Toll Comparative Pathway

Pathway network for the Toll Comparative Pathway SuperPath

Sources:

QIAGEN
GeneGo (Thomson Reuters)

Pathways in the Toll Comparative Pathway SuperPath

#	Name	Source	Genes
1	Toll Comparative Pathway	QIAGEN	CD14 CHUK ECSIT IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 LY96 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE TAB2 TIRAP TLR4 TRAF6 (see all 28) (see less)
2	IL-1 Pathway	QIAGEN	ADCY1 ADCY2 ADCY3 CHUK ECSIT GNA11 GNA12 GNA13 GNA14 GNA15 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 GPR119 IKBKB IKBKE IKBKG IL1A IL1B IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 JUN MAP2K3 MAP2K4 MAP2K6 MAP3K14 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE P2RY13 TAB1 TOLLIP TRAF6 (see all 53) (see less)
3	iNOS Signaling	QIAGEN	ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF7 CALM1 CALM2 CALM3 CD14 CHUK ELAVL1 FOS FOSB FOSL1 FOSL2 HMGA1 IFNG IFNGR1 IFNGR2 IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 IRF1 JAK1 JAK2 JAK3 JUN JUNB JUND LBP MAPK11 MAPK12 MAPK13 MAPK14 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE NOS2 STAT1 TAB1 TLR4 TRAF6 (see all 50) (see less)
4	Immune response MIF in innate immunity response	GeneGo (Thomson Reuters)	CD14 CEBPB CHUK CXCL8 ECSIT EP300 IFNG IKBKB IL1B IL6 IRAK1 IRAK2 IRAK4 JUN LBP LY96 MAP2K4 MAP3K1 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MIF MYD88 NFKB1 NFKBIA NFKBIB NFKBIE NOS2 PTGS2 RELA SPI1 TAB1 TAB2 TLR4 TNF TP53 TRAF6 (see all 42) (see less)
5	TLR-TRIF Pathway	QIAGEN	IRAK1 IRAK2 IRAK3 IRAK4 IRF3 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE TIRAP TLR3 TLR4 TRAF6 (see all 24) (see less)

Gene overlap in member pathways for Toll Comparative Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	5
2	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	5
3	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	5
4	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	5
5	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	5
6	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	5
7	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	5
8	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	5
9	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	5
10	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	5
11	NFKBIB	NFKB Inhibitor Beta	Protein Coding	5
12	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	5
13	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	5
14	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
15	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
16	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	4
17	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	4
18	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	4
19	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	4
20	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	4
21	TLR4	Toll Like Receptor 4	Protein Coding	4
22	CD14	CD14 Molecule	Protein Coding	3
23	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
24	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
25	ECSIT	ECSIT Signaling Integrator	Protein Coding	3
26	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
27	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	3
28	LY96	Lymphocyte Antigen 96	Protein Coding	2
29	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
30	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	2
31	IL1B	Interleukin 1 Beta	Protein Coding	2
32	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
33	IFNG	Interferon Gamma	Protein Coding	2
34	LBP	Lipopolysaccharide Binding Protein	Protein Coding	2
35	NOS2	Nitric Oxide Synthase 2	Protein Coding	2
36	ADCY1	Adenylate Cyclase 1	Protein Coding	1
37	ADCY2	Adenylate Cyclase 2	Protein Coding	1
38	ADCY3	Adenylate Cyclase 3	Protein Coding	1
39	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
40	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
41	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
42	GNA14	G Protein Subunit Alpha 14	Protein Coding	1
43	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
44	GNAS	GNAS Complex Locus	Protein Coding	1
45	GNB1	G Protein Subunit Beta 1	Protein Coding	1
46	GNB2	G Protein Subunit Beta 2	Protein Coding	1
47	GNB3	G Protein Subunit Beta 3	Protein Coding	1
48	GNB4	G Protein Subunit Beta 4	Protein Coding	1
49	GNB5	G Protein Subunit Beta 5	Protein Coding	1
50	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
51	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
52	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
53	GPR119	G Protein-Coupled Receptor 119	Protein Coding	1
54	P2RY13	Purinergic Receptor P2Y13	Protein Coding	1
55	IL1A	Interleukin 1 Alpha	Protein Coding	1
56	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
57	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	1
58	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
59	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
60	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
61	TOLLIP	Toll Interacting Protein	Protein Coding	1
62	ATF1	Activating Transcription Factor 1	Protein Coding	1
63	ATF2	Activating Transcription Factor 2	Protein Coding	1
64	ATF3	Activating Transcription Factor 3	Protein Coding	1
65	ATF4	Activating Transcription Factor 4	Protein Coding	1
66	ATF5	Activating Transcription Factor 5	Protein Coding	1
67	ATF6	Activating Transcription Factor 6	Protein Coding	1
68	ATF7	Activating Transcription Factor 7	Protein Coding	1
69	CALM1	Calmodulin 1	Protein Coding	1
70	CALM2	Calmodulin 2	Protein Coding	1
71	CALM3	Calmodulin 3	Protein Coding	1
72	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	1
73	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
74	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
75	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
76	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
77	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
78	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
79	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
80	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
81	JAK1	Janus Kinase 1	Protein Coding	1
82	JAK2	Janus Kinase 2	Protein Coding	1
83	JAK3	Janus Kinase 3	Protein Coding	1
84	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
85	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
86	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
87	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
88	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
89	IL6	Interleukin 6	Protein Coding	1
90	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
91	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
92	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	1
93	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
94	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
95	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
96	TNF	Tumor Necrosis Factor	Protein Coding	1
97	TP53	Tumor Protein P53	Protein Coding	1
98	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
99	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
100	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
101	TLR3	Toll Like Receptor 3	Protein Coding	1

