TGF-beta receptor signaling in skeletal dysplasias

No Pathway Network information available for TGF-beta receptor signaling in skeletal dysplasias

Pathways in the TGF-beta receptor signaling in skeletal dysplasias SuperPath

#	Name	Source	Genes
1	TGF-beta receptor signaling in skeletal dysplasias	WikiPathways	ADAMTS10 ADAMTSL2 BAMBI BMP4 CREBBP CTNNB1 EGF ENG EP300 FBN1 FKBP1A FOS FOXH1 FST HRAS IFNG INHBA ITGB6 JAK1 JUN LEF1 LEFTY1 LEFTY2 LIF LTBP1 LTBP3 MAPK3 MAPK9 MIR302A NFKB1 NOG RUNX2 RUNX3 SERPINE1 SKI SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SPP1 STAT1 STAT3 TFE3 TGFB1 TGFBR1 TGFBR2 TGFBR3 TGIF1 THBS1 TNF WNT1 ZEB2 ZFYVE9 ZNF423 (see all 59) (see less)
2	TGF-beta receptor signaling	WikiPathways	BAMBI BMP4 CREBBP CTNNB1 EGF ENG EP300 FKBP1A FOS FOXH1 FST HRAS IFNG INHBA ITGB6 JAK1 JUN LEF1 LEFTY1 LEFTY2 LIF LTBP1 MAPK3 MAPK9 MIR302A NFKB1 NOG RUNX2 RUNX3 SERPINE1 SKI SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SPP1 STAT1 STAT3 TFE3 TGFB1 TGFBR1 TGFBR2 TGFBR3 TGIF1 THBS1 TNF WNT1 ZEB2 ZFYVE9 ZNF423 (see all 55) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ZEB2	Zinc Finger E-Box Binding Homeobox 2	Protein Coding	2
2	NOG	Noggin	Protein Coding	2
3	FOXH1	Forkhead Box H1	Protein Coding	2
4	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	2
5	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	2
6	WNT1	Wnt Family Member 1	Protein Coding	2
7	TNF	Tumor Necrosis Factor	Protein Coding	2
8	THBS1	Thrombospondin 1	Protein Coding	2
9	TGIF1	TGFB Induced Factor Homeobox 1	Protein Coding	2
10	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	2
11	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	2
12	LEFTY2	Left-Right Determination Factor 2	Protein Coding	2
13	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	2
14	TFE3	Transcription Factor Binding To IGHM Enhancer 3	Protein Coding	2
15	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
16	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
17	SPP1	Secreted Phosphoprotein 1	Protein Coding	2
18	BMP4	Bone Morphogenetic Protein 4	Protein Coding	2
19	SKIL	SKI Like Proto-Oncogene	Protein Coding	2
20	SKI	SKI Proto-Oncogene	Protein Coding	2
21	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
22	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
23	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	2
24	SERPINE1	Serpin Family E Member 1	Protein Coding	2
25	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
26	SMAD9	SMAD Family Member 9	Protein Coding	2
27	SMAD7	SMAD Family Member 7	Protein Coding	2
28	SMAD6	SMAD Family Member 6	Protein Coding	2
29	SMAD5	SMAD Family Member 5	Protein Coding	2
30	SMAD4	SMAD Family Member 4	Protein Coding	2
31	SMAD3	SMAD Family Member 3	Protein Coding	2
32	SMAD2	SMAD Family Member 2	Protein Coding	2
33	SMAD1	SMAD Family Member 1	Protein Coding	2
34	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	2
35	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	2
36	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
37	JAK1	Janus Kinase 1	Protein Coding	2
38	ITGB6	Integrin Subunit Beta 6	Protein Coding	2
39	INHBA	Inhibin Subunit Beta A	Protein Coding	2
40	IFNG	Interferon Gamma	Protein Coding	2
41	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
42	BAMBI	BMP And Activin Membrane Bound Inhibitor	Protein Coding	2
43	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
44	ZNF423	Zinc Finger Protein 423	Protein Coding	2
45	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	2
46	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
47	ENG	Endoglin	Protein Coding	2
48	EGF	Epidermal Growth Factor	Protein Coding	2
49	CTNNB1	Catenin Beta 1	Protein Coding	2
50	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
51	FST	Follistatin	Protein Coding	2
52	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	2
53	LEFTY1	Left-Right Determination Factor 1	Protein Coding	2
54	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	2
55	MIR302A	MicroRNA 302a	RNA Gene	2
56	ADAMTSL2	ADAMTS Like 2	Protein Coding	1
57	ADAMTS10	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10	Protein Coding	1
58	LTBP3	Latent Transforming Growth Factor Beta Binding Protein 3	Protein Coding	1
59	FBN1	Fibrillin 1	Protein Coding	1

