TGF-beta receptor signaling activates SMADs

Pathway network for the TGF-beta receptor signaling activates SMADs SuperPath

Sources:

Reactome
WikiPathways

Pathways in the TGF-beta receptor signaling activates SMADs SuperPath

#	Name	Source	Genes
1	TGF-beta receptor signaling activates SMADs	Reactome	BAMBI CBL FBN1 FKBP1A FURIN ITGA8 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LTBP1 LTBP2 LTBP3 LTBP4 MTMR4 NEDD4L NEDD8 PMEPA1 PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 STRAP STUB1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 UBA52 UBB UBC UBE2M UCHL5 USP15 XPO1 ZFYVE9 (see all 47) (see less)
2	Downregulation of TGF-beta receptor signaling	Reactome	BAMBI MTMR4 NEDD4L PMEPA1 PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STRAP STUB1 TGFB1 TGFBR1 TGFBR2 UBA52 UBB UBC UCHL5 USP15 XPO1 ZFYVE9 (see all 26) (see less)
3	Signaling by TGF-beta Receptor Complex in Cancer	Reactome	FKBP1A SMAD2 SMAD3 SMAD4 TGFB1 TGFBR1 TGFBR2 ZFYVE9 (see all 8) (see less)
4	Loss of Function of SMAD2/3 in Cancer	Reactome	SMAD2 SMAD3 SMAD4 TGFB1 TGFBR1 TGFBR2 ZFYVE9 (see all 7) (see less)
5	Loss of Function of TGFBR1 in Cancer	Reactome	FKBP1A SMAD2 SMAD3 TGFB1 TGFBR1 TGFBR2 ZFYVE9 (see all 7) (see less)
6	TGFBR1 LBD Mutants in Cancer	Reactome	FKBP1A TGFB1 TGFBR1 TGFBR2
7	TGF-beta signaling pathway	WikiPathways	UCHL5

Gene overlap in member pathways for TGF-beta receptor signaling activates SMADs SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	6
2	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	6
3	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	6
4	SMAD2	SMAD Family Member 2	Protein Coding	5
5	SMAD3	SMAD Family Member 3	Protein Coding	5
6	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	5
7	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	4
8	SMAD4	SMAD Family Member 4	Protein Coding	3
9	UCHL5	Ubiquitin C-Terminal Hydrolase L5	Protein Coding	3
10	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	2
11	STRAP	Serine/Threonine Kinase Receptor Associated Protein	Protein Coding	2
12	NEDD4L	NEDD4 Like E3 Ubiquitin Protein Ligase	Protein Coding	2
13	PPP1R15A	Protein Phosphatase 1 Regulatory Subunit 15A	Protein Coding	2
14	BAMBI	BMP And Activin Membrane Bound Inhibitor	Protein Coding	2
15	SMAD7	SMAD Family Member 7	Protein Coding	2
16	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	2
17	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	2
18	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	2
19	PMEPA1	Prostate Transmembrane Protein, Androgen Induced 1	Protein Coding	2
20	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	2
21	RPS27A	Ribosomal Protein S27a	Protein Coding	2
22	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	2
23	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
24	UBB	Ubiquitin B	Protein Coding	2
25	UBC	Ubiquitin C	Protein Coding	2
26	XPO1	Exportin 1	Protein Coding	2
27	MTMR4	Myotubularin Related Protein 4	Protein Coding	2
28	USP15	Ubiquitin Specific Peptidase 15	Protein Coding	2
29	FBN1	Fibrillin 1	Protein Coding	1
30	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
31	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
32	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
33	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
34	ITGB6	Integrin Subunit Beta 6	Protein Coding	1
35	ITGB8	Integrin Subunit Beta 8	Protein Coding	1
36	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	1
37	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	1
38	LTBP3	Latent Transforming Growth Factor Beta Binding Protein 3	Protein Coding	1
39	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	1
40	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
41	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
42	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
43	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
44	LTBP4	Latent Transforming Growth Factor Beta Binding Protein 4	Protein Coding	1
45	ITGA8	Integrin Subunit Alpha 8	Protein Coding	1
46	CBL	Cbl Proto-Oncogene	Protein Coding	1
47	UBE2M	Ubiquitin Conjugating Enzyme E2 M	Protein Coding	1

