Toll-like receptor signaling pathway

Pathway network for the Toll-like receptor signaling pathway SuperPath

Sources:

WikiPathways

Pathways in the Toll-like receptor signaling pathway SuperPath

#	Name	Source	Genes
1	Toll-like receptor signaling pathway	WikiPathways	AKT1 AKT2 AKT3 CASP8 CCL3 CCL4 CCL5 CD14 CD40 CD80 CD86 CHUK CXCL10 CXCL11 CXCL8 CXCL9 FADD FOS IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IKBKB IKBKE IKBKG IL12A IL12B IL1B IL6 IRAK1 IRAK4 IRF3 IRF5 IRF7 JUN LBP LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 RAC1 RELA RIPK1 SPP1 STAT1 TAB1 TAB2 TAB3 TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF TOLLIP TRAF3 TRAF6 (see all 103) (see less)
2	Hepatitis B infection	WikiPathways	AKT1 AKT2 AKT3 APAF1 ARAF ATF2 ATF4 ATF6B ATP6AP1 BAD BAX BCL2 BID BIRC5 BRAF CASP10 CASP12 CASP3 CASP8 CASP9 CDKN1A CHUK CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CREBBP CXCL8 CYCS DDB1 DDB2 DDX3X EGR2 EGR3 ELK1 EP300 FADD FAS FASLG FOS GRB2 HRAS HSPG2 IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNB1 IKBKB IKBKE IKBKG IL6 IRAK1 IRAK4 IRF3 IRF7 JAK1 JAK2 JAK3 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MAVS MMP9 MYC MYD88 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NRAS PCNA PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKCA PRKCB PRKCG PTK2B RAF1 RELA RIGI SLC10A1 SMAD2 SMAD3 SMAD4 SOS1 SOS2 SRC STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B TAB1 TAB2 TBK1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TICAM1 TICAM2 TIRAP TLR2 TLR3 TLR4 TNF TRAF3 TRAF6 TYK2 VDAC3 YWHAB YWHAQ YWHAZ (see all 151) (see less)
3	Regulation of toll-like receptor signaling pathway	WikiPathways	AKT1 AKT2 AKT3 BTK CASP8 CCL3 CCL4 CCL5 CD14 CD180 CD40 CD80 CD86 CHUK CISH CTNNAL1 CUEDC2 CXCL10 CXCL11 CXCL8 CXCL9 CYLD FADD FBXW5 FOS IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IKBKB IKBKE IKBKG IL12A IL12B IL1B IL6 IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF5 IRF7 JUN LBP LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MBL2 MIR105-1 MIR146A MIR155 MIR98 MIRLET7E MIRLET7I MLST8 MYD88 NFKB1 NFKB2 NFKBIA OTUD5 PELI1 PELI2 PELI3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLK1 PTPN6 RAC1 RBCK1 RELA RIPK1 RNF216 RNF31 RNF41 SARM1 SFTPA2 SFTPD SIGIRR SMAD6 SOCS1 SPP1 SQSTM1 STAT1 SYK TAB1 TAB2 TAB3 TBK1 TICAM1 TICAM2 TIFA TIRAP TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMED7 TNF TNFAIP3 TOLLIP TRAF3 TRAF6 TRAFD1 TREM1 USP7 ZMYND11 (see all 145) (see less)
4	Measles virus infection	WikiPathways	ADAR APAF1 BAD BAK1 BAX BBC3 BCL2 BCL2L1 BID CASP3 CASP8 CASP9 CBLB CCND1 CCND2 CCND3 CCNE1 CCNE2 CD209 CD28 CD3D CD3E CD3G CD46 CDK2 CDK4 CDK6 CDKN1B CHUK CLEC4M CSNK2A1 CSNK2A2 CSNK2A3 CSNK2B CYCS EIF2AK1 EIF2AK2 EIF2AK3 EIF2AK4 EIF2S1 EIF3H FADD FAS FASLG FCGR2B FOS HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IKBKB IKBKE IKBKG IL12A IL12B IL1A IL1B IL2 IL2RA IL2RB IL2RG IL6 IRAK1 IRAK4 IRF3 IRF7 IRF9 JAK1 JAK3 JUN MAP3K7 MAPK10 MAPK8 MAPK9 MAVS MSN MX1 MYD88 NECTIN4 NFKB1 NFKB2 NFKBIA NFKBIB OAS1 OAS2 OAS3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAB9A RAB9B RACK1 RCHY1 RELA RIGI SLAMF1 STAT1 STAT2 STAT3 STAT5A STAT5B TAB2 TBK1 TLR2 TLR4 TLR7 TLR9 TNFAIP3 TP53 TP73 TRADD TRAF3 TRAF6 TYK2 (see all 136) (see less)

