Th17 cell differentiation pathway

No Pathway Network information available for Th17 cell differentiation pathway

Pathways in the Th17 cell differentiation pathway SuperPath

#	Name	Source	Genes
1	Th17 cell differentiation pathway	WikiPathways	AHR BMAL1 CD247 CD3D CD3E CD3G CD4 CLOCK CRY1 FOS FOXP3 GATA3 HIF1A HLA-DMA HSP90AA1 IFNG IFNGR1 IKBKB IL17A IL17F IL1B IL2 IL21 IL21R IL22 IL23A IL23R IL27 IL27RA IL2RA IL4 IL4R IL6 IL6R IRF4 JAK1 JAK2 JUN LAT LCK LOC100506403 MAPK1 MAPK14 MAPK8 MTOR NFATC1 NFIL3 NFKB1 NFKBIA NR1D1 PER1 PLCG1 PPP3CA PRKCQ RARA RORA RORC RXRA SMAD2 SOCS3 STAT1 STAT3 STAT5A STAT6 TBX21 TGFB1 TGFBR1 TYK2 ZAP70 (see all 69) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	1
2	IL27RA	Interleukin 27 Receptor Subunit Alpha	Protein Coding	1
3	CD4	CD4 Molecule	Protein Coding	1
4	CD247	CD247 Molecule	Protein Coding	1
5	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
6	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
7	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
8	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
9	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
10	TYK2	Tyrosine Kinase 2	Protein Coding	1
11	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
12	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
13	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
14	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
15	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
16	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
17	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
18	RORC	RAR Related Orphan Receptor C	Protein Coding	1
19	RORA	RAR Related Orphan Receptor A	Protein Coding	1
20	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
21	IL21	Interleukin 21	Protein Coding	1
22	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
23	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
24	PRKCQ	Protein Kinase C Theta	Protein Coding	1
25	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
26	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
27	PER1	Period Circadian Regulator 1	Protein Coding	1
28	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	1
29	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
30	IL22	Interleukin 22	Protein Coding	1
31	IL21R	Interleukin 21 Receptor	Protein Coding	1
32	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
33	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
34	NFIL3	Nuclear Factor, Interleukin 3 Regulated	Protein Coding	1
35	SMAD2	SMAD Family Member 2	Protein Coding	1
36	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	1
37	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
38	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
39	JAK2	Janus Kinase 2	Protein Coding	1
40	JAK1	Janus Kinase 1	Protein Coding	1
41	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
42	IL17A	Interleukin 17A	Protein Coding	1
43	IL6R	Interleukin 6 Receptor	Protein Coding	1
44	IL6	Interleukin 6	Protein Coding	1
45	IL4R	Interleukin 4 Receptor	Protein Coding	1
46	IL4	Interleukin 4	Protein Coding	1
47	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
48	IL2	Interleukin 2	Protein Coding	1
49	IL1B	Interleukin 1 Beta	Protein Coding	1
50	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
51	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
52	IFNG	Interferon Gamma	Protein Coding	1
53	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
54	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	1
55	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
56	TBX21	T-Box Transcription Factor 21	Protein Coding	1
57	LAT	Linker For Activation Of T Cells	Protein Coding	1
58	GATA3	GATA Binding Protein 3	Protein Coding	1
59	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
60	IL27	Interleukin 27	Protein Coding	1
61	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
62	AHR	Aryl Hydrocarbon Receptor	Protein Coding	1
63	IL23R	Interleukin 23 Receptor	Protein Coding	1
64	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
65	CRY1	Cryptochrome Circadian Regulator 1	Protein Coding	1
66	IL17F	Interleukin 17F	Protein Coding	1
67	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
68	LOC100506403	Uncharacterized LOC100506403	RNA Gene	1
69	CLOCK	Clock Circadian Regulator	Protein Coding	1

