Thyroid stimulating hormone (TSH) signaling pathway

No Pathway Network information available for Thyroid stimulating hormone (TSH) signaling pathway

Pathways in the Thyroid stimulating hormone (TSH) signaling pathway SuperPath

#	Name	Source	Genes
1	Thyroid stimulating hormone (TSH) signaling pathway	WikiPathways	ADCY2 ADCY3 AKT1 APEX1 BRAF CCND3 CCNE1 CDK2 CDK4 CDKN1B CGA CREB1 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS GNB1 GNG2 HRAS IGF1R JAK1 JAK2 KCNIP3 MAP2K1 MAP2K3 MAP2K6 MAPK1 MAPK14 MAPK3 MTOR MYL12B PDE4D PDPK1 PIK3CA PIK3R1 PIK3R2 PLCB1 PLD1 RAF1 RALGDS RAP1A RAP1B RAP1GAP RB1 RBL2 RPS6 RPS6KA1 RPS6KB1 SCRIB SRC STAT1 STAT3 TSHB TSHR (see all 58) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
2	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
3	CCNE1	Cyclin E1	Protein Coding	1
4	CCND3	Cyclin D3	Protein Coding	1
5	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	1
6	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	1
7	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
8	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
9	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
10	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
11	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
12	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
13	RPS6	Ribosomal Protein S6	Protein Coding	1
14	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
15	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
16	RAP1GAP	RAP1 GTPase Activating Protein	Protein Coding	1
17	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
18	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
19	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
20	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
21	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
22	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
23	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
24	PLD1	Phospholipase D1	Protein Coding	1
25	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
26	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
27	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
28	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
29	PDE4D	Phosphodiesterase 4D	Protein Coding	1
30	JAK2	Janus Kinase 2	Protein Coding	1
31	JAK1	Janus Kinase 1	Protein Coding	1
32	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
33	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
34	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
35	GNB1	G Protein Subunit Beta 1	Protein Coding	1
36	GNAS	GNAS Complex Locus	Protein Coding	1
37	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
38	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
39	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
40	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
41	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
42	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
43	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
44	PLCB1	Phospholipase C Beta 1	Protein Coding	1
45	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
46	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
47	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
48	ADCY3	Adenylate Cyclase 3	Protein Coding	1
49	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	1
50	ADCY2	Adenylate Cyclase 2	Protein Coding	1
51	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
52	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
53	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
54	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
55	MYL12B	Myosin Light Chain 12B	Protein Coding	1
56	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
57	KCNIP3	Potassium Voltage-Gated Channel Interacting Protein 3	Protein Coding	1
58	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	1

