Transcriptional Regulation by NPAS4

Pathway network for the Transcriptional Regulation by NPAS4 SuperPath

Sources:

Reactome

Pathways in the Transcriptional Regulation by NPAS4 SuperPath

#	Name	Source	Genes
1	Transcriptional Regulation by NPAS4	Reactome	AGO1 AGO2 AGO3 AGO4 ARNT ARNT2 BDNF BMAL1 CDK5 CDK5R1 CREBBP FOS GEM INS IQSEC3 KCNIP3 MAGED1 MAPK1 MAPK3 MDM2 MOV10 NAMPT NPAS4 NR3C1 PLK2 RBFOX3 REST RET SRF SYT10 TNRC6A TNRC6B TNRC6C XPO1 (see all 34) (see less)
2	NPAS4 regulates expression of target genes	Reactome	ARNT ARNT2 BDNF BMAL1 CDK5 CDK5R1 CREBBP FOS GEM INS IQSEC3 MAGED1 MAPK1 MAPK3 MDM2 NAMPT NPAS4 PLK2 RBFOX3 RET SYT10 XPO1 (see all 22) (see less)
3	Regulation of NPAS4 gene expression	Reactome	AGO1 AGO2 AGO3 AGO4 KCNIP3 MOV10 NPAS4 NR3C1 REST SRF TNRC6A TNRC6B TNRC6C (see all 13) (see less)
4	Regulation of NPAS4 mRNA translation	Reactome	AGO1 AGO2 AGO3 AGO4 MOV10 NPAS4 TNRC6A TNRC6B TNRC6C (see all 9) (see less)
5	Regulation of NPAS4 gene transcription	Reactome	KCNIP3 NR3C1 REST SRF

Gene overlap in member pathways for Transcriptional Regulation by NPAS4 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NPAS4	Neuronal PAS Domain Protein 4	Protein Coding	4
2	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	3
3	AGO4	Argonaute RISC Component 4	Protein Coding	3
4	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	3
5	AGO1	Argonaute RISC Component 1	Protein Coding	3
6	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	3
7	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	3
8	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	3
9	KCNIP3	Potassium Voltage-Gated Channel Interacting Protein 3	Protein Coding	3
10	MOV10	Mov10 RNA Helicase	Protein Coding	3
11	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	3
12	REST	RE1 Silencing Transcription Factor	Protein Coding	3
13	SRF	Serum Response Factor	Protein Coding	3
14	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	2
15	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
16	PLK2	Polo Like Kinase 2	Protein Coding	2
17	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
18	RBFOX3	RNA Binding Fox-1 Homolog 3	Protein Coding	2
19	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
20	GEM	GTP Binding Protein Overexpressed In Skeletal Muscle	Protein Coding	2
21	SYT10	Synaptotagmin 10	Protein Coding	2
22	INS	Insulin	Protein Coding	2
23	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	2
24	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	2
25	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
26	IQSEC3	IQ Motif And Sec7 Domain ArfGEF 3	Protein Coding	2
27	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
28	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
29	RET	Ret Proto-Oncogene	Protein Coding	2
30	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	2
31	XPO1	Exportin 1	Protein Coding	2
32	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	2
33	MAGED1	MAGE Family Member D1	Protein Coding	2
34	ARNT2	Aryl Hydrocarbon Receptor Nuclear Translocator 2	Protein Coding	2