Disorders associated with Th17 cell differentiation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB, LCK, ZAP70	9.62
2	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.90
3	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.90
4	Immunodeficiency 31c	Enrichment	IL21R, STAT1	4.59
5	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1	4.12
6	Type 1 diabetes mellitus	Enrichment	FOXP3, IL6	3.42
7	Chronic mucocutaneous candidiasis	Enrichment	IL17F, STAT1	3.42
8	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, IL2RA	3.28
9	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, IL2RA	3.28
10	Inflammatory bowel disease 1	Enrichment	IL6, PRKCQ	3.05
11	Loeys-dietz syndrome	Enrichment	SMAD2, TGFBR1	3.05
12	Acute promyelocytic leukemia	Enrichment	RARA, STAT3	2.72
13	Behcet syndrome	Enrichment	IFNGR1, IL23R	2.38
14	Helicobacter pylori infection	Enrichment	IFNGR1	2.29
15	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.29
16	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	2.29
17	Immunodeficiency 35	Enrichment	TYK2	2.29
18	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.29
19	Dermatitis, atopic, 4	Enrichment	SOCS3	2.29
20	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.29
21	Candidiasis, familial, 6	Enrichment	IL17F	2.29
22	Immunodeficiency 27a	Enrichment	IFNGR1	2.29
23	Retinitis pigmentosa 85	Enrichment	AHR	2.29
24	Immunodeficiency 15b	Enrichment	IKBKB	2.29
25	Immunodeficiency 69	Enrichment	IFNG	2.29
26	Noonan syndrome 13	Enrichment	MAPK1	2.29
27	Immunodeficiency 15a	Enrichment	IKBKB	2.29
28	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.29
29	Immunodeficiency 131	Enrichment	IRF4	2.29
30	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.29
31	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.29
32	Immunodeficiency 48	Enrichment	ZAP70	2.29
33	Okt4 epitope deficiency	Enrichment	CD4	2.29
34	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.29
35	Foveal hypoplasia 3	Enrichment	AHR	2.29
36	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.29
37	Immunodeficiency 18	Enrichment	CD3E	2.29
38	Immunodeficiency 42	Enrichment	RORC	2.29
39	Immunodeficiency 25	Enrichment	CD247	2.29
40	Immunodeficiency 27b	Enrichment	IFNGR1	2.29
41	Psoriasis 7	Enrichment	IL23R	2.29
42	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.29
43	Immunodeficiency 31a	Enrichment	STAT1	2.29
44	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.29
45	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.29
46	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.29
47	Inflammatory bowel disease 17	Enrichment	IL23R	2.29
48	Immunodeficiency 31b	Enrichment	STAT1	2.29
49	Delayed sleep phase disorder	Enrichment	CRY1	2.29
50	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.29
51	Immunodeficiency 22	Enrichment	LCK	2.29
52	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.29
53	Immunodeficiency 79	Enrichment	CD4	2.29
54	Immunodeficiency 88	Enrichment	TBX21	2.29
55	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.29
56	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.29
57	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.29
58	Immunodeficiency 19	Enrichment	CD3D	2.29
59	Whipple disease	Enrichment	IRF4	2.29
60	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.29
61	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.29
62	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.29
63	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.99
64	Camurati-engelmann disease 1	Enrichment	TGFB1	1.99
65	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	1.99
66	Hemangiopericytoma, malignant	Enrichment	STAT6	1.99
67	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.99
68	Loeys-dietz syndrome 2	Enrichment	TGFBR1	1.99
69	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.99
70	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.99
71	Thrombocythemia 3	Enrichment	JAK2	1.99
72	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1	1.99
73	Cebalid syndrome	Enrichment	MTOR	1.99
74	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.99
75	Immunodeficiency 56	Enrichment	IL21R	1.99
76	Camurati-engelmann disease	Enrichment	TGFB1	1.99
77	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.99
78	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.99
79	Immunodeficiency 17	Enrichment	CD3G	1.99
80	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.99
81	Smith-kingsmore syndrome	Enrichment	MTOR	1.99
82	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.99
83	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Enrichment	RORA	1.99
