Toll Like Receptor 7/8 (TLR7/8) Cascade

Pathway network for the Toll Like Receptor 7/8 (TLR7/8) Cascade SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Toll Like Receptor 7/8 (TLR7/8) Cascade SuperPath

#	Name	Source	Genes
1	Toll Like Receptor 7/8 (TLR7/8) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CD14 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 IRF5 IRF7 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 SLC15A4 TAB1 TAB2 TAB3 TASL TICAM1 TICAM2 TIFA TLR4 TLR7 TLR8 TLR9 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 106) (see less)
2	Toll-like Receptor Cascades	Reactome	AGER ALPK1 APOB APP ATF1 ATF2 BIRC2 BIRC3 BPI BTK BTRC CASP8 CD14 CD180 CD36 CHUK CNPY3 CREB1 CTSB CTSK CTSL CTSS CTSV CUL1 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 EEA1 ELK1 FADD FBXW11 FGA FGB FGG FOS GSDMD GSDME HMGB1 HSP90B1 IKBIP IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF5 IRF7 ITGAM ITGB2 JUN LBP LGMN LRRC14 LY86 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 OPTN PELI1 PELI2 PELI3 PIK3C3 PIK3R4 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 PTPN4 RBSN RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A1 S100A12 S100A8 S100A9 S100B SAA1 SARM1 SFTPA1 SFTPA2 SFTPD SIGIRR SKP1 SLC15A4 SOCS1 TAB1 TAB2 TAB3 TANK TASL TBK1 TICAM1 TICAM2 TIFA TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 UNC93B1 USP14 USP18 VRK3 (see all 170) (see less)
3	Toll Like Receptor 4 (TLR4) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BIRC2 BIRC3 BPI BTK BTRC CASP8 CD14 CD180 CD36 CHUK CREB1 CUL1 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FBXW11 FGA FGB FGG FOS HMGB1 IKBIP IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 ITGAM ITGB2 JUN LBP LRRC14 LY86 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 OPTN PELI1 PELI2 PELI3 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 PTPN4 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A1 S100A12 S100A8 S100A9 S100B SAA1 SARM1 SFTPA1 SFTPA2 SFTPD SIGIRR SKP1 SOCS1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TIFA TIRAP TLR1 TLR2 TLR4 TLR6 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 USP14 USP18 VRK3 (see all 145) (see less)
4	Toll Like Receptor 2 (TLR2) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTK BTRC CASP8 CD14 CD36 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FGA FGB FGG FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK3 IRAK4 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A1 S100A12 S100A8 S100A9 S100B SAA1 SFTPA1 SFTPA2 SFTPD SIGIRR SKP1 SOCS1 TAB1 TAB2 TAB3 TIFA TIRAP TLR1 TLR2 TLR4 TLR6 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 114) (see less)
5	Toll Like Receptor TLR1:TLR2 Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTK BTRC CASP8 CD14 CD36 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FGA FGB FGG FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK3 IRAK4 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A1 S100A12 S100A8 S100A9 S100B SAA1 SFTPA1 SFTPA2 SFTPD SIGIRR SKP1 SOCS1 TAB1 TAB2 TAB3 TIFA TIRAP TLR1 TLR2 TLR4 TLR6 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 114) (see less)
6	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Reactome	AGER ALPK1 APP ATF1 ATF2 BTK BTRC CASP8 CD14 CD36 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FGA FGB FGG FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK3 IRAK4 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A1 S100A12 S100A8 S100A9 S100B SAA1 SIGIRR SKP1 SOCS1 TAB1 TAB2 TAB3 TIFA TIRAP TLR1 TLR2 TLR4 TLR6 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 111) (see less)
7	Toll Like Receptor TLR6:TLR2 Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTK BTRC CASP8 CD14 CD36 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FGA FGB FGG FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK3 IRAK4 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A1 S100A12 S100A8 S100A9 S100B SAA1 SIGIRR SKP1 SOCS1 TAB1 TAB2 TAB3 TIFA TIRAP TLR1 TLR2 TLR4 TLR6 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 111) (see less)
8	MyD88-independent TLR4 cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BIRC2 BIRC3 BTRC CASP8 CD14 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FBXW11 FOS HMGB1 IKBIP IKBKB IKBKE IKBKG IRAK1 IRAK2 IRF3 IRF7 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 OPTN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 SKP1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TIFA TLR4 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 USP14 USP18 VRK3 (see all 110) (see less)
9	TRIF (TICAM1)-mediated TLR4 signaling	Reactome	AGER ALPK1 APP ATF1 ATF2 BIRC2 BIRC3 BTRC CASP8 CD14 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FBXW11 FOS HMGB1 IKBIP IKBKB IKBKE IKBKG IRAK1 IRAK2 IRF3 IRF7 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 OPTN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 SKP1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TIFA TLR4 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 USP14 USP18 VRK3 (see all 110) (see less)
