TGF-beta Signaling Pathways

No Pathway Network information available for TGF-beta Signaling Pathways

Pathways in the TGF-beta Signaling Pathways SuperPath

#	Name	Source	Genes
1	TGF-beta Signaling Pathways	R&D Systems	ACVRL1 AKT1 AKT2 AKT3 AR ARAF ATF1 ATF2 ATF4 BRAF CDC42 CREB1 CREB3L1 DAXX ENG ESR1 ESR2 FOS FOSB FOSL1 FOXH1 FOXO1 FOXO3 GLI3 GRB2 HNF4A HNF4G JUN JUNB JUND KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MAX MEF2C MTOR MYC MYOD1 NFKB1 NFKB2 NR3C1 PAK2 PDPK1 PIK3C2B PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PPARG PPP2CA RAC1 RAF1 REL RELA RELB RHOA ROCK1 ROCK2 RPS6KB1 RUNX1 RUNX2 RUNX3 SHC1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SMAD9 SMURF1 SMURF2 SOS1 SOS2 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TRAF6 (see all 96) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
2	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
3	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
4	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
5	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	1
6	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
7	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
8	ENG	Endoglin	Protein Coding	1
9	DAXX	Death Domain Associated Protein	Protein Coding	1
10	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
11	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
12	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
13	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
14	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
15	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
16	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
17	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
18	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
19	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
20	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
21	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
22	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
23	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
24	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
25	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
26	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
27	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
28	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
29	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
30	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
31	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
32	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
33	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
34	SHC1	SHC Adaptor Protein 1	Protein Coding	1
35	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
36	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
37	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
38	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
39	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
40	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
41	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
42	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
43	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
44	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
45	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
46	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
47	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
48	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
49	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
50	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
51	SMAD1	SMAD Family Member 1	Protein Coding	1
52	SMAD5	SMAD Family Member 5	Protein Coding	1
53	SMAD9	SMAD Family Member 9	Protein Coding	1
54	SMAD4	SMAD Family Member 4	Protein Coding	1
55	SMAD2	SMAD Family Member 2	Protein Coding	1
56	SMAD3	SMAD Family Member 3	Protein Coding	1
57	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
58	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	1
59	SMAD7	SMAD Family Member 7	Protein Coding	1
60	AR	Androgen Receptor	Protein Coding	1
61	ATF1	Activating Transcription Factor 1	Protein Coding	1
62	ATF2	Activating Transcription Factor 2	Protein Coding	1
63	ATF4	Activating Transcription Factor 4	Protein Coding	1
64	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
65	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
66	ESR1	Estrogen Receptor 1	Protein Coding	1
67	ESR2	Estrogen Receptor 2	Protein Coding	1
68	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
69	FOXH1	Forkhead Box H1	Protein Coding	1
70	FOXO1	Forkhead Box O1	Protein Coding	1
71	FOXO3	Forkhead Box O3	Protein Coding	1
72	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
73	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
74	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
75	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
76	HNF4G	Hepatocyte Nuclear Factor 4 Gamma	Protein Coding	1
77	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
78	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
79	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
80	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
81	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
82	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
83	MYOD1	Myogenic Differentiation 1	Protein Coding	1
84	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
85	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
86	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
87	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
88	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
89	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
90	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
91	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	1
92	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
93	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	1
94	RHOA	Ras Homolog Family Member A	Protein Coding	1
95	CDC42	Cell Division Cycle 42	Protein Coding	1
96	RAC1	Rac Family Small GTPase 1	Protein Coding	1

