Trafficking of AMPA receptors

Pathway network for the Trafficking of AMPA receptors SuperPath

Sources:

Reactome

Pathways in the Trafficking of AMPA receptors SuperPath

#	Name	Source	Genes
1	Trafficking of AMPA receptors	Reactome	AKAP5 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CACNG2 CACNG3 CACNG4 CACNG8 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG4 EPB41L1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 MDM2 MYO6 NSF PICK1 PRKCA PRKCB PRKCG TSPAN7 (see all 31) (see less)
2	Glutamate binding, activation of AMPA receptors and synaptic plasticity	Reactome	AKAP5 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CACNG2 CACNG3 CACNG4 CACNG8 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG4 EPB41L1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 MDM2 MYO6 NSF PICK1 PRKCA PRKCB PRKCG TSPAN7 (see all 31) (see less)
3	Trafficking of GluR2-containing AMPA receptors	Reactome	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 NSF PICK1 PRKCA PRKCB PRKCG TSPAN7 (see all 17) (see less)
4	Activation of AMPA receptors	Reactome	GRIA1 GRIA2 GRIA3 GRIA4

Gene overlap in member pathways for Trafficking of AMPA receptors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	4
2	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	4
3	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	4
4	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	4
5	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	3
6	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	3
7	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	3
8	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	3
9	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	3
10	GRIP1	Glutamate Receptor Interacting Protein 1	Protein Coding	3
11	NSF	N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase	Protein Coding	3
12	PRKCA	Protein Kinase C Alpha	Protein Coding	3
13	PRKCB	Protein Kinase C Beta	Protein Coding	3
14	PRKCG	Protein Kinase C Gamma	Protein Coding	3
15	TSPAN7	Tetraspanin 7	Protein Coding	3
16	GRIP2	Glutamate Receptor Interacting Protein 2	Protein Coding	3
17	PICK1	Protein Interacting With PRKCA 1	Protein Coding	3
18	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	2
19	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	2
20	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	2
21	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	2
22	EPB41L1	Erythrocyte Membrane Protein Band 4.1 Like 1	Protein Coding	2
23	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	2
24	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
25	MYO6	Myosin VI	Protein Coding	2
26	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	2
27	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	2
28	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	2
29	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	2
30	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	2
31	AKAP5	A-Kinase Anchoring Protein 5	Protein Coding	2

Disorders associated with Trafficking of AMPA receptors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNG2, CAMK2A, CAMK2B, EPB41L1, GRIA1	7.06
2	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	3.53
3	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	3.53
4	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	3.53
5	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	3.53
6	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	3.53
7	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	3.53
8	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	3.53
9	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.90
10	Intellectual developmental disorder, x-linked 58	Enrichment	TSPAN7	2.90
11	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.90
12	Fraser syndrome 3	Enrichment	GRIP1	2.90
13	Deafness, autosomal dominant 22	Enrichment	MYO6	2.64
14	Chromosome 20q11-q12 deletion syndrome	Enrichment	EPB41L1	2.64
15	Accelerated tumor formation	Enrichment	MDM2	2.64
16	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.64
17	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.64
18	Lessel-kubisch syndrome	Enrichment	MDM2	2.64
19	Deafness, autosomal recessive 37	Enrichment	MYO6	2.64
20	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	2.64
21	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.64
22	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.64
23	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	2.64
24	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	2.64
25	Developmental and epileptic encephalopathy 96	Enrichment	NSF	2.60
26	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.60
27	Dystonia	Enrichment	CAMK2B, GRIA3	2.54
28	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.34
29	Hereditary ataxia	Enrichment	PRKCG	2.30
30	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.16
31	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.16
32	Dedifferentiated liposarcoma	Enrichment	MDM2	2.16
33	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.16
34	Dlg4-related synaptopathy	Enrichment	DLG4	2.16
35	Well-differentiated liposarcoma	Enrichment	MDM2	2.16
36	Fraser syndrome 1	Enrichment	GRIP1	2.13
37	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.04
38	Male infertility due to globozoospermia	Enrichment	PICK1	2.00
39	Developmental and epileptic encephalopathy	Enrichment	GRIA3	1.98
40	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.95
41	West syndrome	Enrichment	GRIA3	1.89
42	Li-fraumeni syndrome	Enrichment	MDM2	1.87
43	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6	1.87
44	Body mass index quantitative trait locus 11	Enrichment	GRIA4	1.83
45	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1	1.77
46	Cleft lip/palate	Enrichment	DLG1	1.50
47	Autism spectrum disorder	Enrichment	GRIA1	1.50
48	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIA4	1.49
49	Non-syndromic x-linked intellectual disability	Enrichment	TSPAN7	1.35
50	Ear malformation	Enrichment	MYO6	1.27
51	Non-syndromic genetic deafness	Enrichment	MYO6	1.10
52	Nonsyndromic hearing loss	Enrichment	MYO6	1.04
53	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYO6	0.95
54	Autism	Enrichment	CAMK2G	0.82
55	Rare genetic deafness	Enrichment	MYO6	0.78
56	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYO6	0.73
57	Congenital nervous system abnormality	Enrichment	CAMK2B	0.67
58	Nervous system disease	Enrichment	CAMK2B	0.67
59	Microcephaly	Enrichment	CAMK2B	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Trafficking of AMPA receptors

Pathway Network for Trafficking of AMPA receptors

Pathway network for the Trafficking of AMPA receptors SuperPath

Member Pathways for Trafficking of AMPA receptors

Pathways in the Trafficking of AMPA receptors SuperPath

Gene overlap in member pathways for Trafficking of AMPA receptors SuperPath

Associated Genes for Trafficking of AMPA receptors

Associated Disorders for Trafficking of AMPA receptors

Disorders associated with Trafficking of AMPA receptors SuperPath

STRING Interaction Network for Trafficking of AMPA receptors

Sources for Trafficking of AMPA receptors