TP53 Regulates Transcription of Cell Death Genes

Pathway network for the TP53 Regulates Transcription of Cell Death Genes SuperPath

Sources:

Reactome

Pathways in the TP53 Regulates Transcription of Cell Death Genes SuperPath

#	Name	Source	Genes
1	TP53 Regulates Transcription of Cell Death Genes	Reactome	AIFM2 ATM BBC3 BCL2L14 BCL6 BIRC5 BNIP3L CASP1 CASP10 CASP2 CHM CRADD CREBBP IGFBP3 NDRG1 NLRC4 PERP PIDD1 PMAIP1 PRELID1 PRELID3A RABGGTA RABGGTB STEAP3 TMEM219 TNFRSF10C TNFRSF10D TP53 TP53AIP1 TP53I3 TP53INP1 TRIAP1 ZNF420 (see all 33) (see less)
2	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Reactome	AIFM2 ATM BBC3 BNIP3L CREBBP PMAIP1 PRELID1 PRELID3A STEAP3 TP53 TP53AIP1 TP53INP1 TRIAP1 ZNF420 (see all 14) (see less)
3	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Reactome	BCL2L14 BCL6 BIRC5 CHM NDRG1 PERP RABGGTA RABGGTB TP53 TP53I3 (see all 10) (see less)
4	TP53 Regulates Transcription of Caspase Activators and Caspases	Reactome	ATM CASP1 CASP10 CASP2 CRADD NLRC4 PIDD1 TP53 (see all 8) (see less)
5	TP53 Regulates Transcription of Death Receptors and Ligands	Reactome	IGFBP3 TMEM219 TNFRSF10C TNFRSF10D TP53
6	The IPAF inflammasome	Reactome	CASP1 NLRC4

Gene overlap in member pathways for TP53 Regulates Transcription of Cell Death Genes SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TP53	Tumor Protein P53	Protein Coding	5
2	ATM	ATM Serine/Threonine Kinase	Protein Coding	3
3	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	3
4	CASP1	Caspase 1	Protein Coding	3
5	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	2
6	PRELID3A	PRELI Domain Containing 3A	Protein Coding	2
7	CHM	CHM Rab Escort Protein	Protein Coding	2
8	TMEM219	Transmembrane Protein 219	Protein Coding	2
9	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
10	ZNF420	Zinc Finger Protein 420	Protein Coding	2
11	BBC3	BCL2 Binding Component 3	Protein Coding	2
12	PRELID1	PRELI Domain Containing 1	Protein Coding	2
13	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	2
14	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	2
15	TRIAP1	TP53 Regulated Inhibitor Of Apoptosis 1	Protein Coding	2
16	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	2
17	STEAP3	STEAP3 Metalloreductase	Protein Coding	2
18	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	2
19	RABGGTA	Rab Geranylgeranyltransferase Subunit Alpha	Protein Coding	2
20	RABGGTB	Rab Geranylgeranyltransferase Subunit Beta	Protein Coding	2
21	BCL6	BCL6 Transcription Repressor	Protein Coding	2
22	TP53AIP1	Tumor Protein P53 Regulated Apoptosis Inducing Protein 1	Protein Coding	2
23	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	2
24	BNIP3L	BCL2 Interacting Protein 3 Like	Protein Coding	2
25	BCL2L14	BCL2 Like 14	Protein Coding	2
26	CASP2	Caspase 2	Protein Coding	2
27	CASP10	Caspase 10	Protein Coding	2
28	AIFM2	AIF Family Member 2	Protein Coding	2
29	CRADD	CARD And Death Domain Containing Adaptor Protein	Protein Coding	2
30	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	2
31	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	2
32	TP53INP1	Tumor Protein P53 Inducible Nuclear Protein 1	Protein Coding	2
33	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	2

