Transcription_P53 signaling pathway

No Pathway Network information available for Transcription_P53 signaling pathway

Pathways in the Transcription_P53 signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Transcription_P53 signaling pathway SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Ovarian cancerEnrichmentATM, CDKN2A, CTNNB1, ERCC2, ERCC3, MAP3K1, RB1, TP53, XPA, XPC16.00
2Bladder cancerEnrichmentATM, CDKN1A, CDKN2A, CTNNB1, ERCC2, RB1, TP5310.81
3Xeroderma pigmentosum, variant typeEnrichmentERCC2, ERCC3, XPA, XPC7.14
4Li-fraumeni syndromeEnrichmentCDKN2A, MDM2, TP535.93
5Adrenocortical carcinomaEnrichmentCDKN2A, CTNNB1, TP535.93
6TrichothiodystrophyEnrichmentERCC2, ERCC3, GTF2H55.31
7Lip and oral cavity carcinomaEnrichmentCDKN2A, RB1, TP534.89
8Xeroderma pigmentosum, complementation group aEnrichmentXPA, XPC4.81
9Osteogenic sarcomaEnrichmentRB1, TP534.33
10Squamous cell carcinomaEnrichmentRB1, TP534.33
11AdenocarcinomaEnrichmentATM, TP534.33
12Bone osteosarcomaEnrichmentRB1, TP534.33
13HepatoblastomaEnrichmentCTNNB1, ERCC2, TP534.12
14Small cell cancer of the lungEnrichmentRB1, TP534.03
15CraniopharyngiomaEnrichmentCTNNB1, ERCC24.03
16Pancreatic cancerEnrichmentATM, CDKN2A, TP533.89
17Xeroderma pigmentosum-cockayne syndrome complexEnrichmentERCC2, ERCC33.81
18Inherited cancer-predisposing syndromeEnrichmentATM, CDKN2A, ERCC3, RB1, TP533.76
19Rubinstein-taybi syndrome 1EnrichmentCREBBP, EP3003.64
20Chromosome 16p13.3 deletion syndrome, proximalEnrichmentCREBBP, EP3003.64
21Gallbladder cancerEnrichmentCTNNB1, TP533.49
22Common variable immunodeficiencyEnrichmentNFKB1, NFKB23.49
23B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentCDKN2A, TP533.49
24Colorectal cancerEnrichmentATM, CTNNB1, EP300, TP533.41
25Adult hepatocellular carcinomaEnrichmentCTNNB1, TP533.26
26Gastric cancerEnrichmentATM, CDKN2A, TP533.18
27Leukemia, chronic lymphocyticEnrichmentATM, TP533.16
28Lung cancer susceptibility 3EnrichmentRB1, TP532.86
29Myeloma, multipleEnrichmentATM, CREBBP, TP532.85
30Corpus callosum, agenesis ofEnrichmentCREBBP, ERCC22.80
31Isolated corpus callosum agenesisEnrichmentCREBBP, ERCC22.80
32Rare genetic intellectual disabilityEnrichmentCREBBP, EP3002.80
33Intellectual disability-hypoplastic corpus callosum-preauricular tag syndromeEnrichmentCREBBP, ERCC22.80
34GliosarcomaEnrichmentATM, TP532.74
35Giant cell glioblastomaEnrichmentATM, TP532.69
36Diffuse large b-cell lymphomaEnrichmentCREBBP, TP532.59
37Hepatocellular carcinomaEnrichmentCTNNB1, TP532.47
38Tooth agenesisEnrichmentRANBP2, SUMO12.47
39Spermatogenic failure, x-linked, 9EnrichmentRBBP72.40
40Xeroderma pigmentosum, complementation group bEnrichmentERCC32.40
41Seckel syndrome 1EnrichmentATR2.40
4246,xy sex reversal 6EnrichmentMAP3K12.40
43Accelerated tumor formationEnrichmentMDM22.40
44Immunodeficiency 92EnrichmentREL2.40
45Lessel-kubisch syndromeEnrichmentMDM22.40
46Bone marrow failure syndrome 5EnrichmentTP532.40
47Orofacial cleft 10EnrichmentSUMO12.40
48Papilloma of choroid plexusEnrichmentTP532.40
49Basal cell carcinoma 7EnrichmentTP532.40