Disorders associated with TGF-beta Signaling Pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	10.64
2	Noonan syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	9.71
3	Rasopathy	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	9.38
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, RAF1, SOS1	9.27
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.62
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.62
7	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	7.66
8	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	6.46
9	Noonan syndrome 3	Enrichment	KRAS, RAF1, SOS1	4.93
10	Gallbladder cancer	Enrichment	BRAF, KRAS, SMAD4	4.93
11	Hereditary hemorrhagic telangiectasia	Enrichment	ACVRL1, ENG, SMAD4	4.93
12	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.93
13	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	4.40
14	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.30
15	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.30
16	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.30
17	Immune system disease	Enrichment	CDC42, PIK3CD	4.30
18	Tafro syndrome	Enrichment	MAP2K2, RUNX1	4.30
19	Lung non-small cell carcinoma	Enrichment	BRAF, KRAS, MAP2K1	4.26
20	Heritable pulmonary arterial hypertension	Enrichment	ACVRL1, ENG, SMAD9	4.26
21	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	3.83
22	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.83
23	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.83
24	Melanoma of soft tissue	Enrichment	ATF1, CREB1	3.83
25	Breast cancer	Enrichment	AKT1, ESR1, JUN, KRAS, SHC1	3.73
26	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.53
27	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.53
28	Congenital generalized lipodystrophy	Enrichment	FOS, PPARG	3.53
29	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.53
30	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.53
31	Arteriovenous malformations of the brain	Enrichment	BRAF, ENG, KRAS	3.51
32	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	3.51
33	Colorectal cancer	Enrichment	AKT1, BRAF, PIK3R1, PPARG, SMAD4	3.43
34	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.31
35	Hemimegalencephaly	Enrichment	AKT3, MTOR	3.31
36	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	ENG, SMAD4	3.31
37	Familial cerebral saccular aneurysm	Enrichment	ENG, TGFBR3	3.31
38	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ACVRL1, ENG	3.14
39	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.14
40	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	2.99
41	Leukemia, chronic myeloid	Enrichment	KRAS, RUNX1	2.99
42	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.99
43	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	2.99
44	Differentiated thyroid carcinoma	Enrichment	BRAF, KRAS, PPARG	2.96
45	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	2.87
46	Primary hyperaldosteronism	Enrichment	BRAF, NR3C1	2.76
47	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.67
48	Type 2 diabetes mellitus	Enrichment	AKT2, HNF4A, PPARG	2.49
49	Pulmonary hypertension, primary, 1	Enrichment	ACVRL1, ENG	2.43
50	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, KRAS	2.43
51	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.37
52	Thrombocytopenia	Enrichment	ACVRL1, RUNX1, SMAD4	2.33
53	Lynch syndrome	Enrichment	KRAS, TGFBR2	2.31
54	Pallister-hall syndrome	Enrichment	GLI3	2.15
55	Proteus syndrome	Enrichment	AKT1	2.15
56	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.15
57	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.15
58	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.15
59	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.15
60	Oculoectodermal syndrome	Enrichment	KRAS	2.15
61	Pallister-killian syndrome	Enrichment	ARAF	2.15
62	Androgen insensitivity, partial	Enrichment	AR	2.15
63	Noonan syndrome 5	Enrichment	RAF1	2.15
64	Telangiectasia, hereditary hemorrhagic, type 2	Enrichment	ACVRL1	2.15
65	Noonan syndrome 4	Enrichment	SOS1	2.15
66	Polydactyly, preaxial iv	Enrichment	GLI3	2.15
67	Melorheostosis, isolated	Enrichment	MAP2K1	2.15
68	Noonan syndrome 7	Enrichment	BRAF	2.15
69	Leopard syndrome 3	Enrichment	BRAF	2.15
70	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.15
71	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.15
72	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.15
73	Noonan syndrome 9	Enrichment	SOS2	2.15
74	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.15
75	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.15
76	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	2.15