84	Polycythemia	Enrichment	JAK2	1.99
85	Immunodeficiency 52	Enrichment	LAT	1.99
86	Lymphomatoid papulosis	Enrichment	TYK2	1.99
87	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.99
88	Hypereosinophilic syndrome	Enrichment	JAK2	1.99
89	Common variable immunodeficiency 12	Enrichment	NFKB1	1.99
90	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	1.99
91	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.82
92	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	1.82
93	Polycythemia vera	Enrichment	JAK2	1.82
94	Tuberous sclerosis 1	Enrichment	IFNG	1.82
95	Hepatitis c virus	Enrichment	IFNG	1.82
96	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.82
97	Tuberous sclerosis 2	Enrichment	IFNG	1.82
98	Hyper ige syndrome	Enrichment	STAT3	1.82
99	Immunodeficiency, common variable, 11	Enrichment	IL21	1.82
100	End stage renal disease	Enrichment	GATA3	1.82
101	Enchondromatosis	Enrichment	HIF1A	1.82
102	Kaposi sarcoma	Enrichment	IL6	1.69
103	Erythrocytosis, familial, 1	Enrichment	JAK2	1.69
104	Budd-chiari syndrome	Enrichment	JAK2	1.69
105	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.69
106	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.69
107	Congenital generalized lipodystrophy	Enrichment	FOS	1.69
108	Hepatitis b	Enrichment	IFNGR1	1.69
109	Aortic aneurysm	Enrichment	TGFBR1	1.69
110	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.69
111	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.69
112	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, TGFBR1	1.68
113	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.60
114	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.60
115	Myeloproliferative neoplasm	Enrichment	JAK2	1.60
116	Histiocytoid hemangioma	Enrichment	FOS	1.60
117	Hemimegalencephaly	Enrichment	MTOR	1.60
118	Idiopathic aplastic anemia	Enrichment	IFNG	1.60
119	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.52
120	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.52
121	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.52
122	Myelofibrosis	Enrichment	JAK2	1.45
123	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.45
124	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.45
125	Essential thrombocythemia	Enrichment	JAK2	1.45
126	Common variable immunodeficiency	Enrichment	NFKB1	1.45
127	Overgrowth syndrome	Enrichment	MTOR	1.45
128	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.40
129	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.35
130	Hydrops fetalis	Enrichment	FOXP3	1.35
131	Marfan syndrome	Enrichment	TGFBR1	1.30
132	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.30
133	Aplastic anemia	Enrichment	IFNG	1.30
134	Pectus excavatum	Enrichment	TGFBR1	1.26
135	Combined immunodeficiency	Enrichment	ZAP70	1.26
136	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.26
137	Specific learning disability	Enrichment	MAPK1	1.26
138	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.26
139	Breast cancer	Enrichment	IL2, JUN	1.25
140	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.13
141	Rare genetic intellectual disability	Enrichment	MTOR	1.13
142	Gliosarcoma	Enrichment	NFKBIA	1.11
143	Giant cell glioblastoma	Enrichment	NFKBIA	1.08
144	Heart, malformation of	Enrichment	MAPK1	1.06
145	Human immunodeficiency virus type 1	Enrichment	IFNG	1.06
146	Arteriovenous malformations of the brain	Enrichment	IL6	1.03
147	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.03
148	Centronuclear myopathy	Enrichment	FOXP3	0.99
149	Cystic fibrosis	Enrichment	TGFB1	0.82
150	Cakut	Enrichment	GATA3	0.80
151	Leukemia, acute myeloid	Enrichment	JAK2	0.73
152	Type 2 diabetes mellitus	Enrichment	IL6	0.71
153	Gastric cancer	Enrichment	IL1B	0.71
154	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.65
155	Myeloma, multiple	Enrichment	RXRA	0.60
156	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.60
157	Primary ovarian insufficiency	Enrichment	JAK2	0.58
158	Microcephaly	Enrichment	MAPK1	0.33
159	Complex neurodevelopmental disorder	Enrichment	RORA	0.33
160	Retinitis pigmentosa	Enrichment	AHR	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Th17 cell differentiation pathway

Pathway Network for Th17 cell differentiation pathway

Member Pathways for Th17 cell differentiation pathway

Pathways in the Th17 cell differentiation pathway SuperPath

Associated Genes for Th17 cell differentiation pathway

Associated Disorders for Th17 cell differentiation pathway

Disorders associated with Th17 cell differentiation pathway SuperPath

STRING Interaction Network for Th17 cell differentiation pathway

Sources for Th17 cell differentiation pathway