10	Toll Like Receptor 9 (TLR9) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CD14 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 EEA1 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 IRF5 IRF7 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PIK3C3 PIK3R4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RBSN RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 SLC15A4 TAB1 TAB2 TAB3 TASL TICAM1 TICAM2 TIFA TLR4 TLR7 TLR9 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 109) (see less)
11	Toll Like Receptor 3 (TLR3) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BIRC2 BIRC3 BTRC CASP8 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FBXW11 FOS HMGB1 IKBIP IKBKB IKBKE IKBKG IRAK1 IRAK2 IRF3 IRF7 JUN LRRC14 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 OPTN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 SKP1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TIFA TLR3 TNIP2 TP53 TRAF2 TRAF3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 USP14 USP18 VRK3 (see all 105) (see less)
12	MyD88 dependent cascade initiated on endosome	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CD14 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 IRF7 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 TAB1 TAB2 TAB3 TICAM1 TICAM2 TIFA TLR4 TLR7 TLR9 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 102) (see less)
13	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CD14 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 JUN LRRC14 LY96 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 TAB1 TAB2 TAB3 TICAM1 TICAM2 TIFA TLR4 TLR7 TLR9 TMED7-TICAM2 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 101) (see less)
14	Toll Like Receptor 10 (TLR10) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 JUN LRRC14 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 TAB1 TAB2 TAB3 TIFA TLR10 TLR5 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 95) (see less)
15	Toll Like Receptor 5 (TLR5) Cascade	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 JUN LRRC14 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 TAB1 TAB2 TAB3 TIFA TLR10 TLR5 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 95) (see less)
16	MyD88 cascade initiated on plasma membrane	Reactome	AGER ALPK1 APP ATF1 ATF2 BTRC CASP8 CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 IRAK4 JUN LRRC14 MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SKP1 TAB1 TAB2 TAB3 TIFA TLR10 TLR5 TNIP2 TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 VRK3 (see all 95) (see less)
17	TAK1-dependent IKK and NF-kappa-B activation	Reactome	AGER ALPK1 APP CASP8 CHUK HMGB1 IKBIP IKBKB IKBKG IRAK1 IRAK2 LRRC14 MAP3K7 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 RELA RIPK2 RPS27A S100A12 S100B SAA1 TAB1 TAB2 TAB3 TIFA TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 (see all 44) (see less)
18	TRAF6 mediated NF-kB activation	Reactome	AGER APP CHUK HMGB1 IFIH1 IKBKB IKBKG MAP3K1 MAVS NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA RIGI RNF135 S100A12 S100B SAA1 TRAF2 TRAF6 TRIM25 TRIM4 (see all 25) (see less)
19	TICAM1, RIP1-mediated IKK complex recruitment	Reactome	BIRC2 BIRC3 CHUK IKBKB IKBKG RIPK1 RIPK3 RPS27A TICAM1 TLR3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 (see all 19) (see less)
20	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Reactome	CD14 IKBKE IRF3 IRF7 LY96 OPTN PTPN11 RPS27A SARM1 TANK TBK1 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF3 UBA52 UBB UBC (see all 19) (see less)
21	Regulation of NF-kappa B signaling	Reactome	CASP8 CHUK IKBIP IKBKB IKBKG LRRC14 N4BP1 NLRC5 NLRX1 RPS27A TP53 TRAF2 TRAF6 UBA52 UBB UBC USP14 USP18 (see all 18) (see less)
22	MYD88 distinct input-output pathway	WikiPathways	IL1A IRAK1 JUN MYD88 NFKB1 TIFA TLR1 TLR10 TLR2 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TRAF6 UBE2N UBE2V1 (see all 18) (see less)
23	TRAF6-mediated induction of TAK1 complex within TLR4 complex	Reactome	CD14 IRAK2 LY96 MAP3K7 RPS27A SARM1 TAB1 TAB2 TAB3 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF6 UBA52 UBB UBC (see all 17) (see less)
24	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Reactome	CD14 IRAK2 LY96 MAP3K7 RPS27A TAB1 TAB2 TAB3 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF6 UBA52 UBB UBC (see all 16) (see less)
25	Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	Reactome	CD14 IKBKE LY96 OPTN RPS27A TANK TBK1 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF3 UBA52 UBB UBC (see all 15) (see less)
26	TICAM1-dependent activation of IRF3/IRF7	Reactome	IKBKE IRF3 IRF7 OPTN RPS27A TANK TBK1 TICAM1 TLR3 TRAF3 UBA52 UBB UBC (see all 13) (see less)
27	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Reactome	IRAK1 IRAK4 IRF7 MYD88 RPS27A TLR7 TLR9 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 13) (see less)
28	Trafficking and processing of endosomal TLR	Reactome	CNPY3 CTSB CTSK CTSL CTSS CTSV HSP90B1 LGMN TLR3 TLR7 TLR8 TLR9 UNC93B1 (see all 13) (see less)
