Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Pathway network for the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

Sources:

Reactome

Pathways in the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

#	Name	Source	Genes
1	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	Reactome	APOE ATAD2 CDKN1A CGA CGB3 CGB5 CGB8 CITED1 CITED2 CITED4 CREBBP DEK EGFR EP300 ERBB2 ESR1 HSPD1 KCTD1 KCTD15 KDM5B KIT MYBL2 MYC NOP2 NPM1 PITX2 SUMO1 TFAP2A TFAP2B TFAP2C TFAP2D TFAP2E TGFA UBE2I VEGFA WWOX YEATS4 YY1 (see all 38) (see less)
2	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	Reactome	ATAD2 CGA CGB3 CGB5 CGB8 EGFR ERBB2 ESR1 KIT TFAP2A TFAP2B TFAP2C TGFA VEGFA YY1 (see all 15) (see less)
3	Activation of the TFAP2 (AP-2) family of transcription factors	Reactome	CITED1 CITED2 CITED4 CREBBP EP300 TFAP2A TFAP2B TFAP2C TFAP2D TFAP2E WWOX YEATS4 (see all 12) (see less)
4	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	Reactome	KCTD1 KCTD15 SUMO1 TFAP2A TFAP2B TFAP2C TFAP2D TFAP2E UBE2I WWOX (see all 10) (see less)
5	TFAP2 (AP-2) family regulates transcription of cell cycle factors	Reactome	CDKN1A KDM5B MYC TFAP2A TFAP2C
6	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Reactome	HSPD1 MYBL2 NOP2 NPM1 TFAP2A
7	TFAP2 (AP-2) family regulates transcription of other transcription factors	Reactome	CITED2 PITX2 TFAP2A TFAP2C

Gene overlap in member pathways for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	7
2	TFAP2C	Transcription Factor AP-2 Gamma	Protein Coding	6
3	TFAP2B	Transcription Factor AP-2 Beta	Protein Coding	4
4	CITED2	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2	Protein Coding	3
5	TFAP2E	Transcription Factor AP-2 Epsilon	Protein Coding	3
6	WWOX	WW Domain Containing Oxidoreductase	Protein Coding	3
7	TFAP2D	Transcription Factor AP-2 Delta	Protein Coding	3
8	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
9	KDM5B	Lysine Demethylase 5B	Protein Coding	2
10	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	2
11	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	2
12	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
13	CITED4	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4	Protein Coding	2
14	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2
15	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
16	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	2
17	ESR1	Estrogen Receptor 1	Protein Coding	2
18	KCTD1	Potassium Channel Tetramerization Domain Containing 1	Protein Coding	2
19	ATAD2	ATPase Family AAA Domain Containing 2	Protein Coding	2
20	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	2
21	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
22	CITED1	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1	Protein Coding	2
23	MYBL2	MYB Proto-Oncogene Like 2	Protein Coding	2
24	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
25	NOP2	NOP2 Nucleolar Protein	Protein Coding	2
26	NPM1	Nucleophosmin 1	Protein Coding	2
27	PITX2	Paired Like Homeodomain 2	Protein Coding	2
28	TGFA	Transforming Growth Factor Alpha	Protein Coding	2
29	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	2
30	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	2
31	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	2
32	YY1	YY1 Transcription Factor	Protein Coding	2
33	KCTD15	Potassium Channel Tetramerization Domain Containing 15	Protein Coding	2
34	YEATS4	YEATS Domain Containing 4	Protein Coding	2
35	CGB5	Chorionic Gonadotropin Subunit Beta 5	Protein Coding	2
36	CGB8	Chorionic Gonadotropin Subunit Beta 8	Protein Coding	2
37	APOE	Apolipoprotein E	Protein Coding	1
38	DEK	DEK Proto-Oncogene	Protein Coding	1

