Transcriptional Regulation by MECP2

Pathway network for the Transcriptional Regulation by MECP2 SuperPath

Sources:
  • Reactome

Pathways in the Transcriptional Regulation by MECP2 SuperPath

#NameSourceGenes
1Transcriptional Regulation by MECP2Reactome
2Regulation of MECP2 expression and activityReactome
3MECP2 regulates neuronal receptors and channelsReactome
4Regulation of PTEN mRNA translationReactome
5MECP2 regulates transcription of neuronal ligandsReactome
6Competing endogenous RNAs (ceRNAs) regulate PTEN translationReactome
7Post-transcriptional silencing by small RNAsReactome
8MECP2 regulates transcription factorsReactome
9Loss of MECP2 binding ability to 5mC-DNAReactome
10MECP2 regulates transcription of genes involved in GABA signalingReactome
11Loss of MECP2 binding ability to 5hmC-DNAReactome

Gene overlap in member pathways for Transcriptional Regulation by MECP2 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Transcriptional Regulation by MECP2 SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Rett syndromeDirect
2Catecholaminergic polymorphic ventricular tachycardiaEnrichmentCALM1, CALM2, CALM36.14
3EpilepsyEnrichmentGRIN2A, GRIN2B, MECP24.80
4Complex neurodevelopmental disorderEnrichmentAGO1, AGO2, TNRC6B4.60
5Long qt syndrome 1EnrichmentCALM1, CALM2, CALM34.29
6Autosomal dominant non-syndromic intellectual disabilityEnrichmentCAMK2A, CAMK2B, DLL1, GRIN2B4.11
7Congenital nervous system abnormalityEnrichmentCAMK2B, FOXG1, GAMT, MECP2, PTEN3.92
8Nervous system diseaseEnrichmentCAMK2B, FOXG1, GAMT, MECP2, PTEN3.92
9Huntington diseaseEnrichmentHTT, SLC2A33.91
10Autism spectrum disorderEnrichmentGRIN2B, MECP2, MEF2C, PTEN, TNRC6B3.86
11Rett syndrome, congenital variantEnrichmentFOXG1, MECP23.80
12Facial hypertrichosisEnrichmentMECP23.66
13Intellectual developmental disorder, x-linked, syndromic, lubs typeEnrichmentMECP23.66
14Autism x-linked 3EnrichmentMECP23.66
15Developmental and epileptic encephalopathy 89EnrichmentGAD13.66
16Syndromic x-linked intellectual disability lubs typeEnrichmentMECP23.66
17AutismEnrichmentMECP2, RBFOX13.56
18Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired languageEnrichmentMEF2C3.43
19Pparg-associated congenital generalized lipodystrophyEnrichmentPPARG3.43
205q14.3 microdeletion syndromeEnrichmentMEF2C3.43
21Complete atrioventricular septal defect without ventricular hypoplasiaEnrichmentMEF2C3.43
22Mef2c-related disorderEnrichmentMEF2C3.43
23Colorectal cancerEnrichmentPPARG, RBFOX13.40
24Stereotypic movement disorderEnrichmentFOXG1, MECP23.36
25Encephalopathy, neonatal severe, due to mecp2 mutationsEnrichmentMECP23.35
26Intellectual developmental disorder, x-linked, syndromic 13EnrichmentMECP23.35
27X-linked intellectual disability-psychosis-macroorchidism syndromeEnrichmentMECP23.35
28Progressive bulbar palsyEnrichmentMECP23.35
29BruxismEnrichmentMECP23.35
30Global developmental delay with speech and behavioral abnormalitiesEnrichmentTNRC6B3.29
31Epilepsy, familial adult myoclonic, 6EnrichmentTNRC6A3.29
32Chromosome 15q24 deletion syndromeEnrichmentSIN3A3.23
33LaryngomalaciaEnrichmentMECP23.18
34Vacterl association with hydrocephalusEnrichmentPTEN3.18
35Papillary tumor of the pineal regionEnrichmentPTEN3.18
36Glioma susceptibility 2EnrichmentPTEN3.18
37Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndromeEnrichmentPTEN3.18
38Carotid intimal medial thickness 1EnrichmentPPARG3.13
39Histiocytoma, angiomatoid fibrousEnrichmentCREB13.13
40Familial partial lipodystrophyEnrichmentPPARG3.13
41Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalitiesEnrichmentGAD13.05
42Spastic quadriplegic cerebral palsyEnrichmentGAD13.05
43Sick sinus syndromeEnrichmentMECP23.05
44Premature ovarian failure 3EnrichmentAGO22.99
45Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizuresEnrichmentAGO12.99