29	Alpha-protein kinase 1 signaling pathway	Reactome	ALPK1 MAP3K7 RPS27A TAB1 TAB2 TAB3 TIFA TRAF6 UBA52 UBB UBC (see all 11) (see less)
30	Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	Reactome	IKBKE OPTN RPS27A TANK TBK1 TICAM1 TLR3 TRAF3 UBA52 UBB UBC (see all 11) (see less)
31	TICAM1,TRAF6-dependent induction of TAK1 complex	Reactome	MAP3K7 RPS27A TAB1 TAB2 TAB3 TICAM1 TLR3 TRAF6 UBA52 UBB UBC (see all 11) (see less)
32	TRIF-mediated programmed cell death	Reactome	CASP8 CD14 FADD LY96 RIPK1 RIPK3 TICAM1 TICAM2 TLR4 TMED7-TICAM2 (see all 10) (see less)
33	IRAK2 mediated activation of TAK1 complex	Reactome	IRAK2 MAP3K7 RPS27A TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC (see all 10) (see less)
34	TLR3-mediated TICAM1-dependent programmed cell death	Reactome	CASP8 FADD RIPK1 RIPK3 TICAM1 TLR3 (see all 6) (see less)
35	SLC15A4:TASL-dependent IRF5 activation	Reactome	CHUK IKBKB IKBKG IRF5 SLC15A4 TASL (see all 6) (see less)
36	TRAF3 deficiency - HSE	Reactome	TICAM1 TLR3 TRAF3
37	UNC93B1 deficiency - HSE	Reactome	TLR3 UNC93B1
38	TICAM1 deficiency - HSE	Reactome	TICAM1 TLR3
39	TLR3 deficiency - HSE	Reactome	TLR3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RPS27A	Ribosomal Protein S27a	Protein Coding	29
2	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	29
3	UBB	Ubiquitin B	Protein Coding	29
4	UBC	Ubiquitin C	Protein Coding	29
5	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	27
6	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	22
7	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	22
8	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	22
9	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	22
10	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	21
11	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	21
12	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	21
13	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	21
14	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	20
15	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	20
16	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	20
17	CASP8	Caspase 8	Protein Coding	20
18	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	19
19	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	19
20	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	19
21	TIFA	TRAF Interacting Protein With Forkhead Associated Domain	Protein Coding	19
22	USP18	Ubiquitin Specific Peptidase 18	Protein Coding	18
23	IKBIP	IKBKB Interacting Protein	Protein Coding	18
24	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	18
25	NKIRAS2	NFKB Inhibitor Interacting Ras Like 2	Protein Coding	18
26	NKIRAS1	NFKB Inhibitor Interacting Ras Like 1	Protein Coding	18
27	HMGB1	High Mobility Group Box 1	Protein Coding	18
28	APP	Amyloid Beta Precursor Protein	Protein Coding	18
29	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	18
30	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	18
31	NFKBIB	NFKB Inhibitor Beta	Protein Coding	18
32	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	18
33	S100A12	S100 Calcium Binding Protein A12	Protein Coding	18
34	S100B	S100 Calcium Binding Protein B	Protein Coding	18
35	SAA1	Serum Amyloid A1	Protein Coding	18
36	TLR4	Toll Like Receptor 4	Protein Coding	18
37	TP53	Tumor Protein P53	Protein Coding	18
38	NLRX1	NLR Family Member X1	Protein Coding	18
39	ALPK1	Alpha Kinase 1	Protein Coding	18
40	NLRC5	NLR Family CARD Domain Containing 5	Protein Coding	18
41	USP14	Ubiquitin Specific Peptidase 14	Protein Coding	18
42	N4BP1	NEDD4 Binding Protein 1	Protein Coding	18
43	LRRC14	Leucine Rich Repeat Containing 14	Protein Coding	18
44	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	17
45	LY96	Lymphocyte Antigen 96	Protein Coding	17
46	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	17
47	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	17
48	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	17
49	CD14	CD14 Molecule	Protein Coding	17
50	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	16
51	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	16
52	ATF2	Activating Transcription Factor 2	Protein Coding	16
53	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	16
54	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	16
55	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	16
56	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	16
57	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	16
58	ELK1	ETS Transcription Factor ELK1	Protein Coding	16
59	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	16
60	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	16
61	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	16
62	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	16
63	ATF1	Activating Transcription Factor 1	Protein Coding	16
64	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	16
65	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	16
66	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	16
67	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	16
68	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	16