77	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.15
78	Noonan syndrome 13	Enrichment	MAPK1	2.15
79	Immunodeficiency 92	Enrichment	REL	2.15
80	Knobloch syndrome 2	Enrichment	PAK2	2.15
81	Short syndrome	Enrichment	PIK3R1	2.15
82	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.15
83	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.15
84	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.15
85	Lymphangioma	Enrichment	BRAF	2.15
86	Camurati-engelmann disease 2	Enrichment	TGFB2	2.15
87	Phace association	Enrichment	BRAF	2.15
88	Ovarian dysgenesis 8	Enrichment	ESR2	2.15
89	Melorheostosis	Enrichment	MAP2K1	2.15
90	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.15
91	Leopard syndrome 2	Enrichment	RAF1	2.15
92	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.15
93	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.15
94	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.15
95	Cowden syndrome 6	Enrichment	AKT1	2.15
96	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.15
97	Congenital myopathy 17	Enrichment	MYOD1	2.15
98	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.15
99	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.15
100	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.15
101	Colorectal cancer 3	Enrichment	SMAD7	2.15
102	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.15
103	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.15
104	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.15
105	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.15
106	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.15
107	Immunodeficiency 53	Enrichment	RELB	2.15
108	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.15
109	Telangiectasis	Enrichment	ACVRL1	2.15
110	Trigonitis	Enrichment	RAF1	2.15
111	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.15
112	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.15
113	Heritable thoracic aortic disease	Enrichment	SMAD4	2.15
114	Capillary hemangioma	Enrichment	AKT3	2.15
115	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.15
116	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.15
117	Congenital pulmonary airway malformation	Enrichment	KRAS	2.15
118	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.15
119	Complete androgen insensitivity syndrome	Enrichment	AR	2.15
120	Nocarh syndrome	Enrichment	CDC42	2.15
121	Syringocystadenoma papilliferum	Enrichment	BRAF	2.15
122	Ganglioglioma	Enrichment	BRAF	2.15
123	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.15
124	Phace syndrome	Enrichment	BRAF	2.15
125	Mef2c-related disorder	Enrichment	MEF2C	2.15
126	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.15
127	Classic hairy cell leukemia	Enrichment	BRAF	2.15
128	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.15
129	Myeloma, multiple	Enrichment	BRAF, KRAS, PIK3R2	2.14
130	Diffuse large b-cell lymphoma	Enrichment	BRAF, FOXO1	2.11
131	Pancreatic cancer	Enrichment	KRAS, SMAD4	1.87
132	Burkitt lymphoma	Enrichment	MYC	1.85
133	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	1.85
134	Maturity-onset diabetes of the young, type 1	Enrichment	HNF4A	1.85
135	Fibromatosis, gingival, 1	Enrichment	SOS1	1.85
136	Myhre syndrome	Enrichment	SMAD4	1.85
137	Camurati-engelmann disease 1	Enrichment	TGFB1	1.85
138	Storage pool platelet disease	Enrichment	RUNX1	1.85
139	Galactosemia ii	Enrichment	NR3C1	1.85
140	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	1.85
141	Carotid intimal medial thickness 1	Enrichment	PPARG	1.85
142	Pulmonary arteriovenous fistulas	Enrichment	ENG	1.85
143	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.85
144	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.85
145	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.85
146	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.85
147	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	1.85
148	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.85
149	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.85
150	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.85
151	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.85
152	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.85
153	46,xy sex reversal 1	Enrichment	AR	1.85
154	Androgen insensitivity syndrome	Enrichment	AR	1.85
155	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.85
156	Cebalid syndrome	Enrichment	MTOR	1.85
157	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.85
158	Tibial hemimelia	Enrichment	GLI3	1.85
159	Hypospadias 1, x-linked	Enrichment	AR	1.85
160	Rela fusion-positive ependymoma	Enrichment	RELA	1.85
161	Senior-loken syndrome 7	Enrichment	AKT3	1.85