46Melanoma of soft tissueEnrichmentCREB12.96
47Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizuresEnrichmentDLL12.93
48Witteveen-kolk syndromeEnrichmentSIN3A2.93
49Epilepsy, focal, with speech disorder and with or without impaired intellectual developmentEnrichmentGRIN2A2.90
50Developmental and epileptic encephalopathy 27EnrichmentGRIN2B2.90
51Spinocerebellar ataxia 41EnrichmentTRPC32.90
52Osteofibrous dysplasiaEnrichmentMET2.90
53Deafness, autosomal recessive 97EnrichmentMET2.90
54Autism 9EnrichmentMET2.90
55Intellectual developmental disorder, autosomal dominant 6, with or without seizuresEnrichmentGRIN2B2.90
56Neurodevelopmental disorder with language impairment and behavioral abnormalitiesEnrichmentGRIA22.90
57Arthrogryposis, distal, type 11EnrichmentMET2.90
58Grin2b-related neurodevelopmental disorderEnrichmentGRIN2B2.90
59Landau-kleffner syndromeEnrichmentGRIN2A2.90
60Gria2-related neurodevelopmental disorderEnrichmentGRIA22.90
61Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutationEnrichmentGRIN2A2.90
62Grin2a-related disordersEnrichmentGRIN2A2.90
63Angelman syndromeEnrichmentMECP22.88
64Vacterl with hydrocephalusEnrichmentPTEN2.88
65Juvenile polyposis of infancyEnrichmentPTEN2.88
66Lipodystrophy, familial partial, type 3EnrichmentPPARG2.83
67Leptin deficiency or dysfunctionEnrichmentPPARG2.83
68Congenital generalized lipodystrophyEnrichmentPPARG2.83
69Lessel-kreienkamp syndromeEnrichmentAGO22.81
70Focal epilepsyEnrichmentMECP22.81
71Laryngeal squamous cell carcinomaEnrichmentPTEN2.70
72Hypothyroidism, congenital, nongoitrous, 8EnrichmentTBL1X2.61
73Greenberg dysplasiaEnrichmentLBR2.61
74Pelger-huet anomalyEnrichmentLBR2.61
75Rhizomelic skeletal dysplasia with or without pelger-huet anomalyEnrichmentLBR2.61
76Intellectual developmental disorder, autosomal recessive 63EnrichmentCAMK2A2.61
77Intellectual developmental disorder, autosomal dominant 54EnrichmentCAMK2B2.61
78Long qt syndrome 16EnrichmentCALM32.61
79Pigmented nodular adrenocortical disease, primary, 4EnrichmentPRKACA2.61
80Reynolds syndromeEnrichmentLBR2.61
81Cardioacrofacial dysplasia 1EnrichmentPRKACA2.61
82Lopes-maciel-rodan syndromeEnrichmentHTT2.61
83Intellectual developmental disorder, autosomal dominant 53EnrichmentCAMK2A2.61
84Intellectual developmental disorder, autosomal dominant 59EnrichmentCAMK2G2.61
85Long qt syndrome 15EnrichmentCALM22.61
86Foxg1 syndrome due to intragenic alterationEnrichmentFOXG12.61
87Foxg1 syndrome due to 14q12 microdeletionEnrichmentFOXG12.61
88Juvenile huntington diseaseEnrichmentHTT2.61
89Childhood hepatocellular carcinomaEnrichmentMET2.60
90Intellectual developmental disorder, autosomal dominant 21EnrichmentGRIN2A2.60
91Papillary renal cell carcinomaEnrichmentMET2.60
92Rolandic epilepsy-speech dyspraxia syndromeEnrichmentGRIN2A2.60
93Epilepsy-aphasia spectrumEnrichmentGRIN2A2.60
94Long qt syndromeEnrichmentCALM1, CALM22.59
95GliomaEnrichmentPTEN2.58
96DystoniaEnrichmentCAMK2B, MECP22.49
97Macrocephaly/autism syndromeEnrichmentPTEN2.48
98HemangiomaEnrichmentPTEN2.48
99Acute megakaryocytic leukemiaEnrichmentPTEN2.48
100HemimegalencephalyEnrichmentPTEN2.48
101Diffuse large b-cell lymphomaEnrichmentPTEN, TBL1XR12.48
102Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentBDNF2.45
103Renal cell carcinomaEnrichmentMET2.43
104Cowden syndrome 1EnrichmentPTEN2.40
105Autosomal dominant sleep-related hypermotor epilepsyEnrichmentCRH2.38
106Thyroid cancer, nonmedullary, 2EnrichmentPTEN2.33
107Squamous cell carcinoma, head and neckEnrichmentPTEN2.33
108Follicular thyroid carcinomaEnrichmentPTEN2.33
109Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentTNRC6B2.33
110Attention deficit-hyperactivity disorderEnrichmentMECP22.31
111Ventricular tachycardia, catecholaminergic polymorphic, 4EnrichmentCALM12.31
112Long qt syndrome 14EnrichmentCALM12.31
