TP53 Regulates Transcription of Cell Cycle Genes

Pathway network for the TP53 Regulates Transcription of Cell Cycle Genes SuperPath

Sources:

Reactome
WikiPathways

Pathways in the TP53 Regulates Transcription of Cell Cycle Genes SuperPath

#	Name	Source	Genes
1	TP53 Regulates Transcription of Cell Cycle Genes	Reactome	ARID3A AURKA BTG2 CARM1 CCNA1 CCNA2 CCNB1 CCNE1 CCNE2 CDC25C CDK1 CDK2 CDKN1A CDKN1B CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 CPAP E2F1 E2F4 E2F7 E2F8 EP300 GADD45A NPM1 PCBP4 PCNA PLAGL1 PLK2 PLK3 PRMT1 RBL1 RBL2 RGCC SFN TFDP1 TFDP2 TNKS1BP1 TP53 ZNF385A (see all 48) (see less)
2	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Reactome	BTG2 CDC25C CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 CPAP NPM1 PLAGL1 PLK2 PLK3 RGCC TNKS1BP1 TP53 (see all 21) (see less)
3	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	Reactome	AURKA CARM1 CCNB1 CDC25C CDK1 E2F4 EP300 GADD45A PCNA PRMT1 RBL1 RBL2 SFN TFDP1 TFDP2 TP53 ZNF385A (see all 17) (see less)
4	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	Reactome	ARID3A CCNA1 CCNA2 CCNE1 CCNE2 CDK2 CDKN1A CDKN1B E2F1 E2F7 E2F8 PCBP4 TP53 ZNF385A (see all 14) (see less)
5	Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer	WikiPathways	CCNE2 TP53

Gene overlap in member pathways for TP53 Regulates Transcription of Cell Cycle Genes SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TP53	Tumor Protein P53	Protein Coding	5
2	ZNF385A	Zinc Finger Protein 385A	Protein Coding	3
3	CCNE2	Cyclin E2	Protein Coding	3
4	CDC25C	Cell Division Cycle 25C	Protein Coding	3
5	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
6	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
7	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	2
8	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	2
9	PLK2	Polo Like Kinase 2	Protein Coding	2
10	PLK3	Polo Like Kinase 3	Protein Coding	2
11	E2F7	E2F Transcription Factor 7	Protein Coding	2
12	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	2
13	ARID3A	AT-Rich Interaction Domain 3A	Protein Coding	2
14	E2F1	E2F Transcription Factor 1	Protein Coding	2
15	E2F4	E2F Transcription Factor 4	Protein Coding	2
16	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
17	CNOT1	CCR4-NOT Transcription Complex Subunit 1	Protein Coding	2
18	CNOT6L	CCR4-NOT Transcription Complex Subunit 6 Like	Protein Coding	2
19	CNOT10	CCR4-NOT Transcription Complex Subunit 10	Protein Coding	2
20	SFN	Stratifin	Protein Coding	2
21	RGCC	Regulator Of Cell Cycle	Protein Coding	2
22	CNOT7	CCR4-NOT Transcription Complex Subunit 7	Protein Coding	2
23	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	2
24	CNOT2	CCR4-NOT Transcription Complex Subunit 2	Protein Coding	2
25	CNOT3	CCR4-NOT Transcription Complex Subunit 3	Protein Coding	2
26	CNOT4	CCR4-NOT Transcription Complex Subunit 4	Protein Coding	2
27	NPM1	Nucleophosmin 1	Protein Coding	2
28	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	2
29	PLAGL1	PLAG1 Like Zinc Finger 1	Protein Coding	2
30	CNOT11	CCR4-NOT Transcription Complex Subunit 11	Protein Coding	2
31	CPAP	Centrosome Assembly And Centriole Elongation Protein	Protein Coding	2
32	PCBP4	Poly(RC) Binding Protein 4	Protein Coding	2
33	CNOT6	CCR4-NOT Transcription Complex Subunit 6	Protein Coding	2
34	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	2
35	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	2
36	AURKA	Aurora Kinase A	Protein Coding	2
37	TFDP1	Transcription Factor Dp-1	Protein Coding	2
38	TFDP2	Transcription Factor Dp-2	Protein Coding	2
39	BTG2	BTG Anti-Proliferation Factor 2	Protein Coding	2
40	E2F8	E2F Transcription Factor 8	Protein Coding	2
41	TNKS1BP1	Tankyrase 1 Binding Protein 1	Protein Coding	2
42	CCNA2	Cyclin A2	Protein Coding	2
43	CCNA1	Cyclin A1	Protein Coding	2
44	CCNB1	Cyclin B1	Protein Coding	2
45	CCNE1	Cyclin E1	Protein Coding	2
46	CNOT9	CCR4-NOT Transcription Complex Subunit 9	Protein Coding	2
47	CNOT8	CCR4-NOT Transcription Complex Subunit 8	Protein Coding	2
48	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2