Disorders associated with TGF-beta receptor signaling in skeletal dysplasias SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	FBN1, SMAD2, SMAD3, TGFBR1, TGFBR2	9.73
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FBN1, SKI, SMAD2, SMAD3, SMAD4, TGFBR1, TGFBR2	9.16
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	7.20
4	Geleophysic dysplasia	Enrichment	ADAMTSL2, FBN1, LTBP3	7.11
5	Aortic aneurysm	Enrichment	FBN1, SMAD3, TGFBR1	6.51
6	Marfan syndrome	Enrichment	FBN1, TGFBR1, TGFBR2	5.04
7	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.79
8	Acromicric dysplasia	Enrichment	FBN1, LTBP3	4.73
9	Aortic aneurysm, familial thoracic 1	Enrichment	FBN1, SMAD3, SMAD6	4.56
10	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.32
11	Weill-marchesani syndrome 1	Enrichment	ADAMTS10, FBN1	4.25
12	Weill-marchesani syndrome	Enrichment	ADAMTS10, FBN1	3.95
13	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	ENG, SMAD4	3.80
14	Familial cerebral saccular aneurysm	Enrichment	ENG, TGFBR3	3.80
15	Goldberg-shprintzen syndrome	Enrichment	FBN1, SKI	3.73
16	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.62
17	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.62
18	Gallbladder cancer	Enrichment	CTNNB1, SMAD4	3.48
19	Hereditary hemorrhagic telangiectasia	Enrichment	ENG, SMAD4	3.48
20	Connective tissue disease	Enrichment	FBN1, SMAD3, TGFBR2	3.45
21	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, ZEB2	3.35
22	Systemic lupus erythematosus	Enrichment	ENG, SPP1, TNF	3.28
23	Adult hepatocellular carcinoma	Enrichment	CTNNB1, EGF	3.24
24	Familial thoracic aortic aneurysm and dissection	Enrichment	FBN1, SMAD3	3.18
25	Heritable pulmonary arterial hypertension	Enrichment	ENG, SMAD9	3.06
26	Pectus excavatum	Enrichment	FBN1, TGFBR1	3.00
27	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.79
28	Septopreoptic holoprosencephaly	Enrichment	FOXH1, TGIF1	2.79
29	Midline interhemispheric variant of holoprosencephaly	Enrichment	FOXH1, TGIF1	2.79
30	Microform holoprosencephaly	Enrichment	FOXH1, TGIF1	2.73
31	Lobar holoprosencephaly	Enrichment	FOXH1, TGIF1	2.73
32	Alobar holoprosencephaly	Enrichment	FOXH1, TGIF1	2.68
33	Semilobar holoprosencephaly	Enrichment	FOXH1, TGIF1	2.63
34	Diffuse large b-cell lymphoma	Enrichment	CREBBP, STAT3	2.58
35	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	2.58
36	Stapes ankylosis with broad thumbs and toes	Enrichment	NOG	2.39
37	Tarsal-carpal coalition syndrome	Enrichment	NOG	2.39
38	Hypomagnesemia 4, renal	Enrichment	EGF	2.39
39	Brachydactyly, type b2	Enrichment	NOG	2.39
40	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.39
41	Holoprosencephaly 4	Enrichment	TGIF1	2.39
42	Symphalangism, proximal, 1a	Enrichment	NOG	2.39
43	Shprintzen-goldberg craniosynostosis syndrome	Enrichment	SKI	2.39
44	Multiple synostoses syndrome 1	Enrichment	NOG	2.39
45	Radioulnar synostosis, nonsyndromic	Enrichment	SMAD6	2.39
46	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.39
47	Immunodeficiency 69	Enrichment	IFNG	2.39
48	Renal cell carcinoma, xp11-associated	Enrichment	TFE3	2.39
49	Intellectual developmental disorder, x-linked, syndromic, with pigmentary mosaicism and coarse facies	Enrichment	TFE3	2.39
50	Microphthalmia, syndromic 6	Enrichment	BMP4	2.39
51	Orofacial cleft 11	Enrichment	BMP4	2.39
52	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.39
53	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.39
54	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.39
55	Ovary adenocarcinoma	Enrichment	INHBA	2.39
56	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.39
57	Immunodeficiency 31a	Enrichment	STAT1	2.39
58	Nephronophthisis 14	Enrichment	ZNF423	2.39
59	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.39
60	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.39
61	Colorectal cancer 3	Enrichment	SMAD7	2.39
62	Immunodeficiency 31b	Enrichment	STAT1	2.39
63	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.39