Gene overlap in member pathways for Toll-like receptor signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FADD	Fas Associated Via Death Domain	Protein Coding	4
2	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	4
3	CASP8	Caspase 8	Protein Coding	4
4	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	4
5	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	4
6	TLR4	Toll Like Receptor 4	Protein Coding	4
7	TLR2	Toll Like Receptor 2	Protein Coding	4
8	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	4
9	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	4
10	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	4
11	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	4
12	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	4
13	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	4
14	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	4
15	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	4
16	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	4
17	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	4
18	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4
19	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	4
20	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	4
21	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	4
22	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
23	IRF7	Interferon Regulatory Factor 7	Protein Coding	4
24	IRF3	Interferon Regulatory Factor 3	Protein Coding	4
25	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	4
26	IL6	Interleukin 6	Protein Coding	4
27	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
28	IFNB1	Interferon Beta 1	Protein Coding	4
29	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	4
30	IFNA10	Interferon Alpha 10	Protein Coding	4
31	IFNA5	Interferon Alpha 5	Protein Coding	4
32	IFNA2	Interferon Alpha 2	Protein Coding	4
33	IFNA1	Interferon Alpha 1	Protein Coding	4
34	TBK1	TANK Binding Kinase 1	Protein Coding	4
35	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
36	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	4
37	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
38	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	4
39	IFNA21	Interferon Alpha 21	Protein Coding	4
40	IFNA17	Interferon Alpha 17	Protein Coding	4
41	IFNA16	Interferon Alpha 16	Protein Coding	4
42	IFNA14	Interferon Alpha 14	Protein Coding	4
43	IFNA13	Interferon Alpha 13	Protein Coding	4
44	IFNA8	Interferon Alpha 8	Protein Coding	4
45	IFNA7	Interferon Alpha 7	Protein Coding	4
46	IFNA6	Interferon Alpha 6	Protein Coding	4
47	IFNA4	Interferon Alpha 4	Protein Coding	4
48	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	4
49	TNF	Tumor Necrosis Factor	Protein Coding	3
50	TLR3	Toll Like Receptor 3	Protein Coding	3
51	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	3
52	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	3
53	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	3
54	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
55	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
56	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
57	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
58	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
59	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
60	TLR9	Toll Like Receptor 9	Protein Coding	3
61	TLR7	Toll Like Receptor 7	Protein Coding	3
62	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
63	IL12B	Interleukin 12B	Protein Coding	3
64	IL12A	Interleukin 12A	Protein Coding	3
65	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	3
66	IL1B	Interleukin 1 Beta	Protein Coding	3
67	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	3
68	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	3
69	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
70	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
71	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	3
72	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
73	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	3
74	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	3
75	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
76	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
77	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	3
78	CD40	CD40 Molecule	Protein Coding	2
79	CD86	CD86 Molecule	Protein Coding	2
80	CD80	CD80 Molecule	Protein Coding	2
81	CD14	CD14 Molecule	Protein Coding	2
82	TLR5	Toll Like Receptor 5	Protein Coding	2
83	TLR1	Toll Like Receptor 1	Protein Coding	2
84	SPP1	Secreted Phosphoprotein 1	Protein Coding	2
85	CXCL11	C-X-C Motif Chemokine Ligand 11	Protein Coding	2
86	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	2
87	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	2
88	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	2
89	RAC1	Rac Family Small GTPase 1	Protein Coding	2
90	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
91	TLR8	Toll Like Receptor 8	Protein Coding	2
92	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	2
93	LBP	Lipopolysaccharide Binding Protein	Protein Coding	2
94	IRF5	Interferon Regulatory Factor 5	Protein Coding	2
95	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	2
96	LY96	Lymphocyte Antigen 96	Protein Coding	2
97	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
98	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	2
99	TLR6	Toll Like Receptor 6	Protein Coding	2
100	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	2
101	TOLLIP	Toll Interacting Protein	Protein Coding	2
102	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
103	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	2
104	CASP9	Caspase 9	Protein Coding	2
105	CASP3	Caspase 3	Protein Coding	2
106	TYK2	Tyrosine Kinase 2	Protein Coding	2
107	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
108	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
109	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
110	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	2
111	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	2
112	BID	BH3 Interacting Domain Death Agonist	Protein Coding	2
113	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
114	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	2
115	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	2
116	CYCS	Cytochrome C, Somatic	Protein Coding	2
117	JAK3	Janus Kinase 3	Protein Coding	2
118	JAK1	Janus Kinase 1	Protein Coding	2
119	FASLG	Fas Ligand	Protein Coding	2
120	FAS	Fas Cell Surface Death Receptor	Protein Coding	2
121	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	2
122	RIGI	RNA Sensor RIG-I	Protein Coding	2
123	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	2
124	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	2
125	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
126	CREB5	CAMP Responsive Element Binding Protein 5	Protein Coding	1
127	CASP10	Caspase 10	Protein Coding	1
128	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
129	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
130	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
131	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
132	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
133	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
134	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
135	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
136	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
137	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
138	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
139	SLC10A1	Solute Carrier Family 10 Member 1	Protein Coding	1
140	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
141	PRKCG	Protein Kinase C Gamma	Protein Coding	1
142	PRKCB	Protein Kinase C Beta	Protein Coding	1
143	PRKCA	Protein Kinase C Alpha	Protein Coding	1
144	ATP6AP1	ATPase H+ Transporting Accessory Protein 1	Protein Coding	1
145	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
