Thyroid hormones production and peripheral downstream signaling effects

No Pathway Network information available for Thyroid hormones production and peripheral downstream signaling effects

Pathways in the Thyroid hormones production and peripheral downstream signaling effects SuperPath

#	Name	Source	Genes
1	Thyroid hormones production and peripheral downstream signaling effects	WikiPathways	ACTL6B ADRB3 AGRP AKT1S1 AKT3 AQP7 ATF2 BAD CASP9 CREB3 CTNNB1 DIO1 DIO2 DIO3 DUOX2 DUOXA2 FGF21 FGFR1 FOXO1 FRS2 GRB2 GSK3B HRAS ITGAV ITGB3 ITPR2 IYD KDM1A KDM3B KLB MAFA MAP2K1 MAPK1 MAPK14 MC4R MDM2 MGLL MLST8 MTOR NHSL1 NOTCH1 NPPB NPR1 NPY PFKFB2 PIK3CA PLIN1 PNPLA2 POMC PPARG PPARGC1A PRDM16 RAF1 RHEB RPS6 RPS6KA6 RPS6KB1 RPTOR RXRA SECISBP2L SHH SIRT6 SLC16A10 SLC16A2 SLC26A4 SLC5A5 SLCO1C1 SOS1 SRC TBC1D4 THRA THRB TP53 TRH TSC1 TSC2 TSHB TSHR TTF1 TTF2 UCP1 WNT4 ZNF516 (see all 83) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NPPB	Natriuretic Peptide B	Protein Coding	1
2	SLC16A2	Solute Carrier Family 16 Member 2	Protein Coding	1
3	KDM3B	Lysine Demethylase 3B	Protein Coding	1
4	PNPLA2	Patatin Like Domain 2, Triacylglycerol Lipase	Protein Coding	1
5	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	1
6	ADRB3	Adrenoceptor Beta 3	Protein Coding	1
7	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
8	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
9	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
10	PFKFB2	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2	Protein Coding	1
11	TBC1D4	TBC1 Domain Family Member 4	Protein Coding	1
12	SECISBP2L	SECIS Binding Protein 2 Like	Protein Coding	1
13	AKT1S1	AKT1 Substrate 1	Protein Coding	1
14	CASP9	Caspase 9	Protein Coding	1
15	UCP1	Uncoupling Protein 1	Protein Coding	1
16	TTF1	Transcription Termination Factor 1	Protein Coding	1
17	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	1
18	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	1
19	TSC2	TSC Complex Subunit 2	Protein Coding	1
20	TSC1	TSC Complex Subunit 1	Protein Coding	1
21	TRH	Thyrotropin Releasing Hormone	Protein Coding	1
22	TP53	Tumor Protein P53	Protein Coding	1
23	THRB	Thyroid Hormone Receptor Beta	Protein Coding	1
24	THRA	Thyroid Hormone Receptor Alpha	Protein Coding	1
25	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
26	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
27	SLC5A5	Solute Carrier Family 5 Member 5	Protein Coding	1
28	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
29	PRDM16	PR/SET Domain 16	Protein Coding	1
30	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
31	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
32	RPS6	Ribosomal Protein S6	Protein Coding	1
33	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
34	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
35	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
36	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
37	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
38	POMC	Proopiomelanocortin	Protein Coding	1
39	WNT4	Wnt Family Member 4	Protein Coding	1
40	SLCO1C1	Solute Carrier Organic Anion Transporter Family Member 1C1	Protein Coding	1
41	PLIN1	Perilipin 1	Protein Coding	1
42	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
43	SLC26A4	Solute Carrier Family 26 Member 4	Protein Coding	1
44	SIRT6	Sirtuin 6	Protein Coding	1
45	ACTL6B	Actin Like 6B	Protein Coding	1
46	DUOX2	Dual Oxidase 2	Protein Coding	1
47	NPY	Neuropeptide Y	Protein Coding	1
48	NOTCH1	Notch Receptor 1	Protein Coding	1
49	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
50	MC4R	Melanocortin 4 Receptor	Protein Coding	1
51	DUOXA2	Dual Oxidase Maturation Factor 2	Protein Coding	1
52	IYD	Iodotyrosine Deiodinase	Protein Coding	1
53	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
54	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
55	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
56	AQP7	Aquaporin 7	Protein Coding	1
57	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
58	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
59	FGF21	Fibroblast Growth Factor 21	Protein Coding	1
60	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
61	FOXO1	Forkhead Box O1	Protein Coding	1
62	KDM1A	Lysine Demethylase 1A	Protein Coding	1
63	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
64	AGRP	Agouti Related Neuropeptide	Protein Coding	1
65	DIO3	Iodothyronine Deiodinase 3	Protein Coding	1
66	DIO2	Iodothyronine Deiodinase 2	Protein Coding	1
67	DIO1	Iodothyronine Deiodinase 1	Protein Coding	1
68	KLB	Klotho Beta	Protein Coding	1
69	CTNNB1	Catenin Beta 1	Protein Coding	1
70	ATF2	Activating Transcription Factor 2	Protein Coding	1
71	MGLL	Monoglyceride Lipase	Protein Coding	1
72	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
73	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
74	ZNF516	Zinc Finger Protein 516	Protein Coding	1
75	TTF2	Transcription Termination Factor 2	Protein Coding	1
76	SLC16A10	Solute Carrier Family 16 Member 10	Protein Coding	1
77	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
78	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
79	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
80	NHSL1	NHS Like 1	Protein Coding	1
81	MAFA	MAF BZIP Transcription Factor A	Protein Coding	1
82	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
83	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1