Disorders associated with Toll Comparative Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.58
2	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	5.52
3	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	5.39
4	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.39
5	Multisystem inflammatory syndrome in children	Enrichment	IRAK3, IRF3, TLR3	5.13
6	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.55
7	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	4.40
8	Anastomosing haemangioma	Enrichment	GNA11, GNA14	4.35
9	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6, MIF	4.25
10	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6, MIF	4.03
11	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.88
12	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	3.75
13	Malaria	Enrichment	IKBKG, TIRAP	2.99
14	Gliosarcoma	Enrichment	NFKBIA, TP53	2.96
15	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.91
16	Diffuse large b-cell lymphoma	Enrichment	MYD88, TP53	2.81
17	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.75
18	Immunodeficiency 68	Enrichment	MYD88	2.75
19	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.75
20	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.75
21	Bacteremia 1	Enrichment	TIRAP	2.75
22	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.75
23	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.75
24	Noonan syndrome 13	Enrichment	MAPK1	2.75
25	Asthma-related traits 5	Enrichment	IRAK3	2.75
26	Immunodeficiency 67	Enrichment	IRAK4	2.75
27	Macular degeneration, age-related, 10	Enrichment	TLR4	2.75
28	Waldenstram macroglobulinemia	Enrichment	MYD88	2.75
29	Incontinentia pigmenti	Enrichment	IKBKG	2.69
30	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.69
31	Fetal encasement syndrome	Enrichment	CHUK	2.69
32	Immunodeficiency 15b	Enrichment	IKBKB	2.69
33	Immunodeficiency 15a	Enrichment	IKBKB	2.69
34	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.69
35	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.69
36	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.69
37	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.69
38	Behcet syndrome	Enrichment	IFNGR1, TLR4	2.66
39	46,xy sex reversal 6	Enrichment	MAP3K1	2.51
40	Immunodeficiency 69	Enrichment	IFNG	2.51
41	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.51
42	Bone marrow failure syndrome 5	Enrichment	TP53	2.51
43	Papilloma of choroid plexus	Enrichment	TP53	2.51
44	Basal cell carcinoma 7	Enrichment	TP53	2.51
45	Anaplastic thyroid carcinoma	Enrichment	TP53	2.51
46	Ductal carcinoma in situ	Enrichment	TP53	2.51
47	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.51
48	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.51
49	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.51
50	Agammaglobulinemia	Enrichment	SPI1	2.51
51	Choroid plexus cancer	Enrichment	TP53	2.51
52	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.51
53	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.45
54	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.45
55	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.45
56	Common variable immunodeficiency 12	Enrichment	NFKB1	2.45
57	Helicobacter pylori infection	Enrichment	IFNGR1	2.43
58	Immunodeficiency 27a	Enrichment	IFNGR1	2.43
59	Immunodeficiency 27b	Enrichment	IFNGR1	2.43
60	Immunodeficiency 31a	Enrichment	STAT1	2.43
61	Long qt syndrome 16	Enrichment	CALM3	2.43
62	Achromatopsia 7	Enrichment	ATF6	2.43
63	Immunodeficiency 31b	Enrichment	STAT1	2.43
64	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.43
65	Long qt syndrome 15	Enrichment	CALM2	2.43
66	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.43
67	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.43
68	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.43