Disorders associated with TP53 Regulates Transcription of Cell Cycle Genes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	4.68
2	Bone marrow failure syndrome 5	Enrichment	TP53	3.83
3	Papilloma of choroid plexus	Enrichment	TP53	3.83
4	Basal cell carcinoma 7	Enrichment	TP53	3.83
5	Anaplastic thyroid carcinoma	Enrichment	TP53	3.83
6	Ductal carcinoma in situ	Enrichment	TP53	3.83
7	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.83
8	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.83
9	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.83
10	Choroid plexus cancer	Enrichment	TP53	3.83
11	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.83
12	Colorectal cancer	Enrichment	AURKA, EP300, TP53	3.79
13	Adrenocortical carcinoma, hereditary	Enrichment	TP53	3.53
14	Cervical cancer	Enrichment	TP53	3.53
15	Lymphoma, hodgkin, classic	Enrichment	TP53	3.53
16	Congenital fibrosarcoma	Enrichment	TP53	3.53
17	Li-fraumeni syndrome 1	Enrichment	TP53	3.53
18	Sarcoma	Enrichment	TP53	3.53
19	Cervix carcinoma	Enrichment	TP53	3.53
20	Hodgkin's lymphoma	Enrichment	TP53	3.53
21	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	3.53
22	Bladder cancer	Enrichment	CDKN1A, TP53	3.40
23	Osteogenic sarcoma	Enrichment	TP53	3.35
24	Nasopharyngeal carcinoma	Enrichment	TP53	3.35
25	Atypical teratoid rhabdoid tumor	Enrichment	TP53	3.35
26	Anaplastic astrocytoma	Enrichment	TP53	3.35
27	Squamous cell carcinoma	Enrichment	TP53	3.35
28	Adenocarcinoma	Enrichment	TP53	3.35
29	Bone osteosarcoma	Enrichment	TP53	3.35
30	Small cell cancer of the lung	Enrichment	TP53	3.23
31	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	3.23
32	Lung sarcomatoid carcinoma	Enrichment	TP53	3.23
33	Embryonal rhabdomyosarcoma	Enrichment	TP53	3.23
34	Rhabdomyosarcoma 2	Enrichment	TP53	3.13
35	Lymphoma	Enrichment	TP53	3.13
36	Acute megakaryocytic leukemia	Enrichment	TP53	3.13
37	Li-fraumeni syndrome	Enrichment	TP53	3.05
38	Adrenocortical carcinoma	Enrichment	TP53	3.05
39	Breast adenocarcinoma	Enrichment	TP53	3.05
40	Esophageal cancer	Enrichment	TP53	2.99
41	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.99
42	Essential thrombocythemia	Enrichment	TP53	2.99
43	Gallbladder cancer	Enrichment	TP53	2.99
44	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.99
45	Neuroendocrine tumor	Enrichment	CDKN1B	2.99
46	Glioma susceptibility 1	Enrichment	TP53	2.93
47	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.93
48	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.90
49	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.90
50	Adult hepatocellular carcinoma	Enrichment	TP53	2.88
51	Primary hyperaldosteronism	Enrichment	TP53	2.88
52	Leukemia, chronic lymphocytic	Enrichment	TP53	2.83
53	Familial colorectal cancer	Enrichment	TP53	2.83
54	Holoprosencephaly 12 with or without pancreatic agenesis	Enrichment	CNOT1	2.81
55	Vissers-bodmer syndrome	Enrichment	CNOT1	2.81
56	Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies	Enrichment	CNOT2	2.81
57	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.81
58	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.81
59	Pancreatic agenesis-holoprosencephaly syndrome	Enrichment	CNOT1	2.81
60	Myelodysplastic syndrome	Enrichment	TP53	2.79
61	Leukemia, acute myeloid	Enrichment	NPM1, TP53	2.76
62	Lip and oral cavity carcinoma	Enrichment	TP53	2.75
63	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.69
64	Lung cancer susceptibility 3	Enrichment	TP53	2.69