146	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
147	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
148	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
149	ATF4	Activating Transcription Factor 4	Protein Coding	1
150	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
151	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
152	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
153	SMAD4	SMAD Family Member 4	Protein Coding	1
154	SMAD3	SMAD Family Member 3	Protein Coding	1
155	SMAD2	SMAD Family Member 2	Protein Coding	1
156	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
157	JAK2	Janus Kinase 2	Protein Coding	1
158	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
159	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	1
160	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
161	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
162	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
163	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
164	EGR3	Early Growth Response 3	Protein Coding	1
165	EGR2	Early Growth Response 2	Protein Coding	1
166	DDX3X	DEAD-Box Helicase 3 X-Linked	Protein Coding	1
167	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
168	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	1
169	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
170	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
171	ATF2	Activating Transcription Factor 2	Protein Coding	1
172	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
173	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
174	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
175	CASP12	Caspase 12 (Gene/Pseudogene)	Protein Coding	1
176	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
177	CREB3L3	CAMP Responsive Element Binding Protein 3 Like 3	Protein Coding	1
178	ATF6B	Activating Transcription Factor 6 Beta	Protein Coding	1
179	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
180	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
181	VDAC3	Voltage Dependent Anion Channel 3	Protein Coding	1
182	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	1
183	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
184	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
185	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
186	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
187	SQSTM1	Sequestosome 1	Protein Coding	1
188	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
189	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
190	SFTPA2	Surfactant Protein A2	Protein Coding	1
191	BTK	Bruton Tyrosine Kinase	Protein Coding	1
192	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
193	SFTPD	Surfactant Protein D	Protein Coding	1
194	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
195	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	1
196	PELI2	Pellino E3 Ubiquitin Protein Ligase Family Member 2	Protein Coding	1
197	RNF31	Ring Finger Protein 31	Protein Coding	1
198	RNF216	Ring Finger Protein 216	Protein Coding	1
199	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	1
200	PLK1	Polo Like Kinase 1	Protein Coding	1
201	TMED7	Transmembrane P24 Trafficking Protein 7	Protein Coding	1
202	MBL2	Mannose Binding Lectin 2	Protein Coding	1
203	SMAD6	SMAD Family Member 6	Protein Coding	1
204	MIR98	MicroRNA 98	RNA Gene	1
205	MIR155	MicroRNA 155	RNA Gene	1
206	MIR146A	MicroRNA 146a	RNA Gene	1
207	MIRLET7I	MicroRNA Let-7i	RNA Gene	1
208	MIRLET7E	MicroRNA Let-7e	RNA Gene	1
209	SARM1	Sterile Alpha And TIR Motif Containing 1	Protein Coding	1
210	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
211	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	1
212	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	1
213	TRAFD1	TRAF-Type Zinc Finger Domain Containing 1	Protein Coding	1
214	ZMYND11	Zinc Finger MYND-Type Containing 11	Protein Coding	1
215	RBCK1	RANBP2-Type And C3HC4-Type Zinc Finger Containing 1	Protein Coding	1
216	TIFA	TRAF Interacting Protein With Forkhead Associated Domain	Protein Coding	1
217	CTNNAL1	Catenin Alpha Like 1	Protein Coding	1
218	RNF41	Ring Finger Protein 41	Protein Coding	1
219	CUEDC2	CUE Domain Containing 2	Protein Coding	1
220	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
221	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	1
222	OTUD5	OTU Deubiquitinase 5	Protein Coding	1
223	FBXW5	F-Box And WD Repeat Domain Containing 5	Protein Coding	1
224	MIR105-1	MicroRNA 105-1	RNA Gene	1
225	CD180	CD180 Molecule	Protein Coding	1
226	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
227	PELI3	Pellino E3 Ubiquitin Protein Ligase Family Member 3	Protein Coding	1
228	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
229	CD28	CD28 Molecule	Protein Coding	1
230	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
231	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
232	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
233	CCNE2	Cyclin E2	Protein Coding	1
234	CCNE1	Cyclin E1	Protein Coding	1
235	CCND3	Cyclin D3	Protein Coding	1
236	CCND2	Cyclin D2	Protein Coding	1
237	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
238	EIF3H	Eukaryotic Translation Initiation Factor 3 Subunit H	Protein Coding	1
239	NECTIN4	Nectin Cell Adhesion Molecule 4	Protein Coding	1
240	TP73	Tumor Protein P73	Protein Coding	1
241	TP53	Tumor Protein P53	Protein Coding	1
242	BCL2L1	BCL2 Like 1	Protein Coding	1
243	CCND1	Cyclin D1	Protein Coding	1
244	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
245	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
246	OAS3	2''-5''-Oligoadenylate Synthetase 3	Protein Coding	1
247	OAS2	2''-5''-Oligoadenylate Synthetase 2	Protein Coding	1
248	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	1
249	MX1	MX Dynamin Like GTPase 1	Protein Coding	1
250	MSN	Moesin	Protein Coding	1
251	EIF2AK4	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4	Protein Coding	1
252	CD46	CD46 Molecule	Protein Coding	1
253	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
254	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
255	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
256	IL2	Interleukin 2	Protein Coding	1
257	IL1A	Interleukin 1 Alpha	Protein Coding	1
258	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
259	HSPA6	Heat Shock Protein Family A (Hsp70) Member 6	Protein Coding	1
260	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	1
261	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	1
262	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
263	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
264	CD209	CD209 Molecule	Protein Coding	1
265	BBC3	BCL2 Binding Component 3	Protein Coding	1
266	EIF2AK1	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1	Protein Coding	1
267	RCHY1	Ring Finger And CHY Zinc Finger Domain Containing 1	Protein Coding	1
268	FCGR2B	Fc Gamma Receptor IIb	Protein Coding	1
269	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
270	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
271	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
272	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
273	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
274	CLEC4M	C-Type Lectin Domain Family 4 Member M	Protein Coding	1
275	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
276	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
277	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
278	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
279	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
280	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
281	IRF9	Interferon Regulatory Factor 9	Protein Coding	1
282	SLAMF1	Signaling Lymphocytic Activation Molecule Family Member 1	Protein Coding	1
283	RAB9B	RAB9B, Member RAS Oncogene Family	Protein Coding	1
284	RAB9A	RAB9A, Member RAS Oncogene Family	Protein Coding	1
285	CSNK2A3	Casein Kinase 2 Alpha 3	Protein Coding	1

