Toll-Like receptor Signaling Pathways

Pathway network for the Toll-Like receptor Signaling Pathways SuperPath

Sources:

R&D Systems
QIAGEN
WikiPathways

Pathways in the Toll-Like receptor Signaling Pathways SuperPath

#	Name	Source	Genes
1	Toll-Like receptor Signaling Pathways	R&D Systems	CD14 CD36 CHUK CXCL8 FOS FOSB FOSL1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA7 IFNA8 IFNB1 IFNK IFNL1 IFNL2 IFNL3 IFNW1 IKBKB IKBKE IKBKG IL18 IL1B IL6 IRAK1 IRAK2 IRAK4 IRF3 IRF7 JUN JUNB JUND LY96 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB RIPK1 TAB1 TAB2 TANK TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF TRAF3 TRAF6 (see all 81) (see less)
2	NOD-like Receptor Signaling Pathways	R&D Systems	ATF2 BIRC2 BIRC3 CARD9 CASP1 CASP5 CHUK CXCL8 FOS FOSB FOSL1 FOSL2 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA7 IFNA8 IFNB1 IFNK IFNW1 IKBKB IKBKE IKBKG IL18 IL1B IL6 IRF3 IRF7 JUN JUNB JUND MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 NAIP NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NLRC3 NLRC4 NLRP1 NLRP12 NLRP3 NLRP7 NLRX1 NOD1 NOD2 P2RX7 PANX1 PYCARD REL RELA RELB RIPK2 TAB1 TAB2 TAB3 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF (see all 88) (see less)
3	Toll-Like Receptors Pathway	QIAGEN	ATF2 ATF4 BTK CD14 CHUK CREB1 CREB3 CREB3L4 ECSIT IKBKB IKBKE IKBKG IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 IRF8 JUN LBP LY96 MAP2K3 MAP2K6 MAP2K7 MAP3K3 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RAC1 RIPK1 RIPK2 RIPK3 RNF216 SIGIRR TAB1 TAB2 TANK TBK1 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMED7 TOLLIP TRAF6 UBE2N UBE2V1 (see all 71) (see less)
4	Inflammasome Activation Pathways	R&D Systems	CASP1 CHUK FOS FOSB FOSL1 IKBKB IKBKE IKBKG IL18 IL1B IL1R1 IL1RAP JUN JUNB JUND MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NLRP3 P2RX7 PANX1 PYCARD REL RELA RELB TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 (see all 52) (see less)
5	TLR4 signaling and tolerance	WikiPathways	IFNB1 IL6 IRAK1 IRAK4 IRF3 IRF7 MYD88 NFKB1 TAB1 TAB2 TBK1 TIRAP TLR4 TRAF3 TRAF6 TRAM1 (see all 16) (see less)
6	Nanomaterial-induced inflammasome activation	WikiPathways	IL1B PYCARD TLR4

