Transcription_Role of VDR in regulation of genes involved in osteoporosis

No Pathway Network information available for Transcription_Role of VDR in regulation of genes involved in osteoporosis

Pathways in the Transcription_Role of VDR in regulation of genes involved in osteoporosis SuperPath

#	Name	Source	Genes
1	Transcription_Role of VDR in regulation of genes involved in osteoporosis	GeneGo (Thomson Reuters)	APOE AR BGLAP CA2 CALB1 CALCA CALCR CALR CDKN1C CDX2 CGA COL1A1 CYP19A1 CYP24A1 CYP27B1 CYP3A4 FASLG FOS FOSL1 IFNG IGF1 IL1A IL1B IL6 JUN NR3C1 PRKACA PRKACB PRKACG PRKCB PTH PTH1R RUNX2 RXRA SMAD3 SPP1 TGFBR1 THRA THRB TNF TNFRSF11A TNFRSF11B TNFSF11 TRPC3 VDR (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APOE	Apolipoprotein E	Protein Coding	1
2	FASLG	Fas Ligand	Protein Coding	1
3	AR	Androgen Receptor	Protein Coding	1
4	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1
5	CA2	Carbonic Anhydrase 2	Protein Coding	1
6	CALB1	Calbindin 1	Protein Coding	1
7	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	1
8	CALCR	Calcitonin Receptor	Protein Coding	1
9	CALR	Calreticulin	Protein Coding	1
10	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
11	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	1
12	CDX2	Caudal Type Homeobox 2	Protein Coding	1
13	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	1
14	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
15	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
16	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	1
17	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	1
18	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	1
19	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
20	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
21	IFNG	Interferon Gamma	Protein Coding	1
22	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
23	IL1A	Interleukin 1 Alpha	Protein Coding	1
24	IL1B	Interleukin 1 Beta	Protein Coding	1
25	IL6	Interleukin 6	Protein Coding	1
26	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
27	SMAD3	SMAD Family Member 3	Protein Coding	1
28	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	1
29	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
30	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
31	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
32	PRKCB	Protein Kinase C Beta	Protein Coding	1
33	PTH	Parathyroid Hormone	Protein Coding	1
34	PTH1R	Parathyroid Hormone 1 Receptor	Protein Coding	1
35	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
36	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
37	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
38	THRA	Thyroid Hormone Receptor Alpha	Protein Coding	1
39	THRB	Thyroid Hormone Receptor Beta	Protein Coding	1
40	TNF	Tumor Necrosis Factor	Protein Coding	1
41	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	1
42	VDR	Vitamin D Receptor	Protein Coding	1
43	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
44	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
45	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	1

