trans-Golgi Network Vesicle Budding

Pathway network for the trans-Golgi Network Vesicle Budding SuperPath

Sources:

Reactome

Pathways in the trans-Golgi Network Vesicle Budding SuperPath

#	Name	Source	Genes
1	trans-Golgi Network Vesicle Budding	Reactome	ACBD3 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP3B1 AP3S1 AP4B1 AP4E1 AP4M1 AP4S1 APP ARF1 ARRB1 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S6 CHMP2A CLINT1 CLTA CLTB CLTC CLVS1 CLVS2 CPD CTSZ DNAJC6 DNASE2 DNM2 DTNBP1 FTH1 FTL GAK GBF1 GNS GOLGB1 HGS HIP1R HSPA8 IGF2R M6PR NAPA NECAP1 OCRL PICALM PIK3C2A PUM1 RAB5C SH3D19 SH3GL2 SNAP23 SNAPIN SNX2 SNX5 SNX9 SORT1 STX4 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 (see all 72) (see less)
2	Golgi Associated Vesicle Biogenesis	Reactome	ACBD3 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP3B1 AP3S1 AP4B1 AP4E1 ARF1 ARRB1 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S6 CLINT1 CLTA CLTC CPD DNAJC6 DNM2 DTNBP1 FTH1 FTL GAK GOLGB1 HIP1R HSPA8 IGF2R NAPA NECAP1 OCRL PICALM PIK3C2A PUM1 RAB5C SH3D19 SH3GL2 SNAPIN SNX2 SNX5 SNX9 SORT1 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 (see all 56) (see less)
3	Lysosome Vesicle Biogenesis	Reactome	AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP4B1 AP4E1 AP4M1 AP4S1 APP ARF1 ARRB1 BLOC1S1 CHMP2A CLTA CLTB CLTC CLVS1 CLVS2 CTSZ DNAJC6 DNASE2 DNM2 GNS HGS HSPA8 M6PR SH3GL2 TXNDC5 VAMP2 VAMP7 VAMP8 (see all 35) (see less)

