THC Differentiation Pathway

No Pathway Network information available for THC Differentiation Pathway

Pathways in the THC Differentiation Pathway SuperPath

#	Name	Source	Genes
1	THC Differentiation Pathway	QIAGEN	ARPC1B CD28 CD40 CD40LG CD86 CDK5R1 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IFNAR1 IFNAR2 IFNG IFNGR1 IFNGR2 IL10 IL10RA IL10RB IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 IL2 IL2RA IL4 IL4R TNF TNFRSF1A TNFRSF1B (see all 40) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	1
2	CD28	CD28 Molecule	Protein Coding	1
3	CD86	CD86 Molecule	Protein Coding	1
4	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
5	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	1
6	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	1
7	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	1
8	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	1
9	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	1
10	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	1
11	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	1
12	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	1
13	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
14	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	1
15	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	1
16	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	1
17	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	1
18	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	1
19	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
20	IFNG	Interferon Gamma	Protein Coding	1
21	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
22	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
23	IL10	Interleukin 10	Protein Coding	1
24	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
25	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
26	IL12A	Interleukin 12A	Protein Coding	1
27	IL12B	Interleukin 12B	Protein Coding	1
28	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
29	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
30	IL18	Interleukin 18	Protein Coding	1
31	IL18R1	Interleukin 18 Receptor 1	Protein Coding	1
32	IL2	Interleukin 2	Protein Coding	1
33	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
34	IL4	Interleukin 4	Protein Coding	1
35	IL4R	Interleukin 4 Receptor	Protein Coding	1
36	TNF	Tumor Necrosis Factor	Protein Coding	1
37	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
38	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
39	CD40	CD40 Molecule	Protein Coding	1
40	CD40LG	CD40 Ligand	Protein Coding	1

Disorders associated with THC Differentiation Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hepatitis b	Enrichment	IFNAR2, IFNGR1, IL10RB	7.02
2	Behcet syndrome	Enrichment	IFNGR1, IL10, IL12A, TNFRSF1A	6.61
3	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA, IL10RB	6.33
4	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1, TNFRSF1A	5.07
5	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	5.07
6	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	5.07
7	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	5.07
8	Mycosis fungoides	Enrichment	CD28, TNFRSF1B	4.60
9	Saczary syndrome	Enrichment	CD28, TNFRSF1B	4.60
10	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	4.30
11	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	4.07
12	Systemic lupus erythematosus	Enrichment	HLA-DRB1, IL10, TNF	3.70
13	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	3.63
14	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.52
15	Human immunodeficiency virus type 1	Enrichment	IFNG, IL10	2.90
16	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.53
17	Helicobacter pylori infection	Enrichment	IFNGR1	2.53
18	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.53
19	Immunodeficiency 30	Enrichment	IL12RB1	2.53
20	Immunodeficiency 27a	Enrichment	IFNGR1	2.53
21	Immunodeficiency 69	Enrichment	IFNG	2.53
22	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.53
23	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.53
24	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.53
25	Graft-versus-host disease	Enrichment	IL10	2.53
26	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.53
27	Immunodeficiency 27b	Enrichment	IFNGR1	2.53
28	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.53
29	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.53
30	Immunodeficiency 29	Enrichment	IL12B	2.53
31	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.53
32	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.53
33	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.53
34	Cd40 ligand deficiency	Enrichment	CD40LG	2.53
35	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.53
36	Severe covid-19	Enrichment	HLA-DQB1, IL10RB	2.49
37	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.23
38	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.23
39	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	2.23
40	Immunodeficiency 45	Enrichment	IFNAR2	2.23
41	Sarcoidosis 1	Enrichment	HLA-DRB1	2.23
42	Immunodeficiency 127	Enrichment	TNF	2.23
43	Inflammatory bowel disease 28	Enrichment	IL10RA	2.23
44	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.23
45	Takayasu arteritis	Enrichment	IL12B	2.05
46	Tuberous sclerosis 1	Enrichment	IFNG	2.05
47	Psoriatic arthritis	Enrichment	TNF	2.05
48	Hepatitis c virus	Enrichment	IFNG	2.05
49	Tuberous sclerosis 2	Enrichment	IFNG	2.05
50	Immunodeficiency 28	Enrichment	IFNGR2	2.05
51	Inflammatory bowel disease 25	Enrichment	IL10RB	2.05
52	Migraine without aura	Enrichment	TNF	2.05
53	Immunodeficiency 44	Enrichment	IFNAR2	2.05
54	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	2.05
55	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	2.05
56	Temporal arteritis	Enrichment	HLA-DRB1	1.93
57	Cerebral malaria	Enrichment	TNF	1.93
58	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.93
59	Follicular lymphoma	Enrichment	HLA-DRB1	1.83
60	Vascular dementia	Enrichment	TNF	1.83
61	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.83
62	Idiopathic aplastic anemia	Enrichment	IFNG	1.83
63	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	1.76
64	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1	1.76
65	Limited scleroderma	Enrichment	HLA-DRB1	1.76
66	Common variable immunodeficiency	Enrichment	CD40LG	1.69
67	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA	1.69
68	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA	1.69
69	Rheumatoid arthritis	Enrichment	IL10	1.58
70	Charge syndrome	Enrichment	TNFRSF1A	1.58
71	Aplastic anemia	Enrichment	IFNG	1.54
72	Asthma	Enrichment	TNF	1.50
73	Combined immunodeficiency	Enrichment	ARPC1B	1.50
74	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.50
75	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.50
76	Alzheimer's disease	Enrichment	TNF	1.42
77	Multisystem inflammatory syndrome in children	Enrichment	IFNAR2	1.20
78	Malaria	Enrichment	TNF	1.18
79	Autoinflammatory disease	Enrichment	TNFRSF1A	1.16
80	Breast cancer	Enrichment	IL2	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

THC Differentiation Pathway

Pathway Network for THC Differentiation Pathway

Member Pathways for THC Differentiation Pathway

Pathways in the THC Differentiation Pathway SuperPath

Associated Genes for THC Differentiation Pathway

Associated Disorders for THC Differentiation Pathway

Disorders associated with THC Differentiation Pathway SuperPath

STRING Interaction Network for THC Differentiation Pathway

Sources for THC Differentiation Pathway