TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

Pathway network for the TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

Sources:

R&D Systems
QIAGEN
Reactome

Pathways in the TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

#	Name	Source	Genes
1	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions	R&D Systems	APP BDNF CD27 CD40 CD40LG CD70 EDA EDA2R EDAR FAS FASLG LTA LTB LTBR NGF NGFR NTF3 NTF4 RELT TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11A TNFRSF11B TNFRSF12A TNFRSF13B TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFRSF4 TNFRSF6B TNFRSF8 TNFRSF9 TNFSF10 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF4 TNFSF8 TNFSF9 (see all 52) (see less)
2	TNF Superfamily Pathway	QIAGEN	CASP1 CASP10 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CD27 CD40 CD40LG CD70 CHUK EDA EDA2R EDAR FADD FAS FASLG FOS IKBKB IKBKE IKBKG JUN LTA LTB LTBR MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 NFKB1 NFKBIA NFKBIB NFKBIE NGF NGFR PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RELT SRC TAB1 TAB2 TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11A TNFRSF11B TNFRSF12A TNFRSF13B TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF10 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF14 TNFSF18 TNFSF4 TNFSF8 TNFSF9 TRADD TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 (see all 96) (see less)
3	TRAF Pathway	QIAGEN	BIRC2 BIRC3 CASP3 CASP6 CASP7 CASP8 CD40 CD40LG CHUK FADD FOS IKBKB IKBKE IKBKG IL12A IL12B IL1A IL1B IL1R1 IRAK1 IRAK2 IRAK3 IRAK4 JUN LTA MADD MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K14 MAP3K5 MAP3K7 MAP4K2 MAP4K5 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE NGF NGFR PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RIPK1 SRC TAB1 TAB2 TANK TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF TNFRSF11A TNFRSF13B TNFRSF17 TNFRSF1A TNFRSF1B TNFSF11 TNFSF13 TNFSF13B TOLLIP TRADD TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBB UBC UBD (see all 90) (see less)
4	14-3-3 Induced Apoptosis	QIAGEN	AKT1 BAD BCL2 BID CASP1 CASP10 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CHUK CYCS FADD FASLG FOS FOXO3 IKBKB IKBKE IKBKG IL1A IL1B IL1R1 IRAK1 IRAK2 IRAK3 IRAK4 JUN LTA MAP2K4 MAP3K14 MAP3K5 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RPS6KA1 TLR4 TNF TNFAIP3 TNFRSF1A TNIP1 TRADD TRAF2 TRAF6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 82) (see less)
5	TNFs bind their physiological receptors	Reactome	CD27 CD70 EDA EDA2R EDAR EDARADD FASLG LTA TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF6B TNFRSF8 TNFRSF9 TNFSF11 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF4 TNFSF8 TNFSF9 (see all 28) (see less)