Disorders associated with Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.97
2	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.97
3	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2	4.20
4	Bladder cancer	Enrichment	CDKN1A, EGFR, ERBB2	4.15
5	Lip and oral cavity carcinoma	Enrichment	EGFR, KIT	4.13
6	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	4.13
7	Acute myeloid leukemia with maturation	Enrichment	KIT, NPM1	4.12
8	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2	3.99
9	Ovarian cancer	Enrichment	EGFR, ERBB2, KIT	3.77
10	Axenfeld-rieger syndrome, type 1	Enrichment	PITX2	3.53
11	Anterior segment dysgenesis 4	Enrichment	PITX2	3.53
12	Ring dermoid of cornea	Enrichment	PITX2	3.53
13	Atrial septal defect 8	Enrichment	CITED2	3.53
14	Sinus venosus atrial septal defect	Enrichment	CITED2	3.53
15	Intellectual developmental disorder, autosomal recessive 65	Enrichment	KDM5B	3.43
16	Spastic paraplegia 13, autosomal dominant	Enrichment	HSPD1	3.43
17	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	3.43
18	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	3.43
19	Lung cancer	Enrichment	EGFR, ERBB2	3.26
20	Axenfeld-rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities	Enrichment	PITX2	3.23
21	Atrial fibrillation, familial, 1	Enrichment	PITX2	3.23
22	Ventricular septal defect 2	Enrichment	CITED2	3.23
23	Esotropia	Enrichment	TFAP2A	3.23
24	Axenfeld-rieger syndrome	Enrichment	PITX2	3.23
25	Lens subluxation	Enrichment	TFAP2A	3.23
26	Burkitt lymphoma	Enrichment	MYC	3.13
27	Leukodystrophy, hypomyelinating, 4	Enrichment	HSPD1	3.13
28	Acute myeloid leukemia without maturation	Enrichment	NPM1	3.13
29	Lymphomatoid papulosis	Enrichment	NPM1	3.13
30	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	3.13
31	Char syndrome	Enrichment	TFAP2B	3.13
32	Scalp-ear-nipple syndrome	Enrichment	KCTD1	3.13
33	Orofacial cleft 10	Enrichment	SUMO1	3.13
34	Patent ductus arteriosus 2	Enrichment	TFAP2B	3.13
35	Esophagus squamous cell carcinoma	Enrichment	WWOX	3.13
36	Menke-hennekam syndrome 1	Enrichment	CREBBP	3.05
37	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	3.05
38	Menke-hennekam syndrome	Enrichment	CREBBP	3.05
39	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.96
40	Paget disease, extramammary	Enrichment	ERBB2	2.96
41	Mastocytosis, cutaneous	Enrichment	KIT	2.96
42	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.96
43	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.96
44	Chronic mast cell leukemia	Enrichment	KIT	2.96
45	Isolated bone marrow mastocytosis	Enrichment	KIT	2.96
46	Smoldering systemic mastocytosis	Enrichment	KIT	2.96
47	Mastocytosis	Enrichment	KIT	2.96
48	Cutaneous mastocytoma	Enrichment	KIT	2.96
49	Typical urticaria pigmentosa	Enrichment	KIT	2.96
50	Nodular urticaria pigmentosa	Enrichment	KIT	2.96
51	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.96
52	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.96
53	Acute mast cell leukemia	Enrichment	KIT	2.96
54	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.96
55	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.96
56	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.96
57	Testis seminoma	Enrichment	KIT	2.96
58	Branchiooculofacial syndrome	Enrichment	TFAP2A	2.93
59	Amblyopia	Enrichment	TFAP2A	2.83
60	Developmental and epileptic encephalopathy 28	Enrichment	WWOX	2.83
61	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	WWOX	2.83
62	Familial patent arterial duct	Enrichment	TFAP2B	2.83
63	Tooth agenesis	Enrichment	SUMO1, TGFA	2.77
64	Branchiootorenal syndrome 1	Enrichment	TFAP2A	2.75
65	Thumb deformity	Enrichment	CREBBP	2.75
66	Menke-hennekam syndrome 2	Enrichment	EP300	2.75
67	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.75
68	Branchiootorenal syndrome	Enrichment	TFAP2A	2.69
69	Piebald trait	Enrichment	KIT	2.66
70	Gabriele-de vries syndrome	Enrichment	YY1	2.66
71	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.66
72	Insulinoma	Enrichment	YY1	2.66
73	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.66
74	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	2.59
75	Tethered spinal cord syndrome	Enrichment	CREBBP	2.58
76	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.58
77	Sea-blue histiocyte disease	Enrichment	APOE	2.55
78	Lipoprotein glomerulopathy	Enrichment	APOE	2.55
79	Cat eye syndrome	Enrichment	TFAP2A	2.53
80	Peters-plus syndrome	Enrichment	PITX2	2.53
81	Estrogen resistance	Enrichment	ESR1	2.48
82	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.48
83	Testicular germ cell cancer	Enrichment	KIT	2.48
84	Migraine without aura	Enrichment	ESR1	2.48
85	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.48
