Thermogenesis

No Pathway Network information available for Thermogenesis

Pathways in the Thermogenesis SuperPath

#	Name	Source	Genes
1	Thermogenesis	WikiPathways	ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACTB ACTG1 ACTL6A ACTL6B ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB3 AKT1S1 ARID1A ARID1B ATF2 BMP8A BMP8B CNR1 CPT1A CPT1B CPT1C CPT2 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 DPF1 DPF3 FGF21 FGFR1 FRS2 GCG GNAS GRB2 HRAS KDM1A KDM3A KDM3B KLB KRAS LIPE MAP2K3 MAP3K5 MAPK11 MAPK12 MAPK13 MAPK14 MGLL MLST8 MTOR NPR1 NRAS PLIN1 PNPLA2 PPARG PPARGC1A PRDM16 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKG1 PRKG2 RHEB RPS6 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KB1 RPS6KB2 RPTOR SIRT6 SLC25A20 SLC25A29 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SOS1 SOS2 TSC1 TSC2 UCP1 ZNF516 (see all 108) (see less)
2	mitochondrial L-carnitine shuttle	PubChem	CPT1A CPT1B CPT1C CPT2 SLC25A20

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC25A20	Solute Carrier Family 25 Member 20	Protein Coding	2
2	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	2
3	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	2
4	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	2
5	CPT1C	Carnitine Palmitoyltransferase 1C	Protein Coding	2
6	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	1
7	CREB5	CAMP Responsive Element Binding Protein 5	Protein Coding	1
8	AKT1S1	AKT1 Substrate 1	Protein Coding	1
9	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	1
10	DPF3	Double PHD Fingers 3	Protein Coding	1
11	UCP1	Uncoupling Protein 1	Protein Coding	1
12	TSC2	TSC Complex Subunit 2	Protein Coding	1
13	TSC1	TSC Complex Subunit 1	Protein Coding	1
14	ACTG1	Actin Gamma 1	Protein Coding	1
15	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
16	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
17	SMARCE1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit E1	Protein Coding	1
18	SMARCD2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D2	Protein Coding	1
19	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	1
20	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	1
21	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
22	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	1
23	PRDM16	PR/SET Domain 16	Protein Coding	1
24	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
25	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
26	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
27	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
28	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
29	RPS6	Ribosomal Protein S6	Protein Coding	1
30	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
31	ACTB	Actin Beta	Protein Coding	1
32	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
33	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	1
34	PNPLA2	Patatin Like Domain 2, Triacylglycerol Lipase	Protein Coding	1
35	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
36	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
37	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
38	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
39	ADCY10	Adenylate Cyclase 10	Protein Coding	1
40	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
41	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
42	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
43	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
44	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
45	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
46	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
47	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
48	PLIN1	Perilipin 1	Protein Coding	1
49	KDM3B	Lysine Demethylase 3B	Protein Coding	1
50	ACSL5	Acyl-CoA Synthetase Long Chain Family Member 5	Protein Coding	1
51	SIRT6	Sirtuin 6	Protein Coding	1
52	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
53	ACTL6B	Actin Like 6B	Protein Coding	1
54	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
55	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	1
56	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
57	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	1
58	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
59	BMP8A	Bone Morphogenetic Protein 8a	Protein Coding	1
60	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
61	GNAS	GNAS Complex Locus	Protein Coding	1
62	GCG	Glucagon	Protein Coding	1
63	FGF21	Fibroblast Growth Factor 21	Protein Coding	1
64	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
65	ACSL6	Acyl-CoA Synthetase Long Chain Family Member 6	Protein Coding	1
66	KDM1A	Lysine Demethylase 1A	Protein Coding	1
67	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
68	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	1
69	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	1
70	ADRB3	Adrenoceptor Beta 3	Protein Coding	1
71	KLB	Klotho Beta	Protein Coding	1
72	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
73	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
74	ATF2	Activating Transcription Factor 2	Protein Coding	1
75	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
76	CNR1	Cannabinoid Receptor 1	Protein Coding	1
77	SLC25A29	Solute Carrier Family 25 Member 29	Protein Coding	1
78	ADCY8	Adenylate Cyclase 8	Protein Coding	1
79	MGLL	Monoglyceride Lipase	Protein Coding	1
80	ADCY7	Adenylate Cyclase 7	Protein Coding	1
81	ADCY6	Adenylate Cyclase 6	Protein Coding	1
82	ADCY5	Adenylate Cyclase 5	Protein Coding	1
83	ADCY3	Adenylate Cyclase 3	Protein Coding	1
84	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
85	ADCY2	Adenylate Cyclase 2	Protein Coding	1
86	ADCY1	Adenylate Cyclase 1	Protein Coding	1
87	ADCY4	Adenylate Cyclase 4	Protein Coding	1
88	ZNF516	Zinc Finger Protein 516	Protein Coding	1
89	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
90	ACTL6A	Actin Like 6A	Protein Coding	1
91	CREB3L3	CAMP Responsive Element Binding Protein 3 Like 3	Protein Coding	1
92	ADCY9	Adenylate Cyclase 9	Protein Coding	1
93	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
94	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
95	DPF1	Double PHD Fingers 1	Protein Coding	1
96	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	1
97	SMARCD1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D1	Protein Coding	1
98	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	1
99	BMP8B	Bone Morphogenetic Protein 8b	Protein Coding	1
100	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	1
101	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
102	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
103	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	1
104	KDM3A	Lysine Demethylase 3A	Protein Coding	1
105	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
106	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
107	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
108	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1