50Xeroderma pigmentosum, complementation group dEnrichmentERCC22.40
51Anaplastic thyroid carcinomaEnrichmentTP532.40
52Microvascular complications of diabetes 1EnrichmentVEGFA2.40
53Trichothiodystrophy 2, photosensitiveEnrichmentERCC32.40
54Xeroderma pigmentosum group bEnrichmentERCC32.40
55Charcot-marie-tooth disease, axonal, type 2fEnrichmentHSPB12.40
56Cerebrooculofacioskeletal syndrome 2EnrichmentERCC22.40
57Cutaneous telangiectasia and cancer syndrome, familialEnrichmentATR2.40
58Trichothiodystrophy 3, photosensitiveEnrichmentGTF2H52.40
59Endometrial serous adenocarcinomaEnrichmentATM2.40
60Ductal carcinoma in situEnrichmentTP532.40
61Deficiency in anterior pituitary function - variable immunodeficiency syndromeEnrichmentNFKB22.40
62Immunodeficiency 53EnrichmentRELB2.40
63Menke-hennekam syndrome 1EnrichmentCREBBP2.40
64Thyroid gland undifferentiated carcinomaEnrichmentTP532.40
65Tufted angioma of skinEnrichmentKDR2.40
66Trilateral retinoblastomaEnrichmentRB12.40
67Small-cell carcinoma of the ovary of hypercalcemic typeEnrichmentTP532.40
68Adenoid ameloblastomaEnrichmentCTNNB12.40
69Cdkn2a cancer predispositionEnrichmentCDKN2A2.40
70Rubinstein-taybi syndrome due to 16p13.3 microdeletionEnrichmentCREBBP2.40
71Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtypeEnrichmentTP532.40
72B-cell non-hodgkin lymphomaEnrichmentATM2.40
73Choroid plexus cancerEnrichmentTP532.40
74Xeroderma pigmentosum group dEnrichmentERCC22.40
75Menke-hennekam syndromeEnrichmentCREBBP2.40
76Pleomorphic xanthoastrocytomaEnrichmentTP532.40
77Familial acute necrotizing encephalopathyEnrichmentRANBP22.40
78Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndromeEnrichmentATR2.40
79Microcystic stromal tumorEnrichmentCTNNB12.40
80Lung oat cell carcinomaEnrichmentRB12.40
81Prostate cancerEnrichmentATM, TP532.23
82Melanoma-astrocytoma syndromeEnrichmentCDKN2A2.10
83Adrenocortical carcinoma, hereditaryEnrichmentTP532.10
84Thumb deformityEnrichmentCREBBP2.10
85Osteopathia striata with cranial sclerosisEnrichmentCTNNB12.10
86Xeroderma pigmentosum, complementation group cEnrichmentXPC2.10
87Cervical cancerEnrichmentTP532.10
88Melanoma, cutaneous malignant 2EnrichmentCDKN2A2.10
89Neuronopathy, distal hereditary motor, autosomal dominant 3EnrichmentHSPB12.10
90Chromosome 13q14 deletion syndromeEnrichmentRB12.10
91Angioma, tuftedEnrichmentKDR2.10
92Lymphoma, hodgkin, classicEnrichmentTP532.10
93Immunodeficiency, common variable, 12, with autoimmunityEnrichmentNFKB12.10
94Immunodeficiency, common variable, 10EnrichmentNFKB22.10
95Cardiac valvular dysplasia, x-linkedEnrichmentATM2.10
96Autoinflammatory disease, familial, behcet-like 3EnrichmentRELA2.10
97Menke-hennekam syndrome 2EnrichmentEP3002.10
98Intravascular large b-cell lymphomaEnrichmentBCL22.10
99Childhood hepatocellular carcinomaEnrichmentCTNNB12.10
100Rela fusion-positive ependymomaEnrichmentRELA2.10
101Acute myeloid leukemia with kat6a-crebbp fusionEnrichmentCREBBP2.10
102Melanoma-pancreatic cancer syndromeEnrichmentCDKN2A2.10
103Congenital fibrosarcomaEnrichmentTP532.10
104High grade gliomaEnrichmentATM2.10