Gene overlap in member pathways for Toll-Like receptor Signaling Pathways SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TLR4	Toll Like Receptor 4	Protein Coding	6
2	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	5
3	TLR1	Toll Like Receptor 1	Protein Coding	4
4	TLR2	Toll Like Receptor 2	Protein Coding	4
5	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	4
6	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	4
7	TLR6	Toll Like Receptor 6	Protein Coding	4
8	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	4
9	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	4
10	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
11	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
12	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	4
13	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	4
14	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	4
15	NFKBIB	NFKB Inhibitor Beta	Protein Coding	4
16	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	4
17	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	4
18	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	4
19	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	4
20	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	4
21	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	4
22	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	4
23	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	4
24	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	4
25	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	4
26	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	4
27	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
28	IL1B	Interleukin 1 Beta	Protein Coding	4
29	TLR3	Toll Like Receptor 3	Protein Coding	4
30	IRF3	Interferon Regulatory Factor 3	Protein Coding	4
31	IRF7	Interferon Regulatory Factor 7	Protein Coding	4
32	TLR5	Toll Like Receptor 5	Protein Coding	4
33	TLR7	Toll Like Receptor 7	Protein Coding	4
34	TLR8	Toll Like Receptor 8	Protein Coding	4
35	TLR9	Toll Like Receptor 9	Protein Coding	4
36	TLR10	Toll Like Receptor 10	Protein Coding	4
37	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	3
38	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	3
39	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
40	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	3
41	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
42	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
43	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	3
44	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3
45	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
46	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
47	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
48	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
49	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
50	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	3
51	IL6	Interleukin 6	Protein Coding	3
52	IL18	Interleukin 18	Protein Coding	3
53	TBK1	TANK Binding Kinase 1	Protein Coding	3
54	IFNB1	Interferon Beta 1	Protein Coding	3
55	PYCARD	PYD And CARD Domain Containing	Protein Coding	3
56	CD14	CD14 Molecule	Protein Coding	2
57	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	2
58	TNF	Tumor Necrosis Factor	Protein Coding	2
59	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	2
60	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	2
61	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	2
62	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	2
63	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	2
64	LY96	Lymphocyte Antigen 96	Protein Coding	2
65	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	2
66	IFNA1	Interferon Alpha 1	Protein Coding	2
67	IFNA2	Interferon Alpha 2	Protein Coding	2
68	IFNA4	Interferon Alpha 4	Protein Coding	2
69	IFNA8	Interferon Alpha 8	Protein Coding	2
70	IFNA10	Interferon Alpha 10	Protein Coding	2
71	IFNA21	Interferon Alpha 21	Protein Coding	2
72	IFNA14	Interferon Alpha 14	Protein Coding	2
73	IFNA16	Interferon Alpha 16	Protein Coding	2
74	IFNA7	Interferon Alpha 7	Protein Coding	2
75	IFNK	Interferon Kappa	Protein Coding	2
76	IFNA17	Interferon Alpha 17	Protein Coding	2
77	IFNA13	Interferon Alpha 13	Protein Coding	2
78	IFNW1	Interferon Omega 1	Protein Coding	2
79	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
80	ATF2	Activating Transcription Factor 2	Protein Coding	2
81	P2RX7	Purinergic Receptor P2X 7	Protein Coding	2
82	PANX1	Pannexin 1	Protein Coding	2
83	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	2
84	CASP1	Caspase 1	Protein Coding	2
85	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
86	IFNL2	Interferon Lambda 2	Protein Coding	1
87	IFNL3	Interferon Lambda 3	Protein Coding	1
88	IFNL1	Interferon Lambda 1	Protein Coding	1
89	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	1
90	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
91	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
92	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	1
93	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	1
94	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	1
95	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
96	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
97	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
98	IFNA5	Interferon Alpha 5	Protein Coding	1
99	NLRC3	NLR Family CARD Domain Containing 3	Protein Coding	1
100	NLRX1	NLR Family Member X1	Protein Coding	1
101	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	1
102	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	1
103	NLRP7	NLR Family Pyrin Domain Containing 7	Protein Coding	1
104	NLRP12	NLR Family Pyrin Domain Containing 12	Protein Coding	1
105	CASP5	Caspase 5	Protein Coding	1
106	NAIP	NLR Family Apoptosis Inhibitory Protein	Protein Coding	1
107	ATF4	Activating Transcription Factor 4	Protein Coding	1
108	BTK	Bruton Tyrosine Kinase	Protein Coding	1
109	TMED7	Transmembrane P24 Trafficking Protein 7	Protein Coding	1
110	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
111	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
112	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
113	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
114	IL1RL1	Interleukin 1 Receptor Like 1	Protein Coding	1
115	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	1
116	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
117	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
118	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
119	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
120	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
121	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
122	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
123	RAC1	Rac Family Small GTPase 1	Protein Coding	1
124	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
125	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	1
126	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
127	TOLLIP	Toll Interacting Protein	Protein Coding	1
128	RNF216	Ring Finger Protein 216	Protein Coding	1
129	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
130	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1
131	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
132	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	1
133	TRAM1	Translocation Associated Membrane Protein 1	Protein Coding	1