Disorders associated with Thyroid hormones production and peripheral downstream signaling effects SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA, TP53, TSC1, TSC2	9.02
2	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	8.88
3	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	8.88
4	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, RHEB	8.19
5	Familial thyroid dyshormonogenesis	Enrichment	DUOX2, DUOXA2, IYD, SLC5A5	7.71
6	Rasopathy	Enrichment	HRAS, MAP2K1, RAF1, SLC26A4, SOS1	6.35
7	Body mass index quantitative trait locus 11	Enrichment	ADRB3, AGRP, AQP7, MC4R, POMC, PPARG	6.25
8	Congenital hypothyroidism	Enrichment	DUOX2, DUOXA2, SLC5A5, TSHR	6.21
9	Bladder cancer	Enrichment	CTNNB1, HRAS, PIK3CA, TP53, TSC1	6.10
10	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, RAF1, SOS1	5.77
11	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.12
12	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA, TP53	5.12
13	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, RAF1, SOS1	4.98
14	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	4.74
15	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.59
16	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	4.45
17	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.43
18	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.43
19	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA, TP53	4.33
20	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.96
21	Hamartoma	Enrichment	TSC1, TSC2	3.96
22	Keratoacanthoma	Enrichment	NOTCH1, PIK3CA	3.96
23	Gliosarcoma	Enrichment	FGFR1, PPARG, TP53	3.93
24	Giant cell glioblastoma	Enrichment	FGFR1, PPARG, TP53	3.85
25	Colorectal cancer	Enrichment	CTNNB1, PIK3CA, PPARG, SRC, TP53	3.72
26	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	3.66
27	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.66
28	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA, TP53	3.50
29	Rhabdomyosarcoma 2	Enrichment	FOXO1, TP53	3.44
30	Ovarian cancer	Enrichment	CTNNB1, PIK3CA, TP53, TSC2, TSHR	3.42
31	Li-fraumeni syndrome	Enrichment	MDM2, TP53	3.26
32	Adrenocortical carcinoma	Enrichment	CTNNB1, TP53	3.26
33	Breast adenocarcinoma	Enrichment	PIK3CA, TP53	3.26
34	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.12
35	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	SLC26A4, TSHR	3.12
36	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.12
37	Pilomyxoid astrocytoma	Enrichment	FGFR1, RAF1	3.12
38	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.00
39	Septooptic dysplasia	Enrichment	FGFR1, SHH	2.63
40	Aortic valve disease 1	Enrichment	NOTCH1, SOS1	2.56
41	Rare genetic intellectual disability	Enrichment	KDM3B, MTOR	2.43
42	Rhabdomyosarcoma	Enrichment	HRAS, TP53	2.38
43	Microform holoprosencephaly	Enrichment	FGFR1, SHH	2.38
44	Lobar holoprosencephaly	Enrichment	FGFR1, SHH	2.38
45	Autism spectrum disorder	Enrichment	ACTL6B, KDM3B, MAP2K1, TSC2	2.35
46	Semilobar holoprosencephaly	Enrichment	FGFR1, SHH	2.27
47	Diffuse large b-cell lymphoma	Enrichment	FOXO1, TP53	2.23
48	Holoprosencephaly 3	Enrichment	SHH	2.21
49	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.21
50	Macrodactyly	Enrichment	PIK3CA	2.21
51	Insulinomatosis and diabetes mellitus	Enrichment	MAFA	2.21
52	Osteoglophonic dysplasia	Enrichment	FGFR1	2.21
53	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.21
54	Trigonocephaly 1	Enrichment	FGFR1	2.21
55	Thyroid dyshormonogenesis 4	Enrichment	IYD	2.21
56	Thyrotropin-releasing hormone deficiency	Enrichment	TRH	2.21
57	Thyroid dyshormonogenesis 1	Enrichment	SLC5A5	2.21
58	Noonan syndrome 5	Enrichment	RAF1	2.21
59	Noonan syndrome 4	Enrichment	SOS1	2.21
60	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.21
61	Melorheostosis, isolated	Enrichment	MAP2K1	2.21
62	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.21
63	Microphthalmia/coloboma 5	Enrichment	SHH	2.21
64	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.21
65	Type 2 diabetes 5	Enrichment	TBC1D4	2.21
66	Cowden syndrome 5	Enrichment	PIK3CA	2.21
67	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.21