Disorders associated with Toll-like receptor signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	16.00
2	Multisystem inflammatory syndrome in children	Enrichment	IFNA21, IFNA4, IFNA6, IFNAR2, IFNB1, IRF3, TLR3, TLR6, TRAF3	10.89
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.74
4	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	10.48
5	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	9.78
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	9.12
7	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.83
8	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.83
9	Herpes simplex virus encephalitis	Enrichment	TBK1, TICAM1, TLR3, TRAF3	7.81
10	Colorectal cancer	Enrichment	AKT1, BAX, BRAF, EP300, NRAS, PIK3CA, PIK3R1, SMAD4, SRC, TLR2	7.38
11	Systemic lupus erythematosus	Enrichment	IRAK1, IRF5, SOCS1, SPP1, TLR7, TNF, TNFAIP3	6.80
12	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	6.30
13	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	6.30
14	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	6.30
15	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA, SMAD4	6.30
16	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	6.00
17	Lung cancer	Enrichment	BRAF, CASP8, FAS, FASLG, KRAS, PIK3CA	5.91
18	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	5.87
19	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	5.87
20	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	5.87
21	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.77
22	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.27
23	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	5.27
24	Severe combined immunodeficiency	Enrichment	CD3D, CD3E, CD3G, IKBKB, JAK3	4.75
25	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	4.58
26	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.34
27	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.34
28	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.34
29	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.34
30	Diffuse large b-cell lymphoma	Enrichment	BRAF, CREBBP, MYD88, STAT3	4.30
31	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.24
32	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.24
33	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	4.24
34	Adult hepatocellular carcinoma	Enrichment	CASP8, PIK3CA, TP53	4.10
35	Malaria	Enrichment	CISH, IKBKG, TIRAP, TNF	4.02
36	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	4.00
37	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	3.97
38	Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Enrichment	RBCK1, RNF31	3.95
39	Pulmonic stenosis	Enrichment	BRAF, SOS1	3.91
40	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.91
41	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.91
42	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	3.91
43	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	3.81
44	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	3.81
45	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.77
46	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.77
47	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.77
48	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	3.56
49	Bladder cancer	Enrichment	CDKN1A, HRAS, KRAS, PIK3CA	3.55
50	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	3.55
51	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	3.53
52	Immunodeficiency 44	Enrichment	IFNAR2, STAT2	3.53
53	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3D, CD3E	3.53
54	Human immunodeficiency virus type 1	Enrichment	CCL3, CCL5, TLR3	3.50
55	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.47
56	Pediatric systemic lupus erythematosus	Enrichment	IRAK1, SPP1	3.47
57	Tethered spinal cord syndrome	Enrichment	BRAF, CREBBP	3.44
58	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.44
59	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	3.44
60	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	3.44
61	Lynch syndrome	Enrichment	KRAS, PIK3CA, TGFBR2	3.25
62	Rare genetic intellectual disability	Enrichment	CREBBP, DDX3X, EP300	3.25
63	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.25
64	Small cell cancer of the lung	Enrichment	TP53, TP73	3.23
65	Anemia, autoimmune hemolytic	Enrichment	SOCS1, TLR8	3.17
66	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.14
67	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.14
68	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.14
69	Behcet syndrome	Enrichment	FAS, IL12A, TLR4	3.07
70	Gastric cancer	Enrichment	CDK4, IL1B, PIK3CA, TP53	3.06
71	Breast cancer	Enrichment	CASP8, IL2, JUN, PIK3CA, TP53	3.03
72	Arteriovenous malformations of the brain	Enrichment	BRAF, IL6, KRAS	2.94
73	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	2.94
74	Hepatocellular carcinoma	Enrichment	CASP8, PIK3CA, TP53	2.88
75	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.75
76	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.75
77	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	2.75
78	Rheumatoid arthritis	Enrichment	IRF5, TLR1	2.70
79	Primary biliary cholangitis	Enrichment	IL12A, IRF5	2.70
80	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.70
81	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.69
82	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	2.69
83	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	2.69
84	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.61
85	Myelofibrosis	Enrichment	JAK2, SRC	2.60
86	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.60
87	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, CASP10	2.48
88	Aicardi-goutiares syndrome	Enrichment	ADAR, IFIH1	2.46
89	Myeloma, multiple	Enrichment	BRAF, CREBBP, KRAS, PIK3R2	2.46
90	Meningioma	Enrichment	AKT1, PIK3CA	2.45
91	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.37
92	Aicardi-goutieres syndrome	Enrichment	ADAR, IFIH1	2.37
93	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1, TBK1	2.32
94	Immune deficiency disease	Enrichment	RIPK1, SYK	2.23
95	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	2.14
96	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	2.14
97	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.12
98	Macrodactyly	Enrichment	PIK3CA	2.12
99	Proteus syndrome	Enrichment	AKT1	2.12
100	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.12
101	Leprosy 3	Enrichment	TLR2	2.12
102	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.12
103	Incontinentia pigmenti	Enrichment	IKBKG	2.12
104	Legionnaire disease	Enrichment	TLR5	2.12
105	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.12
106	Immunodeficiency 68	Enrichment	MYD88	2.12
107	Caspase 8 deficiency	Enrichment	CASP8	2.12
108	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.12
109	Melorheostosis, isolated	Enrichment	MAP2K1	2.12
110	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.12
111	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.12
112	Cowden syndrome 5	Enrichment	PIK3CA	2.12
113	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.12
114	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.12
115	Bacteremia 1	Enrichment	TIRAP	2.12
116	Leprosy 5	Enrichment	TLR1	2.12
117	Fetal encasement syndrome	Enrichment	CHUK	2.12
118	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.12
119	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.12