Gene overlap in member pathways for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LTA	Lymphotoxin Alpha	Protein Coding	5
2	TNFSF13	TNF Superfamily Member 13	Protein Coding	4
3	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	4
4	TNFSF11	TNF Superfamily Member 11	Protein Coding	4
5	FASLG	Fas Ligand	Protein Coding	4
6	TNF	Tumor Necrosis Factor	Protein Coding	4
7	TNFRSF17	TNF Receptor Superfamily Member 17	Protein Coding	4
8	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	4
9	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	4
10	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	4
11	TNFSF9	TNF Superfamily Member 9	Protein Coding	3
12	CD70	CD70 Molecule	Protein Coding	3
13	TNFSF8	TNF Superfamily Member 8	Protein Coding	3
14	CD40LG	CD40 Ligand	Protein Coding	3
15	EDA	Ectodysplasin A	Protein Coding	3
16	TNFSF18	TNF Superfamily Member 18	Protein Coding	3
17	TNFSF14	TNF Superfamily Member 14	Protein Coding	3
18	TNFSF4	TNF Superfamily Member 4	Protein Coding	3
19	NGF	Nerve Growth Factor	Protein Coding	3
20	TNFRSF9	TNF Receptor Superfamily Member 9	Protein Coding	3
21	CD27	CD27 Molecule	Protein Coding	3
22	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3
23	CD40	CD40 Molecule	Protein Coding	3
24	EDAR	Ectodysplasin A Receptor	Protein Coding	3
25	EDA2R	Ectodysplasin A2 Receptor	Protein Coding	3
26	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	3
27	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	3
28	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	3
29	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	3
30	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	3
31	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	3
32	NGFR	Nerve Growth Factor Receptor	Protein Coding	3
33	CASP3	Caspase 3	Protein Coding	3
34	CASP6	Caspase 6	Protein Coding	3
35	CASP7	Caspase 7	Protein Coding	3
36	CASP8	Caspase 8	Protein Coding	3
37	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
38	FADD	Fas Associated Via Death Domain	Protein Coding	3
39	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
40	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
41	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
42	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
43	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
44	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
45	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	3
46	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
47	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	3
48	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
49	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
50	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
51	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
52	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
53	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
54	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	3
55	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
56	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
57	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
58	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	3
59	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	3
60	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	3
61	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
62	TNFSF10	TNF Superfamily Member 10	Protein Coding	2
63	TNFSF15	TNF Superfamily Member 15	Protein Coding	2
64	TNFSF12	TNF Superfamily Member 12	Protein Coding	2
65	LTB	Lymphotoxin Beta	Protein Coding	2
66	TNFRSF13C	TNF Receptor Superfamily Member 13C	Protein Coding	2
67	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	2
68	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	2
69	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	2
70	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	2
71	TNFRSF19	TNF Receptor Superfamily Member 19	Protein Coding	2
72	FAS	Fas Cell Surface Death Receptor	Protein Coding	2
73	TNFRSF6B	TNF Receptor Superfamily Member 6b	Protein Coding	2
74	TNFRSF12A	TNF Receptor Superfamily Member 12A	Protein Coding	2
75	LTBR	Lymphotoxin Beta Receptor	Protein Coding	2
76	TNFRSF21	TNF Receptor Superfamily Member 21	Protein Coding	2
77	RELT	RELT TNF Receptor	Protein Coding	2
78	CASP1	Caspase 1	Protein Coding	2
79	CASP10	Caspase 10	Protein Coding	2
80	CASP2	Caspase 2	Protein Coding	2
81	CASP4	Caspase 4	Protein Coding	2
82	CASP5	Caspase 5	Protein Coding	2
83	CASP9	Caspase 9	Protein Coding	2
84	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
85	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
86	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
87	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
88	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
89	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
90	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
91	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
92	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	2
93	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	2
94	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	2
95	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	2
96	IL1A	Interleukin 1 Alpha	Protein Coding	2
97	IL1B	Interleukin 1 Beta	Protein Coding	2
98	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	2
99	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
100	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	2
101	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	2
102	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	2
103	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	2
104	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
105	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	2
106	TLR4	Toll Like Receptor 4	Protein Coding	2
107	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
108	NTF3	Neurotrophin 3	Protein Coding	1
109	NTF4	Neurotrophin 4	Protein Coding	1
110	APP	Amyloid Beta Precursor Protein	Protein Coding	1
111	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
112	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
113	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
114	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
115	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
116	IL12A	Interleukin 12A	Protein Coding	1
117	IL12B	Interleukin 12B	Protein Coding	1
118	MADD	MAP Kinase Activating Death Domain	Protein Coding	1
119	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
120	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	1
121	MAP4K5	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5	Protein Coding	1
122	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
123	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
124	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	1
125	TLR1	Toll Like Receptor 1	Protein Coding	1
126	TLR10	Toll Like Receptor 10	Protein Coding	1
127	TLR2	Toll Like Receptor 2	Protein Coding	1
128	TLR3	Toll Like Receptor 3	Protein Coding	1
129	TLR5	Toll Like Receptor 5	Protein Coding	1
130	TLR6	Toll Like Receptor 6	Protein Coding	1
131	TLR7	Toll Like Receptor 7	Protein Coding	1
132	TLR8	Toll Like Receptor 8	Protein Coding	1
133	TLR9	Toll Like Receptor 9	Protein Coding	1
134	TOLLIP	Toll Interacting Protein	Protein Coding	1
135	UBB	Ubiquitin B	Protein Coding	1
136	UBC	Ubiquitin C	Protein Coding	1
137	UBD	Ubiquitin Like Modifier D	Protein Coding	1
138	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
139	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
140	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
141	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
142	CYCS	Cytochrome C, Somatic	Protein Coding	1
143	FOXO3	Forkhead Box O3	Protein Coding	1
144	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
145	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
146	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	1
147	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
148	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
149	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
150	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
151	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
152	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
153	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
154	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
155	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
156	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
157	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
158	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
159	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
160	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
161	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
162	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
163	TNIP1	TNFAIP3 Interacting Protein 1	Protein Coding	1
164	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
165	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
166	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
167	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
168	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
169	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
170	EDARADD	EDAR Associated Via Death Domain	Protein Coding	1