162	Synpolydactyly	Enrichment	GLI3	1.85
163	Camurati-engelmann disease	Enrichment	TGFB1	1.85
164	Bardet-biedl syndrome 16	Enrichment	AKT3	1.85
165	Smith-kingsmore syndrome	Enrichment	MTOR	1.85
166	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.85
167	Postaxial polydactyly type b	Enrichment	GLI3	1.85
168	Familial partial lipodystrophy	Enrichment	PPARG	1.85
169	Posterior hypospadias	Enrichment	AR	1.85
170	Hyperinsulinism	Enrichment	HNF4A	1.85
171	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF4A	1.85
172	Common variable immunodeficiency 12	Enrichment	NFKB1	1.85
173	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.68
174	Thyroid carcinoma, familial medullary	Enrichment	ESR2	1.68
175	Ataxia-telangiectasia	Enrichment	BRAF	1.68
176	Juvenile polyposis syndrome	Enrichment	SMAD4	1.68
177	Acrocallosal syndrome	Enrichment	GLI3	1.68
178	Aarskog-scott syndrome	Enrichment	GLI3	1.68
179	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	1.68
180	Nuchal bleb, familial	Enrichment	SOS1	1.68
181	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.68
182	Estrogen resistance	Enrichment	ESR1	1.68
183	Tethered spinal cord syndrome	Enrichment	BRAF	1.68
184	Umbilical hernia	Enrichment	GLI3	1.68
185	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.68
186	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.68
187	Cleidocranial dysplasia	Enrichment	RUNX2	1.68
188	Migraine without aura	Enrichment	ESR1	1.68
189	Myxofibrosarcoma	Enrichment	CREB3L1	1.68
190	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	1.68
191	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	SMAD9	1.68
192	Lung cancer	Enrichment	BRAF, KRAS	1.67
193	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.67
194	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	1.55
195	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.55
196	Hemophilia a	Enrichment	ACVRL1	1.55
197	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.55
198	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.55
199	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.55
200	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.55
201	Maturity-onset diabetes of the young, type 3	Enrichment	HNF4A	1.55
202	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.55
203	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.55
204	Factor viii deficiency	Enrichment	ACVRL1	1.55
205	Leptin deficiency or dysfunction	Enrichment	PPARG	1.55
206	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.55
207	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.55
208	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.55
209	Craniopharyngioma	Enrichment	BRAF	1.55
210	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.55
211	Pilocytic astrocytoma	Enrichment	KRAS	1.55
212	Blood platelet disease	Enrichment	RUNX1	1.55
213	Newborn respiratory distress syndrome	Enrichment	BRAF	1.55
214	Knobloch syndrome	Enrichment	PAK2	1.55
215	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.55
216	Gingival fibromatosis	Enrichment	SOS1	1.55
217	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.55
218	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.55
219	Leukemia, acute myeloid	Enrichment	KRAS, RUNX1	1.49
220	Ovarian cancer	Enrichment	AKT1, AR, KRAS	1.46
221	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.46
222	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.46
223	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.46
224	Knobloch syndrome 1	Enrichment	PAK2	1.46
225	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.46
226	Aggressive systemic mastocytosis	Enrichment	RUNX1	1.46
227	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	RUNX1	1.46
228	Gastric cancer	Enrichment	KRAS, SMAD4	1.43
229	Atrial septal defect 1	Enrichment	TGFB2	1.38
230	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.38
231	Hemihyperplasia, isolated	Enrichment	RHOA	1.38
232	Wilms tumor 5	Enrichment	BRAF	1.38
233	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.38
234	Pancytopenia	Enrichment	RUNX1	1.38
235	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.38
236	Lung squamous cell carcinoma	Enrichment	KRAS	1.38
237	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.38
238	Esophageal cancer	Enrichment	TGFBR2	1.31
239	Nevus, epidermal	Enrichment	KRAS	1.31
240	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.31
241	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.31
242	Megacolon	Enrichment	AKT3	1.31
243	Follicular thyroid carcinoma	Enrichment	BRAF	1.31
244	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.26
245	Lennox-gastaut syndrome	Enrichment	MAPK10	1.26
