TNF signaling

Pathway network for the TNF signaling SuperPath

Sources:

Reactome

Pathways in the TNF signaling SuperPath

#	Name	Source	Genes
1	TNF signaling	Reactome	ADAM17 BIRC2 BIRC3 CASP8 CHUK CLIP3 CYLD FADD IKBKB IKBKE IKBKG MADD MAP3K7 MAPKAPK2 MIB2 NSMAF OPTN OTULIN RACK1 RBCK1 RIPK1 RPS27A SMPD2 SMPD3 SPPL2A SPPL2B STUB1 TAB1 TAB2 TAB3 TAX1BP1 TBK1 TNFAIP3 TRAF1 TRAF2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 ULK1 (see all 43) (see less)
2	Regulation of TNFR1 signaling	Reactome	BIRC2 BIRC3 CASP8 CHUK CLIP3 CYLD FADD IKBKB IKBKE IKBKG MADD MAPKAPK2 MIB2 OPTN OTULIN RACK1 RBCK1 RIPK1 RPS27A SPPL2A SPPL2B STUB1 TAX1BP1 TBK1 TNFAIP3 TRAF1 TRAF2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 ULK1 (see all 35) (see less)
3	TNFR1-induced NF-kappa-B signaling pathway	Reactome	BIRC2 BIRC3 CHUK CYLD IKBKB IKBKG MAP3K7 OPTN RACK1 RBCK1 RIPK1 RPS27A TAB1 TAB2 TAB3 TNFAIP3 TRAF1 TRAF2 UBA52 UBB UBC (see all 21) (see less)
4	TNFR1-induced proapoptotic signaling	Reactome	BIRC2 BIRC3 CASP8 CYLD FADD IKBKE MIB2 OPTN RBCK1 RIPK1 TBK1 TNFAIP3 TRAF2 (see all 13) (see less)
5	TNFR1-mediated ceramide production	Reactome	NSMAF RACK1 SMPD2 SMPD3

Gene overlap in member pathways for TNF signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	OPTN	Optineurin	Protein Coding	4
2	RACK1	Receptor For Activated C Kinase 1	Protein Coding	4
3	RBCK1	RANBP2-Type And C3HC4-Type Zinc Finger Containing 1	Protein Coding	4
4	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	4
5	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	4
6	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	4
7	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	4
8	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	4
9	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	4
10	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
11	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	3
12	TBK1	TANK Binding Kinase 1	Protein Coding	3
13	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
14	RPS27A	Ribosomal Protein S27a	Protein Coding	3
15	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	3
16	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
17	UBB	Ubiquitin B	Protein Coding	3
18	UBC	Ubiquitin C	Protein Coding	3
19	CASP8	Caspase 8	Protein Coding	3
20	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
21	FADD	Fas Associated Via Death Domain	Protein Coding	3
22	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
23	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	2
24	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
25	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
26	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	2
27	CLIP3	CAP-Gly Domain Containing Linker Protein 3	Protein Coding	2
28	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	2
29	SPPL2B	Signal Peptide Peptidase Like 2B	Protein Coding	2
30	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	2
31	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
32	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
33	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
34	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	2
35	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	2
36	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	2
37	NSMAF	Neutral Sphingomyelinase Activation Associated Factor	Protein Coding	2
38	SPPL2A	Signal Peptide Peptidase Like 2A	Protein Coding	2
39	MADD	MAP Kinase Activating Death Domain	Protein Coding	2
40	TAX1BP1	Tax1 Binding Protein 1	Protein Coding	2
41	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	2
42	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
43	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1

