Tgif disruption of Shh signaling

No Pathway Network information available for Tgif disruption of Shh signaling

Pathways in the Tgif disruption of Shh signaling SuperPath

#	Name	Source	Genes
1	Tgif disruption of Shh signaling	WikiPathways	FGF8 FOXG1 GLI3 NKX2-1 NODAL SHH SMAD2 TGIF1 TGIF2 (see all 9) (see less)
2	mir34a and TGIF2 in osteoclastogenesis	WikiPathways	TGIF2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TGIF2	TGFB Induced Factor Homeobox 2	Protein Coding	2
2	NKX2-1	NK2 Homeobox 1	Protein Coding	1
3	TGIF1	TGFB Induced Factor Homeobox 1	Protein Coding	1
4	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
5	NODAL	Nodal Growth Differentiation Factor	Protein Coding	1
6	SMAD2	SMAD Family Member 2	Protein Coding	1
7	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
8	FOXG1	Forkhead Box G1	Protein Coding	1
9	FGF8	Fibroblast Growth Factor 8	Protein Coding	1

Disorders associated with Tgif disruption of Shh signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Septopreoptic holoprosencephaly	Enrichment	FGF8, NODAL, SHH, TGIF1	9.89
2	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8, NODAL, SHH, TGIF1	9.89
3	Microform holoprosencephaly	Enrichment	FGF8, NODAL, SHH, TGIF1	9.71
4	Lobar holoprosencephaly	Enrichment	FGF8, NODAL, SHH, TGIF1	9.71
5	Alobar holoprosencephaly	Enrichment	FGF8, NODAL, SHH, TGIF1	9.64
6	Semilobar holoprosencephaly	Enrichment	FGF8, NODAL, SHH, TGIF1	9.55
7	Holoprosencephaly 3	Enrichment	SHH	3.18
8	Pallister-hall syndrome	Enrichment	GLI3	3.18
9	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	3.18
10	Polydactyly, preaxial iv	Enrichment	GLI3	3.18
11	Microphthalmia/coloboma 5	Enrichment	SHH	3.18
12	Holoprosencephaly 4	Enrichment	TGIF1	3.18
13	Heterotaxy, visceral, 5, autosomal	Enrichment	NODAL	3.18
14	Loeys-dietz syndrome 6	Enrichment	SMAD2	3.18
15	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	3.18
16	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	3.18
17	Foxg1 syndrome due to intragenic alteration	Enrichment	FOXG1	3.18
18	Foxg1 syndrome due to 14q12 microdeletion	Enrichment	FOXG1	3.18
19	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	3.18
20	Solitary median maxillary central incisor	Enrichment	SHH	2.88
21	Tibial hemimelia	Enrichment	GLI3	2.88
22	Synpolydactyly	Enrichment	GLI3	2.88
23	Choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction	Enrichment	NKX2-1	2.88
24	Postaxial polydactyly type b	Enrichment	GLI3	2.88
25	Isolated radial hemimelia	Enrichment	SHH	2.88
26	Nkx2-1-related disorders	Enrichment	NKX2-1	2.88
27	Acrocallosal syndrome	Enrichment	GLI3	2.70
28	Syndactyly, type iv	Enrichment	SHH	2.70
29	Aarskog-scott syndrome	Enrichment	GLI3	2.70
30	Umbilical hernia	Enrichment	GLI3	2.70
31	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.70
32	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.70
33	Chorea, benign hereditary	Enrichment	NKX2-1	2.58
34	Polydactyly, preaxial ii	Enrichment	SHH	2.58
35	Schizencephaly	Enrichment	SHH	2.58
36	Thyroid cancer, nonmedullary, 1	Enrichment	NKX2-1	2.58
37	Hereditary ataxia	Enrichment	NKX2-1	2.58
38	Holoprosencephaly	Enrichment	FGF8	2.48
39	Holoprosencephaly 1	Enrichment	FGF8	2.40
40	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	NKX2-1	2.33
41	Rett syndrome	Enrichment	FOXG1	2.33
42	Rett syndrome, congenital variant	Enrichment	FOXG1	2.28
43	Choreatic disease	Enrichment	NKX2-1	2.28
44	Loeys-dietz syndrome	Enrichment	SMAD2	2.22
45	Optic nerve disease	Enrichment	FOXG1	2.18
46	Septooptic dysplasia	Enrichment	SHH	2.10
47	Diaphragmatic hernia, congenital	Enrichment	GLI3	2.07
48	Stereotypic movement disorder	Enrichment	FOXG1	2.07
49	Polydactyly, postaxial, type a1	Enrichment	GLI3	2.00
50	Wolff-parkinson-white syndrome	Enrichment	NODAL	1.98
51	Isolated congenital microcephaly	Enrichment	FOXG1	1.98
52	Heart, malformation of	Enrichment	NODAL	1.93
53	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF8	1.93
54	Macs syndrome	Enrichment	SHH	1.88
55	Craniosynostosis	Enrichment	GLI3	1.88
56	Lissencephaly	Enrichment	FOXG1	1.86
57	Visceral heterotaxy	Enrichment	NODAL	1.84
58	Kallmann syndrome	Enrichment	FGF8	1.82
59	Strabismus	Enrichment	FOXG1	1.75
60	Hirschsprung disease 1	Enrichment	GLI3	1.72
61	Differentiated thyroid carcinoma	Enrichment	NKX2-1	1.72
62	Visceral heterotaxy 5	Enrichment	NODAL	1.69
63	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2	1.54
64	Myeloma, multiple	Enrichment	NKX2-1	1.44
65	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	1.44
66	Undetermined early-onset epileptic encephalopathy	Enrichment	FOXG1	1.44
67	Autism	Enrichment	SHH	1.33
68	Congenital nervous system abnormality	Enrichment	FOXG1	1.17
69	Nervous system disease	Enrichment	FOXG1	1.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Tgif disruption of Shh signaling

Pathway Network for Tgif disruption of Shh signaling

Member Pathways for Tgif disruption of Shh signaling

Pathways in the Tgif disruption of Shh signaling SuperPath

Associated Genes for Tgif disruption of Shh signaling

Associated Disorders for Tgif disruption of Shh signaling

Disorders associated with Tgif disruption of Shh signaling SuperPath

STRING Interaction Network for Tgif disruption of Shh signaling

Sources for Tgif disruption of Shh signaling