105Li-fraumeni syndrome 1EnrichmentTP532.10
106SarcomaEnrichmentTP532.10
107Cervix carcinomaEnrichmentTP532.10
108Hodgkin's lymphomaEnrichmentTP532.10
109T-cell prolymphocytic leukemiaEnrichmentATM2.10
110Xeroderma pigmentosum group cEnrichmentXPC2.10
111Juvenile nasopharyngeal angiofibromaEnrichmentCTNNB12.10
112TeratomaEnrichmentCTNNB12.10
113Familial retinoblastomaEnrichmentRB12.10
114Common variable immunodeficiency 12EnrichmentNFKB12.10
115Acute necrotizing encephalopathy of childhoodEnrichmentRANBP22.10
116Pleomorphic rhabdomyosarcomaEnrichmentTP532.10
117Desmoid disease, hereditaryEnrichmentCTNNB11.92
118RetinoblastomaEnrichmentRB11.92
119Ataxia-telangiectasiaEnrichmentATM1.92
120Polycythemia veraEnrichmentATM1.92
121Trichothiodystrophy 1, photosensitiveEnrichmentERCC21.92
122Multicentric osteolysis, nodulosis, and arthropathyEnrichmentMMP21.92
123Nasopharyngeal carcinomaEnrichmentTP531.92
124Neurodevelopmental disorder with spastic diplegia and visual defectsEnrichmentCTNNB11.92
125Woolly hair, autosomal recessive 3EnrichmentRB11.92
126Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessiveEnrichmentRANBP21.92
127Anus, imperforateEnrichmentCTNNB11.92
128Exudative vitreoretinopathy 7EnrichmentCTNNB11.92
129Hypotrichosis 8EnrichmentRB11.92
130Tethered spinal cord syndromeEnrichmentCREBBP1.92
131Koolen-de vries syndromeEnrichmentATM1.92
132Desmoid tumorEnrichmentCTNNB11.92
133High-grade b-cell lymphoma double-hit/triple-hitEnrichmentBCL21.92
134Dedifferentiated liposarcomaEnrichmentMDM21.92
135Atypical teratoid rhabdoid tumorEnrichmentTP531.92
136Anaplastic astrocytomaEnrichmentTP531.92
137Intraocular pressure quantitative trait locusEnrichmentCREBBP1.92
138Well-differentiated liposarcomaEnrichmentMDM21.92
139Hereditary breast carcinomaEnrichmentATM, TP531.88
140Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessiveEnrichmentRANBP21.80
141Thyroid cancer, nonmedullary, 1EnrichmentTP531.80
142Immunodeficiency, common variable, 1EnrichmentNFKB21.80
143PilomatrixomaEnrichmentCTNNB11.80
144Lynch syndrome 4EnrichmentRB11.80
145Alazami syndromeEnrichmentCTNNB11.80
146Congenital generalized lipodystrophyEnrichmentFOS1.80
147Mantle cell lymphomaEnrichmentATM1.80
148Lung sarcomatoid carcinomaEnrichmentTP531.80
149Ectodermal dysplasiaEnrichmentRANBP21.80
150Embryonal rhabdomyosarcomaEnrichmentTP531.80
151Oculomotor apraxiaEnrichmentATM1.80
152Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominantEnrichmentRANBP21.70
153Neuronopathy, distal hereditary motor, autosomal dominant 2EnrichmentHSPB11.70
154Exudative vitreoretinopathy 1EnrichmentCTNNB11.70
155Rhabdomyosarcoma 2EnrichmentTP531.70
156Rubinstein-taybi syndrome 2EnrichmentEP3001.70
157Pre-eclampsiaEnrichmentFLT11.70
158Follicular lymphomaEnrichmentBCL21.70
159LymphomaEnrichmentTP531.70
160GlioblastomaEnrichmentATM1.70
161Histiocytoid hemangiomaEnrichmentFOS1.70
162Acute megakaryocytic leukemiaEnrichmentTP531.70
163Autosomal recessive hypohidrotic ectodermal dysplasia syndromeEnrichmentRANBP21.70
164Hereditary breast ovarian cancer syndromeEnrichmentATM, TP531.69
