Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Pathway network for the Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

Sources:

Reactome

Pathways in the Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

#	Name	Source	Genes
1	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	Reactome	AQR CCNH CDK7 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CUL4A CUL4B DDB1 ELL ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GPS1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ISY1 ISY1-RAB43 LIG1 LIG3 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPIE PRPF19 RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A TCEA1 UBA52 UBB UBC USP7 UVSSA XAB2 XPA XRCC1 ZNF830 (see all 77) (see less)
2	Nucleotide Excision Repair	Reactome	ACTB ACTL6A ACTR5 ACTR8 AQR CCNH CDK7 CETN2 CHD1L COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CUL4A CUL4B DDB1 DDB2 ELL ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GPS1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 INO80 INO80B INO80C INO80D INO80E ISY1 ISY1-RAB43 LIG1 LIG3 MCRS1 MNAT1 NFRKB PARP1 PARP2 PCNA PIAS1 PIAS3 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPIE PRPF19 RAD23A RAD23B RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RNF111 RPA1 RPA2 RPA3 RPS27A RUVBL1 SUMO1 SUMO2 SUMO3 TCEA1 TFPT UBA52 UBB UBC UBE2I UBE2N UBE2V2 USP45 USP7 UVSSA XAB2 XPA XPC XRCC1 YY1 ZNF830 (see all 109) (see less)
3	Global Genome Nucleotide Excision Repair (GG-NER)	Reactome	ACTB ACTL6A ACTR5 ACTR8 CCNH CDK7 CETN2 CHD1L COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CUL4A CUL4B DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GPS1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 INO80 INO80B INO80C INO80D INO80E LIG1 LIG3 MCRS1 MNAT1 NFRKB PARP1 PARP2 PCNA PIAS1 PIAS3 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLK RAD23A RAD23B RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RNF111 RPA1 RPA2 RPA3 RPS27A RUVBL1 SUMO1 SUMO2 SUMO3 TFPT UBA52 UBB UBC UBE2I UBE2N UBE2V2 USP45 XPA XPC XRCC1 YY1 (see all 84) (see less)
4	Dual incision in TC-NER	Reactome	AQR CCNH CDK7 CUL4A CUL4B DDB1 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ISY1 ISY1-RAB43 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPIE PRPF19 RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A TCEA1 UBA52 UBB UBC USP7 UVSSA XAB2 XPA ZNF830 (see all 64) (see less)
5	Gap-filling DNA repair synthesis and ligation in TC-NER	Reactome	AQR CCNH CDK7 CUL4A CUL4B DDB1 ERCC2 ERCC3 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ISY1 ISY1-RAB43 LIG1 LIG3 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPIE PRPF19 RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A TCEA1 UBA52 UBB UBC USP7 UVSSA XAB2 XRCC1 ZNF830 (see all 63) (see less)
6	Formation of TC-NER Pre-Incision Complex	Reactome	AQR CCNH CDK7 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CUL4A CUL4B DDB1 ERCC2 ERCC3 ERCC6 ERCC8 GPS1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ISY1 ISY1-RAB43 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPIE PRPF19 RBX1 RPS27A TCEA1 UBA52 UBB UBC USP7 UVSSA XAB2 XPA ZNF830 (see all 52) (see less)
7	Formation of Incision Complex in GG-NER	Reactome	CCNH CDK7 CETN2 CHD1L CUL4A CUL4B DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 MNAT1 PARP1 PARP2 PIAS1 PIAS3 RAD23A RAD23B RBX1 RNF111 RPA1 RPA2 RPA3 RPS27A SUMO1 SUMO2 SUMO3 UBA52 UBB UBC UBE2I UBE2N UBE2V2 USP45 XPA XPC (see all 43) (see less)
8	DNA Damage Recognition in GG-NER	Reactome	ACTB ACTL6A ACTR5 ACTR8 CETN2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CUL4A CUL4B DDB1 DDB2 GPS1 INO80 INO80B INO80C INO80D INO80E MCRS1 NFRKB PARP1 PARP2 RAD23A RAD23B RBX1 RPS27A RUVBL1 TFPT UBA52 UBB UBC XPC YY1 (see all 38) (see less)

