Thiamine metabolic pathways

No Pathway Network information available for Thiamine metabolic pathways

#	Name	Source	Genes
1	Thiamine metabolic pathways	WikiPathways	BCKDK OGDH PDHA1 SLC19A2 SLC19A3 SLC25A19 TKT TPK1 (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC19A3	Solute Carrier Family 19 Member 3	Protein Coding	1
2	TKT	Transketolase	Protein Coding	1
3	SLC25A19	Solute Carrier Family 25 Member 19	Protein Coding	1
4	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
5	OGDH	Oxoglutarate Dehydrogenase	Protein Coding	1
6	TPK1	Thiamin Pyrophosphokinase 1	Protein Coding	1
7	SLC19A2	Solute Carrier Family 19 Member 2	Protein Coding	1
8	BCKDK	Branched Chain Keto Acid Dehydrogenase Kinase	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oxoglutarate dehydrogenase deficiency	Enrichment	OGDH	3.23
2	Basal ganglia disease, biotin-thiamine responsive	Enrichment	SLC19A3	3.23
3	Thiamine metabolism dysfunction syndrome 5	Enrichment	TPK1	3.23
4	Short stature, developmental delay, and congenital heart defects	Enrichment	TKT	3.23
5	Branched-chain keto acid dehydrogenase kinase deficiency	Enrichment	BCKDK	3.23
6	Childhood encephalopathy due to thiamine pyrophosphokinase deficiency	Enrichment	TPK1	3.23
7	Infantile spasms-psychomotor retardation-progressive brain atrophy-basal ganglia disease syndrome	Enrichment	SLC19A3	3.23
8	Thiamine-responsive megaloblastic anemia syndrome	Enrichment	SLC19A2	2.93
9	Microcephaly, amish type	Enrichment	SLC25A19	2.93
10	Thiamine metabolism dysfunction syndrome 4	Enrichment	SLC25A19	2.93
11	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1	2.63
12	Sudden infant death syndrome	Enrichment	PDHA1	2.00
13	Ear malformation	Enrichment	SLC19A2	1.85
14	Sensorineural hearing loss	Enrichment	SLC19A2	1.55
15	Leigh syndrome, nuclear	Enrichment	TPK1	1.40
16	Leigh disease	Enrichment	TPK1	1.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Thiamine metabolic pathways