Th17 Differentiation

No Pathway Network information available for Th17 Differentiation

Pathways in the Th17 Differentiation SuperPath

#	Name	Source	Genes
1	Th17 Differentiation	R&D Systems	CD28 CD3E CD4 CD80 CD86 HLA-DRA IL12B IL12RB1 IL17A IL17F IL1B IL1R1 IL1RAP IL21 IL21R IL22 IL23A IL23R IL26 IL2RG IL6 IL6R IL6ST JAK1 JAK2 JAK3 RORC SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 STAT1 STAT3 STAT4 STAT5A STAT5B TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TYK2 (see all 54) (see less)
2	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types	R&D Systems	CCR7 CXCR5 GZMB HLA-DRA IFNG IL12B IL17F IL17RA IL1B IL21 IL21R IL22 IL23A IL23R IL2RG IL4 IL4R IL6 IL6R IL6ST RORC STAT3 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR9 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TLR1	Toll Like Receptor 1	Protein Coding	2
2	TLR2	Toll Like Receptor 2	Protein Coding	2
3	TLR3	Toll Like Receptor 3	Protein Coding	2
4	TLR4	Toll Like Receptor 4	Protein Coding	2
5	TLR5	Toll Like Receptor 5	Protein Coding	2
6	TLR6	Toll Like Receptor 6	Protein Coding	2
7	TLR7	Toll Like Receptor 7	Protein Coding	2
8	TLR9	Toll Like Receptor 9	Protein Coding	2
9	TLR10	Toll Like Receptor 10	Protein Coding	2
10	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	2
11	IL12B	Interleukin 12B	Protein Coding	2
12	IL6	Interleukin 6	Protein Coding	2
13	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	2
14	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	2
15	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	2
16	IL1B	Interleukin 1 Beta	Protein Coding	2
17	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	2
18	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	2
19	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	2
20	IL6R	Interleukin 6 Receptor	Protein Coding	2
21	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	2
22	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
23	IL21	Interleukin 21	Protein Coding	2
24	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	2
25	IL21R	Interleukin 21 Receptor	Protein Coding	2
26	RORC	RAR Related Orphan Receptor C	Protein Coding	2
27	IL23R	Interleukin 23 Receptor	Protein Coding	2
28	IL17F	Interleukin 17F	Protein Coding	2
29	IL22	Interleukin 22	Protein Coding	2
30	TLR8	Toll Like Receptor 8	Protein Coding	1
31	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
32	CD4	CD4 Molecule	Protein Coding	1
33	CD28	CD28 Molecule	Protein Coding	1
34	CD80	CD80 Molecule	Protein Coding	1
35	CD86	CD86 Molecule	Protein Coding	1
36	SMAD1	SMAD Family Member 1	Protein Coding	1
37	SMAD2	SMAD Family Member 2	Protein Coding	1
38	SMAD3	SMAD Family Member 3	Protein Coding	1
39	SMAD4	SMAD Family Member 4	Protein Coding	1
40	SMAD5	SMAD Family Member 5	Protein Coding	1
41	SMAD9	SMAD Family Member 9	Protein Coding	1
42	JAK1	Janus Kinase 1	Protein Coding	1
43	JAK2	Janus Kinase 2	Protein Coding	1
44	TYK2	Tyrosine Kinase 2	Protein Coding	1
45	JAK3	Janus Kinase 3	Protein Coding	1
46	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	1
47	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
48	IL17A	Interleukin 17A	Protein Coding	1
49	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
50	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
51	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
52	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
53	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
54	IL26	Interleukin 26	Protein Coding	1
55	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	1
56	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
57	IL17RA	Interleukin 17 Receptor A	Protein Coding	1
58	IFNG	Interferon Gamma	Protein Coding	1
59	GZMB	Granzyme B	Protein Coding	1
60	IL4R	Interleukin 4 Receptor	Protein Coding	1
61	IL4	Interleukin 4	Protein Coding	1
62	CCR7	C-C Motif Chemokine Receptor 7	Protein Coding	1