64	Cutis laxa, autosomal recessive, type iie	Enrichment	LTBP1	2.39
65	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.39
66	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.39
67	Adenoid ameloblastoma	Enrichment	CTNNB1	2.39
68	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.39
69	Heritable thoracic aortic disease	Enrichment	SMAD4	2.39
70	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.39
71	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.39
72	Menke-hennekam syndrome	Enrichment	CREBBP	2.39
73	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.39
74	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.39
75	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.39
76	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.39
77	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.39
78	Microcystic stromal tumor	Enrichment	CTNNB1	2.39
79	Ectopia lentis 1, isolated, autosomal dominant	Enrichment	FBN1	2.36
80	Geleophysic dysplasia 1	Enrichment	ADAMTSL2	2.36
81	Lethal short-limb skeletal dysplasia, al gazali type	Enrichment	ADAMTSL2	2.36
82	Weill-marchesani syndrome 2	Enrichment	FBN1	2.36
83	Geleophysic dysplasia 2	Enrichment	FBN1	2.36
84	Protrusio acetabuli	Enrichment	FBN1	2.36
85	Lymphoplasmacytic lymphoma	Enrichment	FBN1	2.36
86	Geleophysic dysplasia 3	Enrichment	LTBP3	2.36
87	Neonatal marfan syndrome	Enrichment	FBN1	2.36
88	Scoliosis	Enrichment	CREBBP, FBN1	2.32
89	Colorectal cancer	Enrichment	CTNNB1, EP300, SMAD4	2.28
90	Bladder cancer	Enrichment	CTNNB1, HRAS	2.21
91	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.09
92	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.09
93	Myhre syndrome	Enrichment	SMAD4	2.09
94	Camurati-engelmann disease 1	Enrichment	TGFB1	2.09
95	Costello syndrome	Enrichment	HRAS	2.09
96	Thumb deformity	Enrichment	CREBBP	2.09
97	Mowat-wilson syndrome	Enrichment	ZEB2	2.09
98	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.09
99	Alveolar soft part sarcoma	Enrichment	TFE3	2.09
100	Pulmonary arteriovenous fistulas	Enrichment	ENG	2.09
101	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.09
102	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.09
103	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.09
104	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.09
105	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.09
106	Immunodeficiency 31c	Enrichment	STAT1	2.09
107	Menke-hennekam syndrome 2	Enrichment	EP300	2.09
108	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.09
109	Immunodeficiency 127	Enrichment	TNF	2.09
110	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.09
111	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.09
112	Split hand-foot malformation	Enrichment	LEF1	2.09
113	Camurati-engelmann disease	Enrichment	TGFB1	2.09
114	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.09
115	Aortic valve disease 2	Enrichment	SMAD6	2.09
116	Proximal symphalangism	Enrichment	NOG	2.09
117	Craniosynostosis 7	Enrichment	SMAD6	2.09
118	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.09
119	Radioulnar synostosis	Enrichment	SMAD6	2.09
120	Teratoma	Enrichment	CTNNB1	2.09
121	Common variable immunodeficiency 12	Enrichment	NFKB1	2.09
122	Wooly hair nevus	Enrichment	HRAS	2.09
123	Stiff skin syndrome	Enrichment	FBN1	2.06
124	Ehlers-danlos syndrome, dermatosparaxis type	Enrichment	ADAMTSL2	2.06
125	Beaulieu-boycott-innes syndrome	Enrichment	FBN1	2.06
126	Aortic dissection	Enrichment	FBN1	2.06
127	Marfanoid-progeroid-lipodystrophy syndrome	Enrichment	FBN1	2.06
128	Lens subluxation	Enrichment	FBN1	2.06
129	Congenital nervous system abnormality	Enrichment	CREBBP, CTNNB1, ZEB2	2.04
130	Nervous system disease	Enrichment	CREBBP, CTNNB1, ZEB2	2.04
131	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.92
132	Desmoid disease, hereditary	Enrichment	CTNNB1	1.92
133	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.92