Disorders associated with Thyroid stimulating hormone (TSH) signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.13
2	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, MAP2K1, PIK3CA	7.01
3	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA, RB1	6.84
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, MAP2K1, RAF1	6.40
5	Noonan syndrome 1	Enrichment	BRAF, HRAS, MAP2K1, RAF1	5.60
6	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, RAF1	5.39
7	Rasopathy	Enrichment	BRAF, HRAS, MAP2K1, RAF1	5.38
8	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.21
9	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.06
10	Colorectal cancer	Enrichment	AKT1, BRAF, PIK3CA, PIK3R1, SRC	4.47
11	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	4.27
12	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.27
13	Ovarian cancer	Enrichment	AKT1, CDKN1B, PIK3CA, RB1, TSHR	4.16
14	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	3.97
15	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.97
16	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	3.97
17	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.97
18	Capillary malformations, congenital	Enrichment	GNAQ, PIK3CA	3.75
19	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	3.75
20	Bladder cancer	Enrichment	HRAS, PIK3CA, RB1	3.60
21	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	3.57
22	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.57
23	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.43
24	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS	3.43
25	Myelofibrosis	Enrichment	JAK2, SRC	3.43
26	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.43
27	Noonan syndrome 3	Enrichment	HRAS, RAF1	3.43
28	Gallbladder cancer	Enrichment	BRAF, PIK3CA	3.43
29	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	3.43
30	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS	3.43
31	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.43
32	Primary hyperaldosteronism	Enrichment	BRAF, GNAS	3.20
33	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.20
34	Meningioma	Enrichment	AKT1, PIK3CA	2.94
35	Lung cancer susceptibility 3	Enrichment	BRAF, RB1	2.80
36	Rare genetic intellectual disability	Enrichment	GNAO1, MTOR	2.74
37	Microcephaly	Enrichment	GNAO1, GNB1, IGF1R, MAPK1	2.73
38	Melanoma, cutaneous malignant 1	Enrichment	BRAF, CDK4	2.63
39	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	2.53
40	Macrodactyly	Enrichment	PIK3CA	2.37
41	Proteus syndrome	Enrichment	AKT1	2.37
42	Noonan syndrome 5	Enrichment	RAF1	2.37
43	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.37
44	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.37
45	Melorheostosis, isolated	Enrichment	MAP2K1	2.37
46	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.37
47	Osseous heteroplasia, progressive	Enrichment	GNAS	2.37
48	Noonan syndrome 7	Enrichment	BRAF	2.37
49	Leopard syndrome 3	Enrichment	BRAF	2.37
50	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.37
51	Cowden syndrome 5	Enrichment	PIK3CA	2.37
52	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.37
53	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.37
54	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.37
55	Sturge-weber syndrome	Enrichment	GNAQ	2.37
56	Ventricular tachycardia, familial	Enrichment	GNAI2	2.37
57	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.37
58	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.37
59	Noonan syndrome 13	Enrichment	MAPK1	2.37
60	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.37
61	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.37
62	Short syndrome	Enrichment	PIK3R1	2.37
63	Hypothyroidism, congenital, nongoitrous, 4	Enrichment	TSHB	2.37
64	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.37
65	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.37
66	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.37
67	Lymphangioma	Enrichment	BRAF	2.37
68	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.37
69	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.37
70	Phace association	Enrichment	BRAF	2.37
71	Melorheostosis	Enrichment	MAP2K1	2.37
72	Neuroendocrine tumor	Enrichment	CDKN1B	2.37
73	Leopard syndrome 2	Enrichment	RAF1	2.37
74	Immunodeficiency 31a	Enrichment	STAT1	2.37
75	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.37
76	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.37
77	Cowden syndrome 6	Enrichment	AKT1	2.37
78	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	2.37
79	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.37
80	Immunodeficiency 31b	Enrichment	STAT1	2.37
81	Disorders of gnas inactivation	Enrichment	GNAS	2.37
82	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.37
83	Thrombocytopenia 6	Enrichment	SRC	2.37
84	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.37
85	Trigonitis	Enrichment	RAF1	2.37
86	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.37
87	Trilateral retinoblastoma	Enrichment	RB1	2.37
88	Hypospadias	Enrichment	PIK3CA	2.37
89	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.37