Disorders associated with Thermogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coffin-siris syndrome 1	Enrichment	ARID1A, ARID1B, SMARCA4, SMARCB1, SMARCC2, SMARCD1, SMARCE1	10.35
2	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	8.42
3	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	8.42
4	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1, SOS2	6.06
5	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1, SOS2	5.78
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.71
7	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	5.31
8	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.78
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	4.78
10	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.20
11	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.20
12	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.20
13	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	4.20
14	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.20
15	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	4.11
16	Bladder cancer	Enrichment	ARID1A, HRAS, KRAS, TSC1	4.11
17	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS, PPARG	4.11
18	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.73
19	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.73
20	Hamartoma	Enrichment	TSC1, TSC2	3.73
21	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS, KDM1A	3.73
22	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	3.73
23	Rare genetic intellectual disability	Enrichment	ARID1B, KDM3B, MTOR	3.68
24	Carnitine-acylcarnitine translocase deficiency	Enrichment	SLC25A20	3.43
25	Nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	3.43
26	Blepharophimosis	Enrichment	ARID1B, SMARCA2	3.43
27	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.43
28	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.43
29	Smarca2-related nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	3.43
30	Hemimegalencephaly	Enrichment	MTOR, RHEB	3.21
31	Body mass index quantitative trait locus 11	Enrichment	ADCY3, ADRB3, GNAS, PPARG	3.18
32	Carnitine palmitoyltransferase ii deficiency, infantile	Enrichment	CPT2	3.13
33	Carnitine palmitoyltransferase ii deficiency, lethal neonatal	Enrichment	CPT2	3.13
34	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	3.13
35	Carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced	Enrichment	CPT2	3.13
36	Encephalopathy, acute, infection-induced 4	Enrichment	CPT2	3.13
37	Spastic paraplegia 73, autosomal dominant	Enrichment	CPT1C	3.13
38	Acute necrotizing encephalopathy of childhood	Enrichment	CPT2	3.13
39	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.89
40	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.89
41	Pilomyxoid astrocytoma	Enrichment	FGFR1, KRAS	2.89
42	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.89
43	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	2.77
44	Gastroesophageal reflux	Enrichment	ACTL6A, RPS6KA3	2.77
45	Autism spectrum disorder	Enrichment	ACTL6B, ARID1B, KDM3B, SMARCB1, TSC2	2.75
46	Non-immune hydrops fetalis	Enrichment	ARID1A, HRAS, KRAS	2.73
47	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.66
48	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	2.66
49	Ventricular septal defect	Enrichment	RPS6KA3, SMARCA4	2.66
50	Meningioma, familial	Enrichment	SMARCB1, SMARCE1	2.48
51	Atrial heart septal defect	Enrichment	ACTL6A, SMARCA4	2.48
52	Interatrial communication	Enrichment	ACTL6A, SMARCA4	2.48
53	Septooptic dysplasia	Enrichment	ARID1A, FGFR1	2.41
54	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.41
55	Meningioma	Enrichment	SMARCB1, SMARCE1	2.41
56	Inherited cancer-predisposing syndrome	Enrichment	SMARCA4, SMARCB1, SMARCE1, TSC1, TSC2	2.39
57	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	ARID1A, ARID1B	2.15
58	Gliosarcoma	Enrichment	FGFR1, PPARG	2.15
59	Giant cell glioblastoma	Enrichment	FGFR1, PPARG	2.10
60	Osteoglophonic dysplasia	Enrichment	FGFR1	2.10
61	Trigonocephaly 1	Enrichment	FGFR1	2.10
62	Torticollis	Enrichment	ACTL6A	2.10
63	Baraitser-winter syndrome 1	Enrichment	ACTB	2.10
64	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.10
65	Oculoectodermal syndrome	Enrichment	KRAS	2.10
66	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	2.10
67	Noonan syndrome 4	Enrichment	SOS1	2.10
68	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.10
69	Osseous heteroplasia, progressive	Enrichment	GNAS	2.10
70	Melanosis, neurocutaneous	Enrichment	NRAS	2.10
