Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCC4 ABCC5 ADK AOX1 GDA GMPS GSTA1 GSTA2 GSTM1 HPRT1 IMPDH1 ITPA NME1 NME2 NT5C2 NUDT15 PPAT PRPS1 RAC1 RRM1 RRM2 SLC28A2 SLC28A3 SLC29A1 SLC29A2 TPMT XDH (see all 27) (see less)
2	Azathioprine ADME	Reactome	ABCC4 ABCC5 GMPS GSTA1 GSTA2 GSTM1 GUK1 HPRT1 IMPDH1 IMPDH2 NME1 NME2 NUDT15 RAC1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 TPMT VAV1 VAV2 VAV3 XDH (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC28A3	Solute Carrier Family 28 Member 3	Protein Coding	2
2	RAC1	Rac Family Small GTPase 1	Protein Coding	2
3	XDH	Xanthine Dehydrogenase	Protein Coding	2
4	TPMT	Thiopurine S-Methyltransferase	Protein Coding	2
5	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	2
6	IMPDH1	Inosine Monophosphate Dehydrogenase 1	Protein Coding	2
7	SLC28A2	Solute Carrier Family 28 Member 2	Protein Coding	2
8	GMPS	Guanine Monophosphate Synthase	Protein Coding	2
9	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	2
10	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	2
11	SLC29A2	Solute Carrier Family 29 Member 2	Protein Coding	2
12	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	2
13	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	2
14	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	2
15	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	2
16	SLC29A1	Solute Carrier Family 29 Member 1 (Augustine Blood Group)	Protein Coding	2
17	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	2
18	NUDT15	Nudix Hydrolase 15	Protein Coding	2
19	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	1
20	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	1
21	GDA	Guanine Deaminase	Protein Coding	1
22	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	1
23	ITPA	Inosine Triphosphatase	Protein Coding	1
24	AOX1	Aldehyde Oxidase 1	Protein Coding	1
25	NT5C2	5''-Nucleotidase, Cytosolic II	Protein Coding	1
26	ADK	Adenosine Kinase	Protein Coding	1
27	PRPS1	Phosphoribosyl Pyrophosphate Synthetase 1	Protein Coding	1
28	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
29	GUK1	Guanylate Kinase 1	Protein Coding	1
30	IMPDH2	Inosine Monophosphate Dehydrogenase 2	Protein Coding	1
31	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
32	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1

Disorders associated with Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Thiopurines, poor metabolism of, 1	Enrichment	TPMT	2.77
2	Retinitis pigmentosa 10	Enrichment	IMPDH1	2.77
3	Impdh2 enzyme activity, variation in	Enrichment	IMPDH2	2.77
4	Hemolytic disease of the fetus	Enrichment	SLC29A1	2.77
5	Leber congenital amaurosis 11	Enrichment	IMPDH1	2.77
6	Thiopurines, poor metabolism of, 2	Enrichment	NUDT15	2.77
7	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.77
8	Charcot-marie-tooth disease, x-linked recessive, 5	Enrichment	PRPS1	2.70
9	Arts syndrome	Enrichment	PRPS1	2.70
10	Hypermethioninemia due to adenosine kinase deficiency	Enrichment	ADK	2.70
11	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	2.70
12	Phosphoribosylpyrophosphate synthetase superactivity	Enrichment	PRPS1	2.70
13	Deafness, x-linked 1	Enrichment	PRPS1	2.70
14	X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome	Enrichment	PRPS1	2.70
15	Xanthinuria, type i	Enrichment	XDH	2.47
16	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.47
17	Mitochondrial dna depletion syndrome 21	Enrichment	GUK1	2.47
18	Inosine triphosphatase deficiency	Enrichment	ITPA	2.40
19	Developmental and epileptic encephalopathy 35	Enrichment	ITPA	2.40
20	Spastic paraplegia 45, autosomal recessive	Enrichment	NT5C2	2.40
21	Lesch-nyhan syndrome	Enrichment	HPRT1	2.29
22	Hyperuricemia, hprt-related	Enrichment	HPRT1	2.29
23	Xanthinuria, type ii	Enrichment	XDH	2.29
24	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	IMPDH2	2.29
25	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	PRPS1	2.10
26	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.82
27	Tooth agenesis, selective, 1	Enrichment	ITPA	1.75
28	Tooth agenesis	Enrichment	ITPA	1.37
29	Developmental and epileptic encephalopathy 1	Enrichment	ITPA	1.31
30	Dystonia	Enrichment	IMPDH2	1.24
31	Developmental and epileptic encephalopathy	Enrichment	ITPA	1.16
32	Hereditary retinal dystrophy	Enrichment	IMPDH1, PRPS1	0.95
33	Fundus dystrophy	Enrichment	IMPDH1, PRPS1	0.95
34	Leber plus disease	Enrichment	IMPDH1	0.83
35	Retinitis pigmentosa	Enrichment	IMPDH1	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Member Pathways for Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

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