Gene overlap in member pathways for Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	8
2	RPS27A	Ribosomal Protein S27a	Protein Coding	8
3	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	8
4	UBB	Ubiquitin B	Protein Coding	8
5	UBC	Ubiquitin C	Protein Coding	8
6	CUL4B	Cullin 4B	Protein Coding	8
7	CUL4A	Cullin 4A	Protein Coding	8
8	RBX1	Ring-Box 1	Protein Coding	8
9	CDK7	Cyclin Dependent Kinase 7	Protein Coding	7
10	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	7
11	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	7
12	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	7
13	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	7
14	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	7
15	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	7
16	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	7
17	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	7
18	CCNH	Cyclin H	Protein Coding	7
19	RPA1	Replication Protein A1	Protein Coding	6
20	RPA2	Replication Protein A2	Protein Coding	6
21	RPA3	Replication Protein A3	Protein Coding	6
22	XPA	XPA, DNA Damage Recognition And Repair Factor	Protein Coding	6
23	ISY1-RAB43	ISY1-RAB43 Readthrough	Protein Coding	5
24	PPIE	Peptidylprolyl Isomerase E	Protein Coding	5
25	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	5
26	COPS8	COP9 Signalosome Subunit 8	Protein Coding	5
27	COPS6	COP9 Signalosome Subunit 6	Protein Coding	5
28	COPS5	COP9 Signalosome Subunit 5	Protein Coding	5
29	ERCC8	ERCC Excision Repair 8, CSA Ubiquitin Ligase Complex Subunit	Protein Coding	5
30	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	5
31	ERCC4	ERCC Excision Repair 4, Endonuclease Catalytic Subunit	Protein Coding	5
32	ERCC5	ERCC Excision Repair 5, Endonuclease	Protein Coding	5
33	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	5
34	PRPF19	Pre-MRNA Processing Factor 19	Protein Coding	5
35	GPS1	G Protein Pathway Suppressor 1	Protein Coding	5
36	COPS7A	COP9 Signalosome Subunit 7A	Protein Coding	5
37	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	5
38	COPS4	COP9 Signalosome Subunit 4	Protein Coding	5
39	POLK	DNA Polymerase Kappa	Protein Coding	5
40	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	5
41	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	5
42	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	5
43	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	5
44	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	5
45	POLR2A	RNA Polymerase II Subunit A	Protein Coding	5
46	POLR2B	RNA Polymerase II Subunit B	Protein Coding	5
47	POLR2C	RNA Polymerase II Subunit C	Protein Coding	5
48	POLR2D	RNA Polymerase II Subunit D	Protein Coding	5
49	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	5
50	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	5
51	POLR2G	RNA Polymerase II Subunit G	Protein Coding	5
52	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	5
53	POLR2I	RNA Polymerase II Subunit I	Protein Coding	5
54	POLR2J	RNA Polymerase II Subunit J	Protein Coding	5
55	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	5