120	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.12
121	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.12
122	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.12
123	Immunodeficiency 15b	Enrichment	IKBKB	2.12
124	Noonan syndrome 13	Enrichment	MAPK1	2.12
125	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.12
126	Immunodeficiency 15a	Enrichment	IKBKB	2.12
127	Short syndrome	Enrichment	PIK3R1	2.12
128	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.12
129	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.12
130	Systemic lupus erythematosus 1	Enrichment	TLR5	2.12
131	X-linked immunodeficiency 74	Enrichment	TLR7	2.12
132	Immunodeficiency 132a	Enrichment	TRAF3	2.12
133	Immunodeficiency 132b	Enrichment	TRAF3	2.12
134	Systemic lupus erythematosus 17	Enrichment	TLR7	2.12
135	Immunodeficiency 39	Enrichment	IRF7	2.12
136	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.12
137	Systemic lupus erythematosus 10	Enrichment	IRF5	2.12
138	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.12
139	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.12
140	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.12
141	Melorheostosis	Enrichment	MAP2K1	2.12
142	Immunodeficiency 67	Enrichment	IRAK4	2.12
143	Immunodeficiency 31a	Enrichment	STAT1	2.12
144	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.12
145	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.12
146	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.12
147	Immunodeficiency 29	Enrichment	IL12B	2.12
148	Cowden syndrome 6	Enrichment	AKT1	2.12
149	Melioidosis	Enrichment	TLR5	2.12
150	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.12
151	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.12
152	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.12
153	Macular degeneration, age-related, 10	Enrichment	TLR4	2.12
154	Immunodeficiency 31b	Enrichment	STAT1	2.12
155	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.12
156	Inflammatory bowel disease 14	Enrichment	IRF5	2.12
157	Corticobasal syndrome	Enrichment	TBK1	2.12
158	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.12
159	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.12
160	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.12
161	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.12
162	Hypospadias	Enrichment	PIK3CA	2.12
163	Capillary hemangioma	Enrichment	AKT3	2.12
164	Rare venous malformation	Enrichment	PIK3CA	2.12
165	Diaphragmatic eventration	Enrichment	PIK3CA	2.12
166	Waldenstram macroglobulinemia	Enrichment	MYD88	2.12
167	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.12
168	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.12
169	Rare combined vascular malformation	Enrichment	PIK3CA	2.12
170	Cavernous lymphangioma	Enrichment	PIK3CA	2.12
171	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.12
172	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.12
173	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.12
174	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.12
175	Macrodactyly of toe	Enrichment	PIK3CA	2.12
176	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.12
177	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.12
178	Aortic valve disease 1	Enrichment	SMAD6, TAB2	2.09
179	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	2.01
180	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.00
181	Immunodeficiency 50	Enrichment	MSN	2.00
182	Immunodeficiency 35	Enrichment	TYK2	2.00
183	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.00
184	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.00
185	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.00
186	Singleton-merten syndrome 1	Enrichment	IFIH1	2.00
187	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.00
188	Pseudo-torch syndrome 3	Enrichment	STAT2	2.00
189	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.00
190	Immunodeficiency 95	Enrichment	IFIH1	2.00
191	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.00
192	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.00
193	Bone marrow failure syndrome 5	Enrichment	TP53	2.00
194	Papilloma of choroid plexus	Enrichment	TP53	2.00
195	Basal cell carcinoma 7	Enrichment	TP53	2.00
196	Type 1 diabetes mellitus 19	Enrichment	IFIH1	2.00
197	Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	Enrichment	EIF2AK1	2.00
198	Anaplastic thyroid carcinoma	Enrichment	TP53	2.00
199	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.00
200	Immunodeficiency 18	Enrichment	CD3E	2.00
201	Thrombocytopenia 4	Enrichment	CYCS	2.00
202	Neuroendocrine tumor	Enrichment	CDKN1B	2.00
203	Dengue virus	Enrichment	CD209	2.00
204	Hemolytic uremic syndrome, atypical 2	Enrichment	CD46	2.00
205	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.00
206	Ectodermal dysplasia-syndactyly syndrome 1	Enrichment	NECTIN4	2.00
207	Ductal carcinoma in situ	Enrichment	TP53	2.00
208	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	2.00
209	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.00
210	Singleton-merten syndrome 2	Enrichment	RIGI	2.00
211	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.00
212	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.00
213	Dystonia 33	Enrichment	EIF2AK2	2.00
214	Immunodeficiency 65 viral infections	Enrichment	IRF9	2.00
215	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.00
216	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.00
217	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	2.00
218	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.00
219	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.00
220	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.00
221	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.00
222	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.00
223	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.00
224	Choroid plexus cancer	Enrichment	TP53	2.00
225	Immunodeficiency 19	Enrichment	CD3D	2.00
226	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.00
227	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	2.00
228	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	2.00
229	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.00
230	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.00
231	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	1.99
232	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	1.99
233	Paget disease of bone 3	Enrichment	SQSTM1	1.97
234	Polyglucosan body myopathy 1 with or without immunodeficiency	Enrichment	RBCK1	1.97
235	Radioulnar synostosis, nonsyndromic	Enrichment	SMAD6	1.97
236	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	1.97
237	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	1.97
238	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	1.97
239	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.97
240	Multiple congenital anomalies-neurodevelopmental syndrome, x-linked	Enrichment	OTUD5	1.97
241	Asthma-related traits 5	Enrichment	IRAK3	1.97
242	Immunodeficiency 115 with autoinflammation	Enrichment	RNF31	1.97
243	Mannose-binding lectin deficiency	Enrichment	MBL2	1.97
244	Colitis	Enrichment	SYK	1.97
245	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	1.97
246	Bullous pyoderma gangrenosum	Enrichment	PTPN6	1.97
247	Pustular pyoderma gangrenosum	Enrichment	PTPN6	1.97
248	Classic pyoderma gangrenosum	Enrichment	PTPN6	1.97
