Transcriptional activation of mitochondrial biogenesis

Pathway network for the Transcriptional activation of mitochondrial biogenesis SuperPath

Sources:

Reactome

Pathways in the Transcriptional activation of mitochondrial biogenesis SuperPath

#	Name	Source	Genes
1	Transcriptional activation of mitochondrial biogenesis	Reactome	ACSS2 ALAS1 ATF2 ATP5F1B CALM1 CALM2 CALM3 CAMK4 CARM1 CHD9 CREB1 CREBBP CRTC1 CRTC2 CRTC3 ESRRA GABPA GABPB1 GLUD1 GLUD2 HCFC1 HDAC3 HELZ2 IDH2 MED1 MEF2C MEF2D MTERF1 NCOA1 NCOA2 NCOA6 NCOR1 NR1D1 NRF1 PERM1 POLG2 POLRMT PPARA PPARGC1A PPARGC1B PPRC1 RXRA SIRT3 SIRT4 SIRT5 SMARCD3 SOD2 SSBP1 TBL1X TBL1XR1 TFAM TFB1M TFB2M TGS1 TWNK (see all 55) (see less)
2	Mitochondrial biogenesis	Reactome	ACSS2 ALAS1 APOO APOOL ATF2 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5MF ATP5MG ATP5MJ ATP5MK ATP5PB ATP5PD ATP5PF ATP5PO CALM1 CALM2 CALM3 CAMK4 CARM1 CHCHD3 CHCHD6 CHD9 CREB1 CREBBP CRTC1 CRTC2 CRTC3 DMAC2L DNAJC11 ESRRA GABPA GABPB1 GLUD1 GLUD2 HCFC1 HDAC3 HELZ2 HSPA9 IDH2 IMMT MAPK11 MAPK12 MAPK14 MED1 MEF2C MEF2D MICOS10 MICOS13 MT-ATP6 MT-ATP8 MTERF1 MTX1 MTX2 NCOA1 NCOA2 NCOA6 NCOR1 NR1D1 NRF1 PERM1 POLG2 POLRMT PPARA PPARGC1A PPARGC1B PPRC1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RXRA SAMM50 SIRT3 SIRT4 SIRT5 SMARCD3 SOD2 SSBP1 TBL1X TBL1XR1 TFAM TFB1M TFB2M TGS1 TMEM11 TWNK (see all 96) (see less)
3	Cristae formation	Reactome	APOO APOOL ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5MF ATP5MG ATP5MJ ATP5MK ATP5PB ATP5PD ATP5PF ATP5PO CHCHD3 CHCHD6 DMAC2L DNAJC11 HSPA9 IMMT MICOS10 MICOS13 MT-ATP6 MT-ATP8 MTX1 MTX2 SAMM50 TMEM11 (see all 33) (see less)
4	Formation of ATP by chemiosmotic coupling	Reactome	ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5MF ATP5MG ATP5MJ ATP5MK ATP5PB ATP5PD ATP5PF ATP5PO DMAC2L MT-ATP6 MT-ATP8 (see all 20) (see less)
5	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	Reactome	MAPK11 MAPK12 MAPK14 PPARGC1A PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 (see all 10) (see less)
6	Transcription from mitochondrial promoters	Reactome	MTERF1 POLRMT TFAM TFB2M
7	Mitochondrial transcription initiation	Reactome	POLRMT TFAM TFB2M
8	Mitochondrial transcription termination	Reactome	MTERF1