Gene overlap in member pathways for trans-Golgi Network Vesicle Budding SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AP1M2	Adaptor Related Protein Complex 1 Subunit Mu 2	Protein Coding	3
2	AP4B1	Adaptor Related Protein Complex 4 Subunit Beta 1	Protein Coding	3
3	AP1S1	Adaptor Related Protein Complex 1 Subunit Sigma 1	Protein Coding	3
4	CLTA	Clathrin Light Chain A	Protein Coding	3
5	CLTC	Clathrin Heavy Chain	Protein Coding	3
6	AP1S3	Adaptor Related Protein Complex 1 Subunit Sigma 3	Protein Coding	3
7	AP1B1	Adaptor Related Protein Complex 1 Subunit Beta 1	Protein Coding	3
8	AP1G1	Adaptor Related Protein Complex 1 Subunit Gamma 1	Protein Coding	3
9	DNM2	Dynamin 2	Protein Coding	3
10	AP4E1	Adaptor Related Protein Complex 4 Subunit Epsilon 1	Protein Coding	3
11	BLOC1S1	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 1	Protein Coding	3
12	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	3
13	ARF1	ARF GTPase 1	Protein Coding	3
14	ARRB1	Arrestin Beta 1	Protein Coding	3
15	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	3
16	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	3
17	VAMP7	Vesicle Associated Membrane Protein 7	Protein Coding	3
18	TXNDC5	Thioredoxin Domain Containing 5	Protein Coding	3
19	VAMP8	Vesicle Associated Membrane Protein 8	Protein Coding	3
20	AP1S2	Adaptor Related Protein Complex 1 Subunit Sigma 2	Protein Coding	3
21	AP1M1	Adaptor Related Protein Complex 1 Subunit Mu 1	Protein Coding	3
22	DNAJC6	DnaJ Heat Shock Protein Family (Hsp40) Member C6	Protein Coding	3
23	TGOLN2	Trans-Golgi Network Protein 2	Protein Coding	2
24	AP4S1	Adaptor Related Protein Complex 4 Subunit Sigma 1	Protein Coding	2
25	AP3S1	Adaptor Related Protein Complex 3 Subunit Sigma 1	Protein Coding	2
26	CLTB	Clathrin Light Chain B	Protein Coding	2
27	CLVS2	Clavesin 2	Protein Coding	2
28	CPD	Carboxypeptidase D	Protein Coding	2
29	CTSZ	Cathepsin Z	Protein Coding	2
30	SH3D19	SH3 Domain Containing 19	Protein Coding	2
31	CLVS1	Clavesin 1	Protein Coding	2
32	DNASE2	Deoxyribonuclease 2, Lysosomal	Protein Coding	2
33	SNAPIN	SNAP Associated Protein	Protein Coding	2
34	FTH1	Ferritin Heavy Chain 1	Protein Coding	2
35	FTL	Ferritin Light Chain	Protein Coding	2
36	GAK	Cyclin G Associated Kinase	Protein Coding	2
37	NECAP1	NECAP Endocytosis Associated 1	Protein Coding	2
38	BLOC1S6	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 6	Protein Coding	2
39	SNX5	Sorting Nexin 5	Protein Coding	2
40	CHMP2A	Charged Multivesicular Body Protein 2A	Protein Coding	2
41	GNS	Glucosamine (N-Acetyl)-6-Sulfatase	Protein Coding	2
42	GOLGB1	Golgin B1	Protein Coding	2
43	YIPF6	Yip1 Domain Family Member 6	Protein Coding	2
44	IGF2R	Insulin Like Growth Factor 2 Receptor	Protein Coding	2
45	APP	Amyloid Beta Precursor Protein	Protein Coding	2
46	BLOC1S3	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 3	Protein Coding	2
47	M6PR	Mannose-6-Phosphate Receptor, Cation Dependent	Protein Coding	2
48	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	2
49	SNX9	Sorting Nexin 9	Protein Coding	2
50	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	2
51	TBC1D8B	TBC1 Domain Family Member 8B	Protein Coding	2
52	BLOC1S4	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 4	Protein Coding	2
53	RAB5C	RAB5C, Member RAS Oncogene Family	Protein Coding	2
54	SORT1	Sortilin 1	Protein Coding	2
55	ACBD3	Acyl-CoA Binding Domain Containing 3	Protein Coding	2
56	SNX2	Sorting Nexin 2	Protein Coding	2
57	TFRC	Transferrin Receptor	Protein Coding	2
58	TPD52	Tumor Protein D52	Protein Coding	2
59	TPD52L1	TPD52 Like 1	Protein Coding	2
60	PICALM	Phosphatidylinositol Binding Clathrin Assembly Protein	Protein Coding	2
61	DTNBP1	Dystrobrevin Binding Protein 1	Protein Coding	2
62	AP3B1	Adaptor Related Protein Complex 3 Subunit Beta 1	Protein Coding	2
63	NAPA	NSF Attachment Protein Alpha	Protein Coding	2
64	AP1G2	Adaptor Related Protein Complex 1 Subunit Gamma 2	Protein Coding	2
65	HIP1R	Huntingtin Interacting Protein 1 Related	Protein Coding	2
66	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	2
67	AP4M1	Adaptor Related Protein Complex 4 Subunit Mu 1	Protein Coding	2
68	CLINT1	Clathrin Interactor 1	Protein Coding	2
69	PUM1	Pumilio RNA Binding Family Member 1	Protein Coding	2
70	STX4	Syntaxin 4	Protein Coding	1
71	GBF1	Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1	Protein Coding	1
72	SNAP23	Synaptosome Associated Protein 23	Protein Coding	1

