TGFBR2 Kinase Domain Mutants in Cancer

Pathway network for the TGFBR2 Kinase Domain Mutants in Cancer SuperPath

Sources:

Reactome
WikiPathways

Pathways in the TGFBR2 Kinase Domain Mutants in Cancer SuperPath

#	Name	Source	Genes
1	TGFBR2 Kinase Domain Mutants in Cancer	Reactome	TGFB1 TGFBR1 TGFBR2
2	TGF /Smad signaling pathway	WikiPathways	CCN2 POSTN SERPINE1 SPARC TGFB1 TGFBR1 TGFBR2 TGFBR3 WWTR1 YWHAG (see all 10) (see less)
3	LDLRAD4 and what we know about it	WikiPathways	ATG16L1 LDLRAD4 NEDD4 PMEPA1 SMAD2 TGFBR1 TGFBR2 (see all 7) (see less)
4	SMAD2/3 Phosphorylation Motif Mutants in Cancer	Reactome	SMAD2 SMAD3 TGFB1 TGFBR1 TGFBR2 ZFYVE9 (see all 6) (see less)
5	TGFBR1 KD Mutants in Cancer	Reactome	SMAD2 SMAD3 TGFB1 TGFBR1 TGFBR2 ZFYVE9 (see all 6) (see less)
6	Loss of Function of TGFBR2 in Cancer	Reactome	TGFB1 TGFBR1 TGFBR2
7	TGFBR2 MSI Frameshift Mutants in Cancer	Reactome	TGFB1 TGFBR2
8	Influenza Virus Induced Apoptosis	Reactome	TGFB1

Gene overlap in member pathways for TGFBR2 Kinase Domain Mutants in Cancer SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	7
2	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	7
3	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	6
4	SMAD2	SMAD Family Member 2	Protein Coding	3
5	SMAD3	SMAD Family Member 3	Protein Coding	2
6	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	2
7	POSTN	Periostin	Protein Coding	1
8	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
9	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
10	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
11	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	1
12	SERPINE1	Serpin Family E Member 1	Protein Coding	1
13	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
14	PMEPA1	Prostate Transmembrane Protein, Androgen Induced 1	Protein Coding	1
15	ATG16L1	Autophagy Related 16 Like 1	Protein Coding	1
16	NEDD4	NEDD4 E3 Ubiquitin Protein Ligase	Protein Coding	1
17	LDLRAD4	Low Density Lipoprotein Receptor Class A Domain Containing 4	Protein Coding	1

Disorders associated with TGFBR2 Kinase Domain Mutants in Cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Influenza	Direct
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFBR1, TGFBR2	10.62
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	10.25
4	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, TGFBR1, TGFBR2	8.84
5	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	7.49
6	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	6.01
7	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	5.83
8	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1, WWTR1	5.53
9	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	4.56
10	Connective tissue disease	Enrichment	SMAD3, TGFBR2	4.09
11	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	3.83
12	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	3.66
13	Camurati-engelmann disease 1	Enrichment	TGFB1	3.53
14	Microvascular complications of diabetes 5	Enrichment	TGFBR2	3.53
15	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	3.53
16	Camurati-engelmann disease	Enrichment	TGFB1	3.53
17	Loeys-dietz syndrome 6	Enrichment	SMAD2	3.35
18	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	3.35
19	Inflammatory bowel disease 10	Enrichment	ATG16L1	3.29
20	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	3.13
21	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	3.13
22	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	3.13
23	Loeys-dietz syndrome 3	Enrichment	SMAD3	3.05
24	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	3.05
25	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	3.05
26	Esophageal cancer	Enrichment	TGFBR2	2.99
27	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	2.88
28	Kyphomelic dysplasia	Enrichment	CCN2	2.83
29	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.83
30	Osteogenesis imperfecta, type xvii	Enrichment	SPARC	2.83
31	Lynch syndrome	Enrichment	TGFBR2	2.66
32	Pectus excavatum	Enrichment	TGFBR1	2.61
33	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1	2.53
34	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	2.43
35	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	2.43
36	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	2.40
37	Limited scleroderma	Enrichment	CCN2	2.35
38	Cystic fibrosis	Enrichment	TGFB1	2.33
39	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	2.21
40	Specific learning disability	Enrichment	YWHAG	2.09
41	Osteogenesis imperfecta, type iv	Enrichment	SPARC	2.02
42	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	1.39
43	Microcephaly	Enrichment	YWHAG	1.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TGFBR2 Kinase Domain Mutants in Cancer

Pathway Network for TGFBR2 Kinase Domain Mutants in Cancer

Pathway network for the TGFBR2 Kinase Domain Mutants in Cancer SuperPath

Member Pathways for TGFBR2 Kinase Domain Mutants in Cancer

Pathways in the TGFBR2 Kinase Domain Mutants in Cancer SuperPath

Gene overlap in member pathways for TGFBR2 Kinase Domain Mutants in Cancer SuperPath

Associated Genes for TGFBR2 Kinase Domain Mutants in Cancer

Associated Disorders for TGFBR2 Kinase Domain Mutants in Cancer

Disorders associated with TGFBR2 Kinase Domain Mutants in Cancer SuperPath

STRING Interaction Network for TGFBR2 Kinase Domain Mutants in Cancer

Sources for TGFBR2 Kinase Domain Mutants in Cancer