134	Juvenile polyposis syndrome	Enrichment	SMAD4	1.92
135	Tuberous sclerosis 1	Enrichment	IFNG	1.92
136	Osteoporosis, juvenile	Enrichment	WNT1	1.92
137	Psoriatic arthritis	Enrichment	TNF	1.92
138	Hepatitis c virus	Enrichment	IFNG	1.92
139	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.92
140	Tuberous sclerosis 2	Enrichment	IFNG	1.92
141	Anus, imperforate	Enrichment	CTNNB1	1.92
142	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.92
143	Tethered spinal cord syndrome	Enrichment	CREBBP	1.92
144	Large congenital melanocytic nevus	Enrichment	HRAS	1.92
145	Autosomal recessive cutis laxa type i	Enrichment	LTBP1	1.92
146	Desmoid tumor	Enrichment	CTNNB1	1.92
147	Hyper ige syndrome	Enrichment	STAT3	1.92
148	Cleidocranial dysplasia	Enrichment	RUNX2	1.92
149	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.92
150	Migraine without aura	Enrichment	TNF	1.92
151	Spermatocytoma	Enrichment	HRAS	1.92
152	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.92
153	Renal cell carcinoma	Enrichment	TFE3	1.92
154	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	SMAD9	1.92
155	Contractural arachnodactyly, congenital	Enrichment	FBN1	1.89
156	Achondroplasia	Enrichment	FBN1	1.89
157	Mccune-albright syndrome	Enrichment	FBN1	1.89
158	Isolated ectopia lentis	Enrichment	FBN1	1.89
159	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.79
160	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.79
161	Pilomatrixoma	Enrichment	CTNNB1	1.79
162	Alazami syndrome	Enrichment	CTNNB1	1.79
163	Congenital generalized lipodystrophy	Enrichment	FOS	1.79
164	Multiple synostoses syndrome	Enrichment	NOG	1.79
165	Malignant epithelioid hemangioendothelioma	Enrichment	TFE3	1.79
166	Orofacial cleft	Enrichment	FST	1.79
167	Craniopharyngioma	Enrichment	CTNNB1	1.79
168	Epidermolytic nevus	Enrichment	HRAS	1.79
169	Cerebral malaria	Enrichment	TNF	1.79
170	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.79
171	Orofacial clefting syndrome	Enrichment	FST	1.79
172	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.79
173	Mitral valve insufficiency	Enrichment	FBN1	1.76
174	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.70
175	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.70
176	Histiocytoid hemangioma	Enrichment	FOS	1.70
177	Vascular dementia	Enrichment	TNF	1.70
178	Idiopathic aplastic anemia	Enrichment	IFNG	1.70
179	Polycystic liver disease 1 with or without kidney cysts	Enrichment	FBN1	1.67
180	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	FBN1	1.67
181	Polycystic liver disease 1	Enrichment	FBN1	1.67
182	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.62
183	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ENG	1.62
184	Split-hand/foot malformation 1	Enrichment	LEF1	1.62
185	Anterior segment dysgenesis 5	Enrichment	BMP4	1.62
186	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.62
187	Adrenocortical carcinoma	Enrichment	CTNNB1	1.62
188	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.62
189	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.62
190	Hypertrichosis	Enrichment	CREBBP	1.62
191	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.62
192	Dental anomalies and short stature	Enrichment	LTBP3	1.59
193	Inguinal hernia	Enrichment	FBN1	1.59
194	Esophageal cancer	Enrichment	TGFBR2	1.55
195	Nevus, epidermal	Enrichment	HRAS	1.55
196	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.55
197	Arima syndrome	Enrichment	ZNF423	1.55
198	Noonan syndrome 3	Enrichment	HRAS	1.55
199	Renal cell carcinoma with mit translocations	Enrichment	TFE3	1.55
200	Megacolon	Enrichment	ZEB2	1.55
201	Common variable immunodeficiency	Enrichment	NFKB1	1.55
202	Follicular thyroid carcinoma	Enrichment	HRAS	1.55
203	Brugada syndrome 1	Enrichment	FBN1	1.52
204	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.50
205	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.50
206	Infantile nephronophthisis	Enrichment	ZNF423	1.50
207	Orthostatic intolerance	Enrichment	FBN1	1.46