Disorders associated with TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tooth agenesis	Enrichment	EDA, EDA2R, EDAR, EDARADD	6.98
2	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	5.86
3	Ectodermal dysplasia 1, hypohidrotic, x-linked	Enrichment	EDA, EDA2R	5.39
4	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1, TNFRSF13B	5.01
5	Multisystem inflammatory syndrome in children	Enrichment	IRAK3, TLR3, TLR6, TRAF3	4.92
6	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	EDAR, EDARADD	4.91
7	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11A, TNFRSF11B	4.84
8	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	EDA, EDAR	4.61
9	Ectodermal dysplasia	Enrichment	EDA, EDAR	4.61
10	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.44
11	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.44
12	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	4.44
13	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	EDAR, EDARADD	4.39
14	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	EDAR, EDARADD	4.39
15	Psoriatic arthritis	Enrichment	LTA, TNF	4.37
16	Systemic lupus erythematosus	Enrichment	IRAK1, TNF, TNFAIP3, TNIP1	4.06
17	Tooth agenesis, selective, 1	Enrichment	EDA, EDA2R	3.83
18	Behcet syndrome	Enrichment	IL12A, TLR4, TNFRSF1A	3.60
19	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.53
20	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.53
21	Herpes simplex virus encephalitis	Enrichment	TLR3, TRAF3	3.37
22	Malaria	Enrichment	IKBKG, TIRAP, TNF	3.34
23	Myocardial infarction	Enrichment	LTA, TNFSF4	3.03
24	Alzheimer's disease	Enrichment	APP, TNF	2.96
25	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.90
26	Lung cancer	Enrichment	CASP8, FAS, FASLG	2.83
27	Specific learning disability	Enrichment	MAPK1, YWHAG	2.72
28	Immune deficiency, familial variable	Enrichment	TNFRSF13B	2.69
29	Leprosy 4	Enrichment	LTA	2.69
30	Immunodeficiency 16	Enrichment	TNFRSF4	2.69
31	Lymphoproliferative syndrome 3	Enrichment	CD70	2.69
32	Tooth agenesis, selective, x-linked, 1	Enrichment	EDA	2.69
33	Immunoglobulin a deficiency 2	Enrichment	TNFRSF13B	2.69
34	Hair morphology 1	Enrichment	EDAR	2.69
35	Ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant	Enrichment	EDARADD	2.69
36	Immunodeficiency 109 with lymphoproliferation	Enrichment	TNFRSF9	2.69
37	Common variable immunodeficiency phenotype due to homozygous taci deficiency	Enrichment	TNFRSF13B	2.69
38	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.42
39	Osteopetrosis, autosomal recessive 7	Enrichment	TNFRSF11A	2.42
40	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.42
41	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.42
42	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.42
43	Glaucoma 1, open angle, o	Enrichment	NTF4	2.42
44	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.42
45	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.42
46	Amelogenesis imperfecta, type iiic	Enrichment	RELT	2.42
47	Cd40 ligand deficiency	Enrichment	CD40LG	2.42
48	Common variable immunodeficiency phenotype due to tweak deficiency	Enrichment	TNFSF12	2.42
49	Immunodeficiency, common variable, 2	Enrichment	TNFRSF13B	2.38
50	Immunodeficiency with hyper-igm, type 2	Enrichment	TNFRSF13B	2.38
51	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.38
52	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	2.31
53	Proteus syndrome	Enrichment	AKT1	2.22
54	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.22
55	Incontinentia pigmenti	Enrichment	IKBKG	2.22
56	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.22
57	Immunodeficiency 68	Enrichment	MYD88	2.22
58	Caspase 8 deficiency	Enrichment	CASP8	2.22
59	Carney complex, type 1	Enrichment	PRKAR1A	2.22
60	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.22
61	Fetal encasement syndrome	Enrichment	CHUK	2.22
62	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.22
63	Immunodeficiency 15b	Enrichment	IKBKB	2.22
64	Noonan syndrome 13	Enrichment	MAPK1	2.22
65	Immunodeficiency 15a	Enrichment	IKBKB	2.22