249	Gliosarcoma	Enrichment	NFKBIA, TP53	1.96
250	Oculoectodermal syndrome	Enrichment	KRAS	1.95
251	Pallister-killian syndrome	Enrichment	ARAF	1.95
252	Noonan syndrome 5	Enrichment	RAF1	1.95
253	Noonan syndrome 4	Enrichment	SOS1	1.95
254	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	1.95
255	Noonan syndrome 7	Enrichment	BRAF	1.95
256	Leopard syndrome 3	Enrichment	BRAF	1.95
257	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.95
258	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.95
259	Melanosis, neurocutaneous	Enrichment	NRAS	1.95
260	Noonan syndrome 9	Enrichment	SOS2	1.95
261	Noonan syndrome 6	Enrichment	NRAS	1.95
262	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	1.95
263	46,xy sex reversal 6	Enrichment	MAP3K1	1.95
264	Corpus callosum, agenesis of, with facial anomalies and robin sequence	Enrichment	DDX3X	1.95
265	Hypertriglyceridemia 2	Enrichment	CREB3L3	1.95
266	White-kernohan syndrome	Enrichment	DDB1	1.95
267	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	1.95
268	Intellectual developmental disorder, x-linked, syndromic, snijders blok type	Enrichment	DDX3X	1.95
269	Systemic lupus erythematosus 11	Enrichment	STAT4	1.95
270	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.95
271	Hypercholanemia, familial, 2	Enrichment	SLC10A1	1.95
272	Lymphangioma	Enrichment	BRAF	1.95
273	Camurati-engelmann disease 2	Enrichment	TGFB2	1.95
274	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	1.95
275	Phace association	Enrichment	BRAF	1.95
276	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.95
277	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.95
278	Leopard syndrome 2	Enrichment	RAF1	1.95
279	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	1.95
280	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.95
281	Loeys-dietz syndrome 5	Enrichment	TGFB3	1.95
282	Thrombocytopenia 6	Enrichment	SRC	1.95
283	Ddx3x-related neurodevelopmental disorder	Enrichment	DDX3X	1.95
284	Menke-hennekam syndrome 1	Enrichment	CREBBP	1.95
285	Trigonitis	Enrichment	RAF1	1.95
286	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.95
287	Heritable thoracic aortic disease	Enrichment	SMAD4	1.95
288	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	1.95
289	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	1.95
290	Congenital pulmonary airway malformation	Enrichment	KRAS	1.95
291	Syringocystadenoma papilliferum	Enrichment	BRAF	1.95
292	Menke-hennekam syndrome	Enrichment	CREBBP	1.95
293	Ganglioglioma	Enrichment	BRAF	1.95
294	Nongerminomatous germ cell tumor	Enrichment	BRAF	1.95
295	Phace syndrome	Enrichment	BRAF	1.95
296	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.95
297	Classic hairy cell leukemia	Enrichment	BRAF	1.95
298	Neurocutaneous melanocytosis	Enrichment	NRAS	1.95
299	X-linked intellectual disability-hypotonia-movement disorder syndrome	Enrichment	DDX3X	1.95
300	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	1.91
301	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	1.89
302	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.82
303	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.82
304	Keratosis, seborrheic	Enrichment	PIK3CA	1.82
305	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.82
306	Immunodeficiency 45	Enrichment	IFNAR2	1.82
307	Noonan syndrome 8	Enrichment	PIK3CA	1.82
308	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.82
309	Immunodeficiency 31c	Enrichment	STAT1	1.82
310	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.82
311	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.82
312	Immunodeficiency 127	Enrichment	TNF	1.82
313	Rela fusion-positive ependymoma	Enrichment	RELA	1.82
314	Senior-loken syndrome 7	Enrichment	AKT3	1.82
315	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.82
316	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	1.82
317	Leprosy 1	Enrichment	TLR6	1.82
318	Congenital dyserythropoietic anemia	Enrichment	IRAK4	1.82
319	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.82
320	Immune system disease	Enrichment	PIK3CD	1.82
321	Bardet-biedl syndrome 16	Enrichment	AKT3	1.82
322	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.82
323	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.82
324	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.82
325	Common variable immunodeficiency 12	Enrichment	NFKB1	1.82
326	Tafro syndrome	Enrichment	MAP2K2	1.82
327	Oculootodental syndrome	Enrichment	FADD	1.82
328	Heart, malformation of	Enrichment	MAPK1, SMAD6	1.81
329	Thrombocytopenia	Enrichment	CYCS, SMAD4, SRC	1.79
330	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.70
331	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	1.70
332	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	1.70
333	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	EIF2AK4	1.70
334	Cervical cancer	Enrichment	TP53	1.70
335	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.70
336	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	1.70
337	Pulmonary venoocclusive disease 2, autosomal recessive	Enrichment	EIF2AK4	1.70
338	Lymphoma, hodgkin, classic	Enrichment	TP53	1.70
339	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.70
340	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	1.70
341	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.70
342	Aicardi-goutieres syndrome 6	Enrichment	ADAR	1.70
343	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.70
344	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	1.70
345	Pulmonary venoocclusive disease 1	Enrichment	EIF2AK4	1.70
346	Pulmonary venoocclusive disease 2	Enrichment	EIF2AK4	1.70
347	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.70
348	Leukodystrophy, hypomyelinating, 17	Enrichment	EIF2AK1	1.70
349	Congenital fibrosarcoma	Enrichment	TP53	1.70
350	Li-fraumeni syndrome 1	Enrichment	TP53	1.70
351	Sarcoma	Enrichment	TP53	1.70
352	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.70
353	Immunodeficiency 17	Enrichment	CD3G	1.70
354	Cervix carcinoma	Enrichment	TP53	1.70
355	Hodgkin's lymphoma	Enrichment	TP53	1.70
356	Lymphomatoid papulosis	Enrichment	TYK2	1.70
357	Basal ganglia disease	Enrichment	IFIH1	1.70
358	Pulmonary venoocclusive disease	Enrichment	EIF2AK4	1.70
359	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	1.70
360	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.70
361	Laron syndrome with immunodeficiency	Enrichment	STAT5B	1.70
362	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	1.70
363	Cylindromatosis, familial	Enrichment	CYLD	1.67
364	Gordon holmes syndrome	Enrichment	RNF216	1.67
365	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	1.67
366	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.67
367	Welander distal myopathy	Enrichment	SQSTM1	1.67
368	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	1.67
369	Agammaglobulinemia, x-linked	Enrichment	BTK	1.67
370	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	1.67
371	Brooke-spiegler syndrome	Enrichment	CYLD	1.67
372	Aortic valve disease 2	Enrichment	SMAD6	1.67
373	Paget's disease of bone	Enrichment	SQSTM1	1.67
374	Hao-fountain syndrome	Enrichment	USP7	1.67
375	Craniosynostosis 7	Enrichment	SMAD6	1.67
376	Radioulnar synostosis	Enrichment	SMAD6	1.67
377	Arthritis	Enrichment	SYK	1.67
378	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	1.67
379	Burkitt lymphoma	Enrichment	MYC	1.65