Disorders associated with TP53 Regulates Transcription of Cell Death Genes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adenocarcinoma	Enrichment	ATM, TP53	6.04
2	Gastric cancer	Enrichment	ATM, CASP10, TP53	5.78
3	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, TP53	5.07
4	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	4.86
5	Myeloma, multiple	Enrichment	ATM, CREBBP, TP53	4.63
6	Gliosarcoma	Enrichment	ATM, TP53	4.44
7	Giant cell glioblastoma	Enrichment	ATM, TP53	4.39
8	Pancreatic cancer	Enrichment	ATM, TP53	4.04
9	Bladder cancer	Enrichment	ATM, TP53	3.91
10	Prostate cancer	Enrichment	ATM, TP53	3.91
11	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	3.83
12	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	3.83
13	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	3.83
14	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TP53	3.78
15	Hereditary breast carcinoma	Enrichment	ATM, TP53	3.55
16	Bone marrow failure syndrome 5	Enrichment	TP53	3.43
17	Papilloma of choroid plexus	Enrichment	TP53	3.43
18	Basal cell carcinoma 7	Enrichment	TP53	3.43
19	Anaplastic thyroid carcinoma	Enrichment	TP53	3.43
20	Ductal carcinoma in situ	Enrichment	TP53	3.43
21	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.43
22	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.43
23	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.43
24	Choroid plexus cancer	Enrichment	TP53	3.43
25	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.43
26	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, TP53	3.35
27	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	3.23
28	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	Enrichment	CRADD	3.23
29	Endometrial serous adenocarcinoma	Enrichment	ATM	3.23
30	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	3.23
31	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.23
32	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	3.23
33	Adrenocortical carcinoma, hereditary	Enrichment	TP53	3.13
34	Cervical cancer	Enrichment	TP53	3.13
35	Lymphoma, hodgkin, classic	Enrichment	TP53	3.13
36	Congenital fibrosarcoma	Enrichment	TP53	3.13
37	Li-fraumeni syndrome 1	Enrichment	TP53	3.13
38	Sarcoma	Enrichment	TP53	3.13
39	Cervix carcinoma	Enrichment	TP53	3.13
40	Hodgkin's lymphoma	Enrichment	TP53	3.13
41	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	3.13
42	Olmsted syndrome 2	Enrichment	PERP	3.13
43	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	3.13
44	Breast cancer	Enrichment	ATM, TP53	3.08
45	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.99
46	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.99
47	Menke-hennekam syndrome	Enrichment	CREBBP	2.99
48	Osteogenic sarcoma	Enrichment	TP53	2.96
49	Nasopharyngeal carcinoma	Enrichment	TP53	2.96
50	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.96
51	Anaplastic astrocytoma	Enrichment	TP53	2.96
52	Squamous cell carcinoma	Enrichment	TP53	2.96
53	Bone osteosarcoma	Enrichment	TP53	2.96
54	Colorectal cancer	Enrichment	ATM, TP53	2.95
55	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.93
56	High grade glioma	Enrichment	ATM	2.93
57	T-cell prolymphocytic leukemia	Enrichment	ATM	2.93
58	Small cell cancer of the lung	Enrichment	TP53	2.83
59	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.83
60	Lung sarcomatoid carcinoma	Enrichment	TP53	2.83
61	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.83
62	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	2.83
63	Intravascular large b-cell lymphoma	Enrichment	BCL6	2.83
64	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	2.83
65	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	2.83
66	Ovarian cancer	Enrichment	ATM, TP53	2.83
67	Ataxia-telangiectasia	Enrichment	ATM	2.75
68	Polycythemia vera	Enrichment	ATM	2.75
69	Koolen-de vries syndrome	Enrichment	ATM	2.75
70	Rhabdomyosarcoma 2	Enrichment	TP53	2.73
71	Lymphoma	Enrichment	TP53	2.73
72	Acute megakaryocytic leukemia	Enrichment	TP53	2.73
73	Thumb deformity	Enrichment	CREBBP	2.69
74	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	2.69
75	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.69
76	Li-fraumeni syndrome	Enrichment	TP53	2.66