Gene overlap in member pathways for Transcriptional activation of mitochondrial biogenesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATP5F1B	ATP Synthase F1 Subunit Beta	Protein Coding	4
2	POLRMT	RNA Polymerase Mitochondrial	Protein Coding	4
3	TFB2M	Transcription Factor B2, Mitochondrial	Protein Coding	4
4	TFAM	Transcription Factor A, Mitochondrial	Protein Coding	4
5	MTERF1	Mitochondrial Transcription Termination Factor 1	Protein Coding	4
6	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	3
7	ATP5PD	ATP Synthase Peripheral Stalk Subunit D	Protein Coding	3
8	ATP5MG	ATP Synthase Membrane Subunit G	Protein Coding	3
9	DMAC2L	Distal Membrane Arm Assembly Component 2 Like	Protein Coding	3
10	MT-ATP6	Mitochondrially Encoded ATP Synthase Membrane Subunit 6	Protein Coding	3
11	MT-ATP8	Mitochondrially Encoded ATP Synthase Membrane Subunit 8	Protein Coding	3
12	ATP5F1A	ATP Synthase F1 Subunit Alpha	Protein Coding	3
13	ATP5F1C	ATP Synthase F1 Subunit Gamma	Protein Coding	3
14	ATP5F1D	ATP Synthase F1 Subunit Delta	Protein Coding	3
15	ATP5F1E	ATP Synthase F1 Subunit Epsilon	Protein Coding	3
16	ATP5PB	ATP Synthase Peripheral Stalk-Membrane Subunit B	Protein Coding	3
17	ATP5MC1	ATP Synthase Membrane Subunit C Locus 1	Protein Coding	3
18	ATP5MC2	ATP Synthase Membrane Subunit C Locus 2	Protein Coding	3
19	ATP5MC3	ATP Synthase Membrane Subunit C Locus 3	Protein Coding	3
20	ATP5ME	ATP Synthase Membrane Subunit E	Protein Coding	3
21	ATP5PF	ATP Synthase Peripheral Stalk Subunit F6	Protein Coding	3
22	ATP5PO	ATP Synthase Peripheral Stalk Subunit OSCP	Protein Coding	3
23	ATP5MK	ATP Synthase Membrane Subunit K	Protein Coding	3
24	ATP5MF	ATP Synthase Membrane Subunit F	Protein Coding	3
25	ATP5MJ	ATP Synthase Membrane Subunit J	Protein Coding	3
26	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	2
27	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	2
28	POLG2	DNA Polymerase Gamma 2, Accessory Subunit	Protein Coding	2
29	PPARGC1B	PPARG Coactivator 1 Beta	Protein Coding	2
30	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
31	ATF2	Activating Transcription Factor 2	Protein Coding	2
32	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
33	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	2
34	ESRRA	Estrogen Related Receptor Alpha	Protein Coding	2
35	ALAS1	5''-Aminolevulinate Synthase 1	Protein Coding	2
36	NCOA6	Nuclear Receptor Coactivator 6	Protein Coding	2
37	PPRC1	PPARG Related Coactivator 1	Protein Coding	2
38	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	2
39	SIRT5	Sirtuin 5	Protein Coding	2
40	SIRT4	Sirtuin 4	Protein Coding	2
41	SIRT3	Sirtuin 3	Protein Coding	2
42	GABPA	GA Binding Protein Transcription Factor Subunit Alpha	Protein Coding	2
43	GABPB1	GA Binding Protein Transcription Factor Subunit Beta 1	Protein Coding	2
44	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	2
45	GLUD2	Glutamate Dehydrogenase 2	Protein Coding	2
46	HCFC1	Host Cell Factor C1	Protein Coding	2
47	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2	Protein Coding	2
48	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	2
49	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	2
50	NRF1	Nuclear Respiratory Factor 1	Protein Coding	2
51	TFB1M	Transcription Factor B1, Mitochondrial	Protein Coding	2
52	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	2
53	MED1	Mediator Complex Subunit 1	Protein Coding	2
54	ACSS2	Acyl-CoA Synthetase Short Chain Family Member 2	Protein Coding	2
55	TWNK	Twinkle MtDNA Helicase	Protein Coding	2
56	RXRA	Retinoid X Receptor Alpha	Protein Coding	2
57	CRTC3	CREB Regulated Transcription Coactivator 3	Protein Coding	2
58	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	2
59	SOD2	Superoxide Dismutase 2	Protein Coding	2
60	SSBP1	Single Stranded DNA Binding Protein 1	Protein Coding	2
61	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	2
62	TBL1XR1	TBL1X/Y Related 1	Protein Coding	2
63	CALM1	Calmodulin 1	Protein Coding	2
64	CHD9	Chromodomain Helicase DNA Binding Protein 9	Protein Coding	2
65	CALM2	Calmodulin 2	Protein Coding	2
66	CALM3	Calmodulin 3	Protein Coding	2
67	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	2
68	PERM1	PPARGC1 And ESRR Induced Regulator, Muscle 1	Protein Coding	2
69	HELZ2	Helicase With Zinc Finger 2	Protein Coding	2
70	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	2
71	HDAC3	Histone Deacetylase 3	Protein Coding	2
72	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	2
73	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	2
74	TGS1	Trimethylguanosine Synthase 1	Protein Coding	2
75	MTX2	Metaxin 2	Protein Coding	2
76	IMMT	Inner Membrane Mitochondrial Protein	Protein Coding	2
77	MICOS13	Mitochondrial Contact Site And Cristae Organizing System Subunit 13	Protein Coding	2
78	APOOL	Apolipoprotein O Like	Protein Coding	2
79	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
80	SAMM50	SAMM50 Sorting And Assembly Machinery Component	Protein Coding	2
81	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	2
82	MICOS10	Mitochondrial Contact Site And Cristae Organizing System Subunit 10	Protein Coding	2
83	MTX1	Metaxin 1	Protein Coding	2
84	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	2
85	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	2
86	CHCHD3	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3	Protein Coding	2
87	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	2
88	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	2
89	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	2
90	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	2
91	DNAJC11	DnaJ Heat Shock Protein Family (Hsp40) Member C11	Protein Coding	2
92	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
93	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
94	APOO	Apolipoprotein O	Protein Coding	2
95	CHCHD6	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6	Protein Coding	2
96	TMEM11	Transmembrane Protein 11	Protein Coding	2

