TNF-alpha signaling pathway

Pathway network for the TNF-alpha signaling pathway SuperPath

Sources:

WikiPathways
Reactome

Pathways in the TNF-alpha signaling pathway SuperPath

#	Name	Source	Genes
1	TNF-alpha signaling pathway	WikiPathways	HRAS KRAS NRAS
2	Signaling by RAS GTPase mutants	Reactome	HRAS KRAS NRAS
3	Signaling by RAS GAP mutants	Reactome	HRAS KRAS NRAS
4	RAS GTPase cycle mutants	Reactome	HRAS KRAS NRAS

Gene overlap in member pathways for TNF-alpha signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	4
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4

Disorders associated with TNF-alpha signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	10.83
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	9.95
3	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	9.39
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	8.96
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	8.37
6	Rasopathy	Enrichment	HRAS, KRAS, NRAS	8.20
7	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	8.06
8	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	7.49
9	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	7.01
10	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	6.71
11	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	6.16
12	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	6.16
13	Noonan syndrome 3	Enrichment	HRAS, KRAS	6.16
14	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	6.16
15	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	6.04
16	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	5.67
17	Bladder cancer	Enrichment	HRAS, KRAS	4.88
18	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	4.82
19	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	4.60
20	Oculoectodermal syndrome	Enrichment	KRAS	3.66
21	Melanosis, neurocutaneous	Enrichment	NRAS	3.66
22	Noonan syndrome 6	Enrichment	NRAS	3.66
23	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.66
24	Congenital pulmonary airway malformation	Enrichment	KRAS	3.66
25	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.66
26	Neurocutaneous melanocytosis	Enrichment	NRAS	3.66
27	Costello syndrome	Enrichment	HRAS	3.35
28	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	3.35
29	Wooly hair nevus	Enrichment	HRAS	3.35
30	Langerhans cell histiocytosis	Enrichment	NRAS	3.18
31	Spermatocytoma	Enrichment	HRAS	3.18
32	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	3.05
33	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	3.05
34	Cardiofaciocutaneous syndrome	Enrichment	KRAS	3.05
35	Lung sarcomatoid carcinoma	Enrichment	KRAS	3.05
36	Pilocytic astrocytoma	Enrichment	KRAS	3.05
37	Epidermolytic nevus	Enrichment	HRAS	3.05
38	Breast adenocarcinoma	Enrichment	KRAS	2.88
39	Lung squamous cell carcinoma	Enrichment	KRAS	2.88
40	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	2.81
41	Gallbladder cancer	Enrichment	KRAS	2.81
42	Pilomyxoid astrocytoma	Enrichment	KRAS	2.81
43	Arteriovenous malformation	Enrichment	HRAS	2.70
44	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	2.66
45	Lip and oral cavity carcinoma	Enrichment	HRAS	2.58
46	Protein-deficiency anemia	Enrichment	NRAS	2.54
47	Lung cancer susceptibility 3	Enrichment	KRAS	2.51
48	Lynch syndrome	Enrichment	KRAS	2.48
49	Rhabdomyosarcoma	Enrichment	HRAS	2.45
50	Arteriovenous malformations of the brain	Enrichment	KRAS	2.38
51	Pancreatic cancer	Enrichment	KRAS	2.26
52	Hydrops fetalis, nonimmune	Enrichment	HRAS	2.24
53	Lung cancer	Enrichment	KRAS	2.15
54	Gastric cancer	Enrichment	KRAS	2.02
55	Hereditary breast carcinoma	Enrichment	KRAS	2.01
56	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.92
57	Myeloma, multiple	Enrichment	KRAS	1.91
58	Breast cancer	Enrichment	KRAS	1.78
59	Colorectal cancer	Enrichment	NRAS	1.72
60	Ovarian cancer	Enrichment	KRAS	1.65

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TNF-alpha signaling pathway

Pathway Network for TNF-alpha signaling pathway

Pathway network for the TNF-alpha signaling pathway SuperPath

Member Pathways for TNF-alpha signaling pathway

Pathways in the TNF-alpha signaling pathway SuperPath

Gene overlap in member pathways for TNF-alpha signaling pathway SuperPath

Associated Genes for TNF-alpha signaling pathway

Associated Disorders for TNF-alpha signaling pathway

Disorders associated with TNF-alpha signaling pathway SuperPath

STRING Interaction Network for TNF-alpha signaling pathway

Sources for TNF-alpha signaling pathway