Disorders associated with trans-Golgi Network Vesicle Budding SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe intellectual disability and progressive spastic paraplegia	Enrichment	AP4B1, AP4E1, AP4M1, AP4S1	10.15
2	Hermansky-pudlak syndrome due to bloc-1 deficiency	Enrichment	BLOC1S3, BLOC1S6, DTNBP1	6.58
3	Hermansky-pudlak syndrome	Enrichment	AP3B1, BLOC1S3, BLOC1S6, DTNBP1	6.46
4	Hermansky-pudlak syndrome 1	Enrichment	AP3B1, BLOC1S3, BLOC1S6, DTNBP1	6.34
5	Mednik syndrome	Enrichment	AP1B1, AP1S1	4.71
6	Congenital nervous system abnormality	Enrichment	AP4B1, AP4E1, AP4M1	2.60
7	Nervous system disease	Enrichment	AP4B1, AP4E1, AP4M1	2.60
8	Keratitis-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	AP1B1	2.59
9	Parkinson disease 19a, juvenile-onset	Enrichment	DNAJC6	2.59
10	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.59
11	Mucopolysaccharidosis, type iiid	Enrichment	GNS	2.59
12	Stuttering	Enrichment	AP4E1	2.59
13	Hereditary spastic paraplegia 51	Enrichment	AP4E1	2.59
14	Usmani-riazuddin syndrome, autosomal recessive	Enrichment	AP1G1	2.59
15	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.59
16	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.59
17	Psoriasis 15, pustular	Enrichment	AP1S3	2.59
18	Spastic paraplegia 51, autosomal recessive	Enrichment	AP4E1	2.59
19	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.59
20	Spastic paraplegia 52, autosomal recessive	Enrichment	AP4S1	2.59
21	Usmani-riazuddin syndrome, autosomal dominant	Enrichment	AP1G1	2.59
22	Autoinflammatory-pancytopenia syndrome	Enrichment	DNASE2	2.59
23	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.59
24	Neurodegeneration with brain iron accumulation 3	Enrichment	FTL	2.38
25	Low density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SORT1	2.38
26	Hermansky-pudlak syndrome 9	Enrichment	BLOC1S6	2.38
27	Hermansky-pudlak syndrome 8	Enrichment	BLOC1S3	2.38
28	Neurodevelopmental disorder with motor abnormalities, seizures, and facial dysmorphism	Enrichment	PUM1	2.38
29	Nephrotic syndrome, type 20	Enrichment	TBC1D8B	2.38
30	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.38
31	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	2.38
32	Hermansky-pudlak syndrome 7	Enrichment	DTNBP1	2.38
33	Immunodeficiency 46	Enrichment	TFRC	2.38
34	L-ferritin deficiency	Enrichment	FTL	2.38
35	Cerebellar ataxia type 47	Enrichment	PUM1	2.38
36	Hermansky-pudlak syndrome due to ap3b1 deficiency	Enrichment	AP3B1	2.38
37	Genetic hyperferritinemia without iron overload	Enrichment	FTL	2.38
38	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.38
39	Pum1-related cerebellar ataxia	Enrichment	PUM1	2.38
40	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.29
41	Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	Enrichment	DNAJC6	2.29
42	Psoriasis 14, pustular	Enrichment	AP1S3	2.29
43	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.29
44	Pettigrew syndrome	Enrichment	AP1S2	2.29
45	Congenital disorder of glycosylation, type ig	Enrichment	AP4E1	2.29
46	Hereditary spastic paraplegia	Enrichment	AP4B1, AP4M1	2.28
47	Charcot-marie-tooth disease, axonal, type 2gg	Enrichment	GBF1	2.28
48	Deafness, autosomal recessive 123	Enrichment	STX4	2.28
49	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.11
50	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.11
51	Spastic paraplegia 50, autosomal recessive	Enrichment	AP4M1	2.11
52	Atypical juvenile parkinsonism	Enrichment	DNAJC6	2.11
53	Vitreoretinochoroidopathy	Enrichment	FTH1	2.08