Disorders associated with Transcriptional activation of mitochondrial biogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Isolated atp synthase deficiency	Enrichment	ATP5F1A, ATP5F1D, ATP5F1E, ATP5MK, MT-ATP6, MT-ATP8	10.60
2	Cardiomyopathy, infantile hypertrophic	Enrichment	MT-ATP6, MT-ATP8	5.69
3	Periodic paralysis with later-onset distal motor neuropathy	Enrichment	MT-ATP6, MT-ATP8	5.69
4	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.46
5	Cardiomyopathy, infantile histiocytoid	Enrichment	MT-ATP6, MT-ATP8	4.91
6	Optic nerve disease	Enrichment	MT-ATP6, MT-ATP8	4.03
7	Leigh syndrome, nuclear	Enrichment	ATP5PO, MT-ATP6, MT-ATP8	3.87
8	Aortic valve disease 1	Enrichment	MT-ATP6, MT-ATP8	3.80
9	Leigh disease	Enrichment	ATP5PO, MT-ATP6, MT-ATP8	3.74
10	Combined oxidative phosphorylation deficiency 55	Enrichment	POLRMT	3.66
11	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	3.63
12	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	POLG2, TWNK	3.62
13	Mitochondrial disease	Enrichment	ATP5F1D, MT-ATP6, MT-ATP8	3.57
14	Lactic acidosis	Enrichment	APOO, ATP5F1A	3.43
15	Mitochondrial dna depletion syndrome 15	Enrichment	TFAM	3.35
16	Mitochondrial complex v deficiency, mitochondrial type 1	Enrichment	MT-ATP6, MT-ATP8	3.18
17	Neuropathy, ataxia, and retinitis pigmentosa	Enrichment	MT-ATP6, MT-ATP8	3.18
18	Striatonigral degeneration, infantile, mitochondrial	Enrichment	MT-ATP6, MT-ATP8	3.18
19	Camptodactyly of fingers	Enrichment	MT-ATP6, MT-ATP8	3.18
20	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	3.13
21	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	3.13
22	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	3.13
23	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-ATP6, MT-ATP8	2.87
24	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-ATP6, MT-ATP8	2.85
25	Ataxia and polyneuropathy, adult-onset	Enrichment	MT-ATP6	2.83
26	Myopathy, lactic acidosis, and sideroblastic anemia 3	Enrichment	MT-ATP6	2.83
27	Dystonia, early-onset, and/or spastic paraplegia	Enrichment	ATP5MC3	2.83
28	Mitochondrial complex v deficiency, nuclear type 6	Enrichment	ATP5MK	2.83
29	Mitochondrial complex v deficiency, nuclear type 4b	Enrichment	ATP5F1A	2.83
30	Combined oxidative phosphorylation deficiency 22	Enrichment	ATP5F1A	2.83
31	Mitochondrial complex v deficiency, nuclear type 4a	Enrichment	ATP5F1A	2.83
32	Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2	Enrichment	ATP5F1B	2.83
33	Maternally-inherited spastic paraplegia	Enrichment	MT-ATP6	2.83
34	Even-plus syndrome	Enrichment	HSPA9	2.61
35	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.61
36	Mandibuloacral dysplasia progeroid syndrome	Enrichment	MTX2	2.61
37	Combined oxidative phosphorylation deficiency 37	Enrichment	MICOS13	2.61
38	Pigmentation anomaly of the skin	Enrichment	MTX2	2.61
39	Hypertelorism	Enrichment	MT-ATP6, MT-ATP8	2.58
40	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TBL1XR1	2.58
41	Charcot-marie-tooth disease, demyelinating, type 1a	Enrichment	MT-ATP6	2.53
42	L-2-hydroxyglutaric aciduria	Enrichment	DMAC2L	2.53
43	Charcot-marie-tooth disease type 1a	Enrichment	MT-ATP6	2.53
44	Retinitis pigmentosa	Enrichment	ATP5ME, MT-ATP6, MT-ATP8	2.45
45	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.39
46	Optic atrophy 13 with retinal and foveal abnormalities	Enrichment	SSBP1	2.39
47	Microvascular complications of diabetes 6	Enrichment	SOD2	2.39
48	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3	Enrichment	TWNK	2.39
