TRAF6 mediated IRF7 activation

Pathway network for the TRAF6 mediated IRF7 activation SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the TRAF6 mediated IRF7 activation SuperPath

#	Name	Source	Genes
1	TRAF6 mediated IRF7 activation	Reactome	CREBBP EP300 IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKE IRF3 IRF7 MAVS RIGI RNF135 SIKE1 TANK TBK1 TRAF2 TRAF6 TRIM25 TRIM4 (see all 30) (see less)
2	Evasion by RSV of host interferon responses	Reactome	CREBBP CUL5 EIF2AK2 ELOB ELOC EP300 IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IRF3 JAK1 MAVS RBX1 RIGI RPS27A STAT2 TRIM25 TYK2 UBA52 UBB UBC (see all 35) (see less)
3	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway	GeneGo (Thomson Reuters)	BECN1 CD14 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKG IRF3 LY96 NFKB1 NFKB2 REL RELA RELB RIPK1 RIPK3 TICAM1 TICAM2 TIRAP TLR3 TLR4 TRAF6 (see all 32) (see less)

Gene overlap in member pathways for TRAF6 mediated IRF7 activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IFNA1	Interferon Alpha 1	Protein Coding	3
2	IFNA2	Interferon Alpha 2	Protein Coding	3
3	IFNA4	Interferon Alpha 4	Protein Coding	3
4	IFNA5	Interferon Alpha 5	Protein Coding	3
5	IFNA6	Interferon Alpha 6	Protein Coding	3
6	IFNA7	Interferon Alpha 7	Protein Coding	3
7	IFNA8	Interferon Alpha 8	Protein Coding	3
8	IFNA10	Interferon Alpha 10	Protein Coding	3
9	IFNA13	Interferon Alpha 13	Protein Coding	3
10	IFNA14	Interferon Alpha 14	Protein Coding	3
11	IFNA16	Interferon Alpha 16	Protein Coding	3
12	IFNA17	Interferon Alpha 17	Protein Coding	3
13	IFNA21	Interferon Alpha 21	Protein Coding	3
14	IFNB1	Interferon Beta 1	Protein Coding	3
15	IRF3	Interferon Regulatory Factor 3	Protein Coding	3
16	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
17	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
18	RIGI	RNA Sensor RIG-I	Protein Coding	2
19	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	2
20	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	2
21	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
22	TRIM25	Tripartite Motif Containing 25	Protein Coding	2
23	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
24	TBK1	TANK Binding Kinase 1	Protein Coding	1
25	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
26	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
27	SIKE1	Suppressor Of IKBKE 1	Protein Coding	1
28	RNF135	Ring Finger Protein 135	Protein Coding	1
29	TRIM4	Tripartite Motif Containing 4	Protein Coding	1
30	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
31	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	1
32	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
33	JAK1	Janus Kinase 1	Protein Coding	1
34	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
35	RPS27A	Ribosomal Protein S27a	Protein Coding	1
36	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
37	ELOC	Elongin C	Protein Coding	1
38	ELOB	Elongin B	Protein Coding	1
39	TYK2	Tyrosine Kinase 2	Protein Coding	1
40	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
41	UBB	Ubiquitin B	Protein Coding	1
42	UBC	Ubiquitin C	Protein Coding	1
43	CUL5	Cullin 5	Protein Coding	1
44	RBX1	Ring-Box 1	Protein Coding	1
45	CD14	CD14 Molecule	Protein Coding	1
46	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
47	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
48	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
49	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
50	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
51	TLR3	Toll Like Receptor 3	Protein Coding	1
52	TLR4	Toll Like Receptor 4	Protein Coding	1
53	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
54	BECN1	Beclin 1	Protein Coding	1
55	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
56	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
57	LY96	Lymphocyte Antigen 96	Protein Coding	1
58	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	1
59	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	1
60	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	1