Disorders associated with Th17 Differentiation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	11.17
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	9.44
3	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.22
4	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	7.22
5	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	5.66
6	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.14
7	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	5.14
8	Immunodeficiency 31c	Enrichment	IL21R, STAT1	4.81
9	Behcet syndrome	Enrichment	IL23R, STAT4, TLR4	4.26
10	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	4.26
11	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.03
12	Chronic mucocutaneous candidiasis	Enrichment	IL17F, IL17RA	3.97
13	Human immunodeficiency virus type 1	Enrichment	IFNG, TLR3	2.97
14	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	2.93
15	Multisystem inflammatory syndrome in children	Enrichment	TLR3, TLR6	2.79
16	Leprosy 3	Enrichment	TLR2	2.56
17	Legionnaire disease	Enrichment	TLR5	2.56
18	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.56
19	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.56
20	Leprosy 5	Enrichment	TLR1	2.56
21	Candidiasis, familial, 6	Enrichment	IL17F	2.56
22	Immunodeficiency 69	Enrichment	IFNG	2.56
23	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.56
24	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.56
25	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.56
26	Systemic lupus erythematosus 1	Enrichment	TLR5	2.56
27	X-linked immunodeficiency 74	Enrichment	TLR7	2.56
28	Systemic lupus erythematosus 17	Enrichment	TLR7	2.56
29	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.56
30	Immunodeficiency 42	Enrichment	RORC	2.56
31	Psoriasis 7	Enrichment	IL23R	2.56
32	Camurati-engelmann disease 2	Enrichment	TGFB2	2.56
33	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.56
34	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.56
35	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.56
36	Immunodeficiency 29	Enrichment	IL12B	2.56
37	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.56
38	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.56
39	Melioidosis	Enrichment	TLR5	2.56
40	Inflammatory bowel disease 17	Enrichment	IL23R	2.56
41	Macular degeneration, age-related, 10	Enrichment	TLR4	2.56
42	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.56
43	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.56
44	Psoriasis	Enrichment	IL17RA	2.56
45	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.56
46	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.56
47	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.56
48	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.56
49	Immunodeficiency 35	Enrichment	TYK2	2.40
50	Immunodeficiency 30	Enrichment	IL12RB1	2.40
51	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.40
52	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.40
53	Okt4 epitope deficiency	Enrichment	CD4	2.40
54	Immunodeficiency 18	Enrichment	CD3E	2.40
55	Systemic lupus erythematosus 11	Enrichment	STAT4	2.40
56	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.40
57	Immunodeficiency 31a	Enrichment	STAT1	2.40
58	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.40
59	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.40
60	Immunodeficiency 31b	Enrichment	STAT1	2.40
61	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.40
62	Immunodeficiency 79	Enrichment	CD4	2.40
63	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.40
64	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.40
65	Heritable thoracic aortic disease	Enrichment	SMAD4	2.40
66	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.40
67	Camurati-engelmann disease 1	Enrichment	TGFB1	2.26
68	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.26
69	Immunodeficiency 51	Enrichment	IL17RA	2.26
70	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.26
71	Immunodeficiency 56	Enrichment	IL21R	2.26
72	Leprosy 1	Enrichment	TLR6	2.26
73	Camurati-engelmann disease	Enrichment	TGFB1	2.26
74	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.15
75	Severe combined immunodeficiency	Enrichment	CD3E, JAK3	2.12
76	Myhre syndrome	Enrichment	SMAD4	2.10
77	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.10
78	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.10
79	Thrombocythemia 3	Enrichment	JAK2	2.10
80	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.10
81	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.10
82	Polycythemia	Enrichment	JAK2	2.10
83	Lymphomatoid papulosis	Enrichment	TYK2	2.10
84	Hypereosinophilic syndrome	Enrichment	JAK2	2.10
85	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.10