68	Thyroid dyshormonogenesis 6	Enrichment	DUOX2	2.21
69	Accelerated tumor formation	Enrichment	MDM2	2.21
70	Intellectual developmental disorder with severe speech and ambulation defects	Enrichment	ACTL6B	2.21
71	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.21
72	Noonan syndrome 13	Enrichment	MAPK1	2.21
73	Lessel-kubisch syndrome	Enrichment	MDM2	2.21
74	Bone marrow failure syndrome 5	Enrichment	TP53	2.21
75	Allan-herndon-dudley syndrome	Enrichment	SLC16A2	2.21
76	Hypothyroidism, congenital, nongoitrous, 4	Enrichment	TSHB	2.21
77	Papilloma of choroid plexus	Enrichment	TP53	2.21
78	Body mass index quantitative trait locus 20	Enrichment	MC4R	2.21
79	Basal cell carcinoma 7	Enrichment	TP53	2.21
80	Anaplastic thyroid carcinoma	Enrichment	TP53	2.21
81	Left ventricular noncompaction 8	Enrichment	PRDM16	2.21
82	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.21
83	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.21
84	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.21
85	Melorheostosis	Enrichment	MAP2K1	2.21
86	Leopard syndrome 2	Enrichment	RAF1	2.21
87	Glycerol quantitative trait locus	Enrichment	AQP7	2.21
88	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.21
89	Ductal carcinoma in situ	Enrichment	TP53	2.21
90	Hartsfield syndrome	Enrichment	FGFR1	2.21
91	Thrombocytopenia 6	Enrichment	SRC	2.21
92	Thyroid hormone metabolism, abnormal, 2	Enrichment	DIO1	2.21
93	Rare genetic epilepsy	Enrichment	KDM3B	2.21
94	Obesity due to melanocortin 4 receptor deficiency	Enrichment	MC4R	2.21
95	Trigonitis	Enrichment	RAF1	2.21
96	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.21
97	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.21
98	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.21
99	Adenoid ameloblastoma	Enrichment	CTNNB1	2.21
100	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.21
101	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.21
102	Hypospadias	Enrichment	PIK3CA	2.21
103	Capillary hemangioma	Enrichment	AKT3	2.21
104	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.21
105	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha	Enrichment	THRA	2.21
106	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.21
107	Choroid plexus cancer	Enrichment	TP53	2.21
108	Rare venous malformation	Enrichment	PIK3CA	2.21
109	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.21
110	Diaphragmatic eventration	Enrichment	PIK3CA	2.21
111	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.21
112	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.21
113	Rare combined vascular malformation	Enrichment	PIK3CA	2.21
114	Cavernous lymphangioma	Enrichment	PIK3CA	2.21
115	Primary triglyceride deposit cardiomyovasculopathy	Enrichment	PNPLA2	2.21
116	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.21
117	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.21
118	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta	Enrichment	THRB	2.21
119	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.21
120	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.21
121	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.21
122	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.21
123	Generalized resistance to thyroid hormone	Enrichment	THRB	2.21
124	Macrodactyly of toe	Enrichment	PIK3CA	2.21
125	Microcystic stromal tumor	Enrichment	CTNNB1	2.21
126	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.21
127	Hepatoblastoma	Enrichment	CTNNB1, TP53	2.14
128	Thyroid hormone resistance, selective pituitary	Enrichment	THRB	1.91
129	Fibromatosis, gingival, 1	Enrichment	SOS1	1.91
130	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.91
131	Costello syndrome	Enrichment	HRAS	1.91
132	Thyroid hormone resistance, generalized, autosomal dominant	Enrichment	THRB	1.91
133	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.91
134	Thyroid dyshormonogenesis 5	Enrichment	DUOXA2	1.91
135	Carotid intimal medial thickness 1	Enrichment	PPARG	1.91
136	Thyroid hormone resistance, generalized, autosomal recessive	Enrichment	THRB	1.91
137	Cervical cancer	Enrichment	TP53	1.91