90	Rare venous malformation	Enrichment	PIK3CA	2.37
91	Diaphragmatic eventration	Enrichment	PIK3CA	2.37
92	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.37
93	Syringocystadenoma papilliferum	Enrichment	BRAF	2.37
94	Rare combined vascular malformation	Enrichment	PIK3CA	2.37
95	Ganglioglioma	Enrichment	BRAF	2.37
96	Cavernous lymphangioma	Enrichment	PIK3CA	2.37
97	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.37
98	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.37
99	Monostotic fibrous dysplasia	Enrichment	GNAS	2.37
100	Phace syndrome	Enrichment	BRAF	2.37
101	Gnao1-related disorder	Enrichment	GNAO1	2.37
102	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.37
103	Classic hairy cell leukemia	Enrichment	BRAF	2.37
104	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.37
105	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.37
106	Mazabraud syndrome	Enrichment	GNAS	2.37
107	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.37
108	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.37
109	Macrodactyly of toe	Enrichment	PIK3CA	2.37
110	Lung oat cell carcinoma	Enrichment	RB1	2.37
111	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS	2.17
112	Lung cancer	Enrichment	BRAF, PIK3CA	2.09
113	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.07
114	Costello syndrome	Enrichment	HRAS	2.07
115	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.07
116	Pulmonic stenosis	Enrichment	BRAF	2.07
117	Hyperthyroidism, familial gestational	Enrichment	TSHR	2.07
118	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.07
119	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.07
120	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.07
121	Keratosis, seborrheic	Enrichment	PIK3CA	2.07
122	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	2.07
123	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.07
124	Noonan syndrome 8	Enrichment	PIK3CA	2.07
125	Thrombocythemia 3	Enrichment	JAK2	2.07
126	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.07
127	Immunodeficiency 31c	Enrichment	STAT1	2.07
128	Cebalid syndrome	Enrichment	MTOR	2.07
129	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.07
130	Acrodysostosis	Enrichment	PDE4D	2.07
131	Pseudohypoparathyroidism	Enrichment	GNAS	2.07
132	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.07
133	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.07
134	Hypopituitarism	Enrichment	GNAI2	2.07
135	Smith-kingsmore syndrome	Enrichment	MTOR	2.07
136	Polycythemia	Enrichment	JAK2	2.07
137	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.07
138	Hypereosinophilic syndrome	Enrichment	JAK2	2.07
139	Familial retinoblastoma	Enrichment	RB1	2.07
140	Cerebral visual impairment	Enrichment	GNB1	2.07
141	Phakomatosis cesioflammea	Enrichment	GNAQ	2.07
142	Wooly hair nevus	Enrichment	HRAS	2.07
143	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.89
144	Mccune-albright syndrome	Enrichment	GNAS	1.89
145	Retinoblastoma	Enrichment	RB1	1.89
146	Ataxia-telangiectasia	Enrichment	BRAF	1.89
147	Polycythemia vera	Enrichment	JAK2	1.89
148	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.89
149	Osteogenic sarcoma	Enrichment	RB1	1.89
150	Hyperthyroidism, nonautoimmune	Enrichment	TSHR	1.89
151	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.89
152	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.89
153	Hypothyroidism, congenital, nongoitrous, 1	Enrichment	TSHR	1.89
154	Hypotrichosis 8	Enrichment	RB1	1.89
155	Tethered spinal cord syndrome	Enrichment	BRAF	1.89
156	Large congenital melanocytic nevus	Enrichment	HRAS	1.89
157	Hyper ige syndrome	Enrichment	STAT3	1.89
158	Dedifferentiated liposarcoma	Enrichment	CDK4	1.89
159	Immunodeficiency 14	Enrichment	PIK3R1	1.89
160	Squamous cell carcinoma	Enrichment	RB1	1.89
161	Bone osteosarcoma	Enrichment	RB1	1.89
162	Spermatocytoma	Enrichment	HRAS	1.89
163	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.89
164	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.89
165	Melanoma of soft tissue	Enrichment	CREB1	1.89
166	Well-differentiated liposarcoma	Enrichment	CDK4	1.89
167	Familial hyperthyroidism due to mutations in tsh receptor	Enrichment	TSHR	1.89
168	Anastomosing haemangioma	Enrichment	GNAQ	1.89
169	Keratoacanthoma	Enrichment	PIK3CA	1.89
170	Gastric cancer	Enrichment	CDK4, PIK3CA	1.84
171	West syndrome	Enrichment	GNAO1, PLCB1	1.82
172	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.82
173	Erythrocytosis, familial, 1	Enrichment	JAK2	1.77
174	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.77
175	Small cell cancer of the lung	Enrichment	RB1	1.77
176	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.77
177	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.77
178	Budd-chiari syndrome	Enrichment	JAK2	1.77
179	Smith-lemli-opitz syndrome	Enrichment	TSHR	1.77
180	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.77
181	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.77
182	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.77
183	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.77