69	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.41
70	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.41
71	Osseous heteroplasia, progressive	Enrichment	GNAS	2.41
72	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.41
73	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.41
74	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.41
75	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.41
76	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.41
77	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.41
78	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.41
79	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.41
80	Disorders of gnas inactivation	Enrichment	GNAS	2.41
81	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.41
82	Sick sinus syndrome 4	Enrichment	GNB2	2.41
83	Immunodeficiency 112	Enrichment	MAP3K14	2.41
84	Monostotic fibrous dysplasia	Enrichment	GNAS	2.41
85	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.41
86	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.41
87	Mazabraud syndrome	Enrichment	GNAS	2.41
88	Nik deficiency	Enrichment	MAP3K14	2.41
89	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.38
90	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.38
91	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.38
92	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.28
93	Long qt syndrome	Enrichment	CALM1, CALM2	2.24
94	Pelvic organ prolapse	Enrichment	TAB2	2.21
95	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.21
96	Cervical cancer	Enrichment	TP53	2.21
97	Lymphoma, hodgkin, classic	Enrichment	TP53	2.21
98	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.21
99	Menke-hennekam syndrome 2	Enrichment	EP300	2.21
100	Immunodeficiency 127	Enrichment	TNF	2.21
101	Rela fusion-positive ependymoma	Enrichment	RELA	2.21
102	Congenital fibrosarcoma	Enrichment	TP53	2.21
103	Li-fraumeni syndrome 1	Enrichment	TP53	2.21
104	Sarcoma	Enrichment	TP53	2.21
105	Cervix carcinoma	Enrichment	TP53	2.21
106	Hodgkin's lymphoma	Enrichment	TP53	2.21
107	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.21
108	Systemic lupus erythematosus	Enrichment	IRAK1, TNF	2.19
109	Severe combined immunodeficiency	Enrichment	IKBKB, JAK3	2.18
110	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.15
111	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.15
112	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.13
113	Thrombocythemia 3	Enrichment	JAK2	2.13
114	Long qt syndrome 14	Enrichment	CALM1	2.13
115	Immunodeficiency 31c	Enrichment	STAT1	2.13
116	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.13
117	Polycythemia	Enrichment	JAK2	2.13
118	Hypereosinophilic syndrome	Enrichment	JAK2	2.13
119	Immunodeficiency 117	Enrichment	IRF1	2.13
120	Gastric cancer	Enrichment	IL1B, TP53	2.11
121	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.11
122	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.11
123	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.11
124	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.11
125	Angioma, tufted	Enrichment	GNA14	2.11
126	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.11
127	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.11
128	Pseudohypoparathyroidism	Enrichment	GNAS	2.11
129	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.11
130	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.11
131	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.11
132	Cerebral visual impairment	Enrichment	GNB1	2.11
133	Phakomatosis cesioflammea	Enrichment	GNA11	2.11
134	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.05
135	Herpes simplex virus encephalitis	Enrichment	TLR3	2.05
136	Tuberous sclerosis 1	Enrichment	IFNG	2.03
137	Osteogenic sarcoma	Enrichment	TP53	2.03
138	Psoriatic arthritis	Enrichment	TNF	2.03
