Th2 Differentiation

No Pathway Network information available for Th2 Differentiation

Pathways in the Th2 Differentiation SuperPath

#	Name	Source	Genes
1	Th2 Differentiation	R&D Systems	AREG BHLHE41 CCL11 CCL17 CCL22 CD28 CD3E CD4 CD80 CD86 CRLF2 FOXP3 GATA3 GFI1 HLA-DRA IFNG IL10 IL12RB2 IL13 IL17RB IL1RL1 IL2 IL25 IL2RA IL2RB IL2RG IL31 IL33 IL4 IL4R IL5 IL9 JAG1 JAG2 JAK1 JAK2 JAK3 MAF MAML1 NOTCH1 RBPJ STAT4 STAT5A STAT6 TNFRSF4 TNFSF4 (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD80	CD80 Molecule	Protein Coding	1
2	CD86	CD86 Molecule	Protein Coding	1
3	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
4	TNFSF4	TNF Superfamily Member 4	Protein Coding	1
5	CD28	CD28 Molecule	Protein Coding	1
6	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
7	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	1
8	CD4	CD4 Molecule	Protein Coding	1
9	IL2	Interleukin 2	Protein Coding	1
10	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
11	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
12	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
13	JAK1	Janus Kinase 1	Protein Coding	1
14	JAK2	Janus Kinase 2	Protein Coding	1
15	JAK3	Janus Kinase 3	Protein Coding	1
16	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
17	IL4	Interleukin 4	Protein Coding	1
18	IL4R	Interleukin 4 Receptor	Protein Coding	1
19	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
20	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
21	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
22	NOTCH1	Notch Receptor 1	Protein Coding	1
23	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
24	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
25	GATA3	GATA Binding Protein 3	Protein Coding	1
26	IL5	Interleukin 5	Protein Coding	1
27	IL13	Interleukin 13	Protein Coding	1
28	IL33	Interleukin 33	Protein Coding	1
29	MAF	MAF BZIP Transcription Factor	Protein Coding	1
30	GFI1	Growth Factor Independent 1 Transcriptional Repressor	Protein Coding	1
31	BHLHE41	Basic Helix-Loop-Helix Family Member E41	Protein Coding	1
32	IL1RL1	Interleukin 1 Receptor Like 1	Protein Coding	1
33	IL10	Interleukin 10	Protein Coding	1
34	IFNG	Interferon Gamma	Protein Coding	1
35	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
36	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
37	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
38	IL9	Interleukin 9	Protein Coding	1
39	IL25	Interleukin 25	Protein Coding	1
40	IL31	Interleukin 31	Protein Coding	1
41	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
42	CCL17	C-C Motif Chemokine Ligand 17	Protein Coding	1
43	CCL22	C-C Motif Chemokine Ligand 22	Protein Coding	1
44	AREG	Amphiregulin	Protein Coding	1
45	CRLF2	Cytokine Receptor Like Factor 2	Protein Coding	1
46	IL17RB	Interleukin 17 Receptor B	Protein Coding	1