54	Dent disease 2	Enrichment	OCRL	2.08
55	Retinitis pigmentosa 50	Enrichment	FTH1	2.08
56	Developmental and epileptic encephalopathy 21	Enrichment	NECAP1	2.08
57	Hyperferritinemia with or without cataract	Enrichment	FTL	2.08
58	Hermansky-pudlak syndrome 2	Enrichment	AP3B1	2.08
59	Hemochromatosis, type 5	Enrichment	FTH1	2.08
60	Neurodegeneration with brain iron accumulation 9	Enrichment	FTH1	2.08
61	Spastic paraplegia 47, autosomal recessive	Enrichment	AP4B1	1.99
62	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.99
63	Cataract 11, multiple types	Enrichment	GBF1	1.98
64	Anterior segment dysgenesis 1	Enrichment	GBF1	1.98
65	Dent disease	Enrichment	OCRL	1.91
66	Myopathy, centronuclear, 1	Enrichment	DNM2	1.81
67	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.81
68	Mucopolysaccharidosis iii	Enrichment	GNS	1.81
69	Bestrophinopathy, autosomal recessive	Enrichment	FTH1	1.78
70	Noonan syndrome 3	Enrichment	CLTC	1.75
71	Alzheimer's disease 1	Enrichment	APP	1.75
72	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.75
73	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.75
74	Macular dystrophy, vitelliform, 2	Enrichment	FTH1	1.69
75	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, NECAP1	1.65
76	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	AP1G2	1.64
77	Isolated tracheo-esophageal fistula	Enrichment	AP1G2	1.59
78	Early-onset parkinson's disease	Enrichment	DNAJC6	1.52
79	Alzheimer's disease	Enrichment	APP	1.48
80	Periventricular nodular heterotopia	Enrichment	ARF1	1.45
81	46,xy partial gonadal dysgenesis	Enrichment	VAMP7	1.45
82	Alzheimer disease, familial, 1	Enrichment	APP	1.37
83	Combined immunodeficiency	Enrichment	TFRC	1.35
84	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.35
85	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.35
86	Esophageal atresia/tracheoesophageal fistula	Enrichment	AP1G2	1.32
87	Centronuclear myopathy	Enrichment	DNM2	1.28
88	Hepatocellular carcinoma	Enrichment	IGF2R	1.06
89	Precursor t-cell acute lymphoblastic leukemia	Enrichment	PICALM	1.04
90	Autoinflammatory disease	Enrichment	AP3B1	1.02
91	Myopathy	Enrichment	DNM2	1.01
92	Charcot-marie-tooth disease	Enrichment	DNM2	1.00
93	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	0.92
94	Genetic steroid-resistant nephrotic syndrome	Enrichment	TBC1D8B	0.88
95	Leukemia, acute myeloid	Enrichment	PICALM	0.82
96	Nephrotic syndrome	Enrichment	TBC1D8B	0.79
97	Spastic ataxia	Enrichment	PUM1	0.71
98	Primary ovarian insufficiency	Enrichment	IGF2R	0.66
99	Sensorineural hearing loss	Enrichment	STX4	0.65
100	Microcephaly	Enrichment	AP4M1	0.56
101	Complex neurodevelopmental disorder	Enrichment	AP1G1	0.56
102	Hereditary retinal dystrophy	Enrichment	FTH1	0.15
103	Fundus dystrophy	Enrichment	FTH1	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

trans-Golgi Network Vesicle Budding

Pathway Network for trans-Golgi Network Vesicle Budding

Pathway network for the trans-Golgi Network Vesicle Budding SuperPath

Member Pathways for trans-Golgi Network Vesicle Budding

Pathways in the trans-Golgi Network Vesicle Budding SuperPath

Gene overlap in member pathways for trans-Golgi Network Vesicle Budding SuperPath

Associated Genes for trans-Golgi Network Vesicle Budding

Associated Disorders for trans-Golgi Network Vesicle Budding

Disorders associated with trans-Golgi Network Vesicle Budding SuperPath

STRING Interaction Network for trans-Golgi Network Vesicle Budding

Sources for trans-Golgi Network Vesicle Budding