Disorders associated with TGF-beta receptor signaling activates SMADs SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FBN1, SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	11.34
2	Loeys-dietz syndrome	Enrichment	FBN1, SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	11.25
3	Marfan syndrome	Enrichment	FBN1, LTBP2, TGFB2, TGFBR1, TGFBR2	10.06
4	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	9.95
5	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	7.19
6	Aortic aneurysm	Enrichment	FBN1, SMAD3, TGFBR1	6.81
7	Acromicric dysplasia	Enrichment	FBN1, LTBP3	4.93
8	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.93
9	Weill-marchesani syndrome 1	Enrichment	FBN1, LTBP2	4.45
10	Geleophysic dysplasia	Enrichment	FBN1, LTBP3	4.45
11	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	4.44
12	Weill-marchesani syndrome	Enrichment	FBN1, LTBP2	4.15
13	Connective tissue disease	Enrichment	SMAD3, TGFBR2	3.95
14	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	3.53
15	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	3.53
16	Familial thoracic aortic aneurysm and dissection	Enrichment	FBN1, SMAD3	3.38
17	Loeys-dietz syndrome 6	Enrichment	SMAD2	3.29
18	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	3.29
19	Heritable thoracic aortic disease	Enrichment	SMAD4	3.29
20	Camurati-engelmann disease 1	Enrichment	TGFB1	3.23
21	Microvascular complications of diabetes 5	Enrichment	TGFBR2	3.23
22	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	3.23
23	Camurati-engelmann disease	Enrichment	TGFB1	3.23
24	Pectus excavatum	Enrichment	FBN1, TGFBR1	3.20
25	Myhre syndrome	Enrichment	SMAD4	2.99
26	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.99
27	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.99
28	Aortic aneurysm, familial thoracic 1	Enrichment	FBN1, SMAD3	2.98
29	Juvenile polyposis syndrome	Enrichment	SMAD4	2.81
30	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	2.75
31	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	2.75
32	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	2.75
33	Colorectal cancer 3	Enrichment	SMAD7	2.72
34	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.72
35	Periventricular nodular heterotopia 7	Enrichment	NEDD4L	2.72
36	Esophageal cancer	Enrichment	TGFBR2	2.69
37	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.59
38	Noonan syndrome 1	Enrichment	CBL, PPP1CB	2.55
39	Ectopia lentis 1, isolated, autosomal dominant	Enrichment	FBN1	2.46
40	Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma	Enrichment	LTBP2	2.46
41	Glaucoma 3, primary congenital, d	Enrichment	LTBP2	2.46
42	Weill-marchesani syndrome 2	Enrichment	FBN1	2.46
43	Geleophysic dysplasia 2	Enrichment	FBN1	2.46
44	Protrusio acetabuli	Enrichment	FBN1	2.46
45	Weill-marchesani syndrome 3	Enrichment	LTBP2	2.46
46	Lymphoplasmacytic lymphoma	Enrichment	FBN1	2.46
47	Camurati-engelmann disease 2	Enrichment	TGFB2	2.46
48	Geleophysic dysplasia 3	Enrichment	LTBP3	2.46
49	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.46
50	Cutis laxa, autosomal recessive, type iie	Enrichment	LTBP1	2.46
51	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.46
52	Glaucoma secondary to spherophakia/ectopia lentis and megalocornea	Enrichment	LTBP2	2.46
53	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.46
54	Neonatal marfan syndrome	Enrichment	FBN1	2.46
55	Gallbladder cancer	Enrichment	SMAD4	2.44
56	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	2.44
57	Rasopathy	Enrichment	CBL, PPP1CB	2.44
58	Spinocerebellar ataxia 48	Enrichment	STUB1	2.42
59	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.42
60	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.42
61	Submucosal cleft palate	Enrichment	UBB	2.42
62	Cleft hard palate	Enrichment	UBB	2.42
63	Lynch syndrome	Enrichment	TGFBR2	2.35
64	Uvula, bifid	Enrichment	UBB	2.24
65	Cleft soft palate	Enrichment	UBB	2.24
66	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	NEDD4L	2.24
67	Stiff skin syndrome	Enrichment	FBN1	2.16
68	Ovarian germ cell cancer	Enrichment	CBL	2.16
69	Cutis laxa, autosomal recessive, type ic	Enrichment	LTBP4	2.16
70	Beaulieu-boycott-innes syndrome	Enrichment	FBN1	2.16
71	Aortic dissection	Enrichment	FBN1	2.16
72	Marfanoid-progeroid-lipodystrophy syndrome	Enrichment	FBN1	2.16
73	Malignant germ cell tumor of ovary	Enrichment	CBL	2.16
74	Lens subluxation	Enrichment	FBN1	2.16
