TRAIL signaling pathway

Pathway network for the TRAIL signaling pathway SuperPath

Sources:

PubChem
Reactome

Pathways in the TRAIL signaling pathway SuperPath

#	Name	Source	Genes
1	TRAIL signaling pathway	PubChem	CASP10 CASP8 CFLAR CHUK DAP3 FADD IKBKB IKBKG MAP2K4 MAP3K1 MAPK3 MAPK8 PIK3CA PIK3CB PIK3R1 RIPK1 SMPD1 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFSF10 TRADD TRAF2 (see all 24) (see less)
2	FAS (CD95) signaling pathway	PubChem	AKT1 BID BIRC2 BTK CASP10 CASP3 CASP8 CFLAR CHUK CLTC EZR FADD FAIM2 FAS FASLG IKBKB IKBKG MAP2K6 MAP2K7 MAP3K1 MAPK14 MAPK8 PDPK1 PIK3CA PIK3CB PIK3R1 PTPN13 RFC1 RIPK1 SMPD1 SRC SYK (see all 32) (see less)
3	TRAIL signaling	Reactome	CASP10 CASP8 FADD TNFRSF10D
4	FasL/ CD95L signaling	Reactome	CASP10 CASP8 FADD

Gene overlap in member pathways for TRAIL signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CASP10	Caspase 10	Protein Coding	4
2	FADD	Fas Associated Via Death Domain	Protein Coding	4
3	CASP8	Caspase 8	Protein Coding	4
4	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	2
5	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	2
6	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
7	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
8	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
9	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
10	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	2
11	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	2
12	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
13	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
14	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
15	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
16	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	1
17	DAP3	Death Associated Protein 3	Protein Coding	1
18	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
19	TNFSF10	TNF Superfamily Member 10	Protein Coding	1
20	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
21	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
22	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	1
23	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
24	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
25	FAIM2	Fas Apoptotic Inhibitory Molecule 2	Protein Coding	1
26	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
27	FASLG	Fas Ligand	Protein Coding	1
28	BTK	Bruton Tyrosine Kinase	Protein Coding	1
29	RFC1	Replication Factor C Subunit 1	Protein Coding	1
30	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
31	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
32	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
33	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
34	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
35	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
36	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
37	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
38	EZR	Ezrin	Protein Coding	1
39	CLTC	Clathrin Heavy Chain	Protein Coding	1
40	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
41	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
42	CASP3	Caspase 3	Protein Coding	1

