Thromboxane A2 receptor signaling

No Pathway Network information available for Thromboxane A2 receptor signaling

Pathways in the Thromboxane A2 receptor signaling SuperPath

#	Name	Source	Genes
1	Thromboxane A2 receptor signaling	PubChem	AKT1 ARHGEF1 ARR3 ARRB2 DNM1 EGF EGFR GNA12 GNAI2 GNB1 GNB5 GNG2 GRK2 ICAM1 LCK MAPK14 NHERF1 NOS3 PIK3CG PIK3R6 PLCB2 PRKACA PRKCZ PTGDR PTGIR RAB11A RAC1 RHOA ROCK1 SELE SYK TBXA2R TGM2 VCAM1 (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARR3	Arrestin 3	Protein Coding	1
2	NHERF1	NHERF Family PDZ Scaffold Protein 1	Protein Coding	1
3	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
4	TGM2	Transglutaminase 2	Protein Coding	1
5	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
6	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
7	GNB5	G Protein Subunit Beta 5	Protein Coding	1
8	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
9	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
10	EGF	Epidermal Growth Factor	Protein Coding	1
11	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
12	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
13	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
14	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
15	SELE	Selectin E	Protein Coding	1
16	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
17	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
18	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
19	ARRB2	Arrestin Beta 2	Protein Coding	1
20	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
21	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
22	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
23	DNM1	Dynamin 1	Protein Coding	1
24	RHOA	Ras Homolog Family Member A	Protein Coding	1
25	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
26	RAC1	Rac Family Small GTPase 1	Protein Coding	1
27	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1
28	GNB1	G Protein Subunit Beta 1	Protein Coding	1
29	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
30	PLCB2	Phospholipase C Beta 2	Protein Coding	1
31	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
32	PTGDR	Prostaglandin D2 Receptor	Protein Coding	1
33	PTGIR	Prostaglandin I2 Receptor	Protein Coding	1
34	TBXA2R	Thromboxane A2 Receptor	Protein Coding	1

Disorders associated with Thromboxane A2 receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	2.60
2	Hypomagnesemia 4, renal	Enrichment	EGF	2.60
3	Nephrolithiasis/osteoporosis, hypophosphatemic, 2	Enrichment	NHERF1	2.60
4	Asthma-related traits 1	Enrichment	PTGDR	2.60
5	Ventricular tachycardia, familial	Enrichment	GNAI2	2.60
6	Immunodeficiency 62	Enrichment	ARHGEF1	2.60
7	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.60
8	Bleeding disorder, platelet-type, 13	Enrichment	TBXA2R	2.60
9	Myopia 26, x-linked, female-limited	Enrichment	ARR3	2.60
10	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.60
11	Cowden syndrome 6	Enrichment	AKT1	2.60
12	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.60
13	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.60
14	Immunodeficiency 22	Enrichment	LCK	2.60
15	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.60
16	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.60
17	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.60
18	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.60
19	Colitis	Enrichment	SYK	2.60
20	Bleeding diathesis due to thromboxane synthesis deficiency	Enrichment	TBXA2R	2.60
21	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.60
22	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.60
23	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.30
24	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.30
25	Hypophosphatemia	Enrichment	NHERF1	2.30
26	Fibrolamellar carcinoma	Enrichment	PRKACA	2.30
27	Hypopituitarism	Enrichment	GNAI2	2.30
28	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.30
29	Arthritis	Enrichment	SYK	2.30
30	Dominant hypophosphatemia with nephrolithiasis or osteoporosis	Enrichment	NHERF1	2.30
31	Cerebral visual impairment	Enrichment	GNB1	2.30
32	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, RAB11A	2.16
33	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.12
34	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.12
35	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.12
36	Cerebral malaria	Enrichment	ICAM1	2.00
37	Alzheimer disease 2	Enrichment	NOS3	1.90
38	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.90
39	Pre-eclampsia	Enrichment	NOS3	1.90
40	Cowden syndrome 1	Enrichment	EGFR	1.83
41	Hemihyperplasia, isolated	Enrichment	RHOA	1.83
42	Breast adenocarcinoma	Enrichment	AKT1	1.83
43	Lung squamous cell carcinoma	Enrichment	EGFR	1.83
44	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.76
45	Lennox-gastaut syndrome	Enrichment	DNM1	1.70
46	Hypothyroidism	Enrichment	GNB1	1.70
47	Ellis-van creveld syndrome	Enrichment	PRKACA	1.65
48	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.65
49	Adult hepatocellular carcinoma	Enrichment	EGF	1.65
50	Cowden syndrome	Enrichment	AKT1	1.65
51	Stroke, ischemic	Enrichment	NOS3	1.61
52	Nephrolithiasis	Enrichment	NHERF1	1.61
53	Ovarian cancer	Enrichment	AKT1, EGFR	1.58
54	Immune deficiency disease	Enrichment	SYK	1.56
55	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.56
56	Myelodysplastic syndrome	Enrichment	GNB1	1.56
57	Lung non-small cell carcinoma	Enrichment	EGFR	1.56
58	Meningioma	Enrichment	AKT1	1.53
59	Lip and oral cavity carcinoma	Enrichment	EGFR	1.53
60	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.49
61	Stereotypic movement disorder	Enrichment	DNM1	1.49
62	Lung cancer susceptibility 3	Enrichment	EGFR	1.46
63	Gliosarcoma	Enrichment	EGFR	1.40
64	Isolated congenital microcephaly	Enrichment	RAB11A	1.40
65	Alzheimer disease, familial, 1	Enrichment	NOS3	1.38
66	Hypertension, essential	Enrichment	NOS3	1.38
67	Cleft palate, isolated	Enrichment	GNB1	1.38
68	Giant cell glioblastoma	Enrichment	EGFR	1.38
69	Arteriovenous malformations of the brain	Enrichment	EGFR	1.33
70	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.27
71	Malaria	Enrichment	ICAM1	1.25
72	Jeune thoracic dystrophy	Enrichment	GRK2	1.22
73	Strabismus	Enrichment	GNB1	1.18
74	Asphyxiating thoracic dystrophy	Enrichment	GRK2	1.17
75	Bladder cancer	Enrichment	EGFR	1.15
76	Lung cancer	Enrichment	EGFR	1.11
77	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	1.10
78	Severe combined immunodeficiency	Enrichment	LCK	1.10
79	Dystonia	Enrichment	GNB1	1.07
80	Cerebral palsy	Enrichment	GNB1	1.03
81	West syndrome	Enrichment	DNM1	0.98
82	Hereditary breast carcinoma	Enrichment	AKT1	0.98
83	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.88
84	Primary ovarian insufficiency	Enrichment	NOS3	0.86
85	Breast cancer	Enrichment	AKT1	0.76
86	Colorectal cancer	Enrichment	AKT1	0.71
87	Congenital nervous system abnormality	Enrichment	GNB5	0.63
88	Nervous system disease	Enrichment	GNB5	0.63
89	Autism spectrum disorder	Enrichment	GNB1	0.62
90	Microcephaly	Enrichment	GNB1	0.57
91	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.55

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Thromboxane A2 receptor signaling

Pathway Network for Thromboxane A2 receptor signaling

Member Pathways for Thromboxane A2 receptor signaling

Pathways in the Thromboxane A2 receptor signaling SuperPath

Associated Genes for Thromboxane A2 receptor signaling

Associated Disorders for Thromboxane A2 receptor signaling

Disorders associated with Thromboxane A2 receptor signaling SuperPath

STRING Interaction Network for Thromboxane A2 receptor signaling

Sources for Thromboxane A2 receptor signaling