138	Pulmonic stenosis	Enrichment	SOS1	1.91
139	Hyperthyroidism, familial gestational	Enrichment	TSHR	1.91
140	Neutral lipid storage disease with myopathy	Enrichment	PNPLA2	1.91
141	Keratosis, seborrheic	Enrichment	PIK3CA	1.91
142	Pfeiffer syndrome	Enrichment	FGFR1	1.91
143	Jackson-weiss syndrome	Enrichment	FGFR1	1.91
144	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	1.91
145	Solitary median maxillary central incisor	Enrichment	SHH	1.91
146	Adams-oliver syndrome 5	Enrichment	NOTCH1	1.91
147	Noonan syndrome 8	Enrichment	PIK3CA	1.91
148	Lymphoma, hodgkin, classic	Enrichment	TP53	1.91
149	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	THRA	1.91
150	Cebalid syndrome	Enrichment	MTOR	1.91
151	Thyroid hormone resistance syndrome	Enrichment	THRB	1.91
152	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.91
153	Diets-jongmans syndrome	Enrichment	KDM3B	1.91
154	Senior-loken syndrome 7	Enrichment	AKT3	1.91
155	Congenital fibrosarcoma	Enrichment	TP53	1.91
156	Li-fraumeni syndrome 1	Enrichment	TP53	1.91
157	Sarcoma	Enrichment	TP53	1.91
158	Cervix carcinoma	Enrichment	TP53	1.91
159	Hodgkin's lymphoma	Enrichment	TP53	1.91
160	Bardet-biedl syndrome 16	Enrichment	AKT3	1.91
161	Smith-kingsmore syndrome	Enrichment	MTOR	1.91
162	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.91
163	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.91
164	Developmental and epileptic encephalopathy 76	Enrichment	ACTL6B	1.91
165	Familial partial lipodystrophy	Enrichment	PPARG	1.91
166	Teratoma	Enrichment	CTNNB1	1.91
167	Isolated radial hemimelia	Enrichment	SHH	1.91
168	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.91
169	Wooly hair nevus	Enrichment	HRAS	1.91
170	Prostate cancer	Enrichment	PIK3CA, TP53	1.87
171	Differentiated thyroid carcinoma	Enrichment	HRAS, PPARG	1.87
172	Desmoid disease, hereditary	Enrichment	CTNNB1	1.74
173	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.74
174	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.74
175	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.74
176	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.74
177	Syndactyly, type iv	Enrichment	SHH	1.74
178	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.74
179	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.74
180	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	1.74
181	Nuchal bleb, familial	Enrichment	SOS1	1.74
182	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.74
183	Osteogenic sarcoma	Enrichment	TP53	1.74
184	Hyperthyroidism, nonautoimmune	Enrichment	TSHR	1.74
185	Nasopharyngeal carcinoma	Enrichment	TP53	1.74
186	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.74
187	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.74
188	Tuberous sclerosis 2	Enrichment	TSC2	1.74
189	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.74
190	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	1.74
191	Anus, imperforate	Enrichment	CTNNB1	1.74
192	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.74
193	Hypothyroidism, congenital, nongoitrous, 1	Enrichment	TSHR	1.74
194	Large congenital melanocytic nevus	Enrichment	HRAS	1.74
195	Desmoid tumor	Enrichment	CTNNB1	1.74
196	Dedifferentiated liposarcoma	Enrichment	MDM2	1.74
197	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.74
198	Anaplastic astrocytoma	Enrichment	TP53	1.74
199	Xanthinuria, type ii	Enrichment	TSC2	1.74
200	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	1.74
201	Squamous cell carcinoma	Enrichment	TP53	1.74
202	Adenocarcinoma	Enrichment	TP53	1.74
203	Bone osteosarcoma	Enrichment	TP53	1.74
204	Spermatocytoma	Enrichment	HRAS	1.74
205	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.74
206	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.74
207	Well-differentiated liposarcoma	Enrichment	MDM2	1.74
208	Familial hyperthyroidism due to mutations in tsh receptor	Enrichment	TSHR	1.74
209	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	1.74
210	Left ventricular noncompaction	Enrichment	PRDM16, RAF1	1.71
211	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.62