165Weyers acrofacial dysostosisEnrichmentCTNNB11.63
166Cerebrooculofacioskeletal syndrome 1EnrichmentERCC21.63
167Hemangioma, capillary infantileEnrichmentKDR1.63
168Inflammatory myofibroblastic tumorEnrichmentRANBP21.63
169Clear cell renal cell carcinomaEnrichmentATM1.63
170Breast adenocarcinomaEnrichmentTP531.63
171Lung squamous cell carcinomaEnrichmentCDKN2A1.63
172HypertrichosisEnrichmentCREBBP1.63
173Esophageal cancerEnrichmentTP531.56
174Multiple endocrine neoplasia, type iEnrichmentCDKN1A1.56
175Mitochondrial dna depletion syndrome 4aEnrichmentRANBP21.56
176Squamous cell carcinoma, head and neckEnrichmentTP531.56
177Renal cell carcinoma, papillary, 1EnrichmentATM1.56
178Essential thrombocythemiaEnrichmentTP531.56
179Glioma susceptibility 1EnrichmentTP531.50
180Lymphoma, non-hodgkin, familialEnrichmentTP531.50
181Mitochondrial dna depletion syndrome 4bEnrichmentRANBP21.50
182Lennox-gastaut syndromeEnrichmentMAPK101.50
183Exudative vitreoretinopathyEnrichmentCTNNB11.50
184Charge syndromeEnrichmentEP3001.45
185Inflammatory bowel disease 1EnrichmentERCC21.45
186Primary hyperaldosteronismEnrichmentTP531.45
187Colonic benign neoplasmEnrichmentATM1.45
188Hypotrichosis simplexEnrichmentERCC21.45
189Breast cancerEnrichmentATM, TP531.45
190Lynch syndrome 1EnrichmentATM1.41
191Ciliary dyskinesia, primary, 3EnrichmentNFKB11.41
192MelanomaEnrichmentCDKN2A1.41
193Familial colorectal cancerEnrichmentTP531.41
194Immune deficiency diseaseEnrichmentATM1.37
195Leukemia, acute lymphoblasticEnrichmentCDKN2A1.37
196Myelodysplastic syndromeEnrichmentTP531.37
19746,xy complete gonadal dysgenesisEnrichmentMAP3K11.37
198Uterine corpus cancerEnrichmentATM1.37
199Familial colorectal cancer type xEnrichmentATM1.37
200Breast-ovarian cancer, familial 1EnrichmentATM1.30
201MedulloblastomaEnrichmentCTNNB11.26
202Seckel syndromeEnrichmentATR1.26
203Heart diseaseEnrichmentCREBBP1.26
20446,xy partial gonadal dysgenesisEnrichmentMAP3K11.26
205Renal cell carcinoma, nonpapillaryEnrichmentATM1.24
206Polydactyly, postaxial, type a1EnrichmentEP3001.24
207RhabdomyosarcomaEnrichmentTP531.21
208Melanoma, cutaneous malignant 1EnrichmentCDKN2A1.18
209Polycystic liver diseaseEnrichmentCTNNB11.18
210Autosomal dominant polycystic liver diseaseEnrichmentCTNNB11.18
211Congenital nervous system abnormalityEnrichmentCREBBP, CTNNB11.18
212Nervous system diseaseEnrichmentCREBBP, CTNNB11.18
213LeukodystrophyEnrichmentERCC21.12
214Endometrial cancerEnrichmentATM1.09
215MicrocephalyEnrichmentCTNNB1, EP3001.07
216Diamond-blackfan anemia 1EnrichmentTP531.06
217Precursor t-cell acute lymphoblastic leukemiaEnrichmentCDKN2A1.06
218ScoliosisEnrichmentCREBBP1.04
219Tetralogy of fallotEnrichmentKDR1.01
220NephronophthisisEnrichmentPIAS10.91
221Diamond-blackfan anemiaEnrichmentTP530.87
222Leukemia, acute myeloidEnrichmentTP530.83
223Charcot-marie-tooth diseaseEnrichmentHSPB10.82
224Familial isolated dilated cardiomyopathyEnrichmentFHL20.72
225Primary ovarian insufficiencyEnrichmentKDR0.68
226AutismEnrichmentCREBBP0.60

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