Disorders associated with TRAIL signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	7.32
2	Lung cancer	Enrichment	CASP8, FAS, FASLG, PIK3CA	6.06
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.05
4	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	4.31
5	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.09
6	Adult hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	3.97
7	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.72
8	Caspase 8 deficiency	Enrichment	CASP8	3.66
9	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	3.66
10	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.66
11	Immune deficiency disease	Enrichment	RIPK1, SYK	3.53
12	Meningioma	Enrichment	AKT1, PIK3CA	3.46
13	Oculootodental syndrome	Enrichment	FADD	3.35
14	Hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	3.17
15	Breast cancer	Enrichment	AKT1, CASP8, PIK3CA	3.14
16	Ovarian cancer	Enrichment	AKT1, MAP3K1, PIK3CA	2.77
17	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	2.75
18	Macrodactyly	Enrichment	PIK3CA	2.75
19	Incontinentia pigmenti	Enrichment	IKBKG	2.75
20	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.75
21	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.75
22	Cowden syndrome 5	Enrichment	PIK3CA	2.75
23	Fetal encasement syndrome	Enrichment	CHUK	2.75
24	46,xy sex reversal 6	Enrichment	MAP3K1	2.75
25	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.75
26	Immunodeficiency 15b	Enrichment	IKBKB	2.75
27	Immunodeficiency 15a	Enrichment	IKBKB	2.75
28	Short syndrome	Enrichment	PIK3R1	2.75
29	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.75
30	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.75
31	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.75
32	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.75
33	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.75
34	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.75
35	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.75
36	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.75
37	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.75
38	Hypospadias	Enrichment	PIK3CA	2.75
39	Perrault syndrome 7	Enrichment	DAP3	2.75
40	Rare venous malformation	Enrichment	PIK3CA	2.75
41	Diaphragmatic eventration	Enrichment	PIK3CA	2.75
42	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.75
43	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.75
44	Rare combined vascular malformation	Enrichment	PIK3CA	2.75
45	Cavernous lymphangioma	Enrichment	PIK3CA	2.75
46	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.75
47	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.75
48	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.75
49	Macrodactyly of toe	Enrichment	PIK3CA	2.75
50	Proteus syndrome	Enrichment	AKT1	2.63
51	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.63
52	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.63
53	Cowden syndrome 6	Enrichment	AKT1	2.63
54	Thrombocytopenia 6	Enrichment	SRC	2.63
55	Colitis	Enrichment	SYK	2.63
56	Gastric cancer	Enrichment	CASP10, PIK3CA	2.59
57	Grange syndrome	Enrichment	DAP3	2.45
58	Immunodeficiency 33	Enrichment	IKBKG	2.45
59	Keratosis, seborrheic	Enrichment	PIK3CA	2.45
60	Noonan syndrome 8	Enrichment	PIK3CA	2.45
61	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.45
62	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.45
63	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.45
64	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.45
65	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.33
66	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	2.33
67	Agammaglobulinemia, x-linked	Enrichment	BTK	2.33
68	Arthritis	Enrichment	SYK	2.33
69	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.32
70	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.28
71	Niemann-pick disease, type a	Enrichment	SMPD1	2.28
72	Niemann-pick disease, type b	Enrichment	SMPD1	2.28
73	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.28
74	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	2.28
75	Immunodeficiency 14	Enrichment	PIK3R1	2.28
76	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	2.28
77	Keratoacanthoma	Enrichment	PIK3CA	2.28
78	Severe covid-19	Enrichment	CASP10	2.19
79	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.15
80	Cerebrovascular disease	Enrichment	PIK3CA	2.15
81	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.15
82	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.15
83	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.15
84	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.15
85	Agammaglobulinemia 1	Enrichment	BTK	2.15
86	Vogt-koyanagi-harada disease	Enrichment	FAS	2.15
87	Capillary malformations, congenital	Enrichment	PIK3CA	2.05
88	Niemann-pick disease, type c1	Enrichment	SMPD1	2.05
89	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.05
90	Niemann-pick disease	Enrichment	SMPD1	2.05
91	Hemimegalencephaly	Enrichment	PIK3CA	2.05
92	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	2.03
93	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.98
94	Cowden syndrome 1	Enrichment	PIK3CA	1.98
95	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.98
96	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.98
97	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.98
98	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.98
99	Nevus, epidermal	Enrichment	PIK3CA	1.91
100	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B	1.91
101	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.91
102	Gallbladder cancer	Enrichment	PIK3CA	1.91
103	Overgrowth syndrome	Enrichment	PIK3R1	1.91
104	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.85
105	Coronary heart disease 5	Enrichment	IKBKG	1.80
106	Arteriovenous malformation	Enrichment	PIK3CA	1.80
107	Myelofibrosis	Enrichment	SRC	1.79
108	Noonan syndrome 3	Enrichment	CLTC	1.79
109	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.79
110	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.76
111	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.76
112	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.71
113	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.71
114	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.68
115	Nk-cell enteropathy	Enrichment	PIK3CB	1.64
116	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.61
117	Lynch syndrome	Enrichment	PIK3CA	1.58
118	Perrault syndrome 1	Enrichment	DAP3	1.55
119	Osteoporosis	Enrichment	SRC	1.49
120	Endometrial cancer	Enrichment	PIK3CA	1.44
121	Malaria	Enrichment	IKBKG	1.40
122	Behcet syndrome	Enrichment	FAS	1.36
123	Diffuse large b-cell lymphoma	Enrichment	BTK	1.36
124	Parkinson's disease	Enrichment	RFC1	1.36
125	Bladder cancer	Enrichment	PIK3CA	1.30
126	Prostate cancer	Enrichment	PIK3CA	1.30
127	Parkinson disease, late-onset	Enrichment	RFC1	1.26
128	Severe combined immunodeficiency	Enrichment	IKBKB	1.25
129	Hypertelorism	Enrichment	PIK3CA	1.05
130	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.03
131	Thrombocytopenia	Enrichment	SRC	0.97
132	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	0.95
133	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC	0.91
134	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TRAIL signaling pathway

Pathway Network for TRAIL signaling pathway

Pathway network for the TRAIL signaling pathway SuperPath

Member Pathways for TRAIL signaling pathway

Pathways in the TRAIL signaling pathway SuperPath

Gene overlap in member pathways for TRAIL signaling pathway SuperPath

Associated Genes for TRAIL signaling pathway

Associated Disorders for TRAIL signaling pathway

Disorders associated with TRAIL signaling pathway SuperPath

STRING Interaction Network for TRAIL signaling pathway

Sources for TRAIL signaling pathway