212	Polydactyly, preaxial ii	Enrichment	SHH	1.62
213	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.62
214	Small cell cancer of the lung	Enrichment	TP53	1.62
215	Schizencephaly	Enrichment	SHH	1.62
216	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.62
217	Smith-lemli-opitz syndrome	Enrichment	TSHR	1.62
218	Lipodystrophy, congenital generalized, type 2	Enrichment	ACTL6B	1.62
219	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.62
220	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.62
221	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.62
222	Pilomatrixoma	Enrichment	CTNNB1	1.62
223	Leptin deficiency or dysfunction	Enrichment	PPARG	1.62
224	Alazami syndrome	Enrichment	CTNNB1	1.62
225	Congenital generalized lipodystrophy	Enrichment	PPARG	1.62
226	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.62
227	Lung sarcomatoid carcinoma	Enrichment	TP53	1.62
228	Cerebrovascular disease	Enrichment	PIK3CA	1.62
229	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.62
230	Craniopharyngioma	Enrichment	CTNNB1	1.62
231	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.62
232	Epidermolytic nevus	Enrichment	HRAS	1.62
233	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.62
234	Gingival fibromatosis	Enrichment	SOS1	1.62
235	Type 2 diabetes mellitus	Enrichment	PPARG, TBC1D4	1.57
236	Gastric cancer	Enrichment	PIK3CA, TP53	1.55
237	Hereditary breast carcinoma	Enrichment	PIK3CA, TP53	1.53
238	Capillary malformations, congenital	Enrichment	PIK3CA	1.52
239	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.52
240	Deafness, autosomal recessive 4, with enlarged vestibular aqueduct	Enrichment	SLC26A4	1.52
241	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.52
242	Lymphoma	Enrichment	TP53	1.52
243	Holoprosencephaly	Enrichment	FGFR1	1.52
244	Acute megakaryocytic leukemia	Enrichment	TP53	1.52
245	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.52
246	Thrombocytopenia	Enrichment	ITGB3, SRC	1.46
247	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.44
248	Cowden syndrome 1	Enrichment	PIK3CA	1.44
249	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.44
250	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.44
251	Holoprosencephaly 1	Enrichment	FGFR1	1.44
252	Pendred syndrome	Enrichment	SLC26A4	1.44
253	Keratoconus	Enrichment	TSC1	1.44
254	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.44
255	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.44
256	Familial isolated dilated cardiomyopathy	Enrichment	PRDM16, RAF1	1.38
257	Esophageal cancer	Enrichment	TP53	1.38
258	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.38
259	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.38
260	Myelofibrosis	Enrichment	SRC	1.38
261	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.38
262	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.38
263	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.38
264	Adams-oliver syndrome	Enrichment	NOTCH1	1.38
265	Polycystic kidney disease 1	Enrichment	TSC2	1.38
266	Essential thrombocythemia	Enrichment	TP53	1.38
267	Megacolon	Enrichment	AKT3	1.38
268	Follicular thyroid carcinoma	Enrichment	HRAS	1.38
269	Overgrowth syndrome	Enrichment	MTOR	1.38
270	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.38
271	Myeloma, multiple	Enrichment	RXRA, TP53	1.34
272	Inherited cancer-predisposing syndrome	Enrichment	TP53, TSC1, TSC2	1.33
273	Glioma susceptibility 1	Enrichment	TP53	1.32
274	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.32
275	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.32
276	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.32
277	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.27
278	Primary hyperaldosteronism	Enrichment	TP53	1.27
279	Cowden syndrome	Enrichment	PIK3CA	1.27
280	Leukemia, chronic lymphocytic	Enrichment	TP53	1.23
281	Polymicrogyria	Enrichment	AKT3	1.23
282	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.23
283	Familial colorectal cancer	Enrichment	TP53	1.23
284	Myelodysplastic syndrome	Enrichment	TP53	1.19
285	Specific learning disability	Enrichment	MAPK1	1.19