246	Difference of sex development	Enrichment	AR	1.26
247	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.21
248	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.21
249	Arteriovenous malformation	Enrichment	MAP2K1	1.21
250	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	1.21
251	Ventricular septal defect	Enrichment	BRAF	1.21
252	Cowden syndrome	Enrichment	AKT1	1.21
253	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.21
254	Inherited cancer-predisposing syndrome	Enrichment	MAX, RUNX1, SMAD4	1.17
255	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.16
256	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.16
257	Polymicrogyria	Enrichment	AKT3	1.16
258	Melanoma	Enrichment	BRAF	1.16
259	Migraine with or without aura 1	Enrichment	ESR1	1.12
260	Pectus excavatum	Enrichment	TGFBR1	1.12
261	46,xy complete gonadal dysgenesis	Enrichment	AR	1.12
262	Specific learning disability	Enrichment	MAPK1	1.12
263	Juvenile myelomonocytic leukemia	Enrichment	KRAS	1.09
264	Meningioma	Enrichment	AKT1	1.09
265	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.09
266	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.09
267	Lip and oral cavity carcinoma	Enrichment	BRAF	1.09
268	Aortic valve disease 1	Enrichment	SOS1	1.05
269	Diaphragmatic hernia, congenital	Enrichment	GLI3	1.05
270	Nk-cell enteropathy	Enrichment	PIK3CB	1.05
271	Pheochromocytoma	Enrichment	MAX	1.02
272	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.02
273	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.02
274	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.02
275	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.00
276	Polydactyly, postaxial, type a1	Enrichment	GLI3	1.00
277	Wilms tumor 1	Enrichment	BRAF	1.00
278	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	1.00
279	Rare genetic intellectual disability	Enrichment	MTOR	1.00
280	Septopreoptic holoprosencephaly	Enrichment	FOXH1	1.00
281	Midline interhemispheric variant of holoprosencephaly	Enrichment	FOXH1	1.00
282	Gliosarcoma	Enrichment	PPARG	0.97
283	Microform holoprosencephaly	Enrichment	FOXH1	0.97
284	Lobar holoprosencephaly	Enrichment	FOXH1	0.97
285	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	0.96
286	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.94
287	Dandy-walker syndrome	Enrichment	BRAF	0.94
288	Polycystic liver disease	Enrichment	HNF4A	0.94
289	Giant cell glioblastoma	Enrichment	PPARG	0.94
290	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	0.94
291	Alobar holoprosencephaly	Enrichment	FOXH1	0.94
292	Heart, malformation of	Enrichment	MAPK1	0.92
293	Semilobar holoprosencephaly	Enrichment	FOXH1	0.92
294	Maturity-onset diabetes of the young	Enrichment	HNF4A	0.88
295	Craniosynostosis	Enrichment	GLI3	0.88
296	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.86
297	Myocardial infarction	Enrichment	ESR1	0.84
298	Brittle bone disorder	Enrichment	CREB3L1	0.82
299	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.82
300	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.80
301	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C	0.74
302	Bladder cancer	Enrichment	KRAS	0.73
303	Hirschsprung disease 1	Enrichment	GLI3	0.73
304	Prostate cancer	Enrichment	AR	0.73
305	Non-immune hydrops fetalis	Enrichment	KRAS	0.70
306	Cystic fibrosis	Enrichment	TGFB1	0.69
307	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.68
308	Male infertility	Enrichment	AR	0.67
309	Left ventricular noncompaction	Enrichment	RAF1	0.66
310	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	0.64
311	Systemic lupus erythematosus	Enrichment	ENG	0.62
312	Distal arthrogryposis	Enrichment	MYOD1	0.59
313	Nephrotic syndrome	Enrichment	RUNX2	0.58
314	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.52
315	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.50
316	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.49
317	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.48
318	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.47
319	Microcephaly	Enrichment	MAPK1	0.23
320	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.23

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TGF-beta Signaling Pathways

Pathway Network for TGF-beta Signaling Pathways

Member Pathways for TGF-beta Signaling Pathways

Pathways in the TGF-beta Signaling Pathways SuperPath

Associated Genes for TGF-beta Signaling Pathways

Associated Disorders for TGF-beta Signaling Pathways

Disorders associated with TGF-beta Signaling Pathways SuperPath

STRING Interaction Network for TGF-beta Signaling Pathways

Sources for TGF-beta Signaling Pathways