49	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.39
50	Perrault syndrome 5	Enrichment	TWNK	2.39
51	Hyperinsulinemic hypoglycemia, familial, 6	Enrichment	GLUD1	2.39
52	Gemistocytic astrocytoma	Enrichment	IDH2	2.39
53	Protoplasmic astrocytoma	Enrichment	IDH2	2.39
54	D-2-hydroxyglutaric aciduria 2	Enrichment	IDH2	2.39
55	Long qt syndrome 16	Enrichment	CALM3	2.39
56	Mixed oligodendroglioma-astrocytoma	Enrichment	IDH2	2.39
57	Anaplastic oligoastrocytoma	Enrichment	IDH2	2.39
58	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.39
59	Long qt syndrome 15	Enrichment	CALM2	2.39
60	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.39
61	Mitochondrial dna depletion syndrome, hepatocerebrorenal form	Enrichment	TWNK	2.39
62	Fibrillary astrocytoma	Enrichment	IDH2	2.39
63	Acute myocardial infarction	Enrichment	IDH2	2.39
64	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.39
65	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.39
66	Menke-hennekam syndrome	Enrichment	CREBBP	2.39
67	Mef2c-related disorder	Enrichment	MEF2C	2.39
68	Mitochondrial complex iv deficiency, nuclear type 5	Enrichment	ATP5F1A	2.35
69	Retinitis pigmentosa 40	Enrichment	ATP5ME	2.35
70	Mitochondrial complex v deficiency, nuclear type 7	Enrichment	ATP5PO	2.35
71	Mitochondrial complex v deficiency, nuclear type 5	Enrichment	ATP5F1D	2.35
72	Gonadal dysgenesis	Enrichment	MT-ATP6	2.35
73	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.31
74	Mitochondrial complex v deficiency, nuclear type 3	Enrichment	ATP5F1E	2.23
75	Familial infantile bilateral striatal necrosis	Enrichment	MT-ATP6	2.23
76	Long qt syndrome	Enrichment	CALM1, CALM2	2.16
77	Albinism, oculocutaneous, type ii	Enrichment	ATP5ME	2.13
78	Kearns-sayre syndrome	Enrichment	MT-ATP8	2.13
79	Thumb deformity	Enrichment	CREBBP	2.09
80	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.09
81	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4	Enrichment	POLG2	2.09
82	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.09
83	Long qt syndrome 14	Enrichment	CALM1	2.09
84	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1	2.09
85	Mitochondrial dna depletion syndrome 16b	Enrichment	POLG2	2.09
86	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.09
87	Oligodendroglioma	Enrichment	IDH2	2.09
88	Depressive disorder	Enrichment	TWNK	2.09
89	Mitochondrial dna depletion syndrome 16	Enrichment	POLG2	2.09
90	Anaplastic oligodendroglioma	Enrichment	IDH2	2.09
91	D-2-hydroxyglutaric aciduria	Enrichment	IDH2	2.09
92	Leber plus disease	Enrichment	MT-ATP6, MT-ATP8	2.07
93	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.93
94	3-methylglutaconic aciduria, type iii	Enrichment	MICOS13	1.92
95	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	HCFC1	1.92
96	Pierpont syndrome	Enrichment	TBL1XR1	1.92
97	Mitochondrial dna depletion syndrome 7	Enrichment	TWNK	1.92
98	Renu syndrome	Enrichment	SIRT4	1.92
99	Tethered spinal cord syndrome	Enrichment	CREBBP	1.92
100	Chronic progressive external ophthalmoplegia	Enrichment	TWNK	1.92
101	Anaplastic astrocytoma	Enrichment	IDH2	1.92
102	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.92
103	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.92
104	Melanoma of soft tissue	Enrichment	CREB1	1.92
105	Acute liver failure	Enrichment	POLG2	1.92
106	Mitochondrial myopathy, infantile, transient	Enrichment	MT-ATP6	1.88
107	Mitochondrial myopathy with reversible cytochrome c oxidase deficiency	Enrichment	MT-ATP6	1.83