56	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	5
57	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	5
58	XAB2	XPA Binding Protein 2~Name Same As:- HGNC:14337	Protein Coding	5
59	ISY1	ISY1 Spliceosome Associated Protein	Protein Coding	5
60	UVSSA	UV Stimulated Scaffold Protein A	Protein Coding	5
61	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	5
62	RFC1	Replication Factor C Subunit 1	Protein Coding	5
63	RFC2	Replication Factor C Subunit 2	Protein Coding	5
64	RFC3	Replication Factor C Subunit 3	Protein Coding	5
65	RFC4	Replication Factor C Subunit 4	Protein Coding	5
66	RFC5	Replication Factor C Subunit 5	Protein Coding	5
67	COPS7B	COP9 Signalosome Subunit 7B	Protein Coding	5
68	TCEA1	Transcription Elongation Factor A1	Protein Coding	5
69	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	5
70	COPS3	COP9 Signalosome Subunit 3	Protein Coding	5
71	ZNF830	Zinc Finger Protein 830	Protein Coding	5
72	COPS2	COP9 Signalosome Subunit 2	Protein Coding	5
73	AQR	Aquarius Intron-Binding Spliceosomal Factor	Protein Coding	5
74	LIG1	DNA Ligase 1	Protein Coding	4
75	LIG3	DNA Ligase 3	Protein Coding	4
76	XRCC1	X-Ray Repair Cross Complementing 1	Protein Coding	4
77	PARP2	Poly(ADP-Ribose) Polymerase 2	Protein Coding	4
78	CETN2	Centrin 2	Protein Coding	4
79	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	4
80	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	4
81	RAD23A	RAD23 Nucleotide Excision Repair Protein A	Protein Coding	4
82	RAD23B	RAD23 Nucleotide Excision Repair Protein B	Protein Coding	4
83	XPC	XPC Complex Subunit, DNA Damage Recognition And Repair Factor	Protein Coding	4
84	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	3
85	MCRS1	Microspherule Protein 1	Protein Coding	3
86	INO80C	INO80 Complex Subunit C	Protein Coding	3
87	INO80E	INO80 Complex Subunit E	Protein Coding	3
88	TFPT	TCF3 Fusion Partner	Protein Coding	3
89	NFRKB	Nuclear Factor Related To KappaB Binding Protein	Protein Coding	3
90	INO80	INO80 Complex ATPase Subunit	Protein Coding	3
91	RNF111	Ring Finger Protein 111	Protein Coding	3
92	INO80D	INO80 Complex Subunit D	Protein Coding	3
93	ACTB	Actin Beta	Protein Coding	3
94	SUMO3	Small Ubiquitin Like Modifier 3	Protein Coding	3
95	SUMO2	Small Ubiquitin Like Modifier 2	Protein Coding	3
96	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	3
97	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	3
98	UBE2V2	Ubiquitin Conjugating Enzyme E2 V2	Protein Coding	3
99	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	3
100	YY1	YY1 Transcription Factor	Protein Coding	3
101	ACTR5	Actin Related Protein 5	Protein Coding	3
102	INO80B	INO80 Complex Subunit B	Protein Coding	3
103	USP45	Ubiquitin Specific Peptidase 45	Protein Coding	3
104	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	3
105	ACTL6A	Actin Like 6A	Protein Coding	3
106	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	3
107	ACTR8	Actin Related Protein 8	Protein Coding	3
108	CHD1L	Chromodomain Helicase DNA Binding Protein 1 Like	Protein Coding	3
109	ELL	Elongation Factor For RNA Polymerase II	Protein Coding	2

