Thyroxine (thyroid hormone) production

No Pathway Network information available for Thyroxine (thyroid hormone) production

Pathways in the Thyroxine (thyroid hormone) production SuperPath

#	Name	Source	Genes
1	Thyroxine (thyroid hormone) production	WikiPathways	ACY1 ANO1 CGA CLCN5 DUOX1 DUOX2 ELK1 MAP2K1 MAP2K2 MAPK1 MAPK3 PRKAA1 PRKAA2 PRKCA SLC26A6 SLC5A5 TG TPO TRH TSHR (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACY1	Aminoacylase 1	Protein Coding	1
2	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	1
3	TRH	Thyrotropin Releasing Hormone	Protein Coding	1
4	TPO	Thyroid Peroxidase	Protein Coding	1
5	TG	Thyroglobulin	Protein Coding	1
6	SLC5A5	Solute Carrier Family 5 Member 5	Protein Coding	1
7	SLC26A6	Solute Carrier Family 26 Member 6	Protein Coding	1
8	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
9	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
10	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
11	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
12	PRKCA	Protein Kinase C Alpha	Protein Coding	1
13	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
14	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
15	DUOX2	Dual Oxidase 2	Protein Coding	1
16	CLCN5	Chloride Voltage-Gated Channel 5	Protein Coding	1
17	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	1
18	ANO1	Anoctamin 1	Protein Coding	1
19	DUOX1	Dual Oxidase 1	Protein Coding	1
20	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with Thyroxine (thyroid hormone) production SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital hypothyroidism	Enrichment	DUOX2, SLC5A5, TG, TPO, TSHR	10.92
2	Familial thyroid dyshormonogenesis	Enrichment	DUOX2, SLC5A5, TG, TPO	10.05
3	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.91
4	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.91
5	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	3.67
6	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	3.29
7	Rasopathy	Enrichment	MAP2K1, MAP2K2	3.18
8	Thyrotropin-releasing hormone deficiency	Enrichment	TRH	2.83
9	Thyroid dyshormonogenesis 1	Enrichment	SLC5A5	2.83
10	Melorheostosis, isolated	Enrichment	MAP2K1	2.83
11	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.83
12	Thyroid dyshormonogenesis 6	Enrichment	DUOX2	2.83
13	Noonan syndrome 13	Enrichment	MAPK1	2.83
14	Moyamoya disease 7	Enrichment	ANO1	2.83
15	Thyroid dyshormonogenesis 3	Enrichment	TG	2.83
16	Intestinal dysmotility syndrome	Enrichment	ANO1	2.83
17	Melorheostosis	Enrichment	MAP2K1	2.83
18	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.83
19	Dent disease 1	Enrichment	CLCN5	2.53
20	Nephrolithiasis, x-linked recessive, with renal failure	Enrichment	CLCN5	2.53
21	Hyperthyroidism, familial gestational	Enrichment	TSHR	2.53
22	Hypophosphatemic rickets, x-linked recessive	Enrichment	CLCN5	2.53
23	Proteinuria, low molecular weight, with hypercalciuria and nephrocalcinosis	Enrichment	CLCN5	2.53
24	Thyroid dyshormonogenesis 2a	Enrichment	TPO	2.53
25	Autoimmune thyroid disease 3	Enrichment	TG	2.53
26	Tafro syndrome	Enrichment	MAP2K2	2.53
27	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.35
28	Hyperthyroidism, nonautoimmune	Enrichment	TSHR	2.35
29	Hypothyroidism, congenital, nongoitrous, 1	Enrichment	TSHR	2.35
30	Dent disease	Enrichment	CLCN5	2.35
31	Familial hyperthyroidism due to mutations in tsh receptor	Enrichment	TSHR	2.35
32	Hypophosphatemic rickets, x-linked dominant	Enrichment	CLCN5	2.23
33	Smith-lemli-opitz syndrome	Enrichment	TSHR	2.23
34	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.23
35	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.23
36	Aminoacylase 1 deficiency	Enrichment	ACY1	2.23
37	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	TSHR	1.99
38	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.99
39	Hypothyroidism	Enrichment	TG	1.93
40	Arteriovenous malformation	Enrichment	MAP2K1	1.88
41	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.83
42	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.79
43	Specific learning disability	Enrichment	MAPK1	1.79
44	Heart, malformation of	Enrichment	MAPK1	1.58
45	Epilepsy	Enrichment	TSHR	1.24
46	Nephrotic syndrome	Enrichment	CLCN5	1.21
47	Ovarian cancer	Enrichment	TSHR	0.86
48	Autism spectrum disorder	Enrichment	MAP2K1	0.83
49	Microcephaly	Enrichment	MAPK1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Thyroxine (thyroid hormone) production

Pathway Network for Thyroxine (thyroid hormone) production

Member Pathways for Thyroxine (thyroid hormone) production

Pathways in the Thyroxine (thyroid hormone) production SuperPath

Associated Genes for Thyroxine (thyroid hormone) production

Associated Disorders for Thyroxine (thyroid hormone) production

Disorders associated with Thyroxine (thyroid hormone) production SuperPath

STRING Interaction Network for Thyroxine (thyroid hormone) production

Sources for Thyroxine (thyroid hormone) production