75	Cystic fibrosis	Enrichment	TGFB1	2.03
76	Contractural arachnodactyly, congenital	Enrichment	FBN1	1.98
77	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.98
78	Achondroplasia	Enrichment	FBN1	1.98
79	Mccune-albright syndrome	Enrichment	FBN1	1.98
80	Exfoliation syndrome	Enrichment	LTBP2	1.98
81	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.98
82	Muscular dystrophy, duchenne type	Enrichment	LTBP4	1.98
83	Autosomal recessive cutis laxa type i	Enrichment	LTBP1	1.98
84	Isolated ectopia lentis	Enrichment	FBN1	1.98
85	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.98
86	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.98
87	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.94
88	Thrombocytopenia	Enrichment	ITGB3, SMAD4	1.92
89	Pancreatic cancer	Enrichment	SMAD4	1.89
90	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.86
91	Glaucoma 3, primary infantile, b	Enrichment	LTBP2	1.86
92	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	1.86
93	Mitral valve insufficiency	Enrichment	FBN1	1.86
94	Polycystic liver disease 1 with or without kidney cysts	Enrichment	FBN1	1.76
95	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.76
96	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	FBN1	1.76
97	Goldberg-shprintzen syndrome	Enrichment	FBN1	1.76
98	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.76
99	Polycystic liver disease 1	Enrichment	FBN1	1.76
100	Myeloproliferative neoplasm	Enrichment	CBL	1.76
101	Juvenile glaucoma	Enrichment	LTBP2	1.76
102	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.76
103	Aggressive systemic mastocytosis	Enrichment	CBL	1.76
104	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.76
105	Atrial septal defect 1	Enrichment	TGFB2	1.69
106	Glaucoma, primary open angle	Enrichment	LTBP2	1.69
107	Dental anomalies and short stature	Enrichment	LTBP3	1.69
108	Inguinal hernia	Enrichment	FBN1	1.69
109	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.69
110	Gastric cancer	Enrichment	SMAD4	1.66
111	Glaucoma 3, primary congenital, a	Enrichment	LTBP2	1.62
112	Brugada syndrome 1	Enrichment	FBN1	1.62
113	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.62
114	Periventricular nodular heterotopia	Enrichment	NEDD4L	1.58
115	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.56
116	Orthostatic intolerance	Enrichment	FBN1	1.56
117	Renal agenesis, bilateral	Enrichment	ITGA8	1.51
118	Dandy-walker syndrome	Enrichment	PPP1CB	1.49
119	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.47
120	Stroke, ischemic	Enrichment	FBN1	1.47
121	Melanoma	Enrichment	FBN1	1.47
122	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.47
123	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.39
124	Cutis laxa	Enrichment	LTBP4	1.39
125	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.39
126	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.39
127	Colorectal cancer	Enrichment	SMAD4	1.36
128	Diaphragmatic hernia, congenital	Enrichment	FBN1	1.36
129	Neural tube defects	Enrichment	ITGB1	1.36
130	Amelogenesis imperfecta	Enrichment	LTBP3	1.36
131	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.32
132	Myopia	Enrichment	FBN1	1.29
133	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.29
134	Perrault syndrome 1	Enrichment	FBN1	1.27
135	Rhabdomyosarcoma	Enrichment	CBL	1.27
136	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	1.18
137	Myocardial infarction	Enrichment	ITGB3	1.13
138	Scoliosis	Enrichment	FBN1	1.10
139	Severe covid-19	Enrichment	ITGAV	1.02
140	Myopathy	Enrichment	FBN1	0.89
141	Dilated cardiomyopathy	Enrichment	FBN1	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TGF-beta receptor signaling activates SMADs

Pathway Network for TGF-beta receptor signaling activates SMADs

Pathway network for the TGF-beta receptor signaling activates SMADs SuperPath

Member Pathways for TGF-beta receptor signaling activates SMADs

Pathways in the TGF-beta receptor signaling activates SMADs SuperPath

Gene overlap in member pathways for TGF-beta receptor signaling activates SMADs SuperPath

Associated Genes for TGF-beta receptor signaling activates SMADs

Associated Disorders for TGF-beta receptor signaling activates SMADs

Disorders associated with TGF-beta receptor signaling activates SMADs SuperPath

STRING Interaction Network for TGF-beta receptor signaling activates SMADs

Sources for TGF-beta receptor signaling activates SMADs