86	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.10
87	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.09
88	Takayasu arteritis	Enrichment	IL12B	2.09
89	Tuberous sclerosis 1	Enrichment	IFNG	2.09
90	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.09
91	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.09
92	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.09
93	Hepatitis c virus	Enrichment	IFNG	2.09
94	Tuberous sclerosis 2	Enrichment	IFNG	2.09
95	Hyper ige syndrome	Enrichment	STAT3	2.09
96	Immunodeficiency, common variable, 11	Enrichment	IL21	2.09
97	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.09
98	Systemic lupus erythematosus	Enrichment	STAT4, TLR7	1.98
99	Kaposi sarcoma	Enrichment	IL6	1.96
100	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.96
101	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.92
102	Juvenile polyposis syndrome	Enrichment	SMAD4	1.92
103	Polycythemia vera	Enrichment	JAK2	1.92
104	Mycosis fungoides	Enrichment	CD28	1.92
105	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.92
106	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3E	1.92
107	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	SMAD9	1.92
108	Saczary syndrome	Enrichment	CD28	1.92
109	Gastric cancer	Enrichment	IL1B, SMAD4	1.90
110	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.87
111	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.87
112	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.87
113	Herpes simplex virus encephalitis	Enrichment	TLR3	1.87
114	Idiopathic aplastic anemia	Enrichment	IFNG	1.87
115	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.87
116	Erythrocytosis, familial, 1	Enrichment	JAK2	1.80
117	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.80
118	Budd-chiari syndrome	Enrichment	JAK2	1.80
119	Adenosine deaminase deficiency	Enrichment	JAK3	1.80
120	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.80
121	Atrial septal defect 1	Enrichment	TGFB2	1.79
122	Type 1 diabetes mellitus	Enrichment	IL6	1.79
123	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.79
124	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.79
125	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.79
126	Esophageal cancer	Enrichment	TGFBR2	1.72
127	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.70
128	Myeloproliferative neoplasm	Enrichment	JAK2	1.70
129	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.70
130	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.67
131	Rheumatoid arthritis	Enrichment	TLR1	1.61
132	Inflammatory bowel disease 1	Enrichment	IL6	1.61
133	Omenn syndrome	Enrichment	IL2RG	1.57
134	Aplastic anemia	Enrichment	IFNG	1.57
135	Myelofibrosis	Enrichment	JAK2	1.56
136	Essential thrombocythemia	Enrichment	JAK2	1.56
137	Gallbladder cancer	Enrichment	SMAD4	1.56
138	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.56
139	Oligoarticular juvenile idiopathic arthritis	Enrichment	STAT4	1.56
140	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	STAT4	1.56
141	Pectus excavatum	Enrichment	TGFBR1	1.53
142	Combined immunodeficiency	Enrichment	IL2RG	1.53
143	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.53
144	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.53
145	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.49
146	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.49
147	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.45
148	Primary biliary cholangitis	Enrichment	IL12RB1	1.45
149	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.45
150	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.43
151	Lynch syndrome	Enrichment	TGFBR2	1.40
152	Heritable pulmonary arterial hypertension	Enrichment	SMAD9	1.37
153	Colorectal cancer	Enrichment	SMAD4, TLR2	1.33
154	Nk-cell enteropathy	Enrichment	JAK3	1.30
155	Arteriovenous malformations of the brain	Enrichment	IL6	1.30
156	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.30
157	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.26
158	Cystic fibrosis	Enrichment	TGFB1	1.08
159	Pancreatic cancer	Enrichment	SMAD4	1.02
160	Type 2 diabetes mellitus	Enrichment	IL6	0.96
161	Severe covid-19	Enrichment	JAK3	0.96
162	Leukemia, acute myeloid	Enrichment	JAK2	0.83
163	Thrombocytopenia	Enrichment	SMAD4	0.76
164	Primary ovarian insufficiency	Enrichment	JAK2	0.68
165	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Th17 Differentiation

Pathway Network for Th17 Differentiation

Member Pathways for Th17 Differentiation

Pathways in the Th17 Differentiation SuperPath

Associated Genes for Th17 Differentiation

Associated Disorders for Th17 Differentiation

Disorders associated with Th17 Differentiation SuperPath

STRING Interaction Network for Th17 Differentiation

Sources for Th17 Differentiation