71	Noonan syndrome 9	Enrichment	SOS2	2.10
72	Coffin-siris syndrome 5	Enrichment	SMARCE1	2.10
73	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.10
74	Noonan syndrome 6	Enrichment	NRAS	2.10
75	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	2.10
76	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.10
77	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.10
78	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.10
79	Intellectual developmental disorder with severe speech and ambulation defects	Enrichment	ACTL6B	2.10
80	Hypertriglyceridemia 2	Enrichment	CREB3L3	2.10
81	Coffin-siris syndrome 11	Enrichment	SMARCD1	2.10
82	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	2.10
83	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	2.10
84	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.10
85	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.10
86	Diarrhea 13	Enrichment	ACSL5	2.10
87	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.10
88	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.10
89	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.10
90	Left ventricular noncompaction 8	Enrichment	PRDM16	2.10
91	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.10
92	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.10
93	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.10
94	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.10
95	Becker nevus syndrome	Enrichment	ACTB	2.10
96	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.10
97	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	2.10
98	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.10
99	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.10
100	Neurilemmoma	Enrichment	SMARCB1	2.10
101	Disorders of gnas inactivation	Enrichment	GNAS	2.10
102	Coffin-siris syndrome 3	Enrichment	SMARCB1	2.10
103	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.10
104	Arid1b-related disorder	Enrichment	ARID1B	2.10
105	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.10
106	Hartsfield syndrome	Enrichment	FGFR1	2.10
107	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.10
108	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.10
109	Rare genetic epilepsy	Enrichment	KDM3B	2.10
110	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	2.10
111	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.10
112	Baraitser-winter syndrome	Enrichment	ACTB	2.10
113	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.10
114	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.10
115	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.10
116	Facial cleft	Enrichment	SMARCE1	2.10
117	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.10
118	Congenital pulmonary airway malformation	Enrichment	KRAS	2.10
119	Idiopathic hypercalciuria	Enrichment	ADCY10	2.10
120	Autosomal recessive severe congenital neutropenia	Enrichment	SMARCD2	2.10
121	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.10
122	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.10
123	Primary triglyceride deposit cardiomyovasculopathy	Enrichment	PNPLA2	2.10
124	Monostotic fibrous dysplasia	Enrichment	GNAS	2.10
125	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.10
126	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.10
127	Mazabraud syndrome	Enrichment	GNAS	2.10
128	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.10
129	Neurocutaneous melanocytosis	Enrichment	NRAS	2.10
130	Fibromatosis, gingival, 1	Enrichment	SOS1	1.80
131	Alopecia, androgenetic, 1	Enrichment	SMARCD1	1.80
132	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.80
133	Hypercalciuria, absorptive, 2	Enrichment	ADCY10	1.80
134	Costello syndrome	Enrichment	HRAS	1.80
135	Trichomegaly	Enrichment	ARID1B	1.80
136	Specific granule deficiency 1	Enrichment	SMARCD2	1.80
137	Carotid intimal medial thickness 1	Enrichment	PPARG	1.80
138	Pulmonic stenosis	Enrichment	SOS1	1.80
139	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.80
140	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	1.80
141	Neutral lipid storage disease with myopathy	Enrichment	PNPLA2	1.80
142	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.80
143	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.80
144	Schwannomatosis 1	Enrichment	SMARCB1	1.80
145	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.80
146	Pfeiffer syndrome	Enrichment	FGFR1	1.80
147	Jackson-weiss syndrome	Enrichment	FGFR1	1.80
148	Chromosome 6q24-q25 deletion syndrome	Enrichment	ARID1B	1.80