139	Hepatitis c virus	Enrichment	IFNG	2.03
140	Tuberous sclerosis 2	Enrichment	IFNG	2.03
141	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.03
142	Anaplastic astrocytoma	Enrichment	TP53	2.03
143	Squamous cell carcinoma	Enrichment	TP53	2.03
144	Adenocarcinoma	Enrichment	TP53	2.03
145	Migraine without aura	Enrichment	TNF	2.03
146	Bone osteosarcoma	Enrichment	TP53	2.03
147	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.99
148	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.96
149	Polycythemia vera	Enrichment	JAK2	1.96
150	Immunodeficiency 28	Enrichment	IFNGR2	1.96
151	Melanoma of soft tissue	Enrichment	ATF1	1.96
152	Mccune-albright syndrome	Enrichment	GNAS	1.93
153	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.93
154	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.93
155	Common variable immunodeficiency	Enrichment	NFKB1	1.91
156	Kaposi sarcoma	Enrichment	IL6	1.91
157	Small cell cancer of the lung	Enrichment	TP53	1.91
158	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.91
159	Lung sarcomatoid carcinoma	Enrichment	TP53	1.91
160	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.91
161	Cerebral malaria	Enrichment	TNF	1.91
162	Lennox-gastaut syndrome	Enrichment	MAPK10	1.85
163	Erythrocytosis, familial, 1	Enrichment	JAK2	1.83
164	Budd-chiari syndrome	Enrichment	JAK2	1.83
165	Congenital generalized lipodystrophy	Enrichment	FOS	1.83
166	Hepatitis b	Enrichment	IFNGR1	1.83
167	Adenosine deaminase deficiency	Enrichment	JAK3	1.83
168	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.83
169	Rhabdomyosarcoma 2	Enrichment	TP53	1.81
170	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.81
171	Lymphoma	Enrichment	TP53	1.81
172	Vascular dementia	Enrichment	TNF	1.81
173	Acute megakaryocytic leukemia	Enrichment	TP53	1.81
174	Idiopathic aplastic anemia	Enrichment	IFNG	1.81
175	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.81
176	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.81
177	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.81
178	Familial sick sinus syndrome	Enrichment	GNB2	1.81
179	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.79
180	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.76
181	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.74
182	Myeloproliferative neoplasm	Enrichment	JAK2	1.74
183	Coronary heart disease 5	Enrichment	IKBKG	1.73
184	Li-fraumeni syndrome	Enrichment	TP53	1.73
185	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.73
186	Type 1 diabetes mellitus	Enrichment	IL6	1.73
187	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.73
188	Adrenocortical carcinoma	Enrichment	TP53	1.73
189	Breast adenocarcinoma	Enrichment	TP53	1.73
190	Specific learning disability	Enrichment	MAPK1	1.71
191	Capillary malformations, congenital	Enrichment	GNA11	1.71
192	Esophageal cancer	Enrichment	TP53	1.67
193	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.67
194	Essential thrombocythemia	Enrichment	TP53	1.67
195	Gallbladder cancer	Enrichment	TP53	1.67
196	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.67
197	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.66
198	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.66
199	Migraine with or without aura 1	Enrichment	TAB2	1.65
200	Breast cancer	Enrichment	JUN, TP53	1.65
201	Melanoma, uveal	Enrichment	GNA11	1.63
202	Glioma susceptibility 1	Enrichment	TP53	1.61
203	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.61
204	Myelofibrosis	Enrichment	JAK2	1.59
205	Aortic valve disease 1	Enrichment	TAB2	1.58
206	Brachydactyly	Enrichment	GNAS	1.57
207	Charge syndrome	Enrichment	EP300	1.56
208	Inflammatory bowel disease 1	Enrichment	IL6	1.56
209	Adult hepatocellular carcinoma	Enrichment	TP53	1.56
210	Primary hyperaldosteronism	Enrichment	TP53	1.56
211	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.54
