Trans-sulfuration pathway

Sources:

#	Name	Source	Genes
1	Trans-sulfuration pathway	WikiPathways	AHCY CBS CSAD CTH DNMT1 GCLM GOT1 MAT2B MPST MTR (see all 10) (see less)
2	Methionine metabolism leading to sulfur amino acids and related disorders	WikiPathways	ADK AHCY CBS CDO1 CSAD CTH GNMT MAT1A MTR (see all 9) (see less)
3	L-cysteine degradation III	PubChem	GOT1 MPST

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CBS	Cystathionine Beta-Synthase	Protein Coding	2
2	CSAD	Cysteine Sulfinic Acid Decarboxylase	Protein Coding	2
3	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	2
4	MPST	Mercaptopyruvate Sulfurtransferase	Protein Coding	2
5	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	2
6	AHCY	Adenosylhomocysteinase	Protein Coding	2
7	CTH	Cystathionine Gamma-Lyase	Protein Coding	2
8	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	1
9	DNMT1	DNA Methyltransferase 1	Protein Coding	1
10	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	1
11	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	1
12	CDO1	Cysteine Dioxygenase Type 1	Protein Coding	1
13	GNMT	Glycine N-Methyltransferase	Protein Coding	1
14	ADK	Adenosine Kinase	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Homocystinuria	Enrichment	CBS, MTR	5.93
2	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	3.83
3	Cystathioninuria	Enrichment	CTH	3.18
4	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	3.18
5	Hypermethioninemia due to adenosine kinase deficiency	Enrichment	ADK	3.18
6	Hyperhomocysteinemia	Enrichment	CBS	3.18
7	Glycine n-methyltransferase deficiency	Enrichment	GNMT	2.88
8	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.88
9	Peroxisome biogenesis disorder 4b	Enrichment	GNMT	2.88
10	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.88
11	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.88
12	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.83
13	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	2.70
14	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	2.70
15	Brown-vialetto-van laere syndrome 2	Enrichment	GNMT	2.70
16	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	2.66
17	Neural tube defects, folate-sensitive	Enrichment	MTR	2.58
18	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	2.29
19	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.99
20	Myocardial infarction	Enrichment	GCLM	1.79
21	Connective tissue disease	Enrichment	CBS	1.68
22	Epilepsy	Enrichment	MTR	1.58
23	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS	1.54
24	Spastic ataxia	Enrichment	DNMT1	1.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Trans-sulfuration pathway