65	Myeloma, multiple	Enrichment	AURKA, TP53	2.66
66	Rhabdomyosarcoma	Enrichment	TP53	2.63
67	Gliosarcoma	Enrichment	TP53	2.63
68	Menke-hennekam syndrome 2	Enrichment	EP300	2.60
69	Giant cell glioblastoma	Enrichment	TP53	2.60
70	Diffuse large b-cell lymphoma	Enrichment	TP53	2.55
71	Microcephaly 6, primary, autosomal recessive	Enrichment	CPAP	2.51
72	Seckel syndrome 4	Enrichment	CPAP	2.51
73	Alopecia-intellectual disability syndrome 4	Enrichment	CNOT1	2.51
74	Lissencephaly 3	Enrichment	CPAP	2.51
75	Acute myeloid leukemia without maturation	Enrichment	NPM1	2.51
76	Lymphomatoid papulosis	Enrichment	NPM1	2.51
77	Paternal uniparental disomy of chromosome 6	Enrichment	PLAGL1	2.51
78	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	2.51
79	Hepatoblastoma	Enrichment	TP53	2.51
80	Hereditary breast ovarian cancer syndrome	Enrichment	PLK2, TP53	2.49
81	Hepatocellular carcinoma	Enrichment	TP53	2.49
82	Diamond-blackfan anemia 1	Enrichment	TP53	2.47
83	Pancreatic cancer	Enrichment	TP53	2.43
84	Primary hyperparathyroidism	Enrichment	CDKN1B	2.38
85	Prostate cancer	Enrichment	TP53	2.37
86	Seckel syndrome 5	Enrichment	CPAP	2.33
87	Ovarian cancer	Enrichment	CDKN1B, TP53	2.33
88	Diamond-blackfan anemia	Enrichment	TP53	2.28
89	Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	Enrichment	CNOT3	2.21
90	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.20
91	Gastric cancer	Enrichment	TP53	2.20
92	Hereditary breast carcinoma	Enrichment	TP53	2.19
93	Rubinstein-taybi syndrome 1	Enrichment	EP300	2.13
94	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	2.13
95	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	CPAP	2.11
96	Microcephaly 1, primary, autosomal recessive	Enrichment	CPAP	2.11
97	Acute myeloid leukemia with maturation	Enrichment	NPM1	2.11
98	Transient neonatal diabetes mellitus	Enrichment	PLAGL1	2.11
99	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, TP53	2.10
100	Breast cancer	Enrichment	TP53	1.96
101	Charge syndrome	Enrichment	EP300	1.95
102	Complex neurodevelopmental disorder	Enrichment	CNOT1, CNOT3	1.81
103	Polydactyly, postaxial, type a1	Enrichment	EP300	1.73
104	Rare genetic intellectual disability	Enrichment	EP300	1.73
105	Acute promyelocytic leukemia	Enrichment	NPM1	1.70
106	Seckel syndrome	Enrichment	CPAP	1.67
107	Isolated congenital microcephaly	Enrichment	CPAP	1.61
108	Dyskeratosis congenita	Enrichment	NPM1	1.54
109	Lissencephaly	Enrichment	CPAP	1.49
110	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CNOT3	1.46
111	Primary autosomal recessive microcephaly	Enrichment	CPAP	1.31
112	Microcephaly	Enrichment	CPAP, EP300	1.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TP53 Regulates Transcription of Cell Cycle Genes

Pathway Network for TP53 Regulates Transcription of Cell Cycle Genes

Pathway network for the TP53 Regulates Transcription of Cell Cycle Genes SuperPath

Member Pathways for TP53 Regulates Transcription of Cell Cycle Genes

Pathways in the TP53 Regulates Transcription of Cell Cycle Genes SuperPath

Gene overlap in member pathways for TP53 Regulates Transcription of Cell Cycle Genes SuperPath

Associated Genes for TP53 Regulates Transcription of Cell Cycle Genes

Associated Disorders for TP53 Regulates Transcription of Cell Cycle Genes

Disorders associated with TP53 Regulates Transcription of Cell Cycle Genes SuperPath

STRING Interaction Network for TP53 Regulates Transcription of Cell Cycle Genes

Sources for TP53 Regulates Transcription of Cell Cycle Genes