Disorders associated with Toll-Like receptor Signaling Pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multisystem inflammatory syndrome in children	Enrichment	IFNA21, IFNA4, IFNB1, IRF3, TLR3, TLR6, TRAF3	10.26
2	Herpes simplex virus encephalitis	Enrichment	TBK1, TICAM1, TLR3, TRAF3	8.23
3	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	5.88
4	Malaria	Enrichment	CD36, IKBKG, TIRAP, TNF	5.02
5	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.84
6	Autoinflammatory disease	Enrichment	NLRC4, NLRP12, NLRP3, NOD2	4.80
7	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.57
8	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.84
9	Cerebral malaria	Enrichment	CD36, TNF	3.68
10	Macular degeneration, age-related, 10	Enrichment	TLR4	3.66
11	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.52
12	Immunodeficiency 68	Enrichment	MYD88	2.93
13	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.93
14	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.93
15	Bacteremia 1	Enrichment	TIRAP	2.93
16	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.93
17	Immunodeficiency 132a	Enrichment	TRAF3	2.93
18	Immunodeficiency 132b	Enrichment	TRAF3	2.93
19	Immunodeficiency 39	Enrichment	IRF7	2.93
20	Immunodeficiency 67	Enrichment	IRAK4	2.93
21	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.93
22	Corticobasal syndrome	Enrichment	TBK1	2.93
23	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.93
24	Waldenstram macroglobulinemia	Enrichment	MYD88	2.93
25	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.93
26	Inflammatory bowel disease 1	Enrichment	IL6, NOD2	2.84
27	Systemic lupus erythematosus	Enrichment	IRAK1, TLR7, TNF	2.79
28	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.63
29	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.63
30	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.63
31	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.63
32	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.63
33	Common variable immunodeficiency 12	Enrichment	NFKB1	2.63
34	Pelvic organ prolapse	Enrichment	TAB2	2.45
35	Leprosy 3	Enrichment	TLR2	2.42
36	Incontinentia pigmenti	Enrichment	IKBKG	2.42
37	Legionnaire disease	Enrichment	TLR5	2.42
38	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.42
39	Cinca syndrome	Enrichment	NLRP3	2.42
40	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.42
41	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.42
42	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.42
43	Leprosy 5	Enrichment	TLR1	2.42
44	Fetal encasement syndrome	Enrichment	CHUK	2.42
45	Muckle-wells syndrome	Enrichment	NLRP3	2.42
46	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.42
47	Immunodeficiency 15b	Enrichment	IKBKB	2.42
48	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.42
49	Immunodeficiency 15a	Enrichment	IKBKB	2.42
50	Immunodeficiency 92	Enrichment	REL	2.42
51	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.42
52	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.42
53	Systemic lupus erythematosus 1	Enrichment	TLR5	2.42
54	X-linked immunodeficiency 74	Enrichment	TLR7	2.42
55	Systemic lupus erythematosus 17	Enrichment	TLR7	2.42
56	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.42
57	Melioidosis	Enrichment	TLR5	2.42
58	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.42
59	Immunodeficiency 53	Enrichment	RELB	2.42
60	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.42
61	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.42
62	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.42
63	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.42
64	Behcet syndrome	Enrichment	TLR4	2.38
65	Diffuse large b-cell lymphoma	Enrichment	BTK, MYD88	2.36
66	Kaposi sarcoma	Enrichment	IL6	2.33
67	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.33
68	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.33
69	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.28
70	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.28
71	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.28
72	Immunodeficiency 32a	Enrichment	IRF8	2.28
73	Short syndrome	Enrichment	PIK3R1	2.28
74	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.28
75	Asthma-related traits 5	Enrichment	IRAK3	2.28
76	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.28
77	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.28
78	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.28
79	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.28
80	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.28
81	Verrucous hemangioma	Enrichment	MAP3K3	2.28
82	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.23
83	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.23
84	Coronary heart disease 7	Enrichment	CD36	2.22
85	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.22
86	Immunodeficiency 103 fungal infections	Enrichment	CARD9	2.19
87	Vitiligo-associated multiple autoimmune disease susceptibility 1	Enrichment	NLRP1	2.19
88	Blau syndrome	Enrichment	NOD2	2.19
89	Noonan syndrome 13	Enrichment	MAPK1	2.19
90	Respiratory papillomatosis, juvenile recurrent, congenital	Enrichment	NLRP1	2.19
91	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	2.19
92	Familial cold autoinflammatory syndrome 2	Enrichment	NLRP12	2.19
93	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	2.19
94	Palmoplantar carcinoma, multiple self-healing	Enrichment	NLRP1	2.19
95	Autoinflammation with arthritis and dyskeratosis	Enrichment	NLRP1	2.19
96	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.19