208	Charge syndrome	Enrichment	EP300	1.44
209	Polydactyly	Enrichment	SMAD6	1.44
210	Arteriovenous malformation	Enrichment	HRAS	1.44
211	Peters-plus syndrome	Enrichment	BMP4	1.40
212	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.40
213	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.40
214	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.40
215	Aplastic anemia	Enrichment	IFNG	1.40
216	Stickler syndrome	Enrichment	BMP4	1.40
217	Stroke, ischemic	Enrichment	FBN1	1.37
218	Melanoma	Enrichment	FBN1	1.37
219	Asthma	Enrichment	TNF	1.36
220	Lung non-small cell carcinoma	Enrichment	HRAS	1.36
221	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.32
222	Lip and oral cavity carcinoma	Enrichment	HRAS	1.32
223	Aortic valve disease 1	Enrichment	SMAD6	1.29
224	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.29
225	Pulmonary hypertension, primary, 1	Enrichment	ENG	1.29
226	Acute promyelocytic leukemia	Enrichment	STAT3	1.29
227	Alzheimer's disease	Enrichment	TNF	1.29
228	Chromosome 1p36 deletion syndrome	Enrichment	SKI	1.29
229	Diaphragmatic hernia, congenital	Enrichment	FBN1	1.26
230	Amelogenesis imperfecta	Enrichment	LTBP3	1.26
231	Osteoporosis	Enrichment	WNT1	1.26
232	Medulloblastoma	Enrichment	CTNNB1	1.26
233	Heart disease	Enrichment	CREBBP	1.26
234	Cleft lip/palate	Enrichment	BMP4	1.26
235	Polydactyly, postaxial, type a1	Enrichment	EP300	1.23
236	Corpus callosum, agenesis of	Enrichment	CREBBP	1.23
237	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.23
238	Lynch syndrome	Enrichment	TGFBR2	1.23
239	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.23
240	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.23
241	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.23
242	Rhabdomyosarcoma	Enrichment	HRAS	1.20
243	Myopia	Enrichment	FBN1	1.20
244	Polycystic liver disease	Enrichment	CTNNB1	1.18
245	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.18
246	Perrault syndrome 1	Enrichment	FBN1	1.17
247	Heart, malformation of	Enrichment	SMAD6	1.15
248	Human immunodeficiency virus type 1	Enrichment	IFNG	1.15
249	Arteriovenous malformations of the brain	Enrichment	ENG	1.13
250	Craniosynostosis	Enrichment	SMAD6	1.11
251	Hepatoblastoma	Enrichment	CTNNB1	1.09
252	Hepatocellular carcinoma	Enrichment	CTNNB1	1.07
253	Visceral heterotaxy	Enrichment	LEFTY2	1.07
254	Microcephaly	Enrichment	CTNNB1, EP300	1.05
255	Noonan syndrome 1	Enrichment	HRAS	1.05
256	Brittle bone disorder	Enrichment	WNT1	1.05
257	Malaria	Enrichment	TNF	1.05
258	Pancreatic cancer	Enrichment	SMAD4	1.01
259	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.00
260	Rasopathy	Enrichment	HRAS	1.00
261	Differentiated thyroid carcinoma	Enrichment	HRAS	0.95
262	Non-immune hydrops fetalis	Enrichment	HRAS	0.93
263	Cystic fibrosis	Enrichment	TGFB1	0.91
264	Myopathy	Enrichment	FBN1	0.80
265	Gastric cancer	Enrichment	SMAD4	0.79
266	Nephrotic syndrome	Enrichment	RUNX2	0.79
267	Thrombocytopenia	Enrichment	SMAD4	0.75
268	Myeloma, multiple	Enrichment	CREBBP	0.69
269	Primary ovarian insufficiency	Enrichment	THBS1	0.67
270	Autism	Enrichment	CREBBP	0.59
271	Breast cancer	Enrichment	JUN	0.58
272	Dilated cardiomyopathy	Enrichment	FBN1	0.53
273	Ovarian cancer	Enrichment	CTNNB1	0.47
274	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TGF-beta receptor signaling in skeletal dysplasias

Pathway Network for TGF-beta receptor signaling in skeletal dysplasias

Member Pathways for TGF-beta receptor signaling in skeletal dysplasias

Pathways in the TGF-beta receptor signaling in skeletal dysplasias SuperPath

Associated Genes for TGF-beta receptor signaling in skeletal dysplasias

Associated Disorders for TGF-beta receptor signaling in skeletal dysplasias

Disorders associated with TGF-beta receptor signaling in skeletal dysplasias SuperPath

STRING Interaction Network for TGF-beta receptor signaling in skeletal dysplasias

Sources for TGF-beta receptor signaling in skeletal dysplasias