113Fibrolamellar carcinomaEnrichmentPRKACA2.31
114AstigmatismEnrichmentGRIN2B2.30
115Congenital central hypoventilation syndromeEnrichmentBDNF2.28
116GliosarcomaEnrichmentPPARG2.23
117Cowden syndromeEnrichmentPTEN2.22
118Major depressive disorderEnrichmentFKBP52.20
119Sleep disorderEnrichmentGRIN2B2.20
120Giant cell glioblastomaEnrichmentPPARG2.20
121MelanomaEnrichmentPTEN2.18
122Meningioma, familialEnrichmentPTEN2.14
123Uterine corpus cancerEnrichmentPTEN2.14
124Pierpont syndromeEnrichmentTBL1XR12.14
125Intellectual developmental disorder, autosomal dominant 41EnrichmentTBL1XR12.14
126MeningiomaEnrichmentPTEN2.10
127Non-syndromic x-linked intellectual disabilityEnrichmentMECP22.10
128Systemic lupus erythematosusEnrichmentMECP22.07
129Renal cell carcinoma, papillary, 1EnrichmentMET2.06
130Septopreoptic holoprosencephalyEnrichmentDLL12.05
131Midline interhemispheric variant of holoprosencephalyEnrichmentDLL12.05
132Cerebral creatine deficiency syndrome 2EnrichmentGAMT2.04
133Cerebral creatine deficiency syndromeEnrichmentGAMT2.04
134Creatine deficiency disordersEnrichmentGAMT2.04
135Microform holoprosencephalyEnrichmentDLL12.03
136Lobar holoprosencephalyEnrichmentDLL12.03
137Arthrogryposis, distal, type 1aEnrichmentMET2.00
138Alobar holoprosencephalyEnrichmentDLL12.00
139MicrocephalyEnrichmentGRIN2B, MECP21.99
140RhabdomyosarcomaEnrichmentPTEN1.98
141Semilobar holoprosencephalyEnrichmentDLL11.98
142Differentiated thyroid carcinomaEnrichmentPPARG1.97
143AsthmaEnrichmentFKBP51.86
144Endometrial cancerEnrichmentPTEN1.86
145Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathyEnrichmentCALM11.84
146Benign epilepsy with centrotemporal spikesEnrichmentRBFOX11.82
147Type 2 diabetes mellitusEnrichmentPPARG1.81
148Centralopathic epilepsyEnrichmentRBFOX11.80
149Microphthalmia, syndromic 3EnrichmentSOX21.74
150Pediatric systemic lupus erythematosusEnrichmentIRAK11.74
151Body mass index quantitative trait locus 11EnrichmentPPARG1.74
152Renal cell carcinoma, nonpapillaryEnrichmentMET1.73
153Bladder cancerEnrichmentPTEN1.72
154Prostate cancerEnrichmentPTEN1.72
155Catecholaminergic polymorphic ventricular tachycardia 1EnrichmentCALM11.71
156Undetermined early-onset epileptic encephalopathyEnrichmentRBFOX11.69
157Frontotemporal dementia and/or amyotrophic lateral sclerosis 7EnrichmentMEF2C1.67
158SchizophreniaEnrichmentRBFOX11.67
159Ellis-van creveld syndromeEnrichmentPRKACA1.66
160Optic nerve diseaseEnrichmentFOXG11.62
161CraniosynostosisEnrichmentGRIN2B1.61
162Myeloma, multipleEnrichmentNCOR2, SGK11.57
163Hepatocellular carcinomaEnrichmentMET1.56
164Gastric cancerEnrichmentPTEN1.55
165Hereditary breast carcinomaEnrichmentPTEN1.54
166ScoliosisEnrichmentGRIN2B1.53
167Acute promyelocytic leukemiaEnrichmentTBL1XR11.51
168Nk-cell enteropathyEnrichmentAURKB1.51
169Hereditary breast ovarian cancer syndromeEnrichmentPTEN1.44
170Isolated congenital microcephalyEnrichmentFOXG11.42
171Lung cancerEnrichmentMET1.40
172Sudden infant death syndromeEnrichmentCALM21.39
173Cerebral palsyEnrichmentGRIN2B1.32
174Breast cancerEnrichmentPTEN1.31
175NanophthalmosEnrichmentSOX21.31
176LissencephalyEnrichmentFOXG11.30
177Septooptic dysplasiaEnrichmentSOX21.27
178West syndromeEnrichmentGRIN2B1.27
179Jeune thoracic dystrophyEnrichmentLBR1.23
180StrabismusEnrichmentFOXG11.20
181Ovarian cancerEnrichmentPTEN1.19
182Asphyxiating thoracic dystrophyEnrichmentLBR1.18
183Short-rib thoracic dysplasia 1 with or without polydactylyEnrichmentLBR1.11
184Parkinson's diseaseEnrichmentGAMT1.08
185Inherited cancer-predisposing syndromeEnrichmentPTEN1.07
186Macs syndromeEnrichmentSOX21.06
187MicrophthalmiaEnrichmentSOX21.02
188Parkinson disease, late-onsetEnrichmentGAMT0.98
189Rare autosomal recessive non-syndromic sensorineural deafness type dfnbEnrichmentMET0.97

Loading...
Loading...
Loading...