Disorders associated with TRAF6 mediated IRF7 activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Respiratory syncytial virus infectious disease	Direct
2	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, IFNA21, IFNA4, IFNA6, IFNB1, IRF3	10.95
3	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	5.33
4	Herpes simplex virus encephalitis	Enrichment	TICAM1, TLR3	4.27
5	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.15
6	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.15
7	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.95
8	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.31
9	Malaria	Enrichment	IKBKG, TIRAP	2.88
10	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.66
11	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.66
12	Singleton-merten syndrome 1	Enrichment	IFIH1	2.66
13	Immunodeficiency 95	Enrichment	IFIH1	2.66
14	Type 1 diabetes mellitus 19	Enrichment	IFIH1	2.66
15	Immunodeficiency 39	Enrichment	IRF7	2.66
16	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.66
17	Singleton-merten syndrome 2	Enrichment	RIGI	2.66
18	Corticobasal syndrome	Enrichment	TBK1	2.66
19	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.66
20	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.66
21	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	2.66
22	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.66
23	Menke-hennekam syndrome	Enrichment	CREBBP	2.66
24	Incontinentia pigmenti	Enrichment	IKBKG	2.63
25	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.63
26	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.63
27	Bacteremia 1	Enrichment	TIRAP	2.63
28	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.63
29	Immunodeficiency 92	Enrichment	REL	2.63
30	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.63
31	Macular degeneration, age-related, 10	Enrichment	TLR4	2.63
32	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.63
33	Immunodeficiency 53	Enrichment	RELB	2.63
34	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.63
35	Thumb deformity	Enrichment	CREBBP	2.35
36	Menke-hennekam syndrome 2	Enrichment	EP300	2.35
37	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.35
38	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.35
39	Basal ganglia disease	Enrichment	IFIH1	2.35
40	Immunodeficiency 33	Enrichment	IKBKG	2.33
41	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.33
42	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.33
43	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.33
44	Rela fusion-positive ependymoma	Enrichment	RELA	2.33
45	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.33
46	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.33
47	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.33
48	Common variable immunodeficiency 12	Enrichment	NFKB1	2.33
49	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	RNF135	2.18
50	Tethered spinal cord syndrome	Enrichment	CREBBP	2.18
51	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.18
52	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.03
53	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.96
54	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.96
55	Spastic diplegia	Enrichment	IFIH1	1.96
56	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.93
57	Hypertrichosis	Enrichment	CREBBP	1.88
58	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.85
59	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.85
60	Motor neuron disease	Enrichment	TBK1	1.81
61	Charge syndrome	Enrichment	EP300	1.70
62	Progressive non-fluent aphasia	Enrichment	TBK1	1.70
63	Aicardi-goutiares syndrome	Enrichment	IFIH1	1.70
64	Coronary heart disease 5	Enrichment	IKBKG	1.68
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.66
66	Aicardi-goutieres syndrome	Enrichment	IFIH1	1.66
67	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.63
68	Immune deficiency disease	Enrichment	RIPK1	1.59
69	Heart disease	Enrichment	CREBBP	1.52
70	Polydactyly, postaxial, type a1	Enrichment	EP300	1.49
71	Corpus callosum, agenesis of	Enrichment	CREBBP	1.49
72	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.49
73	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.49
74	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.38
75	Human immunodeficiency virus type 1	Enrichment	TLR3	1.38
76	Behcet syndrome	Enrichment	TLR4	1.36
77	Scoliosis	Enrichment	CREBBP	1.29
78	Myeloma, multiple	Enrichment	CREBBP	0.93
79	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.92
80	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.91
81	Autism	Enrichment	CREBBP	0.83
82	Colorectal cancer	Enrichment	EP300	0.76
83	Congenital nervous system abnormality	Enrichment	CREBBP	0.68
84	Nervous system disease	Enrichment	CREBBP	0.68
85	Autism spectrum disorder	Enrichment	RNF135	0.67
86	Microcephaly	Enrichment	EP300	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TRAF6 mediated IRF7 activation

Pathway Network for TRAF6 mediated IRF7 activation

Pathway network for the TRAF6 mediated IRF7 activation SuperPath

Member Pathways for TRAF6 mediated IRF7 activation

Pathways in the TRAF6 mediated IRF7 activation SuperPath

Gene overlap in member pathways for TRAF6 mediated IRF7 activation SuperPath

Associated Genes for TRAF6 mediated IRF7 activation

Associated Disorders for TRAF6 mediated IRF7 activation

Disorders associated with TRAF6 mediated IRF7 activation SuperPath

STRING Interaction Network for TRAF6 mediated IRF7 activation

Sources for TRAF6 mediated IRF7 activation