Disorders associated with TNF signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Motor neuron disease	Enrichment	OPTN, TBK1	4.75
2	Caspase 8 deficiency	Enrichment	CASP8	3.02
3	Polyglucosan body myopathy 1 with or without immunodeficiency	Enrichment	RBCK1	3.02
4	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.02
5	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	3.02
6	Corticobasal syndrome	Enrichment	TBK1	3.02
7	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	3.02
8	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	3.02
9	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	3.02
10	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	OPTN, TBK1	2.87
11	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.81
12	Incontinentia pigmenti	Enrichment	IKBKG	2.81
13	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.81
14	Fetal encasement syndrome	Enrichment	CHUK	2.81
15	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.81
16	Immunodeficiency 15b	Enrichment	IKBKB	2.81
17	Immunodeficiency 15a	Enrichment	IKBKB	2.81
18	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.81
19	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.81
20	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.81
21	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.81
22	Cylindromatosis, familial	Enrichment	CYLD	2.72
23	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	2.72
24	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.72
25	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	2.72
26	Brooke-spiegler syndrome	Enrichment	CYLD	2.72
27	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.72
28	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	2.72
29	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	2.72
30	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.72
31	Oculootodental syndrome	Enrichment	FADD	2.72
32	Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Enrichment	RBCK1	2.72
33	Immunodeficiency 107 invasive staphylococcus aureus infection	Enrichment	OTULIN	2.59
34	Deeah syndrome	Enrichment	MADD	2.59
35	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	Enrichment	OTULIN	2.59
36	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.59
37	Immunodeficiency 86	Enrichment	SPPL2A	2.59
38	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	Enrichment	OTULIN	2.59
39	Glycogen storage disease iv	Enrichment	RBCK1	2.54
40	Glaucoma, normal tension	Enrichment	OPTN	2.54
41	Immunodeficiency 33	Enrichment	IKBKG	2.51
42	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.51
43	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.51
44	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.51
45	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.51
46	Submucosal cleft palate	Enrichment	UBB	2.51
47	Cleft hard palate	Enrichment	UBB	2.51
48	Systemic lupus erythematosus	Enrichment	TNFAIP3, UBE2L3	2.35
49	Pelvic organ prolapse	Enrichment	TAB2	2.33
50	Uvula, bifid	Enrichment	UBB	2.33
51	Cleft soft palate	Enrichment	UBB	2.33
52	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.33
53	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	2.32
54	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	2.32
55	Herpes simplex virus encephalitis	Enrichment	TBK1	2.32
56	Spinocerebellar ataxia 48	Enrichment	STUB1	2.29
57	Glaucoma, primary open angle	Enrichment	OPTN	2.24
58	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.24
59	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.24
60	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.20
61	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.11
62	Craniometaphyseal dysplasia, autosomal dominant	Enrichment	OTULIN	2.11
63	Adult hepatocellular carcinoma	Enrichment	CASP8	2.07
64	Progressive non-fluent aphasia	Enrichment	TBK1	2.07
65	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.02
66	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	2.02
67	Chondrocalcinosis 2	Enrichment	OTULIN	1.99
68	Immune deficiency disease	Enrichment	RIPK1	1.98
69	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.89
70	Coronary heart disease 5	Enrichment	IKBKG	1.86
71	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.81
72	Migraine with or without aura 1	Enrichment	TAB2	1.77
73	Aortic valve disease 1	Enrichment	TAB2	1.70
74	Hepatocellular carcinoma	Enrichment	CASP8	1.68
75	Severe covid-19	Enrichment	RBCK1	1.56
76	Patent foramen ovale	Enrichment	TAB2	1.56
77	Lung cancer	Enrichment	CASP8	1.52
78	Left ventricular noncompaction	Enrichment	MIB2	1.48
79	Malaria	Enrichment	IKBKG	1.46
80	Severe combined immunodeficiency	Enrichment	IKBKB	1.30
81	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.29
82	Myeloma, multiple	Enrichment	CYLD	1.28
83	Breast cancer	Enrichment	CASP8	1.16
84	Dilated cardiomyopathy	Enrichment	TAB2	0.93
85	Inherited cancer-predisposing syndrome	Enrichment	CYLD	0.92
86	Complex neurodevelopmental disorder	Enrichment	MADD	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for TNF signaling

Pathway network for the TNF signaling SuperPath

Member Pathways for TNF signaling

Pathways in the TNF signaling SuperPath

Gene overlap in member pathways for TNF signaling SuperPath

Associated Genes for TNF signaling

Associated Disorders for TNF signaling

Disorders associated with TNF signaling SuperPath

STRING Interaction Network for TNF signaling

Sources for TNF signaling