Disorders associated with Th2 Differentiation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.90
2	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.90
3	Human immunodeficiency virus type 1	Enrichment	CCL11, IFNG, IL10	4.54
4	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	4.47
5	Adams-oliver syndrome	Enrichment	NOTCH1, RBPJ	3.63
6	Systemic lupus erythematosus	Enrichment	IL10, STAT4, TNFSF4	3.51
7	Asthma	Enrichment	CCL11, IL13	3.22
8	Behcet syndrome	Enrichment	IL10, STAT4	2.73
9	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.47
10	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	2.47
11	Cataract 21, multiple types	Enrichment	MAF	2.47
12	Short sleep, familial natural, 1	Enrichment	BHLHE41	2.47
13	Immunodeficiency 16	Enrichment	TNFRSF4	2.47
14	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.47
15	Immunodeficiency 69	Enrichment	IFNG	2.47
16	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.47
17	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.47
18	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.47
19	Okt4 epitope deficiency	Enrichment	CD4	2.47
20	Graft-versus-host disease	Enrichment	IL10	2.47
21	Immunodeficiency 18	Enrichment	CD3E	2.47
22	Systemic lupus erythematosus 11	Enrichment	STAT4	2.47
23	Ayme-gripp syndrome	Enrichment	MAF	2.47
24	Allergic rhinitis	Enrichment	IL13	2.47
25	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.47
26	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.47
27	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.47
28	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.47
29	Immunodeficiency 79	Enrichment	CD4	2.47
30	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.47
31	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.47
32	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	2.46
33	Severe combined immunodeficiency	Enrichment	CD3E, JAK3	2.26
34	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	2.17
35	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	2.17
36	Hemangiopericytoma, malignant	Enrichment	STAT6	2.17
37	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.17
38	Neutropenia, nonimmune chronic idiopathic, of adults	Enrichment	GFI1	2.17
39	Developmental and epileptic encephalopathy 28	Enrichment	MAF	2.17
40	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.17
41	Neutropenia, severe congenital, 2, autosomal dominant	Enrichment	GFI1	2.17
42	Thrombocythemia 3	Enrichment	JAK2	2.17
43	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	MAF	2.17
44	Adams-oliver syndrome 3	Enrichment	RBPJ	2.17
45	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.17
46	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	2.17
47	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	2.17
48	Polycythemia	Enrichment	JAK2	2.17
49	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	2.17
50	Hypereosinophilic syndrome	Enrichment	JAK2	2.17
51	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.99
52	Alagille syndrome 1	Enrichment	JAG1	1.99
53	Polycythemia vera	Enrichment	JAK2	1.99
54	Mycosis fungoides	Enrichment	CD28	1.99
55	Tuberous sclerosis 1	Enrichment	IFNG	1.99
56	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.99
57	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.99
58	Hepatitis c virus	Enrichment	IFNG	1.99
59	Tuberous sclerosis 2	Enrichment	IFNG	1.99
60	End stage renal disease	Enrichment	GATA3	1.99
61	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3E	1.99
62	Keratoacanthoma	Enrichment	NOTCH1	1.99
63	Saczary syndrome	Enrichment	CD28	1.99
64	Erythrocytosis, familial, 1	Enrichment	JAK2	1.87
65	Budd-chiari syndrome	Enrichment	JAK2	1.87
66	Adenosine deaminase deficiency	Enrichment	JAK3	1.87
67	Congenital blue dot cataract	Enrichment	MAF	1.87
68	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.87
69	Middle aortic syndrome	Enrichment	JAG1	1.87
70	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.77
71	Myeloproliferative neoplasm	Enrichment	JAK2	1.77
72	Autosomal dominant severe congenital neutropenia	Enrichment	GFI1	1.77
73	Idiopathic aplastic anemia	Enrichment	IFNG	1.77
74	Type 1 diabetes mellitus	Enrichment	FOXP3	1.70
75	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.70
76	Myelofibrosis	Enrichment	JAK2	1.63
77	Essential thrombocythemia	Enrichment	JAK2	1.63
78	Narcolepsy 1	Enrichment	TNFSF4	1.57
79	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.57
80	Cataract - microcornea syndrome	Enrichment	MAF	1.57
81	Rheumatoid arthritis	Enrichment	IL10	1.52
82	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.52
83	Hydrops fetalis	Enrichment	FOXP3	1.52
84	Cataract 30, multiple types	Enrichment	MAF	1.48
85	Omenn syndrome	Enrichment	IL2RG	1.48
86	Aplastic anemia	Enrichment	IFNG	1.48
87	Combined immunodeficiency	Enrichment	IL2RG	1.44
88	Ichthyosis	Enrichment	IL2RB	1.44
89	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.44
90	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.44
91	Aortic valve disease 1	Enrichment	NOTCH1	1.36
92	Nk-cell enteropathy	Enrichment	JAK3	1.36
93	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.33
94	Heart, malformation of	Enrichment	JAG1	1.23
95	Centronuclear myopathy	Enrichment	FOXP3	1.16
96	Hepatoblastoma	Enrichment	JAG1	1.16
97	Myocardial infarction	Enrichment	TNFSF4	1.14
98	Developmental and epileptic encephalopathy 1	Enrichment	MAF	1.09
99	Severe covid-19	Enrichment	JAK3	1.03
100	Connective tissue disease	Enrichment	NOTCH1	0.99
101	Cakut	Enrichment	GATA3	0.96
102	Leukemia, acute myeloid	Enrichment	JAK2	0.90
103	Benign epilepsy with centrotemporal spikes	Enrichment	MAF	0.89
104	Type 2 diabetes mellitus	Enrichment	RBPJ	0.88
105	Centralopathic epilepsy	Enrichment	MAF	0.87
106	West syndrome	Enrichment	MAF	0.86
107	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	0.86
108	Primary ovarian insufficiency	Enrichment	JAK2	0.74
109	Breast cancer	Enrichment	IL2	0.65
110	Hereditary retinal dystrophy	Enrichment	JAG1	0.20
111	Fundus dystrophy	Enrichment	JAG1	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Th2 Differentiation

Pathway Network for Th2 Differentiation

Member Pathways for Th2 Differentiation

Pathways in the Th2 Differentiation SuperPath

Associated Genes for Th2 Differentiation

Associated Disorders for Th2 Differentiation

Disorders associated with Th2 Differentiation SuperPath

STRING Interaction Network for Th2 Differentiation

Sources for Th2 Differentiation