69	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	16
70	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	16
71	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	16
72	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	16
73	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	16
74	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	16
75	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	16
76	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	16
77	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	16
78	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	16
79	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	16
80	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	16
81	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	16
82	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	16
83	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	16
84	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	16
85	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	16
86	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	16
87	TNIP2	TNFAIP3 Interacting Protein 2	Protein Coding	16
88	CUL1	Cullin 1	Protein Coding	16
89	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	16
90	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	16
91	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	16
92	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	15
93	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	14
94	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	14
95	TMED7-TICAM2	TMED7-TICAM2 Readthrough	Protein Coding	13
96	PELI3	Pellino E3 Ubiquitin Protein Ligase Family Member 3	Protein Coding	13
97	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	13
98	PELI2	Pellino E3 Ubiquitin Protein Ligase Family Member 2	Protein Coding	13
99	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	13
100	TLR3	Toll Like Receptor 3	Protein Coding	12
101	IRF7	Interferon Regulatory Factor 7	Protein Coding	11
102	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	10
103	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	9
104	OPTN	Optineurin	Protein Coding	9
105	TBK1	TANK Binding Kinase 1	Protein Coding	9
106	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	9
107	TLR7	Toll Like Receptor 7	Protein Coding	8
108	TLR9	Toll Like Receptor 9	Protein Coding	8
109	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	8
110	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	8
111	TLR6	Toll Like Receptor 6	Protein Coding	7
112	SARM1	Sterile Alpha And TIR Motif Containing 1	Protein Coding	7
113	IRF3	Interferon Regulatory Factor 3	Protein Coding	7
114	TLR1	Toll Like Receptor 1	Protein Coding	7
115	TLR2	Toll Like Receptor 2	Protein Coding	7
116	FADD	Fas Associated Via Death Domain	Protein Coding	7
117	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	6
118	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	6
119	FGA	Fibrinogen Alpha Chain	Protein Coding	6
120	FGB	Fibrinogen Beta Chain	Protein Coding	6
121	FGG	Fibrinogen Gamma Chain	Protein Coding	6
122	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	6
123	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	6
124	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	6
125	S100A1	S100 Calcium Binding Protein A1	Protein Coding	6
126	S100A8	S100 Calcium Binding Protein A8	Protein Coding	6
127	S100A9	S100 Calcium Binding Protein A9	Protein Coding	6
128	BTK	Bruton Tyrosine Kinase	Protein Coding	6
129	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	6
130	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	6
131	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	6
132	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	6
133	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	6
134	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	5
135	TLR5	Toll Like Receptor 5	Protein Coding	5
136	TLR10	Toll Like Receptor 10	Protein Coding	5
137	SLC15A4	Solute Carrier Family 15 Member 4	Protein Coding	4
138	IRF5	Interferon Regulatory Factor 5	Protein Coding	4
139	TLR8	Toll Like Receptor 8	Protein Coding	4
140	TASL	TLR Adaptor Interacting With Endolysosomal SLC15A4	Protein Coding	4
141	SFTPD	Surfactant Protein D	Protein Coding	4
142	SFTPA1	Surfactant Protein A1	Protein Coding	4
143	SFTPA2	Surfactant Protein A2	Protein Coding	4
144	UNC93B1	Unc-93B1 Regulator Of TLR Signaling	Protein Coding	3
145	CNPY3	Canopy FGF Signaling Regulator 3	Protein Coding	2
146	CTSB	Cathepsin B	Protein Coding	2
147	CTSK	Cathepsin K	Protein Coding	2
148	CTSL	Cathepsin L	Protein Coding	2
149	CTSV	Cathepsin V	Protein Coding	2
150	CTSS	Cathepsin S	Protein Coding	2
151	DNM1	Dynamin 1	Protein Coding	2
152	DNM2	Dynamin 2	Protein Coding	2
153	DNM3	Dynamin 3	Protein Coding	2
154	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
155	ITGAM	Integrin Subunit Alpha M	Protein Coding	2
156	ITGB2	Integrin Subunit Beta 2	Protein Coding	2
157	LBP	Lipopolysaccharide Binding Protein	Protein Coding	2
158	CD180	CD180 Molecule	Protein Coding	2
159	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	2
160	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
161	LGMN	Legumain	Protein Coding	2
162	PTPN4	Protein Tyrosine Phosphatase Non-Receptor Type 4	Protein Coding	2
163	RBSN	Rabenosyn, RAB Effector	Protein Coding	2
164	BPI	Bactericidal Permeability Increasing Protein	Protein Coding	2
165	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	2
166	EEA1	Early Endosome Antigen 1	Protein Coding	2
167	LY86	Lymphocyte Antigen 86	Protein Coding	2
168	GSDME	Gasdermin E	Protein Coding	1
169	APOB	Apolipoprotein B	Protein Coding	1
170	GSDMD	Gasdermin D	Protein Coding	1
171	RIGI	RNA Sensor RIG-I	Protein Coding	1
172	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
173	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	1
174	TRIM25	Tripartite Motif Containing 25	Protein Coding	1
175	RNF135	Ring Finger Protein 135	Protein Coding	1
176	TRIM4	Tripartite Motif Containing 4	Protein Coding	1
177	IL1A	Interleukin 1 Alpha	Protein Coding	1

Disorders associated with Toll Like Receptor 7/8 (TLR7/8) Cascade SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immune deficiency disease	Direct
2	Herpes simplex virus encephalitis	Enrichment	TBK1, TICAM1, TLR3, TRAF3	10.81
3	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.27
4	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	6.27
5	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	6.27
6	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	6.07
7	Multisystem inflammatory syndrome in children	Enrichment	IRF3, TLR3, TRAF3	5.98
8	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	5.67
9	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.49
10	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	5.49
11	Motor neuron disease	Enrichment	OPTN, TBK1	4.90
12	Diffuse large b-cell lymphoma	Enrichment	BTK, MYD88, SOCS1, TP53	4.82
13	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.51
14	Malaria	Enrichment	CD36, IKBKG, MAPKAPK3, TIRAP	4.48
15	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.31
16	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	4.23
17	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	4.17
18	Specific learning disability	Enrichment	MAPK1, PTPN11, RPS6KA3	4.09
19	Systemic lupus erythematosus	Enrichment	IRAK1, IRF5, ITGAM, SOCS1, TLR7	3.92
20	Melanoma of soft tissue	Enrichment	ATF1, CREB1	3.84
21	Hepatocellular carcinoma	Enrichment	CASP8, TP53	3.42
22	Caspase 8 deficiency	Enrichment	CASP8	3.35
23	Immunodeficiency 83 viral infections	Enrichment	TLR3	3.35
24	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	3.35
25	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.35
26	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	3.35
27	Incontinentia pigmenti	Enrichment	IKBKG	3.35
28	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	3.35
29	Fetal encasement syndrome	Enrichment	CHUK	3.35
30	Immunodeficiency 15b	Enrichment	IKBKB	3.35
31	Immunodeficiency 15a	Enrichment	IKBKB	3.35
32	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	3.35
33	Systemic lupus erythematosus 10	Enrichment	IRF5	3.35
34	Inflammatory bowel disease 14	Enrichment	IRF5	3.35
35	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.35
36	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.35
37	Lymphoma	Enrichment	PTPN11, TP53	3.19
38	Macular degeneration, age-related, 10	Enrichment	TLR4	3.13
39	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	3.13
40	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	3.13
41	Polyvalvular heart disease syndrome	Enrichment	TAB2	3.13
42	Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome	Enrichment	ALPK1	3.09
43	Alpk1-related autoinflammatory disease	Enrichment	ALPK1	3.09
44	Immunodeficiency 132a	Enrichment	TRAF3	3.09
45	Immunodeficiency 132b	Enrichment	TRAF3	3.09
46	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	3.09
47	Corticobasal syndrome	Enrichment	TBK1	3.09
48	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	3.09
49	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	3.05
50	Oculootodental syndrome	Enrichment	FADD	3.05
51	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	3.05
52	Anemia, autoimmune hemolytic	Enrichment	SOCS1, TLR8	3.04
53	Immunodeficiency 39 viral infections	Enrichment	IRF7	3.02
54	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	3.02
55	Immunodeficiency 39	Enrichment	IRF7	3.02
56	Immunodeficiency 68	Enrichment	MYD88	3.02
57	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	3.02
58	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	3.02
59	X-linked immunodeficiency 74	Enrichment	TLR7	3.02
60	Systemic lupus erythematosus 17	Enrichment	TLR7	3.02
61	Immunodeficiency 67	Enrichment	IRAK4	3.02
62	Waldenstram macroglobulinemia	Enrichment	MYD88	3.02
63	Keratolytic winter erythema	Enrichment	CTSB	3.02
64	Pycnodysostosis	Enrichment	CTSK	3.02
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	OPTN, TBK1	3.02
66	Gliosarcoma	Enrichment	NFKBIA, TP53	2.92
67	Bone marrow failure syndrome 5	Enrichment	TP53	2.88
68	Papilloma of choroid plexus	Enrichment	TP53	2.88
69	Basal cell carcinoma 7	Enrichment	TP53	2.88
70	Anaplastic thyroid carcinoma	Enrichment	TP53	2.88
71	Ductal carcinoma in situ	Enrichment	TP53	2.88
72	Pseudo-torch syndrome 2	Enrichment	USP18	2.88
73	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.88
74	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.88
75	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.88
76	Choroid plexus cancer	Enrichment	TP53	2.88
77	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.88
78	Leprosy 3	Enrichment	TLR2	2.88
79	Legionnaire disease	Enrichment	TLR5	2.88
80	Leprosy 5	Enrichment	TLR1	2.88
81	Systemic lupus erythematosus 1	Enrichment	TLR5	2.88
82	Melioidosis	Enrichment	TLR5	2.88
83	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.87
84	Metachondromatosis	Enrichment	PTPN11	2.85
85	Leopard syndrome 1	Enrichment	PTPN11	2.85
86	Malignant astrocytoma	Enrichment	PTPN11	2.85
87	Lung cancer	Enrichment	CASP8, MAP3K8, PPP2R1B	2.85
88	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.83
89	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.83
90	Submucosal cleft palate	Enrichment	UBB	2.83
91	Cleft hard palate	Enrichment	UBB	2.83
92	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.79
93	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	2.79
94	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	2.79
95	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.73
96	46,xy sex reversal 6	Enrichment	MAP3K1	2.73
97	Singleton-merten syndrome 1	Enrichment	IFIH1	2.73
98	Immunodeficiency 95	Enrichment	IFIH1	2.73
99	Type 1 diabetes mellitus 19	Enrichment	IFIH1	2.73
100	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.73
101	Singleton-merten syndrome 2	Enrichment	RIGI	2.73
102	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.73
103	Serum amyloid a amyloidosis	Enrichment	SAA1	2.73
104	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	2.73
105	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.72
106	Developmental and epileptic encephalopathy 60	Enrichment	CNPY3	2.72
107	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.66
108	Diffuse cutaneous systemic sclerosis	Enrichment	IRF5	2.66
109	Pelvic organ prolapse	Enrichment	TAB2	2.66
110	Uvula, bifid	Enrichment	UBB	2.66
111	Cleft soft palate	Enrichment	UBB	2.66
112	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.66
113	Glaucoma, normal tension	Enrichment	OPTN	2.61
114	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.58
115	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.58
116	Limited scleroderma	Enrichment	IRF5	2.58
117	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.58
118	Cervical cancer	Enrichment	TP53	2.58
119	Lymphoma, hodgkin, classic	Enrichment	TP53	2.58
120	Congenital fibrosarcoma	Enrichment	TP53	2.58
121	Li-fraumeni syndrome 1	Enrichment	TP53	2.58
122	Sarcoma	Enrichment	TP53	2.58
123	Cervix carcinoma	Enrichment	TP53	2.58
124	Hodgkin's lymphoma	Enrichment	TP53	2.58
125	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.58
126	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.58
127	Leprosy 1	Enrichment	TLR6	2.58
128	Common variable immunodeficiency 12	Enrichment	NFKB1	2.58
129	Werner syndrome	Enrichment	PTPN11	2.55
130	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	2.54
131	Encephalopathy, acute, infection-induced 1	Enrichment	UNC93B1	2.54
132	Nail disorder, nonsyndromic congenital, 9	Enrichment	CTSK	2.54
133	Lennox-gastaut syndrome	Enrichment	DNM1, MAPK10	2.52
134	Blau syndrome	Enrichment	NOD2	2.49
135	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.43
136	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.43
137	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.43
138	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.43
139	Diamond-blackfan anemia 12	Enrichment	NKIRAS1	2.43
140	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.43
141	Rela fusion-positive ependymoma	Enrichment	RELA	2.43
142	Basal ganglia disease	Enrichment	IFIH1	2.43
143	Folate malabsorption, hereditary	Enrichment	SARM1	2.43
144	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.42
145	Rheumatoid arthritis	Enrichment	IRF5	2.40
146	Coronary heart disease 5	Enrichment	IKBKG	2.40
147	Primary biliary cholangitis	Enrichment	IRF5	2.40
148	Osteogenic sarcoma	Enrichment	TP53	2.40
149	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.40
150	Anaplastic astrocytoma	Enrichment	TP53	2.40
151	Squamous cell carcinoma	Enrichment	TP53	2.40
152	Adenocarcinoma	Enrichment	TP53	2.40
153	Bone osteosarcoma	Enrichment	TP53	2.40
154	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	2.39
155	Tricuspid valve insufficiency	Enrichment	PTPN11	2.38
156	Breast cancer	Enrichment	CASP8, TP53	2.36
157	Glaucoma, primary open angle	Enrichment	OPTN	2.31
158	Small cell cancer of the lung	Enrichment	TP53	2.28
159	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.28
160	Lung sarcomatoid carcinoma	Enrichment	TP53	2.28
161	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.28
162	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	RNF135	2.26
163	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.25
164	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.25
165	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11	2.19
166	Yao syndrome	Enrichment	NOD2	2.19
167	Crohn's disease	Enrichment	NOD2	2.19
168	Rhabdomyosarcoma 2	Enrichment	TP53	2.18
169	Acute megakaryocytic leukemia	Enrichment	TP53	2.18
170	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	2.16
171	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.15
172	Melorheostosis, isolated	Enrichment	MAP2K1	2.15
173	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.15
174	Noonan syndrome 13	Enrichment	MAPK1	2.15
175	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.15
176	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.15
177	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.15
178	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.15
179	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.15
180	Melorheostosis	Enrichment	MAP2K1	2.15
181	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.15
182	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.15
183	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.15
184	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.15
185	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.15
186	Mef2c-related disorder	Enrichment	MEF2C	2.15
187	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.15
188	Progressive non-fluent aphasia	Enrichment	TBK1	2.14
189	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.13
190	Li-fraumeni syndrome	Enrichment	TP53	2.10
191	Adrenocortical carcinoma	Enrichment	TP53	2.10
192	Breast adenocarcinoma	Enrichment	TP53	2.10
193	Human immunodeficiency virus type 1	Enrichment	TLR3	2.10
194	Myelofibrosis, congenital, with anemia, neutropenia, developmental delay, and ocular abnormalities	Enrichment	RBSN	2.09
195	Kariminejad neurodevelopmental syndrome	Enrichment	RBSN	2.09
196	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	2.09
197	Migraine with or without aura 1	Enrichment	TAB2	2.09
198	Coronary heart disease 7	Enrichment	CD36	2.09
199	Bacteremia 1	Enrichment	TIRAP	2.09
200	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.09
201	Asthma-related traits 5	Enrichment	IRAK3	2.09
202	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.09
203	Congenital fibrinogen deficiency	Enrichment	FGG	2.09
204	Patent ductus arteriosus	Enrichment	PTPN11	2.08
205	Interstitial lung disease 1	Enrichment	SFTPA1	2.08
206	Behcet syndrome	Enrichment	NOD2, TLR4	2.06
207	Interstitial lung disease 2	Enrichment	SFTPA1, SFTPA2	2.06
208	Patent foramen ovale	Enrichment	PTPN11, TAB2	2.04
209	Spastic diplegia	Enrichment	IFIH1	2.04
210	Esophageal cancer	Enrichment	TP53	2.03
211	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.03
212	Essential thrombocythemia	Enrichment	TP53	2.03
213	Gallbladder cancer	Enrichment	TP53	2.03
214	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.03
215	Primary bone dysplasia	Enrichment	CTSK	2.02
216	Aortic valve disease 1	Enrichment	TAB2	2.02
217	Noonan syndrome 3	Enrichment	PTPN11	2.01
218	Osteochondrodysplasia	Enrichment	CTSK	1.98
219	Glioma susceptibility 1	Enrichment	TP53	1.98
220	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.98
221	Systemic lupus erythematosus 6	Enrichment	ITGAM	1.97
222	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	1.97
223	Lethal congenital contracture syndrome 5	Enrichment	DNM2	1.97
224	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	1.97
225	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	1.97
226	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	1.97
227	Primary hyperaldosteronism	Enrichment	TP53	1.93
228	Deafness, autosomal dominant 5	Enrichment	GSDME	1.90
229	Alzheimer's disease 1	Enrichment	APP	1.89
230	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.89
231	Leukemia, chronic lymphocytic	Enrichment	TP53	1.88
232	Familial colorectal cancer	Enrichment	TP53	1.88
233	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.88
234	Scoliosis, isolated 1	Enrichment	MAPK7	1.86
235	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.86
236	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.86
237	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.86
238	Myelodysplastic syndrome	Enrichment	TP53	1.84
239	Severe combined immunodeficiency	Enrichment	IKBKB	1.84
240	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11	1.83
241	Pectus excavatum	Enrichment	PTPN11	1.82
242	Lip and oral cavity carcinoma	Enrichment	TP53	1.80
243	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.79
244	Agammaglobulinemia, x-linked	Enrichment	BTK	1.79
245	Aicardi-goutiares syndrome	Enrichment	IFIH1	1.78
246	Epicanthus	Enrichment	PTPN11	1.78
247	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.78
248	Congenital long qt syndrome	Enrichment	PTPN11	1.78
249	Aicardi-goutieres syndrome	Enrichment	IFIH1	1.74
250	Lung cancer susceptibility 3	Enrichment	TP53	1.73
251	Rasopathy	Enrichment	MAP2K1, PTPN11	1.73
252	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.70
253	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.68
254	Bacteremia 2	Enrichment	MAPKAPK3	1.68
255	Rhabdomyosarcoma	Enrichment	TP53	1.68
256	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.67
257	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.67
258	Scoliosis	Enrichment	CTSK	1.64
259	Alzheimer's disease	Enrichment	APP	1.63
260	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.62
261	Immune thrombocytopenia	Enrichment	SOCS1	1.61
262	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.61
263	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.61
264	Agammaglobulinemia 1	Enrichment	BTK	1.61
265	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	1.60
266	Hypobetalipoproteinemia	Enrichment	APOB	1.60
267	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.59
268	Hepatoblastoma	Enrichment	TP53	1.56
269	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.56
270	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.56
271	Congenital generalized lipodystrophy	Enrichment	FOS	1.56
272	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.56
273	Tuberculosis	Enrichment	MAPKAPK3	1.56
274	Inflammatory bowel disease 1	Enrichment	NOD2	1.54
275	Diamond-blackfan anemia 1	Enrichment	TP53	1.52
276	Alzheimer disease, familial, 1	Enrichment	APP	1.51
277	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.50
278	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.50
279	Blood platelet disease	Enrichment	CD36	1.49
280	Cerebral malaria	Enrichment	CD36	1.49
281	Pancreatic cancer	Enrichment	TP53	1.49
282	Histiocytoid hemangioma	Enrichment	FOS	1.46
283	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.45
284	Hypercholesterolemia, familial, 2	Enrichment	APOB	1.43
285	Strabismus	Enrichment	PTPN11	1.43
286	Bladder cancer	Enrichment	TP53	1.42
287	Prostate cancer	Enrichment	TP53	1.42
288	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.40
289	Long qt syndrome 1	Enrichment	PTPN11	1.38
290	West syndrome	Enrichment	CNPY3	1.38
291	Non-immune hydrops fetalis	Enrichment	PTPN11	1.37
292	Diamond-blackfan anemia	Enrichment	TP53	1.33
293	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.32
294	Leukemia, acute myeloid	Enrichment	TP53	1.29
295	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.28
296	Gastroesophageal reflux	Enrichment	RPS6KA3	1.26
297	Orthostatic intolerance	Enrichment	RPS6KA3	1.26
298	Isolated split hand-split foot malformation	Enrichment	BTRC	1.26
299	Gastric cancer	Enrichment	TP53	1.26
300	Thrombophilia due to thrombin defect	Enrichment	FGA	1.25
301	Hereditary breast carcinoma	Enrichment	TP53	1.25
302	Dilated cardiomyopathy	Enrichment	TAB2	1.24
303	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.23
304	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C, PTPN11	1.23
305	Hyperlipidemia, familial combined, 3	Enrichment	APOB	1.21
306	Arteriovenous malformation	Enrichment	MAP2K1	1.21
307	Ventricular septal defect	Enrichment	RPS6KA3	1.21
308	Myopathy, centronuclear, 1	Enrichment	DNM2	1.20
309	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.20
310	Thrombocytopenia	Enrichment	PTPN11	1.19
311	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.17
312	Myeloma, multiple	Enrichment	TP53	1.14
313	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.13
314	Autoinflammatory disease	Enrichment	NOD2	1.12
315	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.12
316	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.02
317	Colorectal cancer	Enrichment	TP53	0.96
318	Heart, malformation of	Enrichment	MAPK1	0.92
319	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	0.92
320	Ovarian cancer	Enrichment	TP53	0.90
321	Stereotypic movement disorder	Enrichment	DNM1	0.88
322	Kallmann syndrome	Enrichment	DUSP6	0.83
323	Hypercholesterolemia, familial, 1	Enrichment	APOB	0.82
324	Microcephaly	Enrichment	PTPN11	0.80
325	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.79
326	Familial hypercholesterolemia	Enrichment	APOB	0.76
327	Centronuclear myopathy	Enrichment	DNM2	0.69
328	Complex neurodevelopmental disorder	Enrichment	FBXW11, PPP2CA	0.67
329	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.65
330	Hypertelorism	Enrichment	RPS6KA3	0.51
331	Myopathy	Enrichment	DNM2	0.46
332	Charcot-marie-tooth disease	Enrichment	DNM2	0.45
333	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.34
334	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GSDME	0.32
335	Rare genetic deafness	Enrichment	GSDME	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Toll Like Receptor 7/8 (TLR7/8) Cascade

Pathway Network for Toll Like Receptor 7/8 (TLR7/8) Cascade

Pathway network for the Toll Like Receptor 7/8 (TLR7/8) Cascade SuperPath

Member Pathways for Toll Like Receptor 7/8 (TLR7/8) Cascade

Pathways in the Toll Like Receptor 7/8 (TLR7/8) Cascade SuperPath

Associated Genes for Toll Like Receptor 7/8 (TLR7/8) Cascade

Associated Disorders for Toll Like Receptor 7/8 (TLR7/8) Cascade

Disorders associated with Toll Like Receptor 7/8 (TLR7/8) Cascade SuperPath

STRING Interaction Network for Toll Like Receptor 7/8 (TLR7/8) Cascade

Sources for Toll Like Receptor 7/8 (TLR7/8) Cascade