Disorders associated with Transcription_Role of VDR in regulation of genes involved in osteoporosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11A, TNFRSF11B	4.97
2	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.19
3	Classic ehlers-danlos syndrome	Enrichment	COL1A1, TGFBR1	3.80
4	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.42
5	Loeys-dietz syndrome	Enrichment	SMAD3, TGFBR1	3.42
6	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, SMAD3, TGFBR1	3.39
7	Alzheimer's disease	Enrichment	APOE, TNF	3.09
8	Osteoporosis	Enrichment	CALCR, COL1A1	3.02
9	Ehlers-danlos syndrome	Enrichment	COL1A1, SMAD3	2.75
10	Sea-blue histiocyte disease	Enrichment	APOE	2.48
11	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.48
12	Androgen insensitivity, partial	Enrichment	AR	2.48
13	Osteopetrosis, autosomal recessive 7	Enrichment	TNFRSF11A	2.48
14	Lipoprotein glomerulopathy	Enrichment	APOE	2.48
15	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.48
16	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.48
17	Spinocerebellar ataxia 41	Enrichment	TRPC3	2.48
18	Immunodeficiency 69	Enrichment	IFNG	2.48
19	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.48
20	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.48
21	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.48
22	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.48
23	Asphyxia neonatorum	Enrichment	COL1A1	2.48
24	Rickets	Enrichment	VDR	2.48
25	Sirenomelia	Enrichment	CDX2	2.48
26	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha	Enrichment	THRA	2.48
27	Complete androgen insensitivity syndrome	Enrichment	AR	2.48
28	Anorectal malformation	Enrichment	CDX2	2.48
29	Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome	Enrichment	CDKN1C	2.48
30	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta	Enrichment	THRB	2.48
31	Generalized resistance to thyroid hormone	Enrichment	THRB	2.48
32	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.18
33	Thyroid hormone resistance, selective pituitary	Enrichment	THRB	2.18
34	Failure of tooth eruption, primary	Enrichment	PTH1R	2.18
35	Familial expansile osteolysis	Enrichment	TNFRSF11A	2.18
36	Hypoparathyroidism, familial isolated, 1	Enrichment	PTH	2.18
37	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.18
38	Metaphyseal chondrodysplasia, jansen type	Enrichment	PTH1R	2.18
39	Galactosemia ii	Enrichment	NR3C1	2.18
40	Chondrodysplasia, blomstrand type	Enrichment	PTH1R	2.18
41	Thyroid hormone resistance, generalized, autosomal dominant	Enrichment	THRB	2.18
42	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.18
43	Thyroid hormone resistance, generalized, autosomal recessive	Enrichment	THRB	2.18
44	Alzheimer disease 3	Enrichment	APOE	2.18
45	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.18
46	Eiken syndrome	Enrichment	PTH1R	2.18
47	Loeys-dietz syndrome 2	Enrichment	TGFBR1	2.18
48	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	2.18
49	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	CDKN1C	2.18
50	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.18
51	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.18
52	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	THRA	2.18
53	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.18
54	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.18
55	46,xy sex reversal 1	Enrichment	AR	2.18
56	Androgen insensitivity syndrome	Enrichment	AR	2.18
57	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1	2.18
58	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.18
59	Thyroid hormone resistance syndrome	Enrichment	THRB	2.18
60	Osteopetrosis, autosomal recessive 3	Enrichment	CA2	2.18
61	Hypospadias 1, x-linked	Enrichment	AR	2.18
62	Immunodeficiency 127	Enrichment	TNF	2.18
63	Pseudohypoparathyroidism	Enrichment	PTH1R	2.18
64	Stickler syndrome, type ii	Enrichment	COL1A1	2.18
65	Fibrolamellar carcinoma	Enrichment	PRKACA	2.18
66	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1	2.18
67	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1	2.18
68	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.18
69	Posterior hypospadias	Enrichment	AR	2.18
70	Systemic lupus erythematosus	Enrichment	SPP1, TNF	2.13
71	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.00
72	Brachydactyly, type e1	Enrichment	PTH1R	2.00
73	Thrombocythemia 1	Enrichment	CALR	2.00
74	Dysosteosclerosis	Enrichment	TNFRSF11A	2.00
75	Tuberous sclerosis 1	Enrichment	IFNG	2.00
76	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.00
77	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	CYP27B1	2.00
78	Alzheimer disease 4	Enrichment	APOE	2.00
79	Psoriatic arthritis	Enrichment	TNF	2.00
80	Aromatase excess syndrome	Enrichment	CYP19A1	2.00
81	Hepatitis c virus	Enrichment	IFNG	2.00
82	Caffey disease	Enrichment	COL1A1	2.00
83	Tuberous sclerosis 2	Enrichment	IFNG	2.00
84	Familial isolated hypoparathyroidism	Enrichment	PTH	2.00