86	Epicanthus	Enrichment	TFAP2A	2.45
87	Congenital nervous system abnormality	Enrichment	CREBBP, WWOX	2.42
88	Nervous system disease	Enrichment	CREBBP, WWOX	2.42
89	Intestinal pseudo-obstruction	Enrichment	TFAP2B	2.35
90	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.35
91	Barrett esophagus	Enrichment	ERBB2	2.35
92	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.35
93	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	2.35
94	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	2.35
95	Anterior segment dysgenesis	Enrichment	PITX2	2.35
96	Acute promyelocytic leukemia	Enrichment	NPM1	2.32
97	Esophageal cancer	Enrichment	WWOX	2.29
98	Hypertrichosis	Enrichment	CREBBP	2.28
99	Patent foramen ovale	Enrichment	CITED2	2.28
100	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	2.26
101	Leukemia, acute myeloid	Enrichment	KIT, NPM1	2.25
102	Alzheimer disease 3	Enrichment	APOE	2.25
103	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.25
104	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	DEK	2.25
105	Microphthalmia	Enrichment	TFAP2A	2.19
106	Cowden syndrome 1	Enrichment	EGFR	2.18
107	Testicular germ cell tumor	Enrichment	KIT	2.18
108	Lung squamous cell carcinoma	Enrichment	EGFR	2.18
109	Dyskeratosis congenita	Enrichment	NPM1	2.16
110	Familial atrial fibrillation	Enrichment	PITX2	2.15
111	Leukodystrophy	Enrichment	HSPD1	2.13
112	Tetralogy of fallot	Enrichment	CITED2	2.12
113	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.11
114	Gastrointestinal stromal tumor	Enrichment	KIT	2.11
115	Charge syndrome	Enrichment	EP300	2.10
116	Alzheimer disease 4	Enrichment	APOE	2.08
117	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	2.07
118	Glioma susceptibility 1	Enrichment	ERBB2	2.05
119	Inherited cancer-predisposing syndrome	Enrichment	EGFR, KIT	2.04
120	Visceral heterotaxy 5	Enrichment	CITED2	2.04
121	46,xy partial gonadal dysgenesis	Enrichment	WWOX	1.99
122	Macular degeneration, age-related, 1	Enrichment	APOE	1.95
123	Migraine with or without aura 1	Enrichment	ESR1	1.92
124	Heart disease	Enrichment	CREBBP	1.91
125	Polydactyly, postaxial, type a1	Enrichment	EP300	1.88
126	Corpus callosum, agenesis of	Enrichment	CREBBP	1.88
127	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.88
128	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.88
129	Alzheimer disease 2	Enrichment	APOE	1.86
130	Craniosynostosis	Enrichment	TFAP2B	1.83
131	Hypertelorism	Enrichment	TFAP2A	1.82
132	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.78
133	Lipid metabolism disorder	Enrichment	APOE	1.78
134	Gliosarcoma	Enrichment	EGFR	1.76
135	Developmental and epileptic encephalopathy 1	Enrichment	WWOX	1.74
136	Autosomal dominant non-syndromic intellectual disability	Enrichment	KDM5B	1.74
137	Giant cell glioblastoma	Enrichment	EGFR	1.73
138	Arteriovenous malformations of the brain	Enrichment	EGFR	1.68
139	Scoliosis	Enrichment	CREBBP	1.68
140	Autosomal recessive non-syndromic intellectual disability	Enrichment	KDM5B	1.67
141	Myocardial infarction	Enrichment	ESR1	1.62
142	Colorectal cancer	Enrichment	EP300, ERBB2	1.61
143	Epilepsy	Enrichment	WWOX	1.54
144	Benign epilepsy with centrotemporal spikes	Enrichment	WWOX	1.53
145	Centralopathic epilepsy	Enrichment	WWOX	1.50
146	Hirschsprung disease 1	Enrichment	ERBB2	1.50
147	West syndrome	Enrichment	WWOX	1.50
148	Alzheimer's disease	Enrichment	APOE	1.45
149	Autism spectrum disorder	Enrichment	KDM5B	1.40
150	Undetermined early-onset epileptic encephalopathy	Enrichment	WWOX	1.39
151	Familial hypercholesterolemia	Enrichment	APOE	1.38
152	Gastric cancer	Enrichment	ERBB2	1.33
153	Alzheimer disease, familial, 1	Enrichment	APOE	1.33
154	Hereditary breast carcinoma	Enrichment	ESR1	1.32
155	Myeloma, multiple	Enrichment	CREBBP	1.31
156	Autism	Enrichment	CREBBP	1.21
157	Breast cancer	Enrichment	ESR1	1.10
158	Microcephaly	Enrichment	EP300	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Pathway Network for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Pathway network for the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

Member Pathways for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Pathways in the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

Gene overlap in member pathways for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

Associated Genes for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Associated Disorders for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Disorders associated with Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors SuperPath

STRING Interaction Network for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Sources for Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors