TP53 network

No Pathway Network information available for TP53 network

Pathways in the TP53 network SuperPath

#	Name	Source	Genes
1	TP53 network	WikiPathways	ABL1 ATM BAX BBC3 BCL2 BID BOK CDKN1A CDKN2A GADD45A MDM2 MYC OTX2 PMAIP1 TNFSF10 TP53 TP63 TP73 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNFSF10	TNF Superfamily Member 10	Protein Coding	1
2	TP63	Tumor Protein P63	Protein Coding	1
3	TP73	Tumor Protein P73	Protein Coding	1
4	TP53	Tumor Protein P53	Protein Coding	1
5	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
6	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
7	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
8	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
9	OTX2	Orthodenticle Homeobox 2	Protein Coding	1
10	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
11	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
12	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
13	BBC3	BCL2 Binding Component 3	Protein Coding	1
14	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
15	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
16	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
17	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
18	BOK	BCL2 Family Apoptosis Regulator BOK	Protein Coding	1

Disorders associated with TP53 network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	7.41
2	Bladder cancer	Enrichment	ATM, CDKN1A, CDKN2A, TP53	7.30
3	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A, TP53	7.16
4	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A, TP53	6.37
5	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A, MYC	5.47
6	Pancreatic cancer	Enrichment	ATM, CDKN2A, TP53	5.35
7	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	5.30
8	T-cell acute lymphoblastic leukemia	Enrichment	ABL1, BAX	5.30
9	Adenocarcinoma	Enrichment	ATM, TP53	5.30
10	Small cell cancer of the lung	Enrichment	TP53, TP73	5.00
11	Gastric cancer	Enrichment	ATM, CDKN2A, TP53	4.63
12	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	4.60
13	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	4.13
14	Colorectal cancer	Enrichment	ATM, BAX, TP53	3.71
15	Gliosarcoma	Enrichment	ATM, TP53	3.70
16	Giant cell glioblastoma	Enrichment	ATM, TP53	3.65
17	Ovarian cancer	Enrichment	ATM, CDKN2A, TP53	3.52
18	Inherited cancer-predisposing syndrome	Enrichment	ATM, CDKN2A, TP53	3.18
19	Prostate cancer	Enrichment	ATM, TP53	3.18
20	Rapp-hodgkin syndrome	Enrichment	TP63	2.88
21	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.88
22	Split-hand/foot malformation 4	Enrichment	TP63	2.88
23	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.88
24	Adult syndrome	Enrichment	TP63	2.88
25	Accelerated tumor formation	Enrichment	MDM2	2.88
26	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.88
27	Lessel-kubisch syndrome	Enrichment	MDM2	2.88
28	Bone marrow failure syndrome 5	Enrichment	TP53	2.88
29	Papilloma of choroid plexus	Enrichment	TP53	2.88
30	Basal cell carcinoma 7	Enrichment	TP53	2.88
31	Anaplastic thyroid carcinoma	Enrichment	TP53	2.88
32	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.88
33	Microphthalmia, syndromic 5	Enrichment	OTX2	2.88
34	Limb-mammary syndrome	Enrichment	TP63	2.88
35	Premature ovarian failure 21	Enrichment	TP63	2.88
36	Pituitary hormone deficiency, combined, 6	Enrichment	OTX2	2.88
37	Endometrial serous adenocarcinoma	Enrichment	ATM	2.88
38	Ductal carcinoma in situ	Enrichment	TP53	2.88
39	Orofacial cleft 8	Enrichment	TP63	2.88
40	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.88
41	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.88
42	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.88
43	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.88
44	Tp63-related disorders	Enrichment	TP63	2.88
45	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.88
46	Choroid plexus cancer	Enrichment	TP53	2.88
47	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.88
48	Hereditary breast carcinoma	Enrichment	ATM, TP53	2.82
49	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, TP53	2.63
50	Myeloma, multiple	Enrichment	ATM, TP53	2.61
51	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.58
52	Burkitt lymphoma	Enrichment	MYC	2.58
53	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	2.58
54	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.58
55	Agnathia-otocephaly complex	Enrichment	OTX2	2.58
56	Cervical cancer	Enrichment	TP53	2.58
57	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.58
58	Lymphoma, hodgkin, classic	Enrichment	TP53	2.58
59	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.58
60	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.58
61	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.58