66	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.22
67	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.22
68	Short syndrome	Enrichment	PIK3R1	2.22
69	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.22
70	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.22
71	Myxoma, intracardiac	Enrichment	PRKAR1A	2.22
72	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.22
73	Asthma-related traits 5	Enrichment	IRAK3	2.22
74	Thrombocytopenia 4	Enrichment	CYCS	2.22
75	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.22
76	Immunodeficiency 67	Enrichment	IRAK4	2.22
77	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.22
78	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.22
79	Cowden syndrome 6	Enrichment	AKT1	2.22
80	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.22
81	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.22
82	Macular degeneration, age-related, 10	Enrichment	TLR4	2.22
83	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.22
84	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.22
85	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.22
86	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.22
87	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.22
88	Immunodeficiency 112	Enrichment	MAP3K14	2.22
89	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.22
90	Waldenstram macroglobulinemia	Enrichment	MYD88	2.22
91	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.22
92	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.22
93	Nik deficiency	Enrichment	MAP3K14	2.22
94	Mycosis fungoides	Enrichment	TNFRSF1B	2.21
95	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.21
96	Tooth agenesis, selective, 2	Enrichment	EDA	2.21
97	Saczary syndrome	Enrichment	TNFRSF1B	2.21
98	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.18
99	Leprosy 3	Enrichment	TLR2	2.18
100	Legionnaire disease	Enrichment	TLR5	2.18
101	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.18
102	Bacteremia 1	Enrichment	TIRAP	2.18
103	Leprosy 5	Enrichment	TLR1	2.18
104	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.18
105	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.18
106	Systemic lupus erythematosus 1	Enrichment	TLR5	2.18
107	X-linked immunodeficiency 74	Enrichment	TLR7	2.18
108	Immunodeficiency 132a	Enrichment	TRAF3	2.18
109	Immunodeficiency 132b	Enrichment	TRAF3	2.18
110	Systemic lupus erythematosus 17	Enrichment	TLR7	2.18
111	Deeah syndrome	Enrichment	MADD	2.18
112	Immunodeficiency 29	Enrichment	IL12B	2.18
113	Melioidosis	Enrichment	TLR5	2.18
114	Thrombocytopenia 6	Enrichment	SRC	2.18
115	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.18
116	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.18
117	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.18
118	Melorheostosis, isolated	Enrichment	MAP2K1	2.15
119	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.15
120	Melorheostosis	Enrichment	MAP2K1	2.15
121	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.15
122	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.12
123	Familial expansile osteolysis	Enrichment	TNFRSF11A	2.12
124	Immunodeficiency 127	Enrichment	TNF	2.12
125	Immunodeficiency, common variable, 4	Enrichment	TNFRSF13C	2.12
126	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.12
127	Immunodeficiency, common variable, 1	Enrichment	TNFRSF13B	2.08
128	Lymphoproliferative syndrome 2	Enrichment	CD27	2.08
129	Chondrocalcinosis 2	Enrichment	TNFRSF11B	2.08
130	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	2.08
131	Breast cancer	Enrichment	AKT1, CASP8, JUN	1.98
132	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	1.94
133	Dysosteosclerosis	Enrichment	TNFRSF11A	1.94
134	Migraine without aura	Enrichment	TNF	1.94
135	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	1.94
136	Adult-onset myasthenia gravis	Enrichment	TNFRSF11A	1.94
137	Vogt-koyanagi-harada disease	Enrichment	FAS	1.94
138	Scoliosis, isolated 1	Enrichment	MAPK7	1.92
139	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.92