380	Fibromatosis, gingival, 1	Enrichment	SOS1	1.65
381	Myhre syndrome	Enrichment	SMAD4	1.65
382	Camurati-engelmann disease 1	Enrichment	TGFB1	1.65
383	Costello syndrome	Enrichment	HRAS	1.65
384	Thumb deformity	Enrichment	CREBBP	1.65
385	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	1.65
386	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.65
387	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.65
388	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.65
389	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	1.65
390	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.65
391	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	1.65
392	Thrombocythemia 3	Enrichment	JAK2	1.65
393	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.65
394	Menke-hennekam syndrome 2	Enrichment	EP300	1.65
395	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.65
396	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.65
397	Camurati-engelmann disease	Enrichment	TGFB1	1.65
398	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.65
399	Polycythemia	Enrichment	JAK2	1.65
400	Metaphyseal anadysplasia	Enrichment	MMP9	1.65
401	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.65
402	Transient infantile hypertriglyceridemia and hepatosteatosis	Enrichment	CREB3L3	1.65
403	Hypereosinophilic syndrome	Enrichment	JAK2	1.65
404	Xeroderma pigmentosum group e	Enrichment	DDB2	1.65
405	Wooly hair nevus	Enrichment	HRAS	1.65
406	Pelvic organ prolapse	Enrichment	TAB2	1.65
407	Takayasu arteritis	Enrichment	IL12B	1.65
408	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.65
409	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.65
410	Psoriatic arthritis	Enrichment	TNF	1.65
411	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.65
412	Migraine without aura	Enrichment	TNF	1.65
413	Keratoacanthoma	Enrichment	PIK3CA	1.65
414	Ovarian cancer	Enrichment	AKT1, KRAS, MAP3K1, PIK3CA	1.58
415	Precursor t-cell acute lymphoblastic leukemia	Enrichment	DDX3X, MYC	1.57
416	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.53
417	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.53
418	Prognathism, mandibular	Enrichment	CSNK2B	1.53
419	Mycosis fungoides	Enrichment	CD28	1.53
420	Pelizaeus-merzbacher disease	Enrichment	RAB9B	1.53
421	Menkes disease	Enrichment	EIF2AK3	1.53
422	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.53
423	Spastic paraplegia 2, x-linked	Enrichment	RAB9B	1.53
424	Osteogenic sarcoma	Enrichment	TP53	1.53
425	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.53
426	Hyper ige syndrome	Enrichment	STAT3	1.53
427	Dedifferentiated liposarcoma	Enrichment	CDK4	1.53
428	Torsion dystonia 1	Enrichment	EIF2AK2	1.53
429	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.53
430	Anaplastic astrocytoma	Enrichment	TP53	1.53
431	Squamous cell carcinoma	Enrichment	TP53	1.53
432	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.53
433	Adenocarcinoma	Enrichment	TP53	1.53
434	Bone osteosarcoma	Enrichment	TP53	1.53
435	Respiratory failure	Enrichment	TP73	1.53
436	Pelizeaus-merzbacher spectrum disorder	Enrichment	RAB9B	1.53
437	Well-differentiated liposarcoma	Enrichment	CDK4	1.53
438	Genetic atypical hemolytic-uremic syndrome	Enrichment	CD46	1.53
439	Vogt-koyanagi-harada disease	Enrichment	FAS	1.53
440	Saczary syndrome	Enrichment	CD28	1.53
441	Kaposi sarcoma	Enrichment	IL6	1.52
442	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.52
443	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.52
444	Congenital generalized lipodystrophy	Enrichment	FOS	1.52
445	Hepatitis b	Enrichment	IFNAR2	1.52
446	Cerebrovascular disease	Enrichment	PIK3CA	1.52
447	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.52
448	Cerebral malaria	Enrichment	TNF	1.52
449	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.52
450	Pancreatic cancer	Enrichment	KRAS, SMAD4	1.51
451	Glycogen storage disease iv	Enrichment	RBCK1	1.50
452	Immune thrombocytopenia	Enrichment	SOCS1	1.50
453	Neurodegeneration with brain iron accumulation 5	Enrichment	OTUD5	1.50
454	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.50
455	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.50
456	Folate malabsorption, hereditary	Enrichment	SARM1	1.50
457	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.50
458	Agammaglobulinemia 1	Enrichment	BTK	1.50
459	Bacteremia 2	Enrichment	CISH	1.50
460	Intellectual developmental disorder, autosomal dominant 30, with speech delay and behavioral abnormalities	Enrichment	ZMYND11	1.50
461	Ataxia-telangiectasia	Enrichment	BRAF	1.48
462	Juvenile polyposis syndrome	Enrichment	SMAD4	1.48
463	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	1.48
464	Polycythemia vera	Enrichment	JAK2	1.48
465	Nuchal bleb, familial	Enrichment	SOS1	1.48
466	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.48
467	Charcot-marie-tooth disease type 1	Enrichment	EGR2	1.48
468	Spermatocytoma	Enrichment	HRAS	1.48
469	Melanoma of soft tissue	Enrichment	CREB1	1.48
470	Prostate cancer	Enrichment	PIK3CA, TP53	1.47
471	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.43
472	Capillary malformations, congenital	Enrichment	PIK3CA	1.43
473	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.43
474	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.43
475	Histiocytoid hemangioma	Enrichment	FOS	1.43
476	Vascular dementia	Enrichment	TNF	1.43
477	Diffuse cutaneous systemic sclerosis	Enrichment	IRF5	1.43
478	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.40
479	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.40
480	Mantle cell lymphoma	Enrichment	CCND1	1.40
481	Enophthalmos	Enrichment	CSNK2B	1.40
482	Syndactyly	Enrichment	CSNK2B	1.40
483	Lung sarcomatoid carcinoma	Enrichment	TP53	1.40
484	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.40
485	Hellp syndrome	Enrichment	CD46	1.40
486	Adenosine deaminase deficiency	Enrichment	JAK3	1.40
487	Primary hyperparathyroidism	Enrichment	CDKN1B	1.40
488	Thrombotic microangiopathy	Enrichment	CD46	1.40
489	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	1.40
490	Type 2 diabetes mellitus	Enrichment	AKT2, IL6	1.39
491	Severe covid-19	Enrichment	CASP10, JAK3	1.39
492	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.38
493	Tuberculosis	Enrichment	CISH	1.38
494	Paget's disease of bone 2	Enrichment	SQSTM1	1.38
495	Erythrocytosis, familial, 1	Enrichment	JAK2	1.36
496	Hypertriglyceridemia 1	Enrichment	CREB3L3	1.36
497	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.36
498	Budd-chiari syndrome	Enrichment	JAK2	1.36
499	Hereditary ataxia	Enrichment	PRKCG	1.36
500	Craniopharyngioma	Enrichment	BRAF	1.36
501	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.36
502	Pilocytic astrocytoma	Enrichment	KRAS	1.36
503	Newborn respiratory distress syndrome	Enrichment	BRAF	1.36
504	Epidermolytic nevus	Enrichment	HRAS	1.36
505	Gingival fibromatosis	Enrichment	SOS1	1.36
506	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.36
507	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.35
508	Cowden syndrome 1	Enrichment	PIK3CA	1.35
509	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.35
510	Type 1 diabetes mellitus	Enrichment	IL6	1.35
511	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.35
512	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.35
513	Limited scleroderma	Enrichment	IRF5	1.35
514	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.35