184	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.77
185	Lynch syndrome 4	Enrichment	RB1	1.77
186	Achromatopsia 4	Enrichment	GNAI3	1.77
187	Cerebrovascular disease	Enrichment	PIK3CA	1.77
188	Craniopharyngioma	Enrichment	BRAF	1.77
189	Newborn respiratory distress syndrome	Enrichment	BRAF	1.77
190	Epidermolytic nevus	Enrichment	HRAS	1.77
191	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.77
192	Primary hyperparathyroidism	Enrichment	CDKN1B	1.77
193	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.77
194	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, RB1	1.73
195	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.71
196	Insulin-like growth factor i	Enrichment	IGF1R	1.67
197	Myeloproliferative neoplasm	Enrichment	JAK2	1.67
198	Myeloma, multiple	Enrichment	BRAF, PIK3R2	1.62
199	Melanoma, uveal	Enrichment	GNAQ	1.60
200	Cowden syndrome 1	Enrichment	PIK3CA	1.60
201	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.60
202	Wilms tumor 5	Enrichment	BRAF	1.60
203	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.60
204	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.60
205	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.53
206	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	TSHR	1.53
207	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.53
208	Brachydactyly	Enrichment	GNAS	1.53
209	Essential thrombocythemia	Enrichment	JAK2	1.53
210	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.47
211	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.47
212	Hypothyroidism	Enrichment	GNB1	1.47
213	Choreatic disease	Enrichment	GNAO1	1.47
214	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.47
215	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.42
216	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.42
217	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.42
218	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.42
219	Ventricular septal defect	Enrichment	BRAF	1.42
220	Breast cancer	Enrichment	AKT1, PIK3CA	1.39
221	Melanoma	Enrichment	BRAF	1.38
222	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.38
223	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.34
224	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.34
225	Myelodysplastic syndrome	Enrichment	GNB1	1.34
226	Movement disease	Enrichment	GNAO1	1.34
227	Specific learning disability	Enrichment	MAPK1	1.34
228	Congenital hypothyroidism	Enrichment	TSHR	1.30
229	Neural tube defects	Enrichment	SCRIB	1.27
230	Acute promyelocytic leukemia	Enrichment	STAT3	1.27
231	Nk-cell enteropathy	Enrichment	IGF1R	1.27
232	Osteoporosis	Enrichment	SRC	1.23
233	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.21
234	Wilms tumor 1	Enrichment	BRAF	1.21
235	Lynch syndrome	Enrichment	PIK3CA	1.21
236	Rhabdomyosarcoma	Enrichment	HRAS	1.18
237	Cleft palate, isolated	Enrichment	GNB1	1.15
238	Dandy-walker syndrome	Enrichment	BRAF	1.15
239	Heart, malformation of	Enrichment	MAPK1	1.13
240	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.13
241	Arteriovenous malformations of the brain	Enrichment	BRAF	1.11
242	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	1.10
243	Endometrial cancer	Enrichment	PIK3CA	1.06
244	Hepatocellular carcinoma	Enrichment	PIK3CA	1.05
245	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.01
246	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.99
247	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.98
248	Strabismus	Enrichment	GNB1	0.96
249	Prostate cancer	Enrichment	PIK3CA	0.93
250	Non-immune hydrops fetalis	Enrichment	HRAS	0.90
251	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.88
252	Left ventricular noncompaction	Enrichment	RAF1	0.86
253	Dystonia	Enrichment	GNB1	0.86
254	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.84
255	Cerebral palsy	Enrichment	GNB1	0.81
256	Leukemia, acute myeloid	Enrichment	JAK2	0.80
257	Epilepsy	Enrichment	TSHR	0.80
258	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.79
259	Centralopathic epilepsy	Enrichment	PLCB1	0.77
260	Thrombocytopenia	Enrichment	SRC	0.73
261	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.71
262	Hypertelorism	Enrichment	PIK3CA	0.70
263	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.69
264	Primary ovarian insufficiency	Enrichment	JAK2	0.65
265	Congenital nervous system abnormality	Enrichment	GNAO1	0.44
266	Nervous system disease	Enrichment	GNAO1	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Thyroid stimulating hormone (TSH) signaling pathway

Pathway Network for Thyroid stimulating hormone (TSH) signaling pathway

Member Pathways for Thyroid stimulating hormone (TSH) signaling pathway

Pathways in the Thyroid stimulating hormone (TSH) signaling pathway SuperPath

Associated Genes for Thyroid stimulating hormone (TSH) signaling pathway

Associated Disorders for Thyroid stimulating hormone (TSH) signaling pathway

Disorders associated with Thyroid stimulating hormone (TSH) signaling pathway SuperPath

STRING Interaction Network for Thyroid stimulating hormone (TSH) signaling pathway

Sources for Thyroid stimulating hormone (TSH) signaling pathway