Transcription_NF-kB signaling pathway

No Pathway Network information available for Transcription_NF-kB signaling pathway

Pathways in the Transcription_NF-kB signaling pathway SuperPath

#	Name	Source	Genes
1	Transcription_NF-kB signaling pathway	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CD14 CD28 CHUK ECSIT ELP1 IKBKB IKBKG IL1A IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 LBP LTA LTBR LY96 MAP3K1 MAP3K14 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PRKCQ REL RELA RELB RIPK2 SUMO1 TLR4 TNF TNFRSF1A TNFRSF1B TOLLIP TRA TRAC TRADD TRAF2 TRAF6 TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 UBA52 UBB UBC (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
3	CD14	CD14 Molecule	Protein Coding	1
4	CD28	CD28 Molecule	Protein Coding	1
5	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
6	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
7	IL1A	Interleukin 1 Alpha	Protein Coding	1
8	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
9	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	1
10	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
11	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
12	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
13	LTA	Lymphotoxin Alpha	Protein Coding	1
14	LTBR	Lymphotoxin Beta Receptor	Protein Coding	1
15	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
16	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
17	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
18	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
19	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
20	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
21	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
22	PRKCQ	Protein Kinase C Theta	Protein Coding	1
23	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
24	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
25	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
26	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
27	TRB	T Cell Receptor Beta Locus	Protein Coding	1
28	TLR4	Toll Like Receptor 4	Protein Coding	1
29	TNF	Tumor Necrosis Factor	Protein Coding	1
30	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
31	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
32	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
33	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
34	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
35	UBB	Ubiquitin B	Protein Coding	1
36	UBC	Ubiquitin C	Protein Coding	1
37	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	1
38	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
39	ELP1	Elongator Acetyltransferase Complex Subunit 1	Protein Coding	1
40	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
41	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
42	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
43	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
44	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	1
45	LY96	Lymphocyte Antigen 96	Protein Coding	1
46	TRBV17	T Cell Receptor Beta Variable 17 (Non-Functional)	Protein Coding	1
47	TRBV11-3	T Cell Receptor Beta Variable 11-3	Protein Coding	1
48	TRBV11-2	T Cell Receptor Beta Variable 11-2	Protein Coding	1
49	TRBV11-1	T Cell Receptor Beta Variable 11-1	Protein Coding	1
50	TRAV24	T Cell Receptor Alpha Variable 24	Protein Coding	1
51	TRAJ18	T Cell Receptor Alpha Joining 18	Protein Coding	1
52	TRAC	T Cell Receptor Alpha Constant	Protein Coding	1
53	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
54	TOLLIP	Toll Interacting Protein	Protein Coding	1