Disorders associated with Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Xeroderma pigmentosum, variant type	Enrichment	DDB2, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC	16.00
2	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3, ERCC4, ERCC5	9.34
3	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC1, ERCC2, ERCC5, ERCC6	8.17
4	Uv-sensitive syndrome	Enrichment	ERCC6, ERCC8, UVSSA	7.27
5	Ovarian cancer	Enrichment	ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC	6.15
6	Cockayne syndrome a	Enrichment	ERCC4, ERCC6, ERCC8	6.00
7	Cockayne syndrome b	Enrichment	ERCC1, ERCC6, ERCC8	5.70
8	Trichothiodystrophy	Enrichment	ERCC2, ERCC3, GTF2H5	5.61
9	Cockayne syndrome	Enrichment	ERCC4, ERCC6, ERCC8	5.46
10	Xeroderma pigmentosum, complementation group a	Enrichment	XPA, XPC	5.01
11	Cockayne syndrome type 3	Enrichment	ERCC6, ERCC8	4.84
12	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	4.20
13	Familial colorectal cancer type x	Enrichment	POLD1, POLE	2.94
14	Hepatoblastoma	Enrichment	ERCC2, ERCC5	2.70
15	Torticollis	Enrichment	ACTL6A	2.55
16	Baraitser-winter syndrome 1	Enrichment	ACTB	2.55
17	White-kernohan syndrome	Enrichment	DDB1	2.55
18	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.55
19	Becker nevus syndrome	Enrichment	ACTB	2.55
20	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.55
21	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.55
22	Baraitser-winter syndrome	Enrichment	ACTB	2.55
23	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.55
24	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.55
25	Cerebrooculofacioskeletal syndrome 4	Enrichment	ERCC1	2.50
26	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	2.50
27	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.50
28	Orofacial cleft 10	Enrichment	SUMO1	2.50
29	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	2.50
30	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	2.50
31	Xeroderma pigmentosum group b	Enrichment	ERCC3	2.50
32	Xfe progeroid syndrome	Enrichment	ERCC4	2.50
33	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	2.50
34	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	2.50
35	Leber congenital amaurosis 19	Enrichment	USP45	2.50
36	Xeroderma pigmentosum group d	Enrichment	ERCC2	2.50
37	Uv-sensitive syndrome 3	Enrichment	UVSSA	2.42
38	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.33
39	Colorectal cancer 10	Enrichment	POLD1	2.33
40	Colorectal cancer 12	Enrichment	POLE	2.33
41	Immunodeficiency 120	Enrichment	POLD1	2.33
42	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.33
43	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.33
44	Immunodeficiency 96	Enrichment	LIG1	2.33
45	Spinocerebellar ataxia, autosomal recessive 26	Enrichment	XRCC1	2.33
46	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.33
47	Immunodeficiency 122	Enrichment	POLD3	2.33
48	Xeroderma pigmentosum, complementation group c	Enrichment	XPC	2.25
49	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	2.25
50	Intellectual developmental disorder, x-linked, syndromic, cabezas type	Enrichment	CUL4B	2.25
51	Gabriele-de vries syndrome	Enrichment	YY1	2.25
52	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	2.25
53	Pettigrew syndrome	Enrichment	CUL4B	2.25
54	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.25
55	Insulinoma	Enrichment	YY1	2.25
56	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	2.25
57	Xeroderma pigmentosum group c	Enrichment	XPC	2.25
58	Xeroderma pigmentosum group e	Enrichment	DDB2	2.25
59	Submucosal cleft palate	Enrichment	UBB	2.25
60	Cleft hard palate	Enrichment	UBB	2.25
61	Pancreatic cancer	Enrichment	ERCC4, POLD1	2.21
62	Xeroderma pigmentosum, complementation group f	Enrichment	ERCC4	2.20
63	Fanconi anemia, complementation group q	Enrichment	ERCC4	2.20
64	Xeroderma pigmentosum group f	Enrichment	ERCC4	2.20
65	Waardenburg syndrome, type 4c	Enrichment	POLR2F	2.12
66	Mitochondrial complex i deficiency, nuclear type 10	Enrichment	ERCC8	2.12
67	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	2.12
68	Hao-fountain syndrome	Enrichment	USP7	2.12
69	Combined cellular and humoral immune defects with granulomas	Enrichment	INO80	2.08
70	Uvula, bifid	Enrichment	UBB	2.08
71	Cleft soft palate	Enrichment	UBB	2.08
72	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	2.08
73	Umbilical hernia	Enrichment	ACTL6A	2.08
74	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	2.03
75	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	POLK	2.03
76	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	2.03
77	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	2.03
78	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	2.03
79	Mitochondrial dna depletion syndrome 20	Enrichment	LIG3	2.03
80	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	2.02
81	Xeroderma pigmentosum, complementation group g	Enrichment	ERCC5	2.02
82	Cerebrooculofacioskeletal syndrome 3	Enrichment	ERCC5	2.02
83	Wieacker-wolff syndrome	Enrichment	CCNH	2.02