140	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.92
141	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.92
142	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.92
143	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.92
144	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.92
145	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	1.92
146	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.92
147	Usher syndrome, type iv	Enrichment	PRKAR1A	1.92
148	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.92
149	Acrodysostosis	Enrichment	PRKAR1A	1.92
150	Congenital dyserythropoietic anemia	Enrichment	IRAK4	1.92
151	Fibrolamellar carcinoma	Enrichment	PRKACA	1.92
152	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.92
153	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.92
154	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.92
155	Common variable immunodeficiency 12	Enrichment	NFKB1	1.92
156	Oculootodental syndrome	Enrichment	FADD	1.92
157	Leprosy 1	Enrichment	TLR6	1.88
158	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.88
159	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.88
160	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.88
161	Submucosal cleft palate	Enrichment	UBB	1.88
162	Cleft hard palate	Enrichment	UBB	1.88
163	Tafro syndrome	Enrichment	MAP2K2	1.85
164	Mitochondrial dna depletion syndrome 4a	Enrichment	EDAR	1.84
165	Rasopathy	Enrichment	MAP2K1, MAP2K2	1.84
166	Paget disease of bone 2, early-onset	Enrichment	TNFRSF11A	1.82
167	Paget's disease of bone 2	Enrichment	TNFRSF11A	1.82
168	Cerebral malaria	Enrichment	TNF	1.82
169	Narcolepsy 1	Enrichment	TNFSF4	1.79
170	Mitochondrial dna depletion syndrome 4b	Enrichment	EDAR	1.79
171	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.74
172	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.74
173	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.74
174	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.74
175	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.74
176	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.74
177	Immunodeficiency 14	Enrichment	PIK3R1	1.74
178	Primary biliary cholangitis	Enrichment	TNFSF15	1.73
179	Vascular dementia	Enrichment	TNF	1.72
180	Pelvic organ prolapse	Enrichment	TAB2	1.70
181	Takayasu arteritis	Enrichment	IL12B	1.70
182	Uvula, bifid	Enrichment	UBB	1.70
183	Cleft soft palate	Enrichment	UBB	1.70
184	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.70
185	Colorectal cancer	Enrichment	PIK3R1, SRC, TLR2	1.70
186	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.68
187	Immune deficiency disease	Enrichment	CD27	1.65
188	Combined immunodeficiency	Enrichment	CD27	1.65
189	Combined t cell and b cell immunodeficiency	Enrichment	CD27	1.65
190	Combined t and b cell immunodeficiency	Enrichment	CD27	1.65
191	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.64
192	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.62
193	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.62
194	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.62
195	Carney complex variant	Enrichment	PRKAR1A	1.62
196	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.62
197	Congenital generalized lipodystrophy	Enrichment	FOS	1.62
198	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.62
199	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.62
200	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.58
201	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B	1.58
202	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF	1.58
203	Alzheimer's disease 1	Enrichment	APP	1.58
204	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.58
205	Gastric cancer	Enrichment	CASP10, IL1B	1.56
206	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.55
207	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.52
208	Follicular lymphoma	Enrichment	BCL2	1.52
209	Histiocytoid hemangioma	Enrichment	FOS	1.52
210	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.52
211	Endometrial stromal sarcoma	Enrichment	YWHAE	1.52