85	Loeys-dietz syndrome 1	Enrichment	TGFBR1	2.00
86	Cleidocranial dysplasia	Enrichment	RUNX2	2.00
87	Migraine without aura	Enrichment	TNF	2.00
88	Aromatase deficiency	Enrichment	CYP19A1	2.00
89	High bone mass osteogenesis imperfecta	Enrichment	COL1A1	2.00
90	Adult-onset myasthenia gravis	Enrichment	TNFRSF11A	2.00
91	Kaposi sarcoma	Enrichment	IL6	1.88
92	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1	1.88
93	Phenylketonuria	Enrichment	COL1A1	1.88
94	Macular degeneration, age-related, 1	Enrichment	APOE	1.88
95	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.88
96	Budd-chiari syndrome	Enrichment	CALR	1.88
97	Paget disease of bone 2, early-onset	Enrichment	TNFRSF11A	1.88
98	Chondrocalcinosis 2	Enrichment	TNFRSF11B	1.88
99	Bone mineral density quantitative trait locus 15	Enrichment	CALCR	1.88
100	Congenital generalized lipodystrophy	Enrichment	FOS	1.88
101	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	1.88
102	Paget's disease of bone 2	Enrichment	TNFRSF11A	1.88
103	Cerebral malaria	Enrichment	TNF	1.88
104	Silver-russell syndrome due to a point mutation	Enrichment	CDKN1C	1.88
105	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1	1.88
106	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.88
107	Primary hyperparathyroidism	Enrichment	PTH	1.88
108	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.88
109	Enchondromatosis, multiple, ollier type	Enrichment	PTH1R	1.78
110	Alzheimer disease 2	Enrichment	APOE	1.78
111	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.78
112	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.78
113	Insulin-like growth factor i	Enrichment	IGF1	1.78
114	Osteopetrosis	Enrichment	CA2	1.78
115	Histiocytoid hemangioma	Enrichment	FOS	1.78
116	Vascular dementia	Enrichment	TNF	1.78
117	Idiopathic aplastic anemia	Enrichment	IFNG	1.78
118	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1	1.70
119	Osteogenesis imperfecta, type i	Enrichment	COL1A1	1.70
120	Type 1 diabetes mellitus	Enrichment	IL6	1.70
121	Keratoconus	Enrichment	COL1A1	1.70
122	Lipid metabolism disorder	Enrichment	APOE	1.70
123	Osteogenesis imperfecta, type ii	Enrichment	COL1A1	1.64
124	Myelofibrosis	Enrichment	CALR	1.64
125	Essential thrombocythemia	Enrichment	CALR	1.64
126	Difference of sex development	Enrichment	AR	1.58
127	Inflammatory bowel disease 1	Enrichment	IL6	1.53
128	Primary hyperaldosteronism	Enrichment	NR3C1	1.53
129	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.53
130	Marfan syndrome	Enrichment	TGFBR1	1.49
131	Aplastic anemia	Enrichment	IFNG	1.49
132	Primary bone dysplasia	Enrichment	COL1A1	1.49
133	Pectus excavatum	Enrichment	TGFBR1	1.44
134	Asthma	Enrichment	TNF	1.44
135	46,xy complete gonadal dysgenesis	Enrichment	AR	1.44
136	Osteochondrodysplasia	Enrichment	COL1A1	1.44
137	Osteogenesis imperfecta, type iv	Enrichment	COL1A1	1.37
138	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.37
139	Multiple sclerosis	Enrichment	CYP27B1	1.34
140	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.34
141	Osteogenesis imperfecta, type iii	Enrichment	COL1A1	1.31
142	Familial hypercholesterolemia	Enrichment	APOE	1.31
143	Alzheimer disease, familial, 1	Enrichment	APOE	1.26
144	Beckwith-wiedemann syndrome	Enrichment	CDKN1C	1.24
145	Human immunodeficiency virus type 1	Enrichment	IFNG	1.24
146	Arteriovenous malformations of the brain	Enrichment	IL6	1.21
147	Williams-beuren syndrome	Enrichment	CDKN1C	1.19
148	Hepatocellular carcinoma	Enrichment	VDR	1.15
149	Brittle bone disorder	Enrichment	COL1A1	1.13
150	Malaria	Enrichment	TNF	1.13
151	Prostate cancer	Enrichment	AR	1.04
152	Lung cancer	Enrichment	FASLG	1.00
153	Connective tissue disease	Enrichment	SMAD3	1.00
154	Male infertility	Enrichment	AR	0.97
155	Type 2 diabetes mellitus	Enrichment	IL6	0.88
156	Gastric cancer	Enrichment	IL1B	0.88
157	Nephrotic syndrome	Enrichment	RUNX2	0.88
158	Hypertelorism	Enrichment	COL1A1	0.80
159	Myeloma, multiple	Enrichment	RXRA	0.77
160	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.77
161	Primary ovarian insufficiency	Enrichment	CYP19A1	0.75
162	Breast cancer	Enrichment	JUN	0.66
163	Ovarian cancer	Enrichment	AR	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Pathway Network for Transcription_Role of VDR in regulation of genes involved in osteoporosis

Member Pathways for Transcription_Role of VDR in regulation of genes involved in osteoporosis

Pathways in the Transcription_Role of VDR in regulation of genes involved in osteoporosis SuperPath

Associated Genes for Transcription_Role of VDR in regulation of genes involved in osteoporosis

Associated Disorders for Transcription_Role of VDR in regulation of genes involved in osteoporosis

Disorders associated with Transcription_Role of VDR in regulation of genes involved in osteoporosis SuperPath

STRING Interaction Network for Transcription_Role of VDR in regulation of genes involved in osteoporosis

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