149	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.80
150	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.80
151	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.80
152	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	ARID1B	1.80
153	Specific granule deficiency 2	Enrichment	SMARCD2	1.80
154	Coffin-siris syndrome 8	Enrichment	SMARCC2	1.80
155	Cebalid syndrome	Enrichment	MTOR	1.80
156	Diets-jongmans syndrome	Enrichment	KDM3B	1.80
157	Acromesomelic dysplasia 4	Enrichment	PRKG2	1.80
158	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	1.80
159	Pseudohypoparathyroidism	Enrichment	GNAS	1.80
160	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.80
161	Fibrolamellar carcinoma	Enrichment	PRKACA	1.80
162	Otosclerosis 12	Enrichment	SMARCA4	1.80
163	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.80
164	Smith-kingsmore syndrome	Enrichment	MTOR	1.80
165	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	1.80
166	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.80
167	Developmental and epileptic encephalopathy 76	Enrichment	ACTL6B	1.80
168	Familial partial lipodystrophy	Enrichment	PPARG	1.80
169	Transient infantile hypertriglyceridemia and hepatosteatosis	Enrichment	CREB3L3	1.80
170	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.80
171	Specific granule deficiency	Enrichment	SMARCD2	1.80
172	Wooly hair nevus	Enrichment	HRAS	1.80
173	Microcephaly	Enrichment	ACTB, ACTG1, ARID1A, ARID1B	1.78
174	Hydrops fetalis, nonimmune	Enrichment	ARID1A, HRAS	1.74
175	Mccune-albright syndrome	Enrichment	GNAS	1.63
176	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.63
177	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.63
178	Nuchal bleb, familial	Enrichment	SOS1	1.63
179	Langerhans cell histiocytosis	Enrichment	NRAS	1.63
180	Tuberous sclerosis 2	Enrichment	TSC2	1.63
181	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	1.63
182	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.63
183	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	1.63
184	Nail disorder, nonsyndromic congenital, 9	Enrichment	ARID1B	1.63
185	Coffin-siris syndrome 2	Enrichment	ARID1A	1.63
186	Umbilical hernia	Enrichment	ACTL6A	1.63
187	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1	1.63
188	Xanthinuria, type ii	Enrichment	TSC2	1.63
189	Periventricular leukomalacia	Enrichment	ARID1A	1.63
190	Spermatocytoma	Enrichment	HRAS	1.63
191	Schwannomatosis	Enrichment	SMARCB1	1.63
192	Melanoma of soft tissue	Enrichment	CREB1	1.63
193	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.63
194	Chorea, benign hereditary	Enrichment	ADCY5	1.50
195	Hypertriglyceridemia 1	Enrichment	CREB3L3	1.50
196	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.50
197	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.50
198	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.50
199	Lipodystrophy, congenital generalized, type 2	Enrichment	ACTL6B	1.50
200	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.50
201	Amme complex	Enrichment	ACSL4	1.50
202	Aminoacylase 1 deficiency	Enrichment	ACTB	1.50
203	Leptin deficiency or dysfunction	Enrichment	PPARG	1.50
204	Congenital generalized lipodystrophy	Enrichment	PPARG	1.50
205	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.50
206	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.50
207	Pilocytic astrocytoma	Enrichment	KRAS	1.50
208	Epidermolytic nevus	Enrichment	HRAS	1.50
209	Full schwannomatosis	Enrichment	SMARCB1	1.50
210	Gingival fibromatosis	Enrichment	SOS1	1.50
211	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.50
212	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.50
213	Colorectal cancer	Enrichment	ARID1A, NRAS, PPARG	1.49
214	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4, RPS6KA3	1.48
215	Congenital nervous system abnormality	Enrichment	CPT2	1.41
216	Nervous system disease	Enrichment	CPT2	1.41
217	Holoprosencephaly	Enrichment	FGFR1	1.41
218	Coloboma of choroid and retina	Enrichment	ACTG1	1.41
219	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.41
220	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.40
221	Ovarian cancer	Enrichment	KRAS, SMARCB1, TSC2	1.33
222	Holoprosencephaly 1	Enrichment	FGFR1	1.33
223	Wiedemann-steiner syndrome	Enrichment	ARID1B	1.33
224	Inguinal hernia	Enrichment	ACTL6A	1.33
225	Keratoconus	Enrichment	TSC1	1.33
226	Breast adenocarcinoma	Enrichment	KRAS	1.33
227	Lung squamous cell carcinoma	Enrichment	KRAS	1.33
228	Hypertrichosis	Enrichment	ARID1B	1.33
