystic liver disease	Enrichment	CTNNB1	1.22
118	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.22
119	Arteriovenous malformations of the brain	Enrichment	ZFYVE16	1.17
120	Craniosynostosis	Enrichment	TFAP2B	1.15
121	Hepatoblastoma	Enrichment	CTNNB1	1.13
122	Complex neurodevelopmental disorder	Enrichment	PPP2CA, SPTBN1	1.12
123	Noonan syndrome 1	Enrichment	SOS1	1.09
124	Autoinflammatory disease	Enrichment	XIAP	1.07
125	Pancreatic cancer	Enrichment	SMAD4	1.05
126	Rasopathy	Enrichment	SOS1	1.04
127	Bladder cancer	Enrichment	CTNNB1	0.99
128	Cystic fibrosis	Enrichment	TGFB1	0.95
129	Gastric cancer	Enrichment	SMAD4	0.83
130	Thrombocytopenia	Enrichment	SMAD4	0.79
131	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A	0.77
132	Myeloma, multiple	Enrichment	YAP1	0.73
133	Breast cancer	Enrichment	SHC1	0.62
134	Ovarian cancer	Enrichment	CTNNB1	0.51
135	Congenital nervous system abnormality	Enrichment	CTNNB1	0.49
136	Nervous system disease	Enrichment	CTNNB1	0.49
137	Microcephaly	Enrichment	CTNNB1	0.44
138	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TGF-beta receptor signaling

Pathway Network for TGF-beta receptor signaling

Member Pathways for TGF-beta receptor signaling

Pathways in the TGF-beta receptor signaling SuperPath

Associated Genes for TGF-beta receptor signaling

Associated Disorders for TGF-beta receptor signaling

Disorders associated with TGF-beta receptor signaling SuperPath

STRING Interaction Network for TGF-beta receptor signaling

Sources for TGF-beta receptor signaling