286	Meningioma	Enrichment	PIK3CA	1.15
287	Autism	Enrichment	ACTL6B, SHH	1.14
288	Chromosome 1p36 deletion syndrome	Enrichment	PRDM16	1.12
289	Breast cancer	Enrichment	PIK3CA, TP53	1.11
290	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.08
291	Osteoporosis	Enrichment	SRC	1.08
292	Medulloblastoma	Enrichment	CTNNB1	1.08
293	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.08
294	Lung cancer susceptibility 3	Enrichment	TP53	1.08
295	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.08
296	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.06
297	Lynch syndrome	Enrichment	PIK3CA	1.06
298	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.06
299	Kidney disease	Enrichment	TSC1	1.06
300	Septopreoptic holoprosencephaly	Enrichment	SHH	1.06
301	Midline interhemispheric variant of holoprosencephaly	Enrichment	SHH	1.06
302	Wolff-parkinson-white syndrome	Enrichment	SLC26A4	1.03
303	Polycystic liver disease	Enrichment	CTNNB1	1.00
304	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.00
305	Alobar holoprosencephaly	Enrichment	SHH	1.00
306	Heart, malformation of	Enrichment	MAPK1	0.98
307	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	0.98
308	Macs syndrome	Enrichment	SHH	0.94
309	Endometrial cancer	Enrichment	PIK3CA	0.92
310	Myocardial infarction	Enrichment	ITGB3	0.90
311	Tooth agenesis	Enrichment	FGFR1	0.90
312	Diamond-blackfan anemia 1	Enrichment	TP53	0.88
313	Kallmann syndrome	Enrichment	FGFR1	0.88
314	Ear malformation	Enrichment	SLC26A4	0.86
315	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.86
316	Congenital nervous system abnormality	Enrichment	CTNNB1, TSC2	0.86
317	Nervous system disease	Enrichment	CTNNB1, TSC2	0.86
318	Pancreatic cancer	Enrichment	TP53	0.85
319	Tetralogy of fallot	Enrichment	NOTCH1	0.83
320	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.83
321	Severe covid-19	Enrichment	ITGAV	0.79
322	Non-immune hydrops fetalis	Enrichment	HRAS	0.76
323	Microcephaly	Enrichment	CTNNB1, MAPK1	0.76
324	Lung cancer	Enrichment	PIK3CA	0.75
325	Connective tissue disease	Enrichment	NOTCH1	0.75
326	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.74
327	Diamond-blackfan anemia	Enrichment	TP53	0.70
328	Leukemia, acute myeloid	Enrichment	TP53	0.66
329	Epilepsy	Enrichment	TSHR	0.66
330	Hereditary spastic paraplegia	Enrichment	SLC16A2	0.64
331	West syndrome	Enrichment	TSC2	0.63
332	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	0.63
333	Sensorineural hearing loss	Enrichment	SLC26A4	0.59
334	Hypertelorism	Enrichment	PIK3CA	0.56
335	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.54
336	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	KLB	0.54
337	Undetermined early-onset epileptic encephalopathy	Enrichment	ACTL6B	0.54
338	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.52
339	Primary ovarian insufficiency	Enrichment	SIRT6	0.52
340	Deafness, autosomal recessive	Enrichment	SLC26A4	0.49
341	Autosomal recessive nonsyndromic deafness	Enrichment	SLC26A4	0.49
342	Rare genetic deafness	Enrichment	SLC26A4	0.41
343	Dilated cardiomyopathy	Enrichment	RAF1	0.41
344	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	SLC26A4	0.37
345	Complex neurodevelopmental disorder	Enrichment	ACTL6B	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Thyroid hormones production and peripheral downstream signaling effects

Pathway Network for Thyroid hormones production and peripheral downstream signaling effects

Member Pathways for Thyroid hormones production and peripheral downstream signaling effects

Pathways in the Thyroid hormones production and peripheral downstream signaling effects SuperPath

Associated Genes for Thyroid hormones production and peripheral downstream signaling effects

Associated Disorders for Thyroid hormones production and peripheral downstream signaling effects

Disorders associated with Thyroid hormones production and peripheral downstream signaling effects SuperPath

STRING Interaction Network for Thyroid hormones production and peripheral downstream signaling effects

Sources for Thyroid hormones production and peripheral downstream signaling effects