84	Xeroderma pigmentosum group g	Enrichment	ERCC5	2.02
85	Aminoacylase 1 deficiency	Enrichment	ACTB	1.95
86	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.95
87	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.94
88	De sanctis-cacchione syndrome	Enrichment	ERCC6	1.94
89	Uv-sensitive syndrome 1	Enrichment	ERCC6	1.94
90	Uv-sensitive syndrome 2	Enrichment	ERCC8	1.94
91	Premature ovarian failure 11	Enrichment	ERCC6	1.94
92	Hutchinson-gilford progeria syndrome	Enrichment	ERCC4	1.90
93	Craniopharyngioma	Enrichment	ERCC2	1.90
94	Childhood apraxia of speech	Enrichment	RFC3	1.86
95	Deafness, autosomal recessive 1a	Enrichment	ERCC8	1.82
96	Macular degeneration, age-related, 5	Enrichment	ERCC6	1.82
97	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.82
98	Gjb2-related autosomal recessive nonsyndromic hearing loss	Enrichment	ERCC8	1.82
99	Capillary malformations, congenital	Enrichment	CCNH	1.80
100	Autosomal recessive cerebellar ataxia	Enrichment	ERCC4	1.80
101	Polyneuropathy	Enrichment	ERCC5	1.80
102	Inguinal hernia	Enrichment	ACTL6A	1.78
103	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.72
104	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.72
105	Hemangioma, capillary infantile	Enrichment	CCNH	1.72
106	Basal cell carcinoma 1	Enrichment	CCNH	1.72
107	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.72
108	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.66
109	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	1.66
110	Gastroesophageal reflux	Enrichment	ACTL6A	1.65
111	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.64
112	Waardenburg syndrome	Enrichment	POLR2F	1.64
113	Inherited cancer-predisposing syndrome	Enrichment	ERCC3, POLD1, POLE	1.63
114	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.58
115	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.58
116	Inflammatory bowel disease 1	Enrichment	ERCC2	1.55
117	Leukemia, acute lymphoblastic 3	Enrichment	ERCC4	1.55
118	Arteriovenous malformation	Enrichment	CCNH	1.55
119	Hypotrichosis simplex	Enrichment	ERCC2	1.55
120	Atrial heart septal defect	Enrichment	ACTL6A	1.52
121	Interatrial communication	Enrichment	ACTL6A	1.52
122	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	1.50
123	Pectus excavatum	Enrichment	ERCC5	1.46
124	Premature menopause	Enrichment	ERCC1	1.39
125	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	LIG3	1.39
126	Isolated congenital microcephaly	Enrichment	INO80	1.36
127	Corpus callosum, agenesis of	Enrichment	ERCC2	1.33
128	Isolated corpus callosum agenesis	Enrichment	ERCC2	1.33
129	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	1.33
130	Polycystic liver disease	Enrichment	RUVBL1	1.33
131	Autosomal dominant polycystic liver disease	Enrichment	RUVBL1	1.33
132	Combined immunodeficiency	Enrichment	POLD1	1.30
133	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.30
134	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.30
135	Leukodystrophy	Enrichment	ERCC2	1.21
136	Colorectal cancer	Enrichment	POLD1, POLE	1.21
137	Tooth agenesis	Enrichment	SUMO1	1.17
138	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	1.15
139	Kallmann syndrome	Enrichment	POLR2F	1.07
140	Parkinson's disease	Enrichment	RFC1	1.07
141	Bladder cancer	Enrichment	ERCC2	1.06
142	Williams-beuren syndrome	Enrichment	RFC2	1.05
143	Nephronophthisis	Enrichment	PIAS1	1.00
144	Fanconi anemia, complementation group a	Enrichment	ERCC4	0.98
145	Hirschsprung disease 1	Enrichment	POLR2F	0.98
146	Parkinson disease, late-onset	Enrichment	RFC1	0.98
147	Lung cancer	Enrichment	ERCC6	0.94
148	Prostate cancer	Enrichment	POLK	0.90
149	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	ERCC8	0.87
150	Spastic ataxia	Enrichment	ERCC4	0.81
151	Primary ovarian insufficiency	Enrichment	ERCC1	0.77
152	Leber plus disease	Enrichment	USP45	0.58
153	Rare genetic deafness	Enrichment	POLR2F	0.58
154	Microcephaly	Enrichment	ACTB	0.53
155	Complex neurodevelopmental disorder	Enrichment	ACTL6A	0.53
156	Congenital nervous system abnormality	Enrichment	ERCC8	0.47
157	Nervous system disease	Enrichment	ERCC8	0.47
158	Retinitis pigmentosa	Enrichment	TFPT	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Pathway Network for Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Pathway network for the Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

Member Pathways for Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Pathways in the Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

Gene overlap in member pathways for Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

Associated Genes for Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Associated Disorders for Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Disorders associated with Transcription-Coupled Nucleotide Excision Repair (TC-NER) SuperPath

STRING Interaction Network for Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Sources for Transcription-Coupled Nucleotide Excision Repair (TC-NER)