212	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.48
213	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.48
214	Charge syndrome	Enrichment	TNFRSF1A	1.47
215	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.47
216	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.45
217	Breast adenocarcinoma	Enrichment	AKT1	1.45
218	Kidney clear cell sarcoma	Enrichment	YWHAE	1.45
219	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA, YWHAZ	1.44
220	Amelogenesis imperfecta, type ie	Enrichment	RELT	1.42
221	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.41
222	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.41
223	Asthma	Enrichment	TNF	1.38
224	Overgrowth syndrome	Enrichment	PIK3R1	1.38
225	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA, YWHAG	1.35
226	Multiple endocrine neoplasia, type i	Enrichment	MAP4K2	1.34
227	Myelofibrosis	Enrichment	SRC	1.34
228	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	1.32
229	Lennox-gastaut syndrome	Enrichment	MAPK10	1.32
230	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.31
231	Amelogenesis imperfecta	Enrichment	RELT	1.31
232	Multiple sclerosis	Enrichment	TNFRSF1A	1.28
233	Coronary heart disease 5	Enrichment	IKBKG	1.27
234	Adult hepatocellular carcinoma	Enrichment	CASP8	1.27
235	Cowden syndrome	Enrichment	AKT1	1.27
236	Myeloma, multiple	Enrichment	PIK3R2, TRAF5	1.27
237	Rheumatoid arthritis	Enrichment	TLR1	1.24
238	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.23
239	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.23
240	Arteriovenous malformation	Enrichment	MAP2K1	1.21
241	Alzheimer disease, familial, 1	Enrichment	APP	1.20
242	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.16
243	Meningioma	Enrichment	AKT1	1.15
244	Migraine with or without aura 1	Enrichment	TAB2	1.15
245	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.12
246	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.12
247	Aortic valve disease 1	Enrichment	TAB2	1.08
248	Autoinflammatory disease	Enrichment	TNFRSF1A	1.05
249	Osteoporosis	Enrichment	SRC	1.05
250	Gliosarcoma	Enrichment	NFKBIA	1.03
251	Giant cell glioblastoma	Enrichment	NFKBIA	1.01
252	Heart, malformation of	Enrichment	MAPK1	0.99
253	Diffuse large b-cell lymphoma	Enrichment	MYD88	0.96
254	Human immunodeficiency virus type 1	Enrichment	TLR3	0.95
255	Patent foramen ovale	Enrichment	TAB2	0.95
256	Peripheral nervous system disease	Enrichment	NGF	0.94
257	Neuropathy	Enrichment	NGF	0.94
258	Hepatocellular carcinoma	Enrichment	CASP8	0.90
259	Severe covid-19	Enrichment	CASP10	0.79
260	Microcephaly	Enrichment	MAPK1, YWHAG	0.77
261	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.76
262	Severe combined immunodeficiency	Enrichment	IKBKB	0.74
263	Hereditary breast carcinoma	Enrichment	AKT1	0.63
264	Thrombocytopenia	Enrichment	CYCS	0.60
265	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.51
266	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.43
267	Dilated cardiomyopathy	Enrichment	TAB2	0.38
268	Ovarian cancer	Enrichment	AKT1	0.34
269	Autism spectrum disorder	Enrichment	MAP2K1	0.27
270	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.26
271	Complex neurodevelopmental disorder	Enrichment	MADD	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

Pathway Network for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

Pathway network for the TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

Member Pathways for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

Pathways in the TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

Gene overlap in member pathways for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

Associated Genes for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

Associated Disorders for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

Disorders associated with TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions SuperPath

STRING Interaction Network for TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

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