515	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.33
516	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.31
517	Von hippel-lindau syndrome	Enrichment	CCND1	1.31
518	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.31
519	Rhabdomyosarcoma 2	Enrichment	TP53	1.31
520	Follicular lymphoma	Enrichment	BCL2	1.31
521	Spastic diplegia	Enrichment	IFIH1	1.31
522	Lymphoma	Enrichment	TP53	1.31
523	Acute megakaryocytic leukemia	Enrichment	TP53	1.31
524	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.31
525	Motor neuron disease	Enrichment	TBK1	1.28
526	Megacolon	Enrichment	AKT3	1.28
527	Overgrowth syndrome	Enrichment	PIK3R1	1.28
528	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.26
529	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.26
530	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.26
531	Myeloproliferative neoplasm	Enrichment	JAK2	1.26
532	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.26
533	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.26
534	Li-fraumeni syndrome	Enrichment	TP53	1.23
535	Adrenocortical carcinoma	Enrichment	TP53	1.23
536	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	CD46	1.23
537	Lennox-gastaut syndrome	Enrichment	MAPK10	1.23
538	Dilated cardiomyopathy	Enrichment	BRAF, RAF1, TAB2	1.22
539	Atrial septal defect 1	Enrichment	TGFB2	1.19
540	Wilms tumor 5	Enrichment	BRAF	1.19
541	Hypertrichosis	Enrichment	CREBBP	1.19
542	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.19
543	Familial hypercholanemia	Enrichment	SLC10A1	1.19
544	Inflammatory bowel disease 1	Enrichment	IL6	1.18
545	Coronary heart disease 5	Enrichment	IKBKG	1.18
546	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.18
547	Progressive non-fluent aphasia	Enrichment	TBK1	1.18
548	Esophageal cancer	Enrichment	TP53	1.17
549	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.17
550	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.17
551	Essential thrombocythemia	Enrichment	TP53	1.17
552	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.17
553	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.13
554	Polymicrogyria	Enrichment	AKT3	1.13
555	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.12
556	Glioma susceptibility 1	Enrichment	TP53	1.11
557	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.11
558	Migraine with or without aura 1	Enrichment	TAB2	1.09
559	Asthma	Enrichment	TNF	1.09
560	Specific learning disability	Enrichment	MAPK1	1.09
561	Immunodeficiency 47	Enrichment	ATP6AP1	1.07
562	Primary hyperaldosteronism	Enrichment	TP53	1.06
563	Polydactyly	Enrichment	SMAD6	1.04
564	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.04
565	Alzheimer's disease	Enrichment	TNF	1.03
566	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.02
567	Charge syndrome	Enrichment	EP300	1.02
568	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.02
569	Ventricular septal defect	Enrichment	BRAF	1.02
570	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.02
571	Omenn syndrome	Enrichment	IL2RG	1.02
572	Familial colorectal cancer	Enrichment	TP53	1.02
573	Myelodysplastic syndrome	Enrichment	TP53	0.98
574	Combined immunodeficiency	Enrichment	IL2RG	0.98
575	Ichthyosis	Enrichment	IL2RB	0.98
576	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	0.98
577	Heritable pulmonary arterial hypertension	Enrichment	EIF2AK4	0.98
578	Combined t and b cell immunodeficiency	Enrichment	IL2RG	0.98
579	Melanoma	Enrichment	BRAF	0.97
580	Pectus excavatum	Enrichment	TGFBR1	0.94
581	Xeroderma pigmentosum, variant type	Enrichment	DDB2	0.94
582	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	0.94
583	Pulmonary hypertension, primary, 1	Enrichment	EIF2AK4	0.91
584	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.90
585	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.90
586	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1, TBK1	0.89
587	Patent foramen ovale	Enrichment	TAB2	0.89
588	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	0.87
589	Protein-deficiency anemia	Enrichment	NRAS	0.87
590	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	RNF216	0.85
591	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD6	0.85
592	Atypical hemolytic-uremic syndrome	Enrichment	CD46	0.85
593	Osteoporosis	Enrichment	SRC	0.84
594	Heart disease	Enrichment	CREBBP	0.84
595	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.84
596	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, TP53	0.83
597	Endometrial cancer	Enrichment	PIK3CA	0.83
598	Rhabdomyosarcoma	Enrichment	TP53	0.83
599	Polydactyly, postaxial, type a1	Enrichment	EP300	0.81
600	Wilms tumor 1	Enrichment	BRAF	0.81
601	Corpus callosum, agenesis of	Enrichment	CREBBP	0.81
602	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	0.81
603	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.81
604	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.81
605	Melanoma, cutaneous malignant 1	Enrichment	CDK4	0.80
606	Microcephaly	Enrichment	DDX3X, EP300, MAPK1	0.80
607	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DDX3X	0.78
608	Interstitial lung disease 2	Enrichment	SFTPA2	0.78
609	Dandy-walker syndrome	Enrichment	BRAF	0.76
610	Charcot-marie-tooth disease type 4	Enrichment	EGR2	0.74
611	Hepatoblastoma	Enrichment	TP53	0.72
612	Leukodystrophy	Enrichment	RNF216	0.71
613	Craniosynostosis	Enrichment	SMAD6	0.71
614	Diamond-blackfan anemia 1	Enrichment	TP53	0.68
615	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.68
616	Brittle bone disorder	Enrichment	CREB3L1	0.64
617	Auditory neuropathy	Enrichment	RAB9B	0.64
618	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.63
619	Scoliosis	Enrichment	CREBBP	0.63
620	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.60
621	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.56
622	Cystic fibrosis	Enrichment	MBL2	0.54
623	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B	0.52
624	Diamond-blackfan anemia	Enrichment	TP53	0.52
625	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.51
626	Left ventricular noncompaction	Enrichment	RAF1	0.49
627	Hypertelorism	Enrichment	PIK3CA	0.48
628	Non-syndromic x-linked intellectual disability	Enrichment	ATP6AP1	0.48
629	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.46
630	Hereditary spastic paraplegia	Enrichment	RAB9B	0.46
631	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	0.40
632	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.35
633	Primary ovarian insufficiency	Enrichment	JAK2	0.32
634	Autism	Enrichment	CREBBP	0.26
635	Congenital nervous system abnormality	Enrichment	CREBBP	0.16
636	Nervous system disease	Enrichment	CREBBP	0.16
637	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Toll-like receptor signaling pathway

Pathway Network for Toll-like receptor signaling pathway

Pathway network for the Toll-like receptor signaling pathway SuperPath

Member Pathways for Toll-like receptor signaling pathway

Pathways in the Toll-like receptor signaling pathway SuperPath

Gene overlap in member pathways for Toll-like receptor signaling pathway SuperPath

Associated Genes for Toll-like receptor signaling pathway

Associated Disorders for Toll-like receptor signaling pathway

Disorders associated with Toll-like receptor signaling pathway SuperPath

STRING Interaction Network for Toll-like receptor signaling pathway

Sources for Toll-like receptor signaling pathway