Disorders associated with Transcription_NF-kB signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.81
2	Mycosis fungoides	Enrichment	CD28, TNFRSF1B	4.33
3	Psoriatic arthritis	Enrichment	LTA, TNF	4.33
4	Immunodeficiency 7	Enrichment	TRA, TRAC	4.33
5	Saczary syndrome	Enrichment	CD28, TNFRSF1B	4.33
6	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.49
7	Behcet syndrome	Enrichment	TLR4, TNFRSF1A	2.59
8	Malaria	Enrichment	IKBKG, TNF	2.43
9	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	2.43
10	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.40
11	Proteus syndrome	Enrichment	AKT1	2.40
12	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.40
13	Neuropathy, hereditary sensory and autonomic, type iii	Enrichment	ELP1	2.40
14	Incontinentia pigmenti	Enrichment	IKBKG	2.40
15	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.40
16	Immunodeficiency 68	Enrichment	MYD88	2.40
17	Leprosy 4	Enrichment	LTA	2.40
18	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.40
19	Fetal encasement syndrome	Enrichment	CHUK	2.40
20	46,xy sex reversal 6	Enrichment	MAP3K1	2.40
21	Immunodeficiency 15b	Enrichment	IKBKB	2.40
22	Immunodeficiency 15a	Enrichment	IKBKB	2.40
23	Immunodeficiency 92	Enrichment	REL	2.40
24	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.40
25	Orofacial cleft 10	Enrichment	SUMO1	2.40
26	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.40
27	Asthma-related traits 5	Enrichment	IRAK3	2.40
28	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.40
29	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.40
30	Cowden syndrome 6	Enrichment	AKT1	2.40
31	Macular degeneration, age-related, 10	Enrichment	TLR4	2.40
32	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.40
33	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.40
34	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.40
35	Immunodeficiency 53	Enrichment	RELB	2.40
36	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.40
37	Capillary hemangioma	Enrichment	AKT3	2.40
38	Immunodeficiency 112	Enrichment	MAP3K14	2.40
39	Waldenstram macroglobulinemia	Enrichment	MYD88	2.40
40	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.40
41	Nik deficiency	Enrichment	MAP3K14	2.40
42	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.40
43	Immunodeficiency 33	Enrichment	IKBKG	2.10
44	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.10
45	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.10
46	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.10
47	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.10
48	Immunodeficiency 127	Enrichment	TNF	2.10
49	Rela fusion-positive ependymoma	Enrichment	RELA	2.10
50	Senior-loken syndrome 7	Enrichment	AKT3	2.10
51	Trypsinogen deficiency	Enrichment	TRB	2.10
52	Bardet-biedl syndrome 16	Enrichment	AKT3	2.10
53	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.10
54	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.10
55	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	2.10
56	Common variable immunodeficiency 12	Enrichment	NFKB1	2.10
57	Submucosal cleft palate	Enrichment	UBB	2.10
58	Cleft hard palate	Enrichment	UBB	2.10
59	Systemic lupus erythematosus	Enrichment	IRAK1, TNF	1.98
60	Uvula, bifid	Enrichment	UBB	1.92
61	Cleft soft palate	Enrichment	UBB	1.92
62	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.92
63	Migraine without aura	Enrichment	TNF	1.92
64	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.80
65	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.80
66	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.80
67	Cerebral malaria	Enrichment	TNF	1.80
68	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.80
69	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.70
70	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.70
71	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.70
72	Fabry disease	Enrichment	ELP1	1.70
73	Vascular dementia	Enrichment	TNF	1.70
74	Hemimegalencephaly	Enrichment	AKT3	1.70
75	Breast adenocarcinoma	Enrichment	AKT1	1.63
76	Megacolon	Enrichment	AKT3	1.56
77	Charge syndrome	Enrichment	TNFRSF1A	1.45
78	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.45
79	Coronary heart disease 5	Enrichment	IKBKG	1.45
80	Cowden syndrome	Enrichment	AKT1	1.45
81	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.41
82	Polymicrogyria	Enrichment	AKT3	1.41
83	Asthma	Enrichment	TNF	1.37
84	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.37
85	Meningioma	Enrichment	AKT1	1.33
86	Alzheimer's disease	Enrichment	TNF	1.30
87	Multiple sclerosis	Enrichment	TNFRSF1A	1.26
88	Medulloblastoma	Enrichment	ELP1	1.26
89	Hereditary chronic pancreatitis	Enrichment	TRB	1.26
90	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.26
91	Ovarian cancer	Enrichment	AKT1, MAP3K1	1.21
92	Gliosarcoma	Enrichment	NFKBIA	1.21
93	Pancreatitis, hereditary	Enrichment	TRB	1.18
94	Giant cell glioblastoma	Enrichment	NFKBIA	1.18
95	Diffuse large b-cell lymphoma	Enrichment	MYD88	1.14
96	Myocardial infarction	Enrichment	LTA	1.08
97	Tooth agenesis	Enrichment	SUMO1	1.08
98	Multisystem inflammatory syndrome in children	Enrichment	IRAK3	1.08
99	Autoinflammatory disease	Enrichment	TNFRSF1A	1.04
100	Severe combined immunodeficiency	Enrichment	IKBKB	0.91
101	Type 2 diabetes mellitus	Enrichment	AKT2	0.81
102	Hereditary breast carcinoma	Enrichment	AKT1	0.79
103	Breast cancer	Enrichment	AKT1	0.59
104	Colorectal cancer	Enrichment	AKT1	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcription_NF-kB signaling pathway

Pathway Network for Transcription_NF-kB signaling pathway

Member Pathways for Transcription_NF-kB signaling pathway

Pathways in the Transcription_NF-kB signaling pathway SuperPath

Associated Genes for Transcription_NF-kB signaling pathway

Associated Disorders for Transcription_NF-kB signaling pathway

Disorders associated with Transcription_NF-kB signaling pathway SuperPath

STRING Interaction Network for Transcription_NF-kB signaling pathway

Sources for Transcription_NF-kB signaling pathway