TNF receptor signaling pathway

No Pathway Network information available for TNF receptor signaling pathway

Pathways in the TNF receptor signaling pathway SuperPath

#	Name	Source	Genes
1	TNF receptor signaling pathway	PubChem	ADAM17 BAG4 BIRC2 BIRC3 CASP8 CAV1 CHUK CYLD FADD IKBKB IKBKG MADD MAP2K3 MAP2K7 MAP3K1 MAP3K3 MAP3K5 MAP3K7 NFKB1 NSMAF RACK1 RELA RFFL RIPK1 SMPD1 SMPD2 SQSTM1 STAT1 TNF TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF1 TRAF2 TXN (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RFFL	Ring Finger And FYVE Like Domain Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
2	MADD	MAP Kinase Activating Death Domain	Protein Coding	1
3	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
4	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
5	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
6	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
7	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
8	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
9	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
10	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
11	BAG4	BAG Cochaperone 4	Protein Coding	1
12	NSMAF	Neutral Sphingomyelinase Activation Associated Factor	Protein Coding	1
13	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
14	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
15	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
16	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
17	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
18	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
19	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
20	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
21	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
22	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
23	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
24	FADD	Fas Associated Via Death Domain	Protein Coding	1
25	CASP8	Caspase 8	Protein Coding	1
26	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
27	TXN	Thioredoxin	Protein Coding	1
28	CAV1	Caveolin 1	Protein Coding	1
29	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
30	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
31	TNF	Tumor Necrosis Factor	Protein Coding	1
32	SQSTM1	Sequestosome 1	Protein Coding	1
33	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
34	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
35	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
36	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1

Disorders associated with TNF receptor signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Malaria	Enrichment	IKBKG, TNF	2.78
2	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.58
3	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.58
4	Paget disease of bone 3	Enrichment	SQSTM1	2.58
5	Incontinentia pigmenti	Enrichment	IKBKG	2.58
6	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.58
7	Caspase 8 deficiency	Enrichment	CASP8	2.58
8	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.58
9	Fetal encasement syndrome	Enrichment	CHUK	2.58
10	46,xy sex reversal 6	Enrichment	MAP3K1	2.58
11	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.58
12	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.58
13	Immunodeficiency 15b	Enrichment	IKBKB	2.58
14	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.58
15	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.58
16	Immunodeficiency 15a	Enrichment	IKBKB	2.58
17	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.58
18	Deeah syndrome	Enrichment	MADD	2.58
19	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.58
20	Immunodeficiency 31a	Enrichment	STAT1	2.58
21	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.58
22	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.58
23	Immunodeficiency 31b	Enrichment	STAT1	2.58
24	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.58
25	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.58
26	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.58
27	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.58
28	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.58
29	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.58
30	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.58
31	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.58
32	Verrucous hemangioma	Enrichment	MAP3K3	2.58
33	Systemic lupus erythematosus	Enrichment	TNF, TNFAIP3	2.32
34	Cylindromatosis, familial	Enrichment	CYLD	2.28
35	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	2.28
36	Immunodeficiency 33	Enrichment	IKBKG	2.28
37	Welander distal myopathy	Enrichment	SQSTM1	2.28
38	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.28
39	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.28
40	Immunodeficiency 31c	Enrichment	STAT1	2.28
41	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.28
42	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.28
43	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	2.28
44	Brooke-spiegler syndrome	Enrichment	CYLD	2.28
45	Immunodeficiency 127	Enrichment	TNF	2.28
46	Rela fusion-positive ependymoma	Enrichment	RELA	2.28
47	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.28
48	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.28
49	Paget's disease of bone	Enrichment	SQSTM1	2.28
50	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.28
51	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.28
52	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.28
53	Common variable immunodeficiency 12	Enrichment	NFKB1	2.28
54	Oculootodental syndrome	Enrichment	FADD	2.28
55	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.28
56	Mycosis fungoides	Enrichment	TNFRSF1B	2.10
57	Niemann-pick disease, type a	Enrichment	SMPD1	2.10
58	Psoriatic arthritis	Enrichment	TNF	2.10
59	Niemann-pick disease, type b	Enrichment	SMPD1	2.10
60	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	2.10
61	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.10
62	Migraine without aura	Enrichment	TNF	2.10
63	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.10
64	Saczary syndrome	Enrichment	TNFRSF1B	2.10
65	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.98
66	Paget's disease of bone 2	Enrichment	SQSTM1	1.98
67	Cerebral malaria	Enrichment	TNF	1.98
68	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.88
69	Niemann-pick disease, type c1	Enrichment	SMPD1	1.88
70	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.88
71	Niemann-pick disease	Enrichment	SMPD1	1.88
72	Vascular dementia	Enrichment	TNF	1.88
73	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.88
74	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.88
75	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.80
76	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.80
77	Limited scleroderma	Enrichment	CAV1	1.80
78	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.80
79	Common variable immunodeficiency	Enrichment	NFKB1	1.73
80	Charge syndrome	Enrichment	TNFRSF1A	1.63
81	Coronary heart disease 5	Enrichment	IKBKG	1.63
82	Adult hepatocellular carcinoma	Enrichment	CASP8	1.63
83	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.63
84	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.58
85	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.58
86	Immune deficiency disease	Enrichment	RIPK1	1.54
87	Asthma	Enrichment	TNF	1.54
88	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.54
89	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.54
90	Alzheimer's disease	Enrichment	TNF	1.47
91	Multiple sclerosis	Enrichment	TNFRSF1A	1.44
92	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.44
93	Behcet syndrome	Enrichment	TNFRSF1A	1.31
94	Hepatocellular carcinoma	Enrichment	CASP8	1.25
95	Autoinflammatory disease	Enrichment	TNFRSF1A	1.21
96	Lung cancer	Enrichment	CASP8	1.09
97	Severe combined immunodeficiency	Enrichment	IKBKB	1.08
98	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.87
99	Myeloma, multiple	Enrichment	CYLD	0.86
100	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.84
101	Breast cancer	Enrichment	CASP8	0.74
102	Ovarian cancer	Enrichment	MAP3K1	0.63
103	Complex neurodevelopmental disorder	Enrichment	MADD	0.55
104	Inherited cancer-predisposing syndrome	Enrichment	CYLD	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TNF receptor signaling pathway

Pathway Network for TNF receptor signaling pathway

Member Pathways for TNF receptor signaling pathway

Pathways in the TNF receptor signaling pathway SuperPath

Associated Genes for TNF receptor signaling pathway

Associated Disorders for TNF receptor signaling pathway

Disorders associated with TNF receptor signaling pathway SuperPath

STRING Interaction Network for TNF receptor signaling pathway

Sources for TNF receptor signaling pathway