108	Leigh syndrome, mitochondrial	Enrichment	MT-ATP6	1.79
109	Enchondromatosis, multiple, ollier type	Enrichment	IDH2	1.70
110	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	Enrichment	TWNK	1.70
111	Myasthenic syndrome, congenital, 8	Enrichment	PERM1	1.70
112	Myeloma, multiple	Enrichment	CREBBP, RXRA	1.67
113	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C, PPARGC1A	1.64
114	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.62
115	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GLUD1	1.62
116	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.62
117	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.62
118	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.62
119	Hypertrichosis	Enrichment	CREBBP	1.62
120	Nonsyndromic genetic hyperinsulinism	Enrichment	GLUD1	1.62
121	Multiple enchondromatosis, maffucci type	Enrichment	IDH2	1.55
122	Third-degree atrioventricular block	Enrichment	TWNK	1.55
123	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.50
124	Glioma susceptibility 1	Enrichment	IDH2	1.50
125	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	1.50
126	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.50
127	Orofacial cleft 1	Enrichment	ACSS2	1.44
128	Perrault syndrome 2	Enrichment	TWNK	1.44
129	Hypertension	Enrichment	MTX2	1.42
130	Rare mitochondrial non-syndromic sensorineural deafness	Enrichment	TFB1M	1.40
131	Acute promyelocytic leukemia	Enrichment	TBL1XR1	1.29
132	Heart disease	Enrichment	CREBBP	1.26
133	Charcot-marie-tooth disease	Enrichment	MT-ATP6	1.23
134	Corpus callosum, agenesis of	Enrichment	CREBBP	1.23
135	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.23
136	Rare genetic intellectual disability	Enrichment	CREBBP	1.23
137	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.23
138	Perrault syndrome 1	Enrichment	TWNK	1.20
139	Sudden infant death syndrome	Enrichment	CALM2	1.18
140	Scoliosis	Enrichment	CREBBP	1.03
141	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1	0.87
142	Leukemia, acute myeloid	Enrichment	IDH2	0.82
143	Microcephaly	Enrichment	ATP5PO	0.78
144	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLUD2	0.69
145	Cone-rod dystrophy 2	Enrichment	SSBP1	0.62
146	Autism	Enrichment	CREBBP	0.59
147	Congenital nervous system abnormality	Enrichment	CREBBP	0.45
148	Nervous system disease	Enrichment	CREBBP	0.45
149	Hereditary retinal dystrophy	Enrichment	ATP5ME	0.45
150	Fundus dystrophy	Enrichment	ATP5ME	0.45
151	Autism spectrum disorder	Enrichment	MEF2C	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcriptional activation of mitochondrial biogenesis

Pathway Network for Transcriptional activation of mitochondrial biogenesis

Pathway network for the Transcriptional activation of mitochondrial biogenesis SuperPath

Member Pathways for Transcriptional activation of mitochondrial biogenesis

Pathways in the Transcriptional activation of mitochondrial biogenesis SuperPath

Gene overlap in member pathways for Transcriptional activation of mitochondrial biogenesis SuperPath

Associated Genes for Transcriptional activation of mitochondrial biogenesis

Associated Disorders for Transcriptional activation of mitochondrial biogenesis

Disorders associated with Transcriptional activation of mitochondrial biogenesis SuperPath

STRING Interaction Network for Transcriptional activation of mitochondrial biogenesis

Sources for Transcriptional activation of mitochondrial biogenesis