97	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	2.19
98	Recurrent hydatidiform mole	Enrichment	NLRP7	2.19
99	Arteriovenous malformations of the brain	Enrichment	IL6, NLRP3	2.18
100	Type 1 diabetes mellitus	Enrichment	IL6	2.15
101	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.12
102	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.12
103	Oocyte/zygote/embryo maturation arrest 7	Enrichment	PANX1	2.12
104	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.12
105	Rela fusion-positive ependymoma	Enrichment	RELA	2.12
106	Leprosy 1	Enrichment	TLR6	2.12
107	Pericardial effusion	Enrichment	NLRP3	2.12
108	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.12
109	Motor neuron disease	Enrichment	TBK1	2.08
110	Gastric cancer	Enrichment	IL1B	2.02
111	Gordon holmes syndrome	Enrichment	RNF216	1.98
112	Immunodeficiency 32b	Enrichment	IRF8	1.98
113	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.98
114	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.98
115	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.98
116	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.98
117	Agammaglobulinemia, x-linked	Enrichment	BTK	1.98
118	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.98
119	Progressive non-fluent aphasia	Enrichment	TBK1	1.98
120	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.94
121	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.94
122	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.93
123	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.93
124	Immunodeficiency 127	Enrichment	TNF	1.92
125	Migraine with or without aura 1	Enrichment	TAB2	1.89
126	Yao syndrome	Enrichment	NOD2	1.89
127	Crohn's disease	Enrichment	NOD2	1.89
128	Partial hydatidiform mole	Enrichment	NLRP7	1.89
129	Aortic valve disease 1	Enrichment	TAB2	1.82
130	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.82
131	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.82
132	Congenital generalized lipodystrophy	Enrichment	FOS	1.82
133	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.82
134	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.81
135	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.81
136	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.81
137	Agammaglobulinemia 1	Enrichment	BTK	1.81
138	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.81
139	Immunodeficiency 14	Enrichment	PIK3R1	1.81
140	Melanoma of soft tissue	Enrichment	CREB1	1.81
141	Psoriatic arthritis	Enrichment	TNF	1.75
142	Hepatitis c virus	Enrichment	IFNL3	1.75
143	Migraine without aura	Enrichment	TNF	1.75
144	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.72
145	Female infertility due to oocyte meiotic arrest	Enrichment	PANX1	1.72
146	Spinal muscular atrophy, type iii	Enrichment	NAIP	1.71
147	Spinal muscular atrophy, type i	Enrichment	NAIP	1.71
148	Spinal muscular atrophy, type ii	Enrichment	NAIP	1.71
149	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.68
150	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.68
151	Patent foramen ovale	Enrichment	TAB2	1.68
152	Blood platelet disease	Enrichment	CD36	1.63
153	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.59
154	Vascular dementia	Enrichment	TNF	1.53
155	Lennox-gastaut syndrome	Enrichment	MAPK10	1.52
156	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.51
157	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.51
158	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.49
159	Hydatidiform mole, recurrent, 1	Enrichment	NLRP7	1.49
160	Rheumatoid arthritis	Enrichment	TLR1	1.47
161	Coronary heart disease 5	Enrichment	IKBKG	1.47
162	Overgrowth syndrome	Enrichment	PIK3R1	1.44
163	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.42
164	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.34
165	Type 2 diabetes mellitus	Enrichment	IL6	1.31
166	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.29
167	Immune deficiency disease	Enrichment	RIPK1	1.25
168	Gliosarcoma	Enrichment	NFKBIA	1.22
169	Giant cell glioblastoma	Enrichment	NFKBIA	1.20
170	Asthma	Enrichment	TNF	1.20
171	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	1.18
172	Human immunodeficiency virus type 1	Enrichment	TLR3	1.17
173	Specific learning disability	Enrichment	MAPK1	1.16
174	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	RNF216	1.15
175	Alzheimer's disease	Enrichment	TNF	1.13
176	Colorectal cancer	Enrichment	PIK3R1, TLR2	1.12
177	Dilated cardiomyopathy	Enrichment	TAB2	1.04
178	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	1.02
179	Leukodystrophy	Enrichment	RNF216	1.00
180	Heart, malformation of	Enrichment	MAPK1	0.96
181	Severe combined immunodeficiency	Enrichment	IKBKB	0.92
182	Breast cancer	Enrichment	JUN	0.60
183	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.60
184	Myeloma, multiple	Enrichment	PIK3R2	0.59
185	Microcephaly	Enrichment	MAPK1	0.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Toll-Like receptor Signaling Pathways

Pathway Network for Toll-Like receptor Signaling Pathways

Pathway network for the Toll-Like receptor Signaling Pathways SuperPath

Member Pathways for Toll-Like receptor Signaling Pathways

Pathways in the Toll-Like receptor Signaling Pathways SuperPath

Gene overlap in member pathways for Toll-Like receptor Signaling Pathways SuperPath

Associated Genes for Toll-Like receptor Signaling Pathways

Associated Disorders for Toll-Like receptor Signaling Pathways

Disorders associated with Toll-Like receptor Signaling Pathways SuperPath

STRING Interaction Network for Toll-Like receptor Signaling Pathways

Sources for Toll-Like receptor Signaling Pathways