Disorders associated with Transcriptional Regulation by NPAS4 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, TNRC6B	4.22
2	Congenital central hypoventilation syndrome	Enrichment	BDNF, RET	4.05
3	Glucocorticoid resistance, generalized	Enrichment	NR3C1	3.53
4	Wilms tumor 6	Enrichment	REST	3.53
5	Deafness, autosomal dominant 27	Enrichment	REST	3.53
6	Fibromatosis, gingival, 5	Enrichment	REST	3.53
7	Fibromatosis, gingival, 1	Enrichment	REST	3.23
8	Galactosemia ii	Enrichment	NR3C1	3.23
9	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	3.18
10	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	3.18
11	Gingival fibromatosis	Enrichment	REST	2.93
12	Premature ovarian failure 3	Enrichment	AGO2	2.88
13	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.88
14	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.79
15	Accelerated tumor formation	Enrichment	MDM2	2.79
16	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.79
17	Noonan syndrome 13	Enrichment	MAPK1	2.79
18	Lessel-kubisch syndrome	Enrichment	MDM2	2.79
19	Webb-dattani syndrome	Enrichment	ARNT2	2.79
20	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.79
21	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.79
22	Thyroid cancer	Enrichment	RET	2.79
23	Menke-hennekam syndrome	Enrichment	CREBBP	2.79
24	Gastrointestinal system disease	Enrichment	RET	2.79
25	Multiple endocrine neoplasia	Enrichment	RET	2.79
26	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.70
27	Primary hyperaldosteronism	Enrichment	NR3C1	2.58
28	Thumb deformity	Enrichment	CREBBP	2.49
29	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.49
30	Hyperproinsulinemia	Enrichment	INS	2.49
31	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.49
32	Medullary thyroid carcinoma	Enrichment	RET	2.49
33	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.49
34	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.49
35	Wilms tumor 1	Enrichment	REST	2.35
36	Type 1 diabetes mellitus 2	Enrichment	INS	2.31
37	Thyroid carcinoma, familial medullary	Enrichment	RET	2.31
38	Tethered spinal cord syndrome	Enrichment	CREBBP	2.31
39	Dedifferentiated liposarcoma	Enrichment	MDM2	2.31
40	Gingival overgrowth	Enrichment	RET	2.31
41	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.31
42	Well-differentiated liposarcoma	Enrichment	MDM2	2.31
43	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	2.22
44	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.19
45	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	2.19
46	Congenital generalized lipodystrophy	Enrichment	FOS	2.19
47	Neonatal diabetes mellitus	Enrichment	INS	2.19
48	Haddad syndrome	Enrichment	RET	2.19
49	Multiple endocrine neoplasia, type iia	Enrichment	RET	2.09
50	Histiocytoid hemangioma	Enrichment	FOS	2.09
51	Li-fraumeni syndrome	Enrichment	MDM2	2.01
52	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	2.01
53	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	2.01
54	Type 1 diabetes mellitus	Enrichment	INS	2.01
55	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	2.01
56	Hypertrichosis	Enrichment	CREBBP	2.01
57	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	2.01
58	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.89
59	Hypothyroidism	Enrichment	RET	1.89
60	Permanent neonatal diabetes mellitus	Enrichment	INS	1.89
61	Renal agenesis, bilateral	Enrichment	RET	1.84
62	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	1.82
63	Diabetes mellitus	Enrichment	INS	1.75
64	Specific learning disability	Enrichment	MAPK1	1.75
65	Septooptic dysplasia	Enrichment	ARNT2	1.71
66	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.71
67	Pheochromocytoma	Enrichment	RET	1.65
68	Heart disease	Enrichment	CREBBP	1.65
69	Corpus callosum, agenesis of	Enrichment	CREBBP	1.62
70	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.62
71	Rare genetic intellectual disability	Enrichment	CREBBP	1.62
72	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.62
73	Heart, malformation of	Enrichment	MAPK1	1.54
74	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.52
75	Maturity-onset diabetes of the young	Enrichment	INS	1.50
76	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.47
77	Hepatocellular carcinoma	Enrichment	RET	1.45
78	Scoliosis	Enrichment	CREBBP	1.42
79	Tetralogy of fallot	Enrichment	RET	1.38
80	Hirschsprung disease 1	Enrichment	RET	1.34
81	Differentiated thyroid carcinoma	Enrichment	RET	1.34
82	Benign epilepsy with centrotemporal spikes	Enrichment	RBFOX3	1.19
83	Centralopathic epilepsy	Enrichment	RBFOX3	1.17
84	Hereditary breast carcinoma	Enrichment	RET	1.16
85	Autism spectrum disorder	Enrichment	TNRC6B	1.15
86	Sensorineural hearing loss	Enrichment	RET	1.12
87	Body mass index quantitative trait locus 11	Enrichment	BDNF	1.11
88	Hypertelorism	Enrichment	RET	1.09
89	Hereditary breast ovarian cancer syndrome	Enrichment	PLK2	1.07
90	Myeloma, multiple	Enrichment	CREBBP	1.06
91	Autism	Enrichment	CREBBP	0.96
92	Breast cancer	Enrichment	RET	0.94
93	Colorectal cancer	Enrichment	RET	0.88
94	Ovarian cancer	Enrichment	RET	0.82
95	Congenital nervous system abnormality	Enrichment	CREBBP	0.80
96	Nervous system disease	Enrichment	CREBBP	0.80
97	Microcephaly	Enrichment	MAPK1	0.74
98	Inherited cancer-predisposing syndrome	Enrichment	RET	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcriptional Regulation by NPAS4

Pathway Network for Transcriptional Regulation by NPAS4

Pathway network for the Transcriptional Regulation by NPAS4 SuperPath

Member Pathways for Transcriptional Regulation by NPAS4

Pathways in the Transcriptional Regulation by NPAS4 SuperPath

Gene overlap in member pathways for Transcriptional Regulation by NPAS4 SuperPath

Associated Genes for Transcriptional Regulation by NPAS4

Associated Disorders for Transcriptional Regulation by NPAS4

Disorders associated with Transcriptional Regulation by NPAS4 SuperPath

STRING Interaction Network for Transcriptional Regulation by NPAS4

Sources for Transcriptional Regulation by NPAS4