212	Colorectal cancer	Enrichment	EP300, TP53	1.53
213	Leukemia, chronic lymphocytic	Enrichment	TP53	1.52
214	Aplastic anemia	Enrichment	IFNG	1.52
215	Familial colorectal cancer	Enrichment	TP53	1.52
216	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.52
217	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.51
218	Hypothyroidism	Enrichment	GNB1	1.51
219	Heart, malformation of	Enrichment	MAPK1	1.50
220	Human immunodeficiency virus type 1	Enrichment	TLR3	1.50
221	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.49
222	Asthma	Enrichment	TNF	1.47
223	Myelodysplastic syndrome	Enrichment	TP53	1.47
224	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.47
225	Achromatopsia	Enrichment	ATF6	1.44
226	Patent foramen ovale	Enrichment	TAB2	1.44
227	Lip and oral cavity carcinoma	Enrichment	TP53	1.44
228	Ovarian cancer	Enrichment	MAP3K1, TP53	1.41
229	Alzheimer's disease	Enrichment	TNF	1.40
230	Lung non-small cell carcinoma	Enrichment	IRF1	1.40
231	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.38
232	Lung cancer susceptibility 3	Enrichment	TP53	1.37
233	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.37
234	Polydactyly, postaxial, type a1	Enrichment	EP300	1.34
235	Rare genetic intellectual disability	Enrichment	EP300	1.34
236	Nk-cell enteropathy	Enrichment	JAK3	1.33
237	Rhabdomyosarcoma	Enrichment	TP53	1.31
238	Arteriovenous malformations of the brain	Enrichment	IL6	1.24
239	Sudden infant death syndrome	Enrichment	CALM2	1.22
240	Hepatoblastoma	Enrichment	TP53	1.20
241	Hypertension, essential	Enrichment	GNB3	1.19
242	Cleft palate, isolated	Enrichment	GNB1	1.19
243	Hepatocellular carcinoma	Enrichment	TP53	1.18
244	Diamond-blackfan anemia 1	Enrichment	TP53	1.16
245	Pancreatic cancer	Enrichment	TP53	1.13
246	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.08
247	Bladder cancer	Enrichment	TP53	1.07
248	Prostate cancer	Enrichment	TP53	1.07
249	Congenital stationary night blindness	Enrichment	GNB3	1.06
250	Cystic fibrosis	Enrichment	MIF	1.02
251	Strabismus	Enrichment	GNB1	1.00
252	Severe covid-19	Enrichment	JAK3	0.99
253	Diamond-blackfan anemia	Enrichment	TP53	0.98
254	Lung cancer	Enrichment	IRF1	0.95
255	Leukemia, acute myeloid	Enrichment	TP53	0.93
256	Type 2 diabetes mellitus	Enrichment	IL6	0.91
257	Hereditary breast carcinoma	Enrichment	TP53	0.89
258	Dystonia	Enrichment	GNB1	0.89
259	Cerebral palsy	Enrichment	GNB1	0.85
260	Dilated cardiomyopathy	Enrichment	TAB2	0.82
261	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.80
262	Myeloma, multiple	Enrichment	TP53	0.80
263	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.75
264	Primary ovarian insufficiency	Enrichment	JAK2	0.71
265	Microcephaly	Enrichment	MAPK1	0.71
266	Cone-rod dystrophy 2	Enrichment	ATF6	0.65
267	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.53
268	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.47
269	Congenital nervous system abnormality	Enrichment	GNB5	0.47
270	Nervous system disease	Enrichment	GNB5	0.47
271	Autism spectrum disorder	Enrichment	GNB1	0.46
272	Complex neurodevelopmental disorder	Enrichment	GNB2	0.41
273	Hereditary retinal dystrophy	Enrichment	ATF6	0.18
274	Fundus dystrophy	Enrichment	ATF6	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Toll Comparative Pathway

Pathway Network for Toll Comparative Pathway

Pathway network for the Toll Comparative Pathway SuperPath

Member Pathways for Toll Comparative Pathway

Pathways in the Toll Comparative Pathway SuperPath

Gene overlap in member pathways for Toll Comparative Pathway SuperPath

Associated Genes for Toll Comparative Pathway

Associated Disorders for Toll Comparative Pathway

Disorders associated with Toll Comparative Pathway SuperPath

STRING Interaction Network for Toll Comparative Pathway

Sources for Toll Comparative Pathway