77	Adrenocortical carcinoma	Enrichment	TP53	2.66
78	Breast adenocarcinoma	Enrichment	TP53	2.66
79	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	2.66
80	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	2.66
81	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	2.63
82	Mantle cell lymphoma	Enrichment	ATM	2.63
83	Oculomotor apraxia	Enrichment	ATM	2.63
84	Inherited cancer-predisposing syndrome	Enrichment	ATM, TP53	2.60
85	Esophageal cancer	Enrichment	TP53	2.59
86	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.59
87	Essential thrombocythemia	Enrichment	TP53	2.59
88	Gallbladder cancer	Enrichment	TP53	2.59
89	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.59
90	Glioblastoma	Enrichment	ATM	2.53
91	Glioma susceptibility 1	Enrichment	TP53	2.53
92	Choroideremia	Enrichment	CHM	2.53
93	Tethered spinal cord syndrome	Enrichment	CREBBP	2.51
94	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.51
95	Adult hepatocellular carcinoma	Enrichment	TP53	2.48
96	Primary hyperaldosteronism	Enrichment	TP53	2.48
97	Clear cell renal cell carcinoma	Enrichment	ATM	2.45
98	Autoinflammatory disease	Enrichment	NLRC4	2.45
99	Follicular lymphoma	Enrichment	BCL6	2.43
100	Night blindness	Enrichment	CHM	2.43
101	Familial colorectal cancer	Enrichment	TP53	2.43
102	Myelodysplastic syndrome	Enrichment	TP53	2.39
103	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.38
104	Lip and oral cavity carcinoma	Enrichment	TP53	2.35
105	Lung cancer susceptibility 3	Enrichment	TP53	2.29
106	Colonic benign neoplasm	Enrichment	ATM	2.28
107	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	CRADD	2.28
108	Lynch syndrome 1	Enrichment	ATM	2.23
109	Rhabdomyosarcoma	Enrichment	TP53	2.23
110	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	2.21
111	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	2.21
112	Hypertrichosis	Enrichment	CREBBP	2.21
113	Immune deficiency disease	Enrichment	ATM	2.19
114	Uterine corpus cancer	Enrichment	ATM	2.19
115	Familial colorectal cancer type x	Enrichment	ATM	2.19
116	Breast-ovarian cancer, familial 1	Enrichment	ATM	2.12
117	Hepatoblastoma	Enrichment	TP53	2.11
118	Hepatocellular carcinoma	Enrichment	TP53	2.09
119	Diamond-blackfan anemia 1	Enrichment	TP53	2.07
120	Renal cell carcinoma, nonpapillary	Enrichment	ATM	2.05
121	Endometrial cancer	Enrichment	ATM	1.91
122	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	1.88
123	Diamond-blackfan anemia	Enrichment	TP53	1.88
124	Heart disease	Enrichment	CREBBP	1.84
125	Leukemia, acute myeloid	Enrichment	TP53	1.83
126	Corpus callosum, agenesis of	Enrichment	CREBBP	1.81
127	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.81
128	Rare genetic intellectual disability	Enrichment	CREBBP	1.81
129	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.81
130	Severe covid-19	Enrichment	CASP10	1.77
131	Scoliosis	Enrichment	CREBBP	1.61
132	Eye disease	Enrichment	CHM	1.59
133	Charcot-marie-tooth disease	Enrichment	NDRG1	1.53
134	Autosomal recessive non-syndromic intellectual disability	Enrichment	CRADD	1.47
135	Autism	Enrichment	CREBBP	1.14
136	Congenital nervous system abnormality	Enrichment	CREBBP	0.98
137	Nervous system disease	Enrichment	CREBBP	0.98
138	Retinitis pigmentosa	Enrichment	CHM	0.84
139	Hereditary retinal dystrophy	Enrichment	CHM	0.71
140	Fundus dystrophy	Enrichment	CHM	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TP53 Regulates Transcription of Cell Death Genes

Pathway Network for TP53 Regulates Transcription of Cell Death Genes

Pathway network for the TP53 Regulates Transcription of Cell Death Genes SuperPath

Member Pathways for TP53 Regulates Transcription of Cell Death Genes

Pathways in the TP53 Regulates Transcription of Cell Death Genes SuperPath

Gene overlap in member pathways for TP53 Regulates Transcription of Cell Death Genes SuperPath

Associated Genes for TP53 Regulates Transcription of Cell Death Genes

Associated Disorders for TP53 Regulates Transcription of Cell Death Genes

Disorders associated with TP53 Regulates Transcription of Cell Death Genes SuperPath

STRING Interaction Network for TP53 Regulates Transcription of Cell Death Genes

Sources for TP53 Regulates Transcription of Cell Death Genes