229	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.26
230	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.26
231	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.26
232	Brachydactyly	Enrichment	GNAS	1.26
233	Polycystic kidney disease 1	Enrichment	TSC2	1.26
234	Gallbladder cancer	Enrichment	KRAS	1.26
235	Congenital hydrocephalus	Enrichment	SMARCC1	1.26
236	Overgrowth syndrome	Enrichment	MTOR	1.26
237	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.21
238	Orthostatic intolerance	Enrichment	RPS6KA3	1.21
239	Neuroblastoma	Enrichment	SMARCA4	1.21
240	Arteriovenous malformation	Enrichment	HRAS	1.16
241	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.16
242	Primary hyperaldosteronism	Enrichment	GNAS	1.16
243	Cat eye syndrome	Enrichment	ACTG1	1.11
244	Stroke, ischemic	Enrichment	ACSL4	1.11
245	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.11
246	Specific learning disability	Enrichment	RPS6KA3	1.07
247	Lip and oral cavity carcinoma	Enrichment	HRAS	1.04
248	Aortic valve disease 1	Enrichment	SOS1	1.01
249	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.01
250	Chromosome 1p36 deletion syndrome	Enrichment	PRDM16	1.01
251	Protein-deficiency anemia	Enrichment	NRAS	1.01
252	Nk-cell enteropathy	Enrichment	SMARCB1	1.01
253	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.98
254	Lung cancer susceptibility 3	Enrichment	KRAS	0.98
255	Pituitary stalk interruption syndrome	Enrichment	SMARCA2	0.98
256	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.98
257	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	0.95
258	Corpus callosum, agenesis of	Enrichment	ARID1B	0.95
259	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	0.95
260	Familial hypercholesterolemia	Enrichment	SMARCA4	0.95
261	Lynch syndrome	Enrichment	KRAS	0.95
262	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.95
263	Kidney disease	Enrichment	TSC1	0.95
264	Isolated corpus callosum agenesis	Enrichment	ARID1B	0.95
265	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ARID1B	0.95
266	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	0.92
267	Rhabdomyosarcoma	Enrichment	HRAS	0.92
268	Microform holoprosencephaly	Enrichment	FGFR1	0.92
269	Lobar holoprosencephaly	Enrichment	FGFR1	0.92
270	Cleft palate, isolated	Enrichment	SMARCA4	0.90
271	Semilobar holoprosencephaly	Enrichment	FGFR1	0.87
272	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	0.87
273	Arteriovenous malformations of the brain	Enrichment	KRAS	0.85
274	Lissencephaly	Enrichment	ACTG1	0.81
275	Tooth agenesis	Enrichment	FGFR1	0.79
276	Brittle bone disorder	Enrichment	CREB3L1	0.77
277	Kallmann syndrome	Enrichment	FGFR1	0.77
278	Pancreatic cancer	Enrichment	KRAS	0.74
279	Lung cancer	Enrichment	KRAS	0.65
280	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.63
281	Cakut	Enrichment	ACTG1	0.62
282	Left ventricular noncompaction	Enrichment	PRDM16	0.61
283	Non-syndromic genetic deafness	Enrichment	ACTG1	0.60
284	Complex neurodevelopmental disorder	Enrichment	ACTL6A, ACTL6B	0.59
285	Cerebral palsy	Enrichment	SMARCA4	0.57
286	Type 2 diabetes mellitus	Enrichment	PPARG	0.54
287	Nonsyndromic hearing loss	Enrichment	ACTG1	0.54
288	Gastric cancer	Enrichment	KRAS	0.54
289	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.54
290	West syndrome	Enrichment	TSC2	0.53
291	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	0.53
292	Hereditary breast carcinoma	Enrichment	KRAS	0.53
293	Hypertelorism	Enrichment	RPS6KA3	0.47
294	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.47
295	Familial isolated dilated cardiomyopathy	Enrichment	PRDM16	0.46
296	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.45
297	Myeloma, multiple	Enrichment	KRAS	0.44
298	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	KLB	0.44
299	Undetermined early-onset epileptic encephalopathy	Enrichment	ACTL6B	0.44
300	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.43
301	Primary ovarian insufficiency	Enrichment	SIRT6	0.42
302	Autism	Enrichment	ACTL6B	0.36
303	Breast cancer	Enrichment	KRAS	0.35
304	Rare genetic deafness	Enrichment	ACTG1	0.33
305	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Thermogenesis

Pathway Network for Thermogenesis

Member Pathways for Thermogenesis

Pathways in the Thermogenesis SuperPath

Associated Genes for Thermogenesis

Associated Disorders for Thermogenesis

Disorders associated with Thermogenesis SuperPath

STRING Interaction Network for Thermogenesis

Sources for Thermogenesis