62	Bladder exstrophy	Enrichment	TP63	2.58
63	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.58
64	Congenital fibrosarcoma	Enrichment	TP53	2.58
65	High grade glioma	Enrichment	ATM	2.58
66	Li-fraumeni syndrome 1	Enrichment	TP53	2.58
67	Sarcoma	Enrichment	TP53	2.58
68	Cervix carcinoma	Enrichment	TP53	2.58
69	Hodgkin's lymphoma	Enrichment	TP53	2.58
70	T-cell prolymphocytic leukemia	Enrichment	ATM	2.58
71	Fissured tongue	Enrichment	TP63	2.58
72	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.58
73	Ataxia-telangiectasia	Enrichment	ATM	2.40
74	Polycythemia vera	Enrichment	ATM	2.40
75	Osteogenic sarcoma	Enrichment	TP53	2.40
76	Nasopharyngeal carcinoma	Enrichment	TP53	2.40
77	Koolen-de vries syndrome	Enrichment	ATM	2.40
78	Dedifferentiated liposarcoma	Enrichment	MDM2	2.40
79	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.40
80	Anaplastic astrocytoma	Enrichment	TP53	2.40
81	Squamous cell carcinoma	Enrichment	TP53	2.40
82	Bone osteosarcoma	Enrichment	TP53	2.40
83	Butterfly-shaped pigment dystrophy	Enrichment	OTX2	2.40
84	Respiratory failure	Enrichment	TP73	2.40
85	Well-differentiated liposarcoma	Enrichment	MDM2	2.40
86	Breast cancer	Enrichment	ATM, TP53	2.36
87	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.28
88	Mantle cell lymphoma	Enrichment	ATM	2.28
89	Lung sarcomatoid carcinoma	Enrichment	TP53	2.28
90	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.28
91	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.28
92	Cleft lip and alveolus	Enrichment	TP63	2.28
93	Oculomotor apraxia	Enrichment	ATM	2.28
94	Rhabdomyosarcoma 2	Enrichment	TP53	2.18
95	Follicular lymphoma	Enrichment	BCL2	2.18
96	Lymphoma	Enrichment	TP53	2.18
97	Glioblastoma	Enrichment	ATM	2.18
98	Acute megakaryocytic leukemia	Enrichment	TP53	2.18
99	Cleft upper lip	Enrichment	TP63	2.18
100	Anxiety	Enrichment	OTX2	2.10
101	Clear cell renal cell carcinoma	Enrichment	ATM	2.10
102	Breast adenocarcinoma	Enrichment	TP53	2.10
103	Lung squamous cell carcinoma	Enrichment	CDKN2A	2.10
104	Esophageal cancer	Enrichment	TP53	2.03
105	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	2.03
106	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.03
107	Leukemia, chronic myeloid	Enrichment	ABL1	2.03
108	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.03
109	Essential thrombocythemia	Enrichment	TP53	2.03
110	Gallbladder cancer	Enrichment	TP53	2.03
111	Moyamoya angiopathy	Enrichment	ABL1	2.03
112	Glioma susceptibility 1	Enrichment	TP53	1.98
113	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.98
114	Isolated split hand-split foot malformation	Enrichment	TP63	1.98
115	Combined pituitary hormone deficiency	Enrichment	OTX2	1.98
116	Adult hepatocellular carcinoma	Enrichment	TP53	1.93
117	Primary hyperaldosteronism	Enrichment	TP53	1.93
118	Colonic benign neoplasm	Enrichment	ATM	1.93
119	Lynch syndrome 1	Enrichment	ATM	1.88
120	Melanoma	Enrichment	CDKN2A	1.88
121	Familial colorectal cancer	Enrichment	TP53	1.88
122	Immune deficiency disease	Enrichment	ATM	1.84
123	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.84
124	Myelodysplastic syndrome	Enrichment	TP53	1.84
125	Nanophthalmos	Enrichment	OTX2	1.84
126	Uterine corpus cancer	Enrichment	ATM	1.84
127	Familial colorectal cancer type x	Enrichment	ATM	1.84
128	Septooptic dysplasia	Enrichment	OTX2	1.80
129	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.77
130	Premature menopause	Enrichment	TP63	1.77
131	Lung cancer susceptibility 3	Enrichment	TP53	1.73
132	Heart disease	Enrichment	ABL1	1.73
133	Cleft lip/palate	Enrichment	TP63	1.73
134	46,xy partial gonadal dysgenesis	Enrichment	OTX2	1.73
135	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.70
136	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.70
137	Rhabdomyosarcoma	Enrichment	TP53	1.68
138	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.65
139	Diffuse large b-cell lymphoma	Enrichment	TP53	1.60
140	Macs syndrome	Enrichment	OTX2	1.58
141	Endometrial cancer	Enrichment	ATM	1.56
142	Hepatoblastoma	Enrichment	TP53	1.56
143	Hepatocellular carcinoma	Enrichment	TP53	1.54
144	Microphthalmia	Enrichment	OTX2	1.54
145	Diamond-blackfan anemia 1	Enrichment	TP53	1.52
146	Diamond-blackfan anemia	Enrichment	TP53	1.33
147	Leukemia, acute myeloid	Enrichment	TP53	1.29
148	Primary ovarian insufficiency	Enrichment	TP63	1.12
149	Leber plus disease	Enrichment	OTX2	0.92
150	Microcephaly	Enrichment	ABL1	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TP53 network

Pathway Network for TP53 network

Member Pathways for TP53 network

Pathways in the TP53 network SuperPath

Associated Genes for TP53 network

Associated Disorders for TP53 network

Disorders associated with TP